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The map label for this gene is glmU [C]

Identifier: 150401072

GI number: 150401072

Start: 659700

End: 660935

Strand: Reverse

Name: glmU [C]

Synonym: Maeo_0642

Alternate gene names: 150401072

Gene position: 660935-659700 (Counterclockwise)

Preceding gene: 150401075

Following gene: 150401069

Centisome position: 42.11

GC content: 28.96

Gene sequence:

>1236_bases
ATGGATGCTGTAATATTATGTGCTGGAAAAGGAACAAGATTAATGCCATTAACAGAAAATATACCAAAGCCAATGTTGCC
AGTTGGGGGAGCTCCCATTTTAGAACGAATTATTAATAAAATTGATAAACTGGTGGAAAATATATATTTAATTGTGAAAT
ATGAAAAAGAAATAATAATAAACCACTTCAAAAACAATGATAAAATAAAATTTATAGAACAGACGGATATAGACGGAACA
GGATATGCCGTATTAATGGCAAAAAATCATATAAGCGGAGATTTTTTAGTAATAAATGGAGACATAATATTTGATGACGA
TTTAACAAATATAGTAAATGATGATGTTAAAAACATAATAACACTAAATGAGGTAGATAATCCAAGTAATTTCGGGGTTA
TTGTAGTGGATAATCAAAATAATATAATAGAATTACAGGAAAAGCCAAAAAATCCAAAATCTAATCTAATAAATGCGGGA
ATTTACAAATTTGAAAATAAAATATTTGATATATTGGAAACATTACGGCCATCAGAGAGGGGAGAGGTAGAATTAACTGA
TGCAATTAAGGAACTAATTAAAGAAAATAATATAAAAGGAATTAAATTAAACGGATATTGGAATGACATAGGCAAACCAT
GGGATTTATTAGATGCAAATACCCATATTCTAAAAAACATAAAAACAGACATAAAAGGAAAAATCGGGAAAAATGTGGTA
ATTGAAGGAGCCGTAATAATAGAGGAAGGGACGGAAATAAAACCAAATACTGTGATAGAGGGACCTGCAATAATAAAATC
TGGTGCAATTGTTGGACCATTGGCACACATAAGACCAAATACTGTTTTAATGGAAAATACAGGTGTGGGTAATTCCTCAG
AAATAAAAGGAAGCATAATAATGAAAAATTCAAAAGTGCCACATTTATCATATATTGGAGATAGCATAATAGGAGAAAAT
TGTAATATGGGTTGCAACACCATTACAGCAAATTTAAGATTCGATAACAAACCAGTAATGGTAAATATTAAAGAGGAAAA
AGTTAAAAGTGTTAGAAAATTTGGGGCAATAATCGGCCACAATGTAAAAACAGGAATACAGGTTTCATTTATGCCTGGTG
TAAAAATAGGAAGTAATAGCTGGATTGGTGCAAATTGCTTAATTAATAATGATATAGAAAAAGATAGTTTTGTTTATAAA
AAAGAAGAAATAATAATTAAAACAAAAAGAAAATAA

Upstream 100 bases:

>100_bases
TATGGTTAGTGATATATAATATATAAATGATAATTATAAAAACGACAATAAAAATAATAAAAATAATTATAAAATTATAA
AAACAAAAATAGGGGAAAAT

Downstream 100 bases:

>100_bases
AAGATAAAAGAAATTGTTAATATTTTCAATTAATATACATATTTAATTTATATTAATTTTAGCCATCAAGCTGGTTTTTA
AAATATCCATTATAATCATC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MDAVILCAGKGTRLMPLTENIPKPMLPVGGAPILERIINKIDKLVENIYLIVKYEKEIIINHFKNNDKIKFIEQTDIDGT
GYAVLMAKNHISGDFLVINGDIIFDDDLTNIVNDDVKNIITLNEVDNPSNFGVIVVDNQNNIIELQEKPKNPKSNLINAG
IYKFENKIFDILETLRPSERGEVELTDAIKELIKENNIKGIKLNGYWNDIGKPWDLLDANTHILKNIKTDIKGKIGKNVV
IEGAVIIEEGTEIKPNTVIEGPAIIKSGAIVGPLAHIRPNTVLMENTGVGNSSEIKGSIIMKNSKVPHLSYIGDSIIGEN
CNMGCNTITANLRFDNKPVMVNIKEEKVKSVRKFGAIIGHNVKTGIQVSFMPGVKIGSNSWIGANCLINNDIEKDSFVYK
KEEIIIKTKRK

Sequences:

>Translated_411_residues
MDAVILCAGKGTRLMPLTENIPKPMLPVGGAPILERIINKIDKLVENIYLIVKYEKEIIINHFKNNDKIKFIEQTDIDGT
GYAVLMAKNHISGDFLVINGDIIFDDDLTNIVNDDVKNIITLNEVDNPSNFGVIVVDNQNNIIELQEKPKNPKSNLINAG
IYKFENKIFDILETLRPSERGEVELTDAIKELIKENNIKGIKLNGYWNDIGKPWDLLDANTHILKNIKTDIKGKIGKNVV
IEGAVIIEEGTEIKPNTVIEGPAIIKSGAIVGPLAHIRPNTVLMENTGVGNSSEIKGSIIMKNSKVPHLSYIGDSIIGEN
CNMGCNTITANLRFDNKPVMVNIKEEKVKSVRKFGAIIGHNVKTGIQVSFMPGVKIGSNSWIGANCLINNDIEKDSFVYK
KEEIIIKTKRK
>Mature_411_residues
MDAVILCAGKGTRLMPLTENIPKPMLPVGGAPILERIINKIDKLVENIYLIVKYEKEIIINHFKNNDKIKFIEQTDIDGT
GYAVLMAKNHISGDFLVINGDIIFDDDLTNIVNDDVKNIITLNEVDNPSNFGVIVVDNQNNIIELQEKPKNPKSNLINAG
IYKFENKIFDILETLRPSERGEVELTDAIKELIKENNIKGIKLNGYWNDIGKPWDLLDANTHILKNIKTDIKGKIGKNVV
IEGAVIIEEGTEIKPNTVIEGPAIIKSGAIVGPLAHIRPNTVLMENTGVGNSSEIKGSIIMKNSKVPHLSYIGDSIIGEN
CNMGCNTITANLRFDNKPVMVNIKEEKVKSVRKFGAIIGHNVKTGIQVSFMPGVKIGSNSWIGANCLINNDIEKDSFVYK
KEEIIIKTKRK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761619, Length=341, Percent_Identity=25.2199413489736, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI11761621, Length=359, Percent_Identity=25.0696378830084, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1790168, Length=457, Percent_Identity=25.164113785558, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790224, Length=238, Percent_Identity=26.890756302521, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788351, Length=235, Percent_Identity=26.8085106382979, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788355, Length=288, Percent_Identity=26.0416666666667, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787488, Length=258, Percent_Identity=27.1317829457364, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=337, Percent_Identity=29.080118694362, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17509979, Length=342, Percent_Identity=25.7309941520468, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17509981, Length=333, Percent_Identity=24.9249249249249, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320148, Length=342, Percent_Identity=29.5321637426901, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21355443, Length=335, Percent_Identity=28.0597014925373, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24644084, Length=335, Percent_Identity=28.0597014925373, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653912, Length=389, Percent_Identity=21.5938303341902, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_META3 (A6UUQ4)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324838.1
- ProteinModelPortal:   A6UUQ4
- SMR:   A6UUQ4
- STRING:   A6UUQ4
- GeneID:   5326905
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0642
- eggNOG:   arNOG04117
- HOGENOM:   HBG688195
- OMA:   GPNCFIR
- ProtClustDB:   CLSK876450
- BioCyc:   MAEO419665:MAEO_0642-MONOMER
- InterPro:   IPR005835
- InterPro:   IPR011004

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 45556; Mature: 45556

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 308-308 BINDING 74-74 BINDING 79-79 BINDING 80-80 BINDING 132-132 BINDING 144-144 BINDING 158-158 BINDING 384-384 BINDING 401-401

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVILCAGKGTRLMPLTENIPKPMLPVGGAPILERIINKIDKLVENIYLIVKYEKEIII
CCEEEEECCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECCEEEE
NHFKNNDKIKFIEQTDIDGTGYAVLMAKNHISGDFLVINGDIIFDDDLTNIVNDDVKNII
EECCCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEEECCEEECCCHHHHHHHHHHHEE
TLNEVDNPSNFGVIVVDNQNNIIELQEKPKNPKSNLINAGIYKFENKIFDILETLRPSER
EEECCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GEVELTDAIKELIKENNIKGIKLNGYWNDIGKPWDLLDANTHILKNIKTDIKGKIGKNVV
CCEEHHHHHHHHHHHCCCCEEEECCEECCCCCCCEEECCCHHHHHHHHHHHCCCCCCCEE
IEGAVIIEEGTEIKPNTVIEGPAIIKSGAIVGPLAHIRPNTVLMENTGVGNSSEIKGSII
EEEEEEEECCCCCCCCEEECCCCEEECCCEECCHHHCCCCEEEEECCCCCCCCCCCEEEE
MKNSKVPHLSYIGDSIIGENCNMGCNTITANLRFDNKPVMVNIKEEKVKSVRKFGAIIGH
EECCCCCCHHHCCCHHCCCCCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHCC
NVKTGIQVSFMPGVKIGSNSWIGANCLINNDIEKDSFVYKKEEIIIKTKRK
CCCCCEEEEEECCEEECCCCEEEEEEEECCCCCCCCEEEEEEEEEEEECCC
>Mature Secondary Structure
MDAVILCAGKGTRLMPLTENIPKPMLPVGGAPILERIINKIDKLVENIYLIVKYEKEIII
CCEEEEECCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECCEEEE
NHFKNNDKIKFIEQTDIDGTGYAVLMAKNHISGDFLVINGDIIFDDDLTNIVNDDVKNII
EECCCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEEECCEEECCCHHHHHHHHHHHEE
TLNEVDNPSNFGVIVVDNQNNIIELQEKPKNPKSNLINAGIYKFENKIFDILETLRPSER
EEECCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GEVELTDAIKELIKENNIKGIKLNGYWNDIGKPWDLLDANTHILKNIKTDIKGKIGKNVV
CCEEHHHHHHHHHHHCCCCEEEECCEECCCCCCCEEECCCHHHHHHHHHHHCCCCCCCEE
IEGAVIIEEGTEIKPNTVIEGPAIIKSGAIVGPLAHIRPNTVLMENTGVGNSSEIKGSII
EEEEEEEECCCCCCCCEEECCCCEEECCCEECCHHHCCCCEEEEECCCCCCCCCCCEEEE
MKNSKVPHLSYIGDSIIGENCNMGCNTITANLRFDNKPVMVNIKEEKVKSVRKFGAIIGH
EECCCCCCHHHCCCHHCCCCCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHCC
NVKTGIQVSFMPGVKIGSNSWIGANCLINNDIEKDSFVYKKEEIIIKTKRK
CCCCCEEEEEECCEEECCCCEEEEEEEECCCCCCCCEEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA