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The map label for this gene is mtaD

Identifier: 150400987

GI number: 150400987

Start: 570271

End: 571557

Strand: Reverse

Name: mtaD

Synonym: Maeo_0556

Alternate gene names: 150400987

Gene position: 571557-570271 (Counterclockwise)

Preceding gene: 150400988

Following gene: 150400984

Centisome position: 36.42

GC content: 29.06

Gene sequence:

>1287_bases
ATGATATTAATTCAAGATGCCACCATAAATAACAAAGTTCAAGACATTCTAATTGAAAAAAATAAGATAAAAAAAATAGG
AAAAAACCTAATACAAAAGGAAAACCTAAACAGAAAGGACTTAAAAATAATAGATGGAAAAAATAAAATAATAATTCCCG
GATTAGTAAATACCCACACACATACACCAATGACATTATTTAGGGGAGTTGCTGATGATTTGCCATTAATGGACTGGTTA
AATAATTATATTTGGAAAATGGAGGCAAATCTAAATGAAAAAATTGTTTATGATGCAACAATGCTTGGATGTATGGAAAT
GATTAAAAGCGGAACAACCACATTCAACGATATGTATTTTTATATGAATGGAATTATAAAGGGAGTTCAAGAAACAGGAA
TTAGGGCATATTTGGGCTATGGAATGATTGATTTATTTGACGAAGAGAAAAGGGAAAATGAATTAAAAGAAACAGTCAAT
ACTGTTGAAAATATACAAAAATTAAATAATCCAAAAATAAATCCAACTGTATCGCCACATGCACCATATACCTGTTCTAT
GGAGCTCCTACAAGAATCCCATAATTTGGCAAAAAAATACAATGTTCCACTACATATACATTTAAATGAAACTATTGATG
AGATAAAAACCGTAGAAGAAATGACTAATAAAAGACCTTTTGAATATTTGGATTCATTTGGATTTTTTAACGGTGTAAAA
GTAATATCTGCCCACAATGTCCATCTATCCAATAAAGAAATTGAAATAATTAAAAATAAAAATATTGCCATATCGCATAA
TCCAATAAGTAATTTAAAATTAGCATCTGGTATAGCCCCAATTCCTAAATTAATGGAAAATACCGTATTAATAACTTTGG
GAACAGATGGTTGTGGTAGTAATAACAATTTAAATTTATTTGAAGAAATAAAAATGGCATCACTTATTCATAAGGGAAAT
TCGTTAAATCCTACTGTGGTTAGTGCATCTCAATCCTTTGAATTTGCCACAAAAAACGGAGCTAACGCCTTAGGTTTAAA
TGCCGGTGAGTTGGTGGAGGGAGCTCTTGCCGATGTTGTTATAATAGACATAAATAAGCCTTATTTAATACCAAATGAAA
ATATTTATTCCCATTTGGTTTATTCCTTTAATGGGGTTGTAGATATGGTTATAATTGACGGGGAAATTGTATTAAATAAT
GGAAAAATGGTAAATATTAATGAAGAAAAAGTTTATGAAAATGCCGAAAAATCATACAATAAATTATTAAATAATTCCGA
TGAATAA

Upstream 100 bases:

>100_bases
GGGGCAGTGTAAGAACCAGAACAACGATATGTTAATGTTAATATATAATTTATATAATCTAATTATATTTAAAAATAAAT
TAAAATAAAAAAGTGATATT

Downstream 100 bases:

>100_bases
TTTTTATTTTTTCTTTTTTATTCTAATTTTTATTCTTTATTATATTATATTATATTATATTATATTATATTATATTATAT
TATACAATAAATATAGTCCC

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MILIQDATINNKVQDILIEKNKIKKIGKNLIQKENLNRKDLKIIDGKNKIIIPGLVNTHTHTPMTLFRGVADDLPLMDWL
NNYIWKMEANLNEKIVYDATMLGCMEMIKSGTTTFNDMYFYMNGIIKGVQETGIRAYLGYGMIDLFDEEKRENELKETVN
TVENIQKLNNPKINPTVSPHAPYTCSMELLQESHNLAKKYNVPLHIHLNETIDEIKTVEEMTNKRPFEYLDSFGFFNGVK
VISAHNVHLSNKEIEIIKNKNIAISHNPISNLKLASGIAPIPKLMENTVLITLGTDGCGSNNNLNLFEEIKMASLIHKGN
SLNPTVVSASQSFEFATKNGANALGLNAGELVEGALADVVIIDINKPYLIPNENIYSHLVYSFNGVVDMVIIDGEIVLNN
GKMVNINEEKVYENAEKSYNKLLNNSDE

Sequences:

>Translated_428_residues
MILIQDATINNKVQDILIEKNKIKKIGKNLIQKENLNRKDLKIIDGKNKIIIPGLVNTHTHTPMTLFRGVADDLPLMDWL
NNYIWKMEANLNEKIVYDATMLGCMEMIKSGTTTFNDMYFYMNGIIKGVQETGIRAYLGYGMIDLFDEEKRENELKETVN
TVENIQKLNNPKINPTVSPHAPYTCSMELLQESHNLAKKYNVPLHIHLNETIDEIKTVEEMTNKRPFEYLDSFGFFNGVK
VISAHNVHLSNKEIEIIKNKNIAISHNPISNLKLASGIAPIPKLMENTVLITLGTDGCGSNNNLNLFEEIKMASLIHKGN
SLNPTVVSASQSFEFATKNGANALGLNAGELVEGALADVVIIDINKPYLIPNENIYSHLVYSFNGVVDMVIIDGEIVLNN
GKMVNINEEKVYENAEKSYNKLLNNSDE
>Mature_428_residues
MILIQDATINNKVQDILIEKNKIKKIGKNLIQKENLNRKDLKIIDGKNKIIIPGLVNTHTHTPMTLFRGVADDLPLMDWL
NNYIWKMEANLNEKIVYDATMLGCMEMIKSGTTTFNDMYFYMNGIIKGVQETGIRAYLGYGMIDLFDEEKRENELKETVN
TVENIQKLNNPKINPTVSPHAPYTCSMELLQESHNLAKKYNVPLHIHLNETIDEIKTVEEMTNKRPFEYLDSFGFFNGVK
VISAHNVHLSNKEIEIIKNKNIAISHNPISNLKLASGIAPIPKLMENTVLITLGTDGCGSNNNLNLFEEIKMASLIHKGN
SLNPTVVSASQSFEFATKNGANALGLNAGELVEGALADVVIIDINKPYLIPNENIYSHLVYSFNGVVDMVIIDGEIVLNN
GKMVNINEEKVYENAEKSYNKLLNNSDE

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=339, Percent_Identity=28.9085545722714, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI87082177, Length=448, Percent_Identity=27.4553571428571, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789249, Length=365, Percent_Identity=26.5753424657534, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17540282, Length=354, Percent_Identity=22.8813559322034, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319963, Length=375, Percent_Identity=26.9333333333333, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24643849, Length=346, Percent_Identity=27.1676300578035, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_META3 (A6UUG9)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324753.1
- ProteinModelPortal:   A6UUG9
- SMR:   A6UUG9
- STRING:   A6UUG9
- GeneID:   5327216
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0556
- eggNOG:   arNOG04550
- HOGENOM:   HBG668170
- OMA:   KVIDMAT
- ProtClustDB:   CLSK876616
- BioCyc:   MAEO419665:MAEO_0556-MONOMER
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 48096; Mature: 48096

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: BINDING 88-88 BINDING 180-180 BINDING 210-210 BINDING 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIQDATINNKVQDILIEKNKIKKIGKNLIQKENLNRKDLKIIDGKNKIIIPGLVNTHT
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCC
HTPMTLFRGVADDLPLMDWLNNYIWKMEANLNEKIVYDATMLGCMEMIKSGTTTFNDMYF
CCHHHHHHHHHCCCCHHHHHHHHEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHH
YMNGIIKGVQETGIRAYLGYGMIDLFDEEKRENELKETVNTVENIQKLNNPKINPTVSPH
HHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
APYTCSMELLQESHNLAKKYNVPLHIHLNETIDEIKTVEEMTNKRPFEYLDSFGFFNGVK
CCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEE
VISAHNVHLSNKEIEIIKNKNIAISHNPISNLKLASGIAPIPKLMENTVLITLGTDGCGS
EEEEEEEEECCCEEEEEECCCEEEECCCCCCCCHHCCCCHHHHHHCCEEEEEECCCCCCC
NNNLNLFEEIKMASLIHKGNSLNPTVVSASQSFEFATKNGANALGLNAGELVEGALADVV
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCEECCCHHHHHHCCCCCEE
IIDINKPYLIPNENIYSHLVYSFNGVVDMVIIDGEIVLNNGKMVNINEEKVYENAEKSYN
EEECCCCEECCCCCHHHHHHHHHCCEEEEEEECCEEEECCCEEEEECHHHHHHHHHHHHH
KLLNNSDE
HHHCCCCC
>Mature Secondary Structure
MILIQDATINNKVQDILIEKNKIKKIGKNLIQKENLNRKDLKIIDGKNKIIIPGLVNTHT
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCC
HTPMTLFRGVADDLPLMDWLNNYIWKMEANLNEKIVYDATMLGCMEMIKSGTTTFNDMYF
CCHHHHHHHHHCCCCHHHHHHHHEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHH
YMNGIIKGVQETGIRAYLGYGMIDLFDEEKRENELKETVNTVENIQKLNNPKINPTVSPH
HHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
APYTCSMELLQESHNLAKKYNVPLHIHLNETIDEIKTVEEMTNKRPFEYLDSFGFFNGVK
CCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEE
VISAHNVHLSNKEIEIIKNKNIAISHNPISNLKLASGIAPIPKLMENTVLITLGTDGCGS
EEEEEEEEECCCEEEEEECCCEEEECCCCCCCCHHCCCCHHHHHHCCEEEEEECCCCCCC
NNNLNLFEEIKMASLIHKGNSLNPTVVSASQSFEFATKNGANALGLNAGELVEGALADVV
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCEECCCHHHHHHCCCCCEE
IIDINKPYLIPNENIYSHLVYSFNGVVDMVIIDGEIVLNNGKMVNINEEKVYENAEKSYN
EEECCCCEECCCCCHHHHHHHHHCCEEEEEEECCEEEECCCEEEEECHHHHHHHHHHHHH
KLLNNSDE
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA