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The map label for this gene is argF

Identifier: 150400787

GI number: 150400787

Start: 375139

End: 376053

Strand: Reverse

Name: argF

Synonym: Maeo_0354

Alternate gene names: 150400787

Gene position: 376053-375139 (Counterclockwise)

Preceding gene: 150400788

Following gene: 150400778

Centisome position: 23.96

GC content: 30.82

Gene sequence:

>915_bases
GTGCATCTCCTAACTCTTGAAAATTTAGAAAGAAAAGATATTGAAAATATATTAAATGATGCAATATATTTTAAAAAAAA
TAGAAAATCAGAAAATATTTTAAAAGAAAAAACCGTAGCATTGATTTTCGAAAGTCCATCGACAAGAACGAGAATAAGCT
TTGATATTGCTGTAAATGAATTGGGTGGGCATTCTTTAACATTAAACACGGGGGAAACTCATGTGAGTAAGAAAGAAAGC
ACAAAAGATACGGCAAAAGTATTAAGTAGATTTGTAGATGTAATTGTTGCCCGAGTTAAAGAACACAGTACACTCGAAGA
CTTTACTAAATATGGAAATGTTCCAGTTATAAATGCTTTAAGTGATTTATCTCATCCATGCCAAATATTAGCTGACCTTT
TAACAATCAAAGAACATAAAAATAAATTAAGTGGTCTTAAATTTGCATATTTCGGAGATGGAAATAATGTTTGCAATTCC
CTTATTTTAGGATGTGCCATTATGGGTATGGATATATTTGTTGCCACTCCCGAAGGTTATGAACCAAATGAAAAATTTGT
TAAAATGGCACAACAAATAATAGATAAACAGGGGGAGGGTAGTATAACTATAACAGATGATGCAATAATCTGTGCAAAAG
ATGCCGATGTGCTTTATACTGATGTATGGGTTAGTATGAGTGATAAAAATAAAAATATCGATGAAGTTTTAAAAATATTC
CCTCCATATCAAATAAATGAAAAACTTTTAAGTTATGCTAAAAAAGATGCTATTGTTATGCACTGTTTACCTGCAAATAG
GGGTATGGAAATAACTGACGAGGTAATCGATGGAGAACAATCCGTTGTATATGATGAAGCCGAAAATAGACTTCATGCCC
AAAAAGCAGTATTTAAATATATTTTTAGCAAATAA

Upstream 100 bases:

>100_bases
TATCTGCTATAACGGCATAAAATATCAATAATATAAAATATTTTGAAGTTAAAAAATTCCTGAACCTGCCGTAATAGATA
TACTTTTTATTGGTGATACC

Downstream 100 bases:

>100_bases
TTTAATAATTTTTGTTTATCTTGTTTTATTTTTTTATTATTTTAAATTTATAATATATAAATAGAAAAATAGGAAAATAG
TAATAATATATTAAAAATAA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MHLLTLENLERKDIENILNDAIYFKKNRKSENILKEKTVALIFESPSTRTRISFDIAVNELGGHSLTLNTGETHVSKKES
TKDTAKVLSRFVDVIVARVKEHSTLEDFTKYGNVPVINALSDLSHPCQILADLLTIKEHKNKLSGLKFAYFGDGNNVCNS
LILGCAIMGMDIFVATPEGYEPNEKFVKMAQQIIDKQGEGSITITDDAIICAKDADVLYTDVWVSMSDKNKNIDEVLKIF
PPYQINEKLLSYAKKDAIVMHCLPANRGMEITDEVIDGEQSVVYDEAENRLHAQKAVFKYIFSK

Sequences:

>Translated_304_residues
MHLLTLENLERKDIENILNDAIYFKKNRKSENILKEKTVALIFESPSTRTRISFDIAVNELGGHSLTLNTGETHVSKKES
TKDTAKVLSRFVDVIVARVKEHSTLEDFTKYGNVPVINALSDLSHPCQILADLLTIKEHKNKLSGLKFAYFGDGNNVCNS
LILGCAIMGMDIFVATPEGYEPNEKFVKMAQQIIDKQGEGSITITDDAIICAKDADVLYTDVWVSMSDKNKNIDEVLKIF
PPYQINEKLLSYAKKDAIVMHCLPANRGMEITDEVIDGEQSVVYDEAENRLHAQKAVFKYIFSK
>Mature_304_residues
MHLLTLENLERKDIENILNDAIYFKKNRKSENILKEKTVALIFESPSTRTRISFDIAVNELGGHSLTLNTGETHVSKKES
TKDTAKVLSRFVDVIVARVKEHSTLEDFTKYGNVPVINALSDLSHPCQILADLLTIKEHKNKLSGLKFAYFGDGNNVCNS
LILGCAIMGMDIFVATPEGYEPNEKFVKMAQQIIDKQGEGSITITDDAIICAKDADVLYTDVWVSMSDKNKNIDEVLKIF
PPYQINEKLLSYAKKDAIVMHCLPANRGMEITDEVIDGEQSVVYDEAENRLHAQKAVFKYIFSK

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=292, Percent_Identity=39.7260273972603, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI18105007, Length=311, Percent_Identity=27.0096463022508, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1790703, Length=328, Percent_Identity=35.3658536585366, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1786469, Length=322, Percent_Identity=35.7142857142857, Blast_Score=198, Evalue=3e-52,
Organism=Escherichia coli, GI2367364, Length=314, Percent_Identity=29.6178343949045, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI48994908, Length=297, Percent_Identity=27.6094276094276, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=326, Percent_Identity=26.0736196319018, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322373, Length=310, Percent_Identity=36.1290322580645, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322331, Length=312, Percent_Identity=27.5641025641026, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24642586, Length=308, Percent_Identity=26.6233766233766, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_META3 (A6UTW9)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324553.1
- ProteinModelPortal:   A6UTW9
- SMR:   A6UTW9
- STRING:   A6UTW9
- GeneID:   5327412
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0354
- eggNOG:   arNOG04256
- HOGENOM:   HBG579429
- OMA:   GGHETIE
- ProtClustDB:   PRK00779
- BioCyc:   MAEO419665:MAEO_0354-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34166; Mature: 34166

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 98-98 BINDING 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLLTLENLERKDIENILNDAIYFKKNRKSENILKEKTVALIFESPSTRTRISFDIAVNE
CEEEECCCCCHHHHHHHHHHHHHEECCCCHHHHHHHCEEEEEECCCCCCEEEEEEEEEEC
LGGHSLTLNTGETHVSKKESTKDTAKVLSRFVDVIVARVKEHSTLEDFTKYGNVPVINAL
CCCCEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEHHH
SDLSHPCQILADLLTIKEHKNKLSGLKFAYFGDGNNVCNSLILGCAIMGMDIFVATPEGY
HHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCC
EPNEKFVKMAQQIIDKQGEGSITITDDAIICAKDADVLYTDVWVSMSDKNKNIDEVLKIF
CCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCEEEEEEEEEECCCCCCHHHHHHHC
PPYQINEKLLSYAKKDAIVMHCLPANRGMEITDEVIDGEQSVVYDEAENRLHAQKAVFKY
CCCCCCHHHHHHHHCCEEEEEEECCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
IFSK
HHCC
>Mature Secondary Structure
MHLLTLENLERKDIENILNDAIYFKKNRKSENILKEKTVALIFESPSTRTRISFDIAVNE
CEEEECCCCCHHHHHHHHHHHHHEECCCCHHHHHHHCEEEEEECCCCCCEEEEEEEEEEC
LGGHSLTLNTGETHVSKKESTKDTAKVLSRFVDVIVARVKEHSTLEDFTKYGNVPVINAL
CCCCEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEHHH
SDLSHPCQILADLLTIKEHKNKLSGLKFAYFGDGNNVCNSLILGCAIMGMDIFVATPEGY
HHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCC
EPNEKFVKMAQQIIDKQGEGSITITDDAIICAKDADVLYTDVWVSMSDKNKNIDEVLKIF
CCCHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCEEEEEEEEEECCCCCCHHHHHHHC
PPYQINEKLLSYAKKDAIVMHCLPANRGMEITDEVIDGEQSVVYDEAENRLHAQKAVFKY
CCCCCCHHHHHHHHCCEEEEEEECCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
IFSK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA