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The map label for this gene is ilvD

Identifier: 150401110

GI number: 150401110

Start: 697171

End: 698823

Strand: Reverse

Name: ilvD

Synonym: Maeo_0680

Alternate gene names: 150401110

Gene position: 698823-697171 (Counterclockwise)

Preceding gene: 150401111

Following gene: 150401109

Centisome position: 44.53

GC content: 37.51

Gene sequence:

>1653_bases
ATGATAAGTGATAACTTAAAGAAGGGAGTTTCCAGAGCTCCAAACAGAAGTTTATTAAAGGCATGCGGATATACGGACGA
AGAAATAGAAAAACCATTCATAGGTATAGTAAATAGCTTTACAGAAGTAGTTCCCGGGCATATTCATTTAAATACATTGG
CAGAAGCTGCAAAAAAGGGAGTTTATGCAAACGGCGGAACACCTTTTGAATTTAACACTATGGCCGTATGTGATGGTATA
GCTATGGGACATGAGGGAATGAGATATTCATTACCATCAAGAGAGATAATAGCTGATACAGTAGAAAGTATGGCGAAAGC
TCATGGATTTGATGGATTGGTGCTTATTCCGTCCTGTGATAAAATTGTTCCTGGTATGATTATGGGGGCTCTAAGATTAA
ATATTCCATTCATAGTAATAACTGGCGGACCTATGCAACCTGGGGAGCTCCACGGTAAAAAGTATGACCTTATAAGTGTG
TTTGAAGGAGTTGGAGAATATAATGTTGGAAAAATTACAAAAGAGGAATTAATGGAAATTGAAACCTGTGCCTGTCCGGG
AGCTGGTAGCTGTGCTGGATTATTTACGGCAAATAGTATGGCCTGTTTAACCGAAACACTTGGTTTATCCCTTCCTATGT
GTGCTACTACACATGCAACAGATGCCGAAAAGGTGAGAATTGCAAAAAGAAGCGGTATGAAAATAGTTGATTTGGTAAAA
GAAGATATAAAACCAACAGATTTATTAACAAAGGAATCATTTGAAAATGCAATATTGGTTGATTTGGCTTTGGGAGGTTC
TTCAAATACAACACTTCATATTCCAGCTTTGGCTTATGAAATAGCACCAGAGTTTATAACTCTTGACGATTTTGATAGGT
TATGCGACGAGGTGCCACATATTGCTTCATTAAGGCCGGGGGGAGACCACTTTATAAGCGATTTGCATAGGGCAGGAGGT
ATTCCAGCTGTTTTAAAAATATTGGAGCAAAAAATAAGGGATGCTAACACTGTAAGCGGTAAATCTATTAAAGAGATAAT
AAATGAGGTAAAATACATTGATTATAATATAATTAGACCAGTGGATAAACCAGTGCATGAGACCGCAGGATTAAGGATAT
TAAAAGGAAATATAGCACCTGATGGCTGTGTTGTAAAAATTAGTGCTGTAAATCCAAAGATGTATAAACACGAGGGGCCT
GCACGGGTATTTAATTCAGAGGAGGAAACCATTGACGCAATACTTGGGGGGGACATTAAAGAAGGAGATGTTGTTGTAAT
AAGATATGAAGGTCCAGCAGGAGGTCCGGGAATGAGAGAAATGTTGTCTCCAACTTCTGCTATTTGTGGTATGGGATTAG
ATGACTCTGTTGCACTTATTACAGATGGTAGATTTAGTGGGGGAAGTAGAGGTCCATGTATTGGACATATCTCACCAGAG
GCAATGGCAGGAGGTCCAATAGCCATAATTGAAGAAGGAGATATAATTGCTATTGATATGATGGCAAAAGAAATAAACTT
AAAAATAAGCGAAGAAGAGATAAAAGAAAGATTAGCTAATTGGAAAAAACCAGAAATAAAAGTTAAAAAAGGATATATAT
CAAGATATGCTAAATTAGTATCTTCGGCAAATGAAGGGGCAGTATTGAAATAA

Upstream 100 bases:

>100_bases
CAAAGAATTTTATAAAAATATTTTAATATTATTAATTAGCTTTTATATAGTATATACATTTTTAATTTTTTATATTTCAT
TTTTTTTATATGGTGATAAT

Downstream 100 bases:

>100_bases
CAAATGACTATCATATTTTTTATTTTTATATAATATTTCTATTTTTTTATTTTTTATTTTTTATTTTTGCTATTTTATTA
TAAAATCGTTGAAAACTCCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MISDNLKKGVSRAPNRSLLKACGYTDEEIEKPFIGIVNSFTEVVPGHIHLNTLAEAAKKGVYANGGTPFEFNTMAVCDGI
AMGHEGMRYSLPSREIIADTVESMAKAHGFDGLVLIPSCDKIVPGMIMGALRLNIPFIVITGGPMQPGELHGKKYDLISV
FEGVGEYNVGKITKEELMEIETCACPGAGSCAGLFTANSMACLTETLGLSLPMCATTHATDAEKVRIAKRSGMKIVDLVK
EDIKPTDLLTKESFENAILVDLALGGSSNTTLHIPALAYEIAPEFITLDDFDRLCDEVPHIASLRPGGDHFISDLHRAGG
IPAVLKILEQKIRDANTVSGKSIKEIINEVKYIDYNIIRPVDKPVHETAGLRILKGNIAPDGCVVKISAVNPKMYKHEGP
ARVFNSEEETIDAILGGDIKEGDVVVIRYEGPAGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
AMAGGPIAIIEEGDIIAIDMMAKEINLKISEEEIKERLANWKKPEIKVKKGYISRYAKLVSSANEGAVLK

Sequences:

>Translated_550_residues
MISDNLKKGVSRAPNRSLLKACGYTDEEIEKPFIGIVNSFTEVVPGHIHLNTLAEAAKKGVYANGGTPFEFNTMAVCDGI
AMGHEGMRYSLPSREIIADTVESMAKAHGFDGLVLIPSCDKIVPGMIMGALRLNIPFIVITGGPMQPGELHGKKYDLISV
FEGVGEYNVGKITKEELMEIETCACPGAGSCAGLFTANSMACLTETLGLSLPMCATTHATDAEKVRIAKRSGMKIVDLVK
EDIKPTDLLTKESFENAILVDLALGGSSNTTLHIPALAYEIAPEFITLDDFDRLCDEVPHIASLRPGGDHFISDLHRAGG
IPAVLKILEQKIRDANTVSGKSIKEIINEVKYIDYNIIRPVDKPVHETAGLRILKGNIAPDGCVVKISAVNPKMYKHEGP
ARVFNSEEETIDAILGGDIKEGDVVVIRYEGPAGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
AMAGGPIAIIEEGDIIAIDMMAKEINLKISEEEIKERLANWKKPEIKVKKGYISRYAKLVSSANEGAVLK
>Mature_550_residues
MISDNLKKGVSRAPNRSLLKACGYTDEEIEKPFIGIVNSFTEVVPGHIHLNTLAEAAKKGVYANGGTPFEFNTMAVCDGI
AMGHEGMRYSLPSREIIADTVESMAKAHGFDGLVLIPSCDKIVPGMIMGALRLNIPFIVITGGPMQPGELHGKKYDLISV
FEGVGEYNVGKITKEELMEIETCACPGAGSCAGLFTANSMACLTETLGLSLPMCATTHATDAEKVRIAKRSGMKIVDLVK
EDIKPTDLLTKESFENAILVDLALGGSSNTTLHIPALAYEIAPEFITLDDFDRLCDEVPHIASLRPGGDHFISDLHRAGG
IPAVLKILEQKIRDANTVSGKSIKEIINEVKYIDYNIIRPVDKPVHETAGLRILKGNIAPDGCVVKISAVNPKMYKHEGP
ARVFNSEEETIDAILGGDIKEGDVVVIRYEGPAGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
AMAGGPIAIIEEGDIIAIDMMAKEINLKISEEEIKERLANWKKPEIKVKKGYISRYAKLVSSANEGAVLK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=602, Percent_Identity=41.1960132890365, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI2367371, Length=503, Percent_Identity=33.2007952286282, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1786464, Length=490, Percent_Identity=33.265306122449, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI1788157, Length=551, Percent_Identity=29.4010889292196, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322476, Length=551, Percent_Identity=41.1978221415608, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_META3 (A6UUU2)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324876.1
- ProteinModelPortal:   A6UUU2
- SMR:   A6UUU2
- STRING:   A6UUU2
- GeneID:   5327023
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0680
- eggNOG:   arNOG04340
- HOGENOM:   HBG671001
- OMA:   QSERWES
- ProtClustDB:   PRK00911
- BioCyc:   MAEO419665:MAEO_0680-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58997; Mature: 58997

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDNLKKGVSRAPNRSLLKACGYTDEEIEKPFIGIVNSFTEVVPGHIHLNTLAEAAKKG
CCCCHHHHHHHCCCCHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHHHCC
VYANGGTPFEFNTMAVCDGIAMGHEGMRYSLPSREIIADTVESMAKAHGFDGLVLIPSCD
EECCCCCCEEECHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCEEECCCCC
KIVPGMIMGALRLNIPFIVITGGPMQPGELHGKKYDLISVFEGVGEYNVGKITKEELMEI
HHHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHH
ETCACPGAGSCAGLFTANSMACLTETLGLSLPMCATTHATDAEKVRIAKRSGMKIVDLVK
HHHCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCHHHHHHH
EDIKPTDLLTKESFENAILVDLALGGSSNTTLHIPALAYEIAPEFITLDDFDRLCDEVPH
HCCCCHHHHHHHCCCCEEEEEEEECCCCCCEEEECHHHHHHCCCEEEHHHHHHHHHHCCC
IASLRPGGDHFISDLHRAGGIPAVLKILEQKIRDANTVSGKSIKEIINEVKYIDYNIIRP
HHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECC
VDKPVHETAGLRILKGNIAPDGCVVKISAVNPKMYKHEGPARVFNSEEETIDAILGGDIK
CCCHHHHHCCCEEEECCCCCCCEEEEEEECCCHHHCCCCCHHHCCCCHHHHHHHHCCCCC
EGDVVVIRYEGPAGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
CCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHH
AMAGGPIAIIEEGDIIAIDMMAKEINLKISEEEIKERLANWKKPEIKVKKGYISRYAKLV
HHCCCCEEEEECCCEEEEEEEEEHHCCEECHHHHHHHHHCCCCCCEEEHHHHHHHHHHHH
SSANEGAVLK
HCCCCCCCCC
>Mature Secondary Structure
MISDNLKKGVSRAPNRSLLKACGYTDEEIEKPFIGIVNSFTEVVPGHIHLNTLAEAAKKG
CCCCHHHHHHHCCCCHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHHHCC
VYANGGTPFEFNTMAVCDGIAMGHEGMRYSLPSREIIADTVESMAKAHGFDGLVLIPSCD
EECCCCCCEEECHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCEEECCCCC
KIVPGMIMGALRLNIPFIVITGGPMQPGELHGKKYDLISVFEGVGEYNVGKITKEELMEI
HHHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHH
ETCACPGAGSCAGLFTANSMACLTETLGLSLPMCATTHATDAEKVRIAKRSGMKIVDLVK
HHHCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCHHHHHHH
EDIKPTDLLTKESFENAILVDLALGGSSNTTLHIPALAYEIAPEFITLDDFDRLCDEVPH
HCCCCHHHHHHHCCCCEEEEEEEECCCCCCEEEECHHHHHHCCCEEEHHHHHHHHHHCCC
IASLRPGGDHFISDLHRAGGIPAVLKILEQKIRDANTVSGKSIKEIINEVKYIDYNIIRP
HHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECC
VDKPVHETAGLRILKGNIAPDGCVVKISAVNPKMYKHEGPARVFNSEEETIDAILGGDIK
CCCHHHHHCCCEEEECCCCCCCEEEEEEECCCHHHCCCCCHHHCCCCHHHHHHHHCCCCC
EGDVVVIRYEGPAGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
CCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHH
AMAGGPIAIIEEGDIIAIDMMAKEINLKISEEEIKERLANWKKPEIKVKKGYISRYAKLV
HHCCCCEEEEECCCEEEEEEEEEHHCCEECHHHHHHHHHCCCCCCEEEHHHHHHHHHHHH
SSANEGAVLK
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA