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The map label for this gene is purC [H]

Identifier: 150400900

GI number: 150400900

Start: 491275

End: 492003

Strand: Direct

Name: purC [H]

Synonym: Maeo_0468

Alternate gene names: 150400900

Gene position: 491275-492003 (Clockwise)

Preceding gene: 150400899

Following gene: 150400901

Centisome position: 31.3

GC content: 32.37

Gene sequence:

>729_bases
ATGGAAATAAATATTAACGAAATCTTAAAAAATGAACCATTATACAGTGGAAAGGCAAAATCAATATATGAAATAGACGA
TGAAAAAGTATTAATTGAATTTAGGGACGATATTACCGCAGGAGATGGAGAAAAGCACGATATAAAAAAAGGAAAAGGTC
ATTTAAATGCTTTAATATCTTCAAAATTATTCGAACTTTTGGAAGAAAATGGGGTCCCCACACAGTTTATGGAATATGTT
GAACCAATATATATGGTTGCTAAAAATGTGGAAATTATATTAATTGAAGTAATTGTAAGAAATATTACAGCAGGTAGTTT
ATGTAGAAGATACCCATTTGAAGAAGGTAAAGAATTGACCACTCCTATTGTGCAATTTGACTATAAAGACGACGACTATG
GGGACCCCATGTTAAACGAGGATATAGCCATTGCACTAAATCTTGCAACTGAGGAGGAGTTAAAAGAGTTAAAAGAGTTG
GCACTAATAGTAAATGAAATTCTAAAAAAATTCTTTGACGAAAAGGGCATAATCCTTGTAGATTTCAAAATCGAGATTGG
AAGAACAAAAGATGGAAAATTGGTAGTTGCAGACGAGATAAGCCCGGACACCATGAGATTATGGGATAAAGAAACAAAAG
ATGTTCTTGATAAAGATGTATATAGAAAAGACATGGGCGATGTTGTTGGAAAATACGAAGTTGTAGCAAAAAGAATAGGA
TGCATTTAA

Upstream 100 bases:

>100_bases
TAATGCCATTGAAAATATGGGCAATATGGATATTGAAGTGTATAGCATATAGAATAATATAAACAAAAAAAGAAATAAAC
AAAAAAGAAAGGTGTTAATA

Downstream 100 bases:

>100_bases
ATTAATTAAATTAATTATATTATTATTTTTTTATATCTAAAAAGATGGCTTTATTTTTAAATTGAATGAAAATAGTGTAA
TATAAAATAGTGTAAGATAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MEININEILKNEPLYSGKAKSIYEIDDEKVLIEFRDDITAGDGEKHDIKKGKGHLNALISSKLFELLEENGVPTQFMEYV
EPIYMVAKNVEIILIEVIVRNITAGSLCRRYPFEEGKELTTPIVQFDYKDDDYGDPMLNEDIAIALNLATEEELKELKEL
ALIVNEILKKFFDEKGIILVDFKIEIGRTKDGKLVVADEISPDTMRLWDKETKDVLDKDVYRKDMGDVVGKYEVVAKRIG
CI

Sequences:

>Translated_242_residues
MEININEILKNEPLYSGKAKSIYEIDDEKVLIEFRDDITAGDGEKHDIKKGKGHLNALISSKLFELLEENGVPTQFMEYV
EPIYMVAKNVEIILIEVIVRNITAGSLCRRYPFEEGKELTTPIVQFDYKDDDYGDPMLNEDIAIALNLATEEELKELKEL
ALIVNEILKKFFDEKGIILVDFKIEIGRTKDGKLVVADEISPDTMRLWDKETKDVLDKDVYRKDMGDVVGKYEVVAKRIG
CI
>Mature_242_residues
MEININEILKNEPLYSGKAKSIYEIDDEKVLIEFRDDITAGDGEKHDIKKGKGHLNALISSKLFELLEENGVPTQFMEYV
EPIYMVAKNVEIILIEVIVRNITAGSLCRRYPFEEGKELTTPIVQFDYKDDDYGDPMLNEDIAIALNLATEEELKELKEL
ALIVNEILKKFFDEKGIILVDFKIEIGRTKDGKLVVADEISPDTMRLWDKETKDVLDKDVYRKDMGDVVGKYEVVAKRIG
CI

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=247, Percent_Identity=33.6032388663968, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI5453539, Length=247, Percent_Identity=33.6032388663968, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI119220559, Length=254, Percent_Identity=32.6771653543307, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=40.948275862069, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17531275, Length=228, Percent_Identity=31.5789473684211, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI18860083, Length=217, Percent_Identity=32.258064516129, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583917, Length=218, Percent_Identity=28.8990825688073, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27681; Mature: 27681

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEININEILKNEPLYSGKAKSIYEIDDEKVLIEFRDDITAGDGEKHDIKKGKGHLNALIS
CCCCHHHHHCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHCHHHHHHHHH
SKLFELLEENGVPTQFMEYVEPIYMVAKNVEIILIEVIVRNITAGSLCRRYPFEEGKELT
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
TPIVQFDYKDDDYGDPMLNEDIAIALNLATEEELKELKELALIVNEILKKFFDEKGIILV
CCEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
DFKIEIGRTKDGKLVVADEISPDTMRLWDKETKDVLDKDVYRKDMGDVVGKYEVVAKRIG
EEEEEECCCCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CI
CC
>Mature Secondary Structure
MEININEILKNEPLYSGKAKSIYEIDDEKVLIEFRDDITAGDGEKHDIKKGKGHLNALIS
CCCCHHHHHCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHCHHHHHHHHH
SKLFELLEENGVPTQFMEYVEPIYMVAKNVEIILIEVIVRNITAGSLCRRYPFEEGKELT
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
TPIVQFDYKDDDYGDPMLNEDIAIALNLATEEELKELKELALIVNEILKKFFDEKGIILV
CCEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
DFKIEIGRTKDGKLVVADEISPDTMRLWDKETKDVLDKDVYRKDMGDVVGKYEVVAKRIG
EEEEEECCCCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]