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The map label for this gene is hisE

Identifier: 150400607

GI number: 150400607

Start: 187123

End: 187413

Strand: Direct

Name: hisE

Synonym: Maeo_0169

Alternate gene names: 150400607

Gene position: 187123-187413 (Clockwise)

Preceding gene: 150400606

Following gene: 150400609

Centisome position: 11.92

GC content: 30.93

Gene sequence:

>291_bases
ATGGATATTTTAAAAGAAGAATTTGAAATAATAAAACAAAGAATAAAAGATAAACCAGAAGGTTCTTATGTGGCCTACCT
TACAACAGCCGACAAAAAAACACCAATAAATAAAATATGTGAAAAAGTAGGGGAGGAGGCAACTGAAACAATTTTAGCCG
CAAAAGACCAGGATAAACAAGAGTTAATATATGAAAGTGCGGATTTAATTTTTCATATCTTGGTGCTATTGGCCAACAAT
GGTATTGAATATGAGGAATTAATGGAAGAATTTGAGAGAAGAAGAAAATAA

Upstream 100 bases:

>100_bases
TTAAATGATTTATAATTTTTCATATTTTTCGTTTTAAATAATTTTTTACCTTATTATATTATTGTATTTTTATATTATTT
TTATTTAGGTGTGTGATAAT

Downstream 100 bases:

>100_bases
ATATGATATATTTGGAAACTTTTTTACAACTTTTTTAACATAATATAATAGAAGTCTCAAAATTTACCAGTTGAAAAATA
GGAAAAAATGGGAGCTCCTA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 96; Mature: 96

Protein sequence:

>96_residues
MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQELIYESADLIFHILVLLANN
GIEYEELMEEFERRRK

Sequences:

>Translated_96_residues
MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQELIYESADLIFHILVLLANN
GIEYEELMEEFERRRK
>Mature_96_residues
MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQELIYESADLIFHILVLLANN
GIEYEELMEEFERRRK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=37.5, Blast_Score=64, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_META3 (A6UTD9)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324373.1
- ProteinModelPortal:   A6UTD9
- SMR:   A6UTD9
- STRING:   A6UTD9
- GeneID:   5327496
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0169
- eggNOG:   arNOG13425
- HOGENOM:   HBG646527
- OMA:   INKICEK
- ProtClustDB:   PRK00400
- BioCyc:   MAEO419665:MAEO_0169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11236; Mature: 11236

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQ
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
ELIYESADLIFHILVLLANNGIEYEELMEEFERRRK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQ
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
ELIYESADLIFHILVLLANNGIEYEELMEEFERRRK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA