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The map label for this gene is prs [H]

Identifier: 150400605

GI number: 150400605

Start: 185687

End: 186568

Strand: Direct

Name: prs [H]

Synonym: Maeo_0167

Alternate gene names: 150400605

Gene position: 185687-186568 (Clockwise)

Preceding gene: 150400603

Following gene: 150400606

Centisome position: 11.83

GC content: 30.84

Gene sequence:

>882_bases
ATGCTAATAGTATCGGGTTCAAATTCTCAAAATTTGGCTCACAAAGTTTCAAAATTAACTAATTCAAAACTAATTAGAAC
AGAATTTAAAAAATTCCCTGATGGGGAGCTATATGTAAAAATAAATGGTAGCGTAGAAGGAGAGGATGTTTTCTTAATCA
ATACCCAAAATAACCAAAATGAATCAATAATAGAAACCATATTATTATGCGACGCATTAAATGATGAAGGGGCAAGAAGT
ATAAACTTAGTAATTCCTTATATGGCTTATGCTAGACAAGATAAAAAGTTTAAAGATGGTGAATCAATTAGTATTAGAGC
TTTGGCAAAAGTTTATTCTACCATATGCGATAGCATATTTATAATAAATCCACATGAAAAAGATATATGTTCTTTTTTTG
ATGTTCCGTTGGTATATGGTGATGCAGTTCCCGAAATTGCAAAATACATAGCCAATAAATACGATGGCTCAAATTTTGTA
GTGCTTTCTCCAGATAAGGGAGCAATACGAATGGCAAAAGTTGCATCCAATATATTAAATTGCCCCTACGATTATCTTGA
AAAAACCAGAATATCTCCAACAGAAATAAGCATTGCACCAAAAAATTTAGATGTAAAAGATAAGGATGTTCTTATCATTG
ATGATATAATCTCAACAGGTGGAACTGTGGCTACAACTATAAAGATGTTAAAGGAACAAGGTGCAAAAACAGTTATAGCA
TCATGTATTCATCCTGTTCTTATTGGTGATGCATTGAATAAATTATTTGATGGAGGGGCTGATGAAGTCATTGGAACAGA
TGCATATTTGTCCGAAGTTAGTATAATTAGTGTGGATAATATTGTTGCAGATTTAATTAATAAACATATTAATAATATAT
AA

Upstream 100 bases:

>100_bases
TCTTTTAAACTATAAAATACAGTTAAAAGATGTTTAGATACATGGACTGATAAAGGACAGTTAATTAAAGATGACTATAT
TAACACTAAATGGTGATTAT

Downstream 100 bases:

>100_bases
TTGAAACATATAATTAAATATAAGAAAAATGTGAAAAACTATATAAAAAGGTGTAATCATGGTAAAATTGGGATTTGTTA
TAGCTGAATTTAACAGAGAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLIVSGSNSQNLAHKVSKLTNSKLIRTEFKKFPDGELYVKINGSVEGEDVFLINTQNNQNESIIETILLCDALNDEGARS
INLVIPYMAYARQDKKFKDGESISIRALAKVYSTICDSIFIINPHEKDICSFFDVPLVYGDAVPEIAKYIANKYDGSNFV
VLSPDKGAIRMAKVASNILNCPYDYLEKTRISPTEISIAPKNLDVKDKDVLIIDDIISTGGTVATTIKMLKEQGAKTVIA
SCIHPVLIGDALNKLFDGGADEVIGTDAYLSEVSIISVDNIVADLINKHINNI

Sequences:

>Translated_293_residues
MLIVSGSNSQNLAHKVSKLTNSKLIRTEFKKFPDGELYVKINGSVEGEDVFLINTQNNQNESIIETILLCDALNDEGARS
INLVIPYMAYARQDKKFKDGESISIRALAKVYSTICDSIFIINPHEKDICSFFDVPLVYGDAVPEIAKYIANKYDGSNFV
VLSPDKGAIRMAKVASNILNCPYDYLEKTRISPTEISIAPKNLDVKDKDVLIIDDIISTGGTVATTIKMLKEQGAKTVIA
SCIHPVLIGDALNKLFDGGADEVIGTDAYLSEVSIISVDNIVADLINKHINNI
>Mature_293_residues
MLIVSGSNSQNLAHKVSKLTNSKLIRTEFKKFPDGELYVKINGSVEGEDVFLINTQNNQNESIIETILLCDALNDEGARS
INLVIPYMAYARQDKKFKDGESISIRALAKVYSTICDSIFIINPHEKDICSFFDVPLVYGDAVPEIAKYIANKYDGSNFV
VLSPDKGAIRMAKVASNILNCPYDYLEKTRISPTEISIAPKNLDVKDKDVLIIDDIISTGGTVATTIKMLKEQGAKTVIA
SCIHPVLIGDALNKLFDGGADEVIGTDAYLSEVSIISVDNIVADLINKHINNI

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=300, Percent_Identity=29, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI84875539, Length=305, Percent_Identity=28.5245901639344, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI4506129, Length=302, Percent_Identity=27.8145695364238, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI28557709, Length=300, Percent_Identity=28.6666666666667, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI194018537, Length=314, Percent_Identity=25.1592356687898, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4506133, Length=317, Percent_Identity=24.2902208201893, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1787458, Length=302, Percent_Identity=30.1324503311258, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25149168, Length=300, Percent_Identity=28.3333333333333, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17554704, Length=300, Percent_Identity=28.3333333333333, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17554702, Length=300, Percent_Identity=28.3333333333333, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71989924, Length=300, Percent_Identity=28.3333333333333, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321776, Length=290, Percent_Identity=29.6551724137931, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320946, Length=285, Percent_Identity=29.1228070175439, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319403, Length=270, Percent_Identity=30.3703703703704, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322667, Length=180, Percent_Identity=28.8888888888889, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355239, Length=268, Percent_Identity=29.8507462686567, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45551540, Length=291, Percent_Identity=27.4914089347079, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651458, Length=327, Percent_Identity=25.0764525993884, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651456, Length=327, Percent_Identity=25.0764525993884, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281362873, Length=327, Percent_Identity=25.0764525993884, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651454, Length=327, Percent_Identity=25.0764525993884, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651462, Length=175, Percent_Identity=30.8571428571429, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651464, Length=175, Percent_Identity=30.8571428571429, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45552010, Length=175, Percent_Identity=30.8571428571429, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 32090; Mature: 32090

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVSGSNSQNLAHKVSKLTNSKLIRTEFKKFPDGELYVKINGSVEGEDVFLINTQNNQN
CEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCC
ESIIETILLCDALNDEGARSINLVIPYMAYARQDKKFKDGESISIRALAKVYSTICDSIF
HHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCEEE
IINPHEKDICSFFDVPLVYGDAVPEIAKYIANKYDGSNFVVLSPDKGAIRMAKVASNILN
EECCCCHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHC
CPYDYLEKTRISPTEISIAPKNLDVKDKDVLIIDDIISTGGTVATTIKMLKEQGAKTVIA
CCHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHCCHHHHHH
SCIHPVLIGDALNKLFDGGADEVIGTDAYLSEVSIISVDNIVADLINKHINNI
HHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHEEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIVSGSNSQNLAHKVSKLTNSKLIRTEFKKFPDGELYVKINGSVEGEDVFLINTQNNQN
CEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCC
ESIIETILLCDALNDEGARSINLVIPYMAYARQDKKFKDGESISIRALAKVYSTICDSIF
HHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCEEE
IINPHEKDICSFFDVPLVYGDAVPEIAKYIANKYDGSNFVVLSPDKGAIRMAKVASNILN
EECCCCHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHC
CPYDYLEKTRISPTEISIAPKNLDVKDKDVLIIDDIISTGGTVATTIKMLKEQGAKTVIA
CCHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHCCHHHHHH
SCIHPVLIGDALNKLFDGGADEVIGTDAYLSEVSIISVDNIVADLINKHINNI
HHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHEEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]