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The map label for this gene is deoA [C]

Identifier: 150401048

GI number: 150401048

Start: 632724

End: 634238

Strand: Reverse

Name: deoA [C]

Synonym: Maeo_0618

Alternate gene names: 150401048

Gene position: 634238-632724 (Counterclockwise)

Preceding gene: 150401049

Following gene: 150401041

Centisome position: 40.41

GC content: 36.57

Gene sequence:

>1515_bases
ATGCTATTTTTAGAAGTTAAATTTTTAGACTTGGATTTAGAGGCTAATGCCGTGATTATAAATGAGGAGGATATAAAAGG
CACAGCATATTATTCACAAGACAGAGTATTAATAGAATCCAAAACATGTTCTTTTATCGGGACACTTCAATCAACAAAAA
CAATGATTAAACCGGGCGAAGTAGGAGTTAGCAAATATATTAAAGATGTAAAATTAAATGAAGGTGAAGAGGTTCGAGTA
AGACATGCTCAAAAACCACAGTCTGTCTCATATATACGAAAAAAAATGAATGGTCAAACCTTAACTGCTGATGAAATTCA
TACCATTATTGATGAAATAGTTTCAAAAAAATTAACCAATGTCGAACTTTCTGCATTTTTAGTATCCACATACATAAGAG
GAATGAATACGGAGGAAATAGTAGCGATGACAAAAAGAATGGCGGAGACAGGGGACACAATACAATGGGAAAAAAGACCC
GTTGTAGATGTCCATAGTATTGGGGGCGTTCCAGGTAACAAATATGCTCTTTTAACTATTCCCATAGTGGCAGCGGCCGG
AATGACTATTCCAAAAACCTCTTCTCGAGCAATTACCTCCGCAGCTGGAACAGCTGATGTTTTAGAAGTAATAACAAATG
TAAATTTAAGCTGTGAGGAAATACAAAGAGTGGCAAAAACAACAGGAGGATGTTTGGCATGGGGCGGAGCTGTAAATTTA
GCACCTGCTGACGATATTATTATAAATGTGGAAAGGCCCTTATCAATAGACCCACAACCTCAATTATTGGCAAGTGTAAT
GGCTAAAAAGATAGCAACTGGAATTGATTATACGGTAATAGATATACCTGTTGGATATGGAGTTAAAATAAAAAATGAAA
AGGAAGGAAACCAGTTGGCAAGAAAATTTATAGAGTTGGGGGAGCTCCTCGGTATTCGTGTTGAATGTGTTTTAACCTAT
GGTGGTCAGCCAATAGGTAGGGCAATAGGTCCAGCTCTTGAAATAAAAGAGGCTCTAATGGCATTGCACGACCCAAAATC
AGCACCAAATAGTTTAATTGAAAAATCAGTATCTCTTGCAGGAGTATTATTGGAGCTCGGGGGTAGAGCACAAATTGGGC
AAGGTCAAAAAGTGGCGTGGGAAATATTGGAATCTGGAAAAGCACTTGAAAAATTCAATGAAATAGTGGTTGAACAGGGG
GGAACAATAACAAAGCCGGAGGAAATTGAATTGGGAGAATATACAATGGATATTCGCTCACCAAAAGATGGATATGTTAC
GGGAATATCGAATAAATTAATAACAAAATTGGCAAAAGAGGCAGGATGCCCAAAGGATAAAAAAGCAGGAATTTTTTTAG
GGGTAAAAACAGGAAATAAGGTAAATAAAGAGGATATATTATATACCATATATTCAAGTTCAGAGGAGCGATTAGATGCA
GCCGTTAATTTTGCAAGAAGAACATATCCCATTAAAGTTGAGGGAATGATGCTTAAAAGATTGAGTAAATTTTAA

Upstream 100 bases:

>100_bases
TTTTATTTTTTTATTTTTTTTAAATTTTATCTCTATTTTTACACATATTTTTATATACTGTCCAATACAAATTATAATAT
ATAATTATTGGAGGGATATT

Downstream 100 bases:

>100_bases
ATTATAATATTGGAGCTCCGATAAACATGCTTTCCGAAGGACTATAATAAATCTTCAATTTTTTCCGATATTGGGTATAT
TTTATGATAATCCAATGAAT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MLFLEVKFLDLDLEANAVIINEEDIKGTAYYSQDRVLIESKTCSFIGTLQSTKTMIKPGEVGVSKYIKDVKLNEGEEVRV
RHAQKPQSVSYIRKKMNGQTLTADEIHTIIDEIVSKKLTNVELSAFLVSTYIRGMNTEEIVAMTKRMAETGDTIQWEKRP
VVDVHSIGGVPGNKYALLTIPIVAAAGMTIPKTSSRAITSAAGTADVLEVITNVNLSCEEIQRVAKTTGGCLAWGGAVNL
APADDIIINVERPLSIDPQPQLLASVMAKKIATGIDYTVIDIPVGYGVKIKNEKEGNQLARKFIELGELLGIRVECVLTY
GGQPIGRAIGPALEIKEALMALHDPKSAPNSLIEKSVSLAGVLLELGGRAQIGQGQKVAWEILESGKALEKFNEIVVEQG
GTITKPEEIELGEYTMDIRSPKDGYVTGISNKLITKLAKEAGCPKDKKAGIFLGVKTGNKVNKEDILYTIYSSSEERLDA
AVNFARRTYPIKVEGMMLKRLSKF

Sequences:

>Translated_504_residues
MLFLEVKFLDLDLEANAVIINEEDIKGTAYYSQDRVLIESKTCSFIGTLQSTKTMIKPGEVGVSKYIKDVKLNEGEEVRV
RHAQKPQSVSYIRKKMNGQTLTADEIHTIIDEIVSKKLTNVELSAFLVSTYIRGMNTEEIVAMTKRMAETGDTIQWEKRP
VVDVHSIGGVPGNKYALLTIPIVAAAGMTIPKTSSRAITSAAGTADVLEVITNVNLSCEEIQRVAKTTGGCLAWGGAVNL
APADDIIINVERPLSIDPQPQLLASVMAKKIATGIDYTVIDIPVGYGVKIKNEKEGNQLARKFIELGELLGIRVECVLTY
GGQPIGRAIGPALEIKEALMALHDPKSAPNSLIEKSVSLAGVLLELGGRAQIGQGQKVAWEILESGKALEKFNEIVVEQG
GTITKPEEIELGEYTMDIRSPKDGYVTGISNKLITKLAKEAGCPKDKKAGIFLGVKTGNKVNKEDILYTIYSSSEERLDA
AVNFARRTYPIKVEGMMLKRLSKF
>Mature_504_residues
MLFLEVKFLDLDLEANAVIINEEDIKGTAYYSQDRVLIESKTCSFIGTLQSTKTMIKPGEVGVSKYIKDVKLNEGEEVRV
RHAQKPQSVSYIRKKMNGQTLTADEIHTIIDEIVSKKLTNVELSAFLVSTYIRGMNTEEIVAMTKRMAETGDTIQWEKRP
VVDVHSIGGVPGNKYALLTIPIVAAAGMTIPKTSSRAITSAAGTADVLEVITNVNLSCEEIQRVAKTTGGCLAWGGAVNL
APADDIIINVERPLSIDPQPQLLASVMAKKIATGIDYTVIDIPVGYGVKIKNEKEGNQLARKFIELGELLGIRVECVLTY
GGQPIGRAIGPALEIKEALMALHDPKSAPNSLIEKSVSLAGVLLELGGRAQIGQGQKVAWEILESGKALEKFNEIVVEQG
GTITKPEEIELGEYTMDIRSPKDGYVTGISNKLITKLAKEAGCPKDKKAGIFLGVKTGNKVNKEDILYTIYSSSEERLDA
AVNFARRTYPIKVEGMMLKRLSKF

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=321, Percent_Identity=31.7757009345794, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI4503445, Length=321, Percent_Identity=31.7757009345794, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI166158922, Length=321, Percent_Identity=31.7757009345794, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1790842, Length=318, Percent_Identity=29.559748427673, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_META3 (A6UUN0)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324814.1
- ProteinModelPortal:   A6UUN0
- SMR:   A6UUN0
- STRING:   A6UUN0
- GeneID:   5326374
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0618
- eggNOG:   arNOG04585
- HOGENOM:   HBG460532
- OMA:   ACADGRM
- ProtClustDB:   PRK04350
- BioCyc:   MAEO419665:MAEO_0618-MONOMER
- HAMAP:   MF_00703
- InterPro:   IPR017713
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR03327
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 54896; Mature: 54896

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLEVKFLDLDLEANAVIINEEDIKGTAYYSQDRVLIESKTCSFIGTLQSTKTMIKPGE
CEEEEEEEEEEECCCCEEEEECCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCC
VGVSKYIKDVKLNEGEEVRVRHAQKPQSVSYIRKKMNGQTLTADEIHTIIDEIVSKKLTN
CCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
VELSAFLVSTYIRGMNTEEIVAMTKRMAETGDTIQWEKRPVVDVHSIGGVPGNKYALLTI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEHHCCCCCCCCEEEEEE
PIVAAAGMTIPKTSSRAITSAAGTADVLEVITNVNLSCEEIQRVAKTTGGCLAWGGAVNL
EEHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCEEEC
APADDIIINVERPLSIDPQPQLLASVMAKKIATGIDYTVIDIPVGYGVKIKNEKEGNQLA
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCHHHHH
RKFIELGELLGIRVECVLTYGGQPIGRAIGPALEIKEALMALHDPKSAPNSLIEKSVSLA
HHHHHHHHHHCEEEEEEEEECCCCHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVLLELGGRAQIGQGQKVAWEILESGKALEKFNEIVVEQGGTITKPEEIELGEYTMDIRS
HHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCC
PKDGYVTGISNKLITKLAKEAGCPKDKKAGIFLGVKTGNKVNKEDILYTIYSSSEERLDA
CCCCEEECCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHH
AVNFARRTYPIKVEGMMLKRLSKF
HHHHHHHCCCEEECHHHHHHHHCC
>Mature Secondary Structure
MLFLEVKFLDLDLEANAVIINEEDIKGTAYYSQDRVLIESKTCSFIGTLQSTKTMIKPGE
CEEEEEEEEEEECCCCEEEEECCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCC
VGVSKYIKDVKLNEGEEVRVRHAQKPQSVSYIRKKMNGQTLTADEIHTIIDEIVSKKLTN
CCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
VELSAFLVSTYIRGMNTEEIVAMTKRMAETGDTIQWEKRPVVDVHSIGGVPGNKYALLTI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEHHCCCCCCCCEEEEEE
PIVAAAGMTIPKTSSRAITSAAGTADVLEVITNVNLSCEEIQRVAKTTGGCLAWGGAVNL
EEHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCEEEC
APADDIIINVERPLSIDPQPQLLASVMAKKIATGIDYTVIDIPVGYGVKIKNEKEGNQLA
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCHHHHH
RKFIELGELLGIRVECVLTYGGQPIGRAIGPALEIKEALMALHDPKSAPNSLIEKSVSLA
HHHHHHHHHHCEEEEEEEEECCCCHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVLLELGGRAQIGQGQKVAWEILESGKALEKFNEIVVEQGGTITKPEEIELGEYTMDIRS
HHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCC
PKDGYVTGISNKLITKLAKEAGCPKDKKAGIFLGVKTGNKVNKEDILYTIYSSSEERLDA
CCCCEEECCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHH
AVNFARRTYPIKVEGMMLKRLSKF
HHHHHHHCCCEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA