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The map label for this gene is tyrS [H]

Identifier: 150400632

GI number: 150400632

Start: 209852

End: 210805

Strand: Direct

Name: tyrS [H]

Synonym: Maeo_0194

Alternate gene names: 150400632

Gene position: 209852-210805 (Clockwise)

Preceding gene: 150400622

Following gene: 150400633

Centisome position: 13.37

GC content: 32.7

Gene sequence:

>954_bases
ATGGAAACAAAATTAGAAAATATTTTAAAAAATACCTCCGAAGTCGTATCGGAAGAAGAATTAAAAGAATTATTAAATGA
AATATCAAAAGGCAACGATAAAATAGCCTATATCGGATTTGAGCCAAGTGGAAGAATACATTTAGGGCACTACCTCCAAA
TAAAAAAAATGATAGATTTGCAAAATGCAGGATTTAAAATTATTATTCTTCTTGCTGACCTCCATGCCTATTTAAACCAA
AAGGGAACAATGGAAGAAATAAAGGAATTGGCAGAACAGAACAAAAAAGTATTTGATGCCATAGGATTAAATGCCACATA
TATATATGGAAGCGAATTTCAATTAAAACCAGAATACAATTTGGATTTATACAAAGTGGCAGTTAATACAACCCTAAAAA
GAGCAAGAAGAAGCATGGAGGTAATAGCAAGAGAGGACGATAATCCAAAAGTTGCAGGTGTTGTTTATCCACTTATGCAG
GTAATAGATATTAAACATCTAAATGCCGATGTGGCCGTTGGAGGAATGGAACAGAGAAAAATACACATGCTTGCAAGGGA
AATTTTACCATCTATGGATTATAAGGCCCCAGTTTGCATACATAACCCAGTTCTTACGGGATTAGATGGAGAAGGTAAAA
TGTCCTCCTCAAAAGGAAATTTCATAGCTGTTGATGATGACGATGCTACAATTAAATCAAAAATAAAAAAGGCATATTGT
CCAATAGGGGAGGTTGAGGGAAATCCAATATTAGAAATTGCAAAATATTATTTAAATTATCCTATAACAATAGAAAGACC
AGAGAAATTTGGGGGAAATTTAATAATCAACAGCTACAATGGGCTTGAAGAATTATACAAAAATAAGGATTTGCATCCAA
TGGATTTAAAAAATGCTGTTGTAAAAGGAATAATTGAAATGCTAACTCTAATTAGGGGCCCAAATAGTGAATAA

Upstream 100 bases:

>100_bases
AGTGATAAAATACACAAAATCAGAGATTTTGAATACAATAGCTCTGCTTTTGTTTAATATTCCGAAGGATATTGAATAAT
TTCTCTCAGAGGTCGAAATT

Downstream 100 bases:

>100_bases
TATAAATAAGGCAATGATAAATAAAATGGATTAAATCATTGTCAATCTTCGGTCTTTTTCATAAATATGCTGTGATTAAA
ACTAATCTCTACCATATTAT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
METKLENILKNTSEVVSEEELKELLNEISKGNDKIAYIGFEPSGRIHLGHYLQIKKMIDLQNAGFKIIILLADLHAYLNQ
KGTMEEIKELAEQNKKVFDAIGLNATYIYGSEFQLKPEYNLDLYKVAVNTTLKRARRSMEVIAREDDNPKVAGVVYPLMQ
VIDIKHLNADVAVGGMEQRKIHMLAREILPSMDYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDDATIKSKIKKAYC
PIGEVEGNPILEIAKYYLNYPITIERPEKFGGNLIINSYNGLEELYKNKDLHPMDLKNAVVKGIIEMLTLIRGPNSE

Sequences:

>Translated_317_residues
METKLENILKNTSEVVSEEELKELLNEISKGNDKIAYIGFEPSGRIHLGHYLQIKKMIDLQNAGFKIIILLADLHAYLNQ
KGTMEEIKELAEQNKKVFDAIGLNATYIYGSEFQLKPEYNLDLYKVAVNTTLKRARRSMEVIAREDDNPKVAGVVYPLMQ
VIDIKHLNADVAVGGMEQRKIHMLAREILPSMDYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDDATIKSKIKKAYC
PIGEVEGNPILEIAKYYLNYPITIERPEKFGGNLIINSYNGLEELYKNKDLHPMDLKNAVVKGIIEMLTLIRGPNSE
>Mature_317_residues
METKLENILKNTSEVVSEEELKELLNEISKGNDKIAYIGFEPSGRIHLGHYLQIKKMIDLQNAGFKIIILLADLHAYLNQ
KGTMEEIKELAEQNKKVFDAIGLNATYIYGSEFQLKPEYNLDLYKVAVNTTLKRARRSMEVIAREDDNPKVAGVVYPLMQ
VIDIKHLNADVAVGGMEQRKIHMLAREILPSMDYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDDATIKSKIKKAYC
PIGEVEGNPILEIAKYYLNYPITIERPEKFGGNLIINSYNGLEELYKNKDLHPMDLKNAVVKGIIEMLTLIRGPNSE

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507947, Length=323, Percent_Identity=33.7461300309598, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71992775, Length=269, Percent_Identity=31.2267657992565, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321624, Length=325, Percent_Identity=34.7692307692308, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21357223, Length=320, Percent_Identity=31.875, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 35668; Mature: 35668

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKLENILKNTSEVVSEEELKELLNEISKGNDKIAYIGFEPSGRIHLGHYLQIKKMIDL
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECHHHHHHHHHHH
QNAGFKIIILLADLHAYLNQKGTMEEIKELAEQNKKVFDAIGLNATYIYGSEFQLKPEYN
CCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCC
LDLYKVAVNTTLKRARRSMEVIAREDDNPKVAGVVYPLMQVIDIKHLNADVAVGGMEQRK
CEEEEHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHH
IHMLAREILPSMDYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDDATIKSKIKKAYC
HHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHC
PIGEVEGNPILEIAKYYLNYPITIERPEKFGGNLIINSYNGLEELYKNKDLHPMDLKNAV
CCCCCCCCHHHHHHHHHHCCCEEEECHHHCCCEEEEECCCCHHHHHHCCCCCCCHHHHHH
VKGIIEMLTLIRGPNSE
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure
METKLENILKNTSEVVSEEELKELLNEISKGNDKIAYIGFEPSGRIHLGHYLQIKKMIDL
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECHHHHHHHHHHH
QNAGFKIIILLADLHAYLNQKGTMEEIKELAEQNKKVFDAIGLNATYIYGSEFQLKPEYN
CCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCC
LDLYKVAVNTTLKRARRSMEVIAREDDNPKVAGVVYPLMQVIDIKHLNADVAVGGMEQRK
CEEEEHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHH
IHMLAREILPSMDYKAPVCIHNPVLTGLDGEGKMSSSKGNFIAVDDDDATIKSKIKKAYC
HHHHHHHHHCCCCCCCCEEECCCEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHC
PIGEVEGNPILEIAKYYLNYPITIERPEKFGGNLIINSYNGLEELYKNKDLHPMDLKNAV
CCCCCCCCHHHHHHHHHHCCCEEEECHHHCCCEEEEECCCCHHHHHHCCCCCCCHHHHHH
VKGIIEMLTLIRGPNSE
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA