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The map label for this gene is trxA [H]

Identifier: 150401020

GI number: 150401020

Start: 606588

End: 606974

Strand: Reverse

Name: trxA [H]

Synonym: Maeo_0589

Alternate gene names: 150401020

Gene position: 606974-606588 (Counterclockwise)

Preceding gene: 150401021

Following gene: 150401019

Centisome position: 38.67

GC content: 32.3

Gene sequence:

>387_bases
ATGAGCAAATATATAAAACTGTTAATATTGTGTTCCCTATCTTCAATGATATTATTTGCTGGATGTGTGGGGACAGCAGA
TGGGACAAATAACAATGAAAACCATGAGATAAGTTTAAATATTACAGACAATACGGTTATGCTTGAATTTTATGCCGACT
GGTGCGGATATTGTAAGGCCCTTGAACCTACAATAAAAGACCTTGAAAATGAAGGAATTGAAGTAATAAAAATAGACACA
GATAAAAATCAAAATTTGGCAAATCAATATGGCGTAAGGGCATTGCCTACCATCGTATATATTAAAGATGGAAAAATTGT
TGATAAAACCATTGGATACAAGCCAGAGGAAATAAAGGAAAAGGCAAAAAAGATATACAATAACTAA

Upstream 100 bases:

>100_bases
ATCGCACCCCCATGGAATTAAAGTTCGTTTAACTGGTGGCGAAGTGGGTAGGGTTAAAAAAATATATGAAACTGAGAATA
TTTAAATTTTAGATGATAAA

Downstream 100 bases:

>100_bases
TTACTATTTTTTTATTTTATATTTTCGACCTCTGGGAGAAAATATTTAAAATCTCCTGATTTTATGTATATTTTCGACCT
CTGGGAGAAAATATACAATA

Product: thioredoxin domain-containing protein

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 128; Mature: 127

Protein sequence:

>128_residues
MSKYIKLLILCSLSSMILFAGCVGTADGTNNNENHEISLNITDNTVMLEFYADWCGYCKALEPTIKDLENEGIEVIKIDT
DKNQNLANQYGVRALPTIVYIKDGKIVDKTIGYKPEEIKEKAKKIYNN

Sequences:

>Translated_128_residues
MSKYIKLLILCSLSSMILFAGCVGTADGTNNNENHEISLNITDNTVMLEFYADWCGYCKALEPTIKDLENEGIEVIKIDT
DKNQNLANQYGVRALPTIVYIKDGKIVDKTIGYKPEEIKEKAKKIYNN
>Mature_127_residues
SKYIKLLILCSLSSMILFAGCVGTADGTNNNENHEISLNITDNTVMLEFYADWCGYCKALEPTIKDLENEGIEVIKIDTD
KNQNLANQYGVRALPTIVYIKDGKIVDKTIGYKPEEIKEKAKKIYNN

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=79, Percent_Identity=35.4430379746835, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1788936, Length=77, Percent_Identity=32.4675324675325, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI87082331, Length=74, Percent_Identity=31.0810810810811, Blast_Score=62, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=81, Percent_Identity=34.5679012345679, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=81, Percent_Identity=34.5679012345679, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=125, Percent_Identity=35.2, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=80, Percent_Identity=36.25, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=31.7647058823529, Blast_Score=60, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17530795, Length=84, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639826, Length=92, Percent_Identity=32.6086956521739, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=83, Percent_Identity=34.9397590361446, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 14399; Mature: 14268

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYIKLLILCSLSSMILFAGCVGTADGTNNNENHEISLNITDNTVMLEFYADWCGYCKA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHH
LEPTIKDLENEGIEVIKIDTDKNQNLANQYGVRALPTIVYIKDGKIVDKTIGYKPEEIKE
CCHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCCCCEEEEEECCEEEEHHCCCCCHHHHH
KAKKIYNN
HHHHHCCC
>Mature Secondary Structure 
SKYIKLLILCSLSSMILFAGCVGTADGTNNNENHEISLNITDNTVMLEFYADWCGYCKA
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHH
LEPTIKDLENEGIEVIKIDTDKNQNLANQYGVRALPTIVYIKDGKIVDKTIGYKPEEIKE
CCHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCCCCEEEEEECCEEEEHHCCCCCHHHHH
KAKKIYNN
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]