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The map label for this gene is aroE

Identifier: 150400882

GI number: 150400882

Start: 472656

End: 473492

Strand: Reverse

Name: aroE

Synonym: Maeo_0450

Alternate gene names: 150400882

Gene position: 473492-472656 (Counterclockwise)

Preceding gene: 150400903

Following gene: 150400881

Centisome position: 30.17

GC content: 29.87

Gene sequence:

>837_bases
ATGATAAACTCAAAAACAAAACTATTAGGACTTATTGGACATCCCGTGGAACATTCGTTATCTCCAACAATGCATAATGA
AGCCATAAAAGATAAAGATTTAAATTATGTATATTTGGCTTTTGATGTAGAATCAGAAAATTTAAAAGATGTGGTTAATG
GTGCAAAAGCCATAGGCTGGAAAGGGTTTAACATCACAATACCCCATAAAATAGAAATAATGAAATATCTTGATAAAATT
GACAACGATGCAAAATTAATTGGTGCTGTAAATACTGTAAAAATAGAAAATAATAAAGCAATAGGATATAATACGGACGG
AATAGGGGCCCGGCTATCAATTGAAGAAATAATAGGGGAAGTAAAAGATTATAATATTTTAGTAATTGGAGCAGGAGGTT
CTTCTCGTGCAGTGTGTTGCGAATTAGCCAAAAACAATAATTTGACCATAATAAATAGGACAGTTGAAAAAGCAGAAATA
ATAGCAAATGATTTGTCCAATAAATTAAATAATGCCGTATATTATGGGGGATTAAATCACAATTACAACATGGCAAATTT
TGATATTATAATAAATACAACTTCTTTGGGAATGTATCCTAATGTCGATAATAAACCACCAATAAGCATGCAAAATATCA
AAAAAGATGCAGTTGTAATGGATTTAATATACAATCCAAAAGAAACGCTATTTTTAAAAGAGGCAAAGGAAAAAGGTTGC
GCCACAATAAATGGGCTTGGTATGTTAATTTATCAAGGTGCAAAATCTTTTGAAATATGGACTGGTGTAAAACCCGATAT
AAATATTATGAAAAATGCAATAATTGATATATTATAA

Upstream 100 bases:

>100_bases
TATGTGGTAAAATTGATTTATCCTAATATGGCGTATTATATAATATATATAATAAAAATATAACCTAATAATATAGATAA
AAAGAAAGGAAGGCATAATA

Downstream 100 bases:

>100_bases
TAAATATATATGGTAAAAGCGAAATATATCAATAAAGTATATATACTTAAAAAAACAGGTATTTAATACAGTCTACACCA
CAATAAACATATACATATAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MINSKTKLLGLIGHPVEHSLSPTMHNEAIKDKDLNYVYLAFDVESENLKDVVNGAKAIGWKGFNITIPHKIEIMKYLDKI
DNDAKLIGAVNTVKIENNKAIGYNTDGIGARLSIEEIIGEVKDYNILVIGAGGSSRAVCCELAKNNNLTIINRTVEKAEI
IANDLSNKLNNAVYYGGLNHNYNMANFDIIINTTSLGMYPNVDNKPPISMQNIKKDAVVMDLIYNPKETLFLKEAKEKGC
ATINGLGMLIYQGAKSFEIWTGVKPDINIMKNAIIDIL

Sequences:

>Translated_278_residues
MINSKTKLLGLIGHPVEHSLSPTMHNEAIKDKDLNYVYLAFDVESENLKDVVNGAKAIGWKGFNITIPHKIEIMKYLDKI
DNDAKLIGAVNTVKIENNKAIGYNTDGIGARLSIEEIIGEVKDYNILVIGAGGSSRAVCCELAKNNNLTIINRTVEKAEI
IANDLSNKLNNAVYYGGLNHNYNMANFDIIINTTSLGMYPNVDNKPPISMQNIKKDAVVMDLIYNPKETLFLKEAKEKGC
ATINGLGMLIYQGAKSFEIWTGVKPDINIMKNAIIDIL
>Mature_278_residues
MINSKTKLLGLIGHPVEHSLSPTMHNEAIKDKDLNYVYLAFDVESENLKDVVNGAKAIGWKGFNITIPHKIEIMKYLDKI
DNDAKLIGAVNTVKIENNKAIGYNTDGIGARLSIEEIIGEVKDYNILVIGAGGSSRAVCCELAKNNNLTIINRTVEKAEI
IANDLSNKLNNAVYYGGLNHNYNMANFDIIINTTSLGMYPNVDNKPPISMQNIKKDAVVMDLIYNPKETLFLKEAKEKGC
ATINGLGMLIYQGAKSFEIWTGVKPDINIMKNAIIDIL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=270, Percent_Identity=32.5925925925926, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=32.5670498084291, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320332, Length=288, Percent_Identity=29.5138888888889, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_META3 (A6UU64)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324648.1
- ProteinModelPortal:   A6UU64
- SMR:   A6UU64
- STRING:   A6UU64
- GeneID:   5326852
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0450
- eggNOG:   arNOG05588
- HOGENOM:   HBG553408
- OMA:   GYNTDAS
- ProtClustDB:   PRK00258
- BioCyc:   MAEO419665:MAEO_0450-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30672; Mature: 30672

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSKTKLLGLIGHPVEHSLSPTMHNEAIKDKDLNYVYLAFDVESENLKDVVNGAKAIGW
CCCCCCEEEEEECCCHHHCCCCCHHCHHHCCCCCCEEEEEEEECCCHHHHHHCCHHHCCC
KGFNITIPHKIEIMKYLDKIDNDAKLIGAVNTVKIENNKAIGYNTDGIGARLSIEEIIGE
CCCEEECCCHHHHHHHHHHCCCCCEEEEEEEEEEEECCEEEEECCCCCCCEEEHHHHHHH
VKDYNILVIGAGGSSRAVCCELAKNNNLTIINRTVEKAEIIANDLSNKLNNAVYYGGLNH
HCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEECCCCC
NYNMANFDIIINTTSLGMYPNVDNKPPISMQNIKKDAVVMDLIYNPKETLFLKEAKEKGC
CCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHCCCCEEEEEEEECCCHHEEEEHHHHCCC
ATINGLGMLIYQGAKSFEIWTGVKPDINIMKNAIIDIL
EEECCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MINSKTKLLGLIGHPVEHSLSPTMHNEAIKDKDLNYVYLAFDVESENLKDVVNGAKAIGW
CCCCCCEEEEEECCCHHHCCCCCHHCHHHCCCCCCEEEEEEEECCCHHHHHHCCHHHCCC
KGFNITIPHKIEIMKYLDKIDNDAKLIGAVNTVKIENNKAIGYNTDGIGARLSIEEIIGE
CCCEEECCCHHHHHHHHHHCCCCCEEEEEEEEEEEECCEEEEECCCCCCCEEEHHHHHHH
VKDYNILVIGAGGSSRAVCCELAKNNNLTIINRTVEKAEIIANDLSNKLNNAVYYGGLNH
HCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEECCCCC
NYNMANFDIIINTTSLGMYPNVDNKPPISMQNIKKDAVVMDLIYNPKETLFLKEAKEKGC
CCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHCCCCEEEEEEEECCCHHEEEEHHHHCCC
ATINGLGMLIYQGAKSFEIWTGVKPDINIMKNAIIDIL
EEECCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA