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The map label for this gene is pyrH

Identifier: 150401173

GI number: 150401173

Start: 764920

End: 765597

Strand: Direct

Name: pyrH

Synonym: Maeo_0744

Alternate gene names: 150401173

Gene position: 764920-765597 (Clockwise)

Preceding gene: 150401172

Following gene: 150401174

Centisome position: 48.74

GC content: 34.22

Gene sequence:

>678_bases
ATGAAAATAGTTTTTGCATTAGGTGGTTCTGTATTAATGCCTAAAGAAGGGGCATCGGTAGATAAAATAAAAGAATATGC
TGATGTGTTTAAAAAAATGAAGGATGAAAATAATGAAATATGTATTGTGGTCGGAGGAGGAAACACGGCACGGACTTACA
TTTCTGTTGCAAGAGAATTTGCAAATGAATCATTTTGTGATGAAATTGGAATACTTGCCACAAGAATGAATAGTATGTTG
TTAATATCTGCACTAGATAATTATGCCGTTAAAAAAGTGCCTGAAAATTTCAAGGATGCGGAAATAATATTAAATTTAAA
TAAAATTGTGGTAATGGGGGGAACACATCCAGCACATACAACAGATGCTGTTGCGGCATCACTTGCGGAATATATTGATG
CCGATATGCTTGTAGTAGCTACAAATGTAGATGGAGTATATGATAAAGACCCGCGAAAACATGCTGATGCTAAAAAAATA
AAACAATTAACTACAAAAGAATTATTAAATATTACTGGTTCAGCGTCAATTGAAGCAGGGAGCTCCACGATTATTGACCC
ATTGGCATCAAAAATTATCGACAGGGCAAAATTAAAAACCATTGTTATTGAGGGAGCTCCCGAAGAGATTTTAAAAATAC
TAAATAATACCCACAGCGGAACAATAATAAATCCATAG

Upstream 100 bases:

>100_bases
TTATATATAATATCTATAACTATATCATTAAAATATTCTAATGAACTTAATGAATATAACAATACAATTATATTTTAAAC
AAAATAATAAAGGAGATATG

Downstream 100 bases:

>100_bases
GTGATAATATGGCAGTAGAAAAACATAGCCATTGTATAATGTGCGGAGTATCAATTCCGCCAGATGAAATATTATGCTCC
GAAAAATGTAGGGAAGCATA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKIVFALGGSVLMPKEGASVDKIKEYADVFKKMKDENNEICIVVGGGNTARTYISVAREFANESFCDEIGILATRMNSML
LISALDNYAVKKVPENFKDAEIILNLNKIVVMGGTHPAHTTDAVAASLAEYIDADMLVVATNVDGVYDKDPRKHADAKKI
KQLTTKELLNITGSASIEAGSSTIIDPLASKIIDRAKLKTIVIEGAPEEILKILNNTHSGTIINP

Sequences:

>Translated_225_residues
MKIVFALGGSVLMPKEGASVDKIKEYADVFKKMKDENNEICIVVGGGNTARTYISVAREFANESFCDEIGILATRMNSML
LISALDNYAVKKVPENFKDAEIILNLNKIVVMGGTHPAHTTDAVAASLAEYIDADMLVVATNVDGVYDKDPRKHADAKKI
KQLTTKELLNITGSASIEAGSSTIIDPLASKIIDRAKLKTIVIEGAPEEILKILNNTHSGTIINP
>Mature_225_residues
MKIVFALGGSVLMPKEGASVDKIKEYADVFKKMKDENNEICIVVGGGNTARTYISVAREFANESFCDEIGILATRMNSML
LISALDNYAVKKVPENFKDAEIILNLNKIVVMGGTHPAHTTDAVAASLAEYIDADMLVVATNVDGVYDKDPRKHADAKKI
KQLTTKELLNITGSASIEAGSSTIIDPLASKIIDRAKLKTIVIEGAPEEILKILNNTHSGTIINP

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=184, Percent_Identity=30.9782608695652, Blast_Score=74, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_META3 (A6UV05)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324939.1
- ProteinModelPortal:   A6UV05
- SMR:   A6UV05
- STRING:   A6UV05
- GeneID:   5327351
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0744
- eggNOG:   arNOG05927
- HOGENOM:   HBG497552
- OMA:   TRANAML
- ProtClustDB:   PRK00358
- BioCyc:   MAEO419665:MAEO_0744-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24274; Mature: 24274

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: BINDING 46-46 BINDING 47-47 BINDING 51-51 BINDING 67-67 BINDING 141-141 BINDING 142-142 BINDING 147-147 BINDING 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFALGGSVLMPKEGASVDKIKEYADVFKKMKDENNEICIVVGGGNTARTYISVAREF
CEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
ANESFCDEIGILATRMNSMLLISALDNYAVKKVPENFKDAEIILNLNKIVVMGGTHPAHT
HCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCEEEEEECEEEEECCCCCCCH
TDAVAASLAEYIDADMLVVATNVDGVYDKDPRKHADAKKIKQLTTKELLNITGSASIEAG
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
SSTIIDPLASKIIDRAKLKTIVIEGAPEEILKILNNTHSGTIINP
CCHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure
MKIVFALGGSVLMPKEGASVDKIKEYADVFKKMKDENNEICIVVGGGNTARTYISVAREF
CEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
ANESFCDEIGILATRMNSMLLISALDNYAVKKVPENFKDAEIILNLNKIVVMGGTHPAHT
HCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCEEEEEECEEEEECCCCCCCH
TDAVAASLAEYIDADMLVVATNVDGVYDKDPRKHADAKKIKQLTTKELLNITGSASIEAG
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
SSTIIDPLASKIIDRAKLKTIVIEGAPEEILKILNNTHSGTIINP
CCHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA