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The map label for this gene is eif6

Identifier: 150400563

GI number: 150400563

Start: 140759

End: 141442

Strand: Reverse

Name: eif6

Synonym: Maeo_0125

Alternate gene names: 150400563

Gene position: 141442-140759 (Counterclockwise)

Preceding gene: 150400564

Following gene: 150400562

Centisome position: 9.01

GC content: 32.46

Gene sequence:

>684_bases
ATGATTATAAAAGAATACATCTCTGGAATATCCACAATAGGTGTTCTATCCCTTTCCACTGAAAAATTTGGATTAGCCCC
ATATTTTGCTGAGGAAAACACAATAAATAAATTTAAGAAAGTTCTTGATGTTCCAGTAAAGGCATTAAATATTGGAAATA
GTTCTTTAATTGGTGCATTATGTTGTGCTAATTCTTATGGTATAATATTGCCCCCATTTACATTAAATAGGGAAAAAACC
ATATTATCAGATTTTTTAAAAGAAAATGATATTGACATAATTGTTAAAGAAATAAATGCTAAAAATACAGCATTTGGAAA
TTTAATCCTACTTAATGATAAAGGTTGTATCATTTCCGAAGAATTAGCCGATTTCAGAAAAACATTTGAAGATATTTTTG
ATGTGGAAGTTGTAGCGAAAAATATTGCGGAGCTCCCCACAGTTGGTTCAAATGGTGTGGCAACTAATAAAGGAGCTTTG
GTGCATCCTGACACAACAGATGAAGAGCTGGAATTAATAAAAGATGTTCTAAAACTCAAATGTATTGAAAGAGGCACTGC
AAGTAAAGGAACTCCTTCGGTTGGTGCATGTATTGTAGCAAATTCAAATGGTGCAGTGATTGGCGGAGATACCACAGGAC
CAGAGATGTTAAAAATAGAAGAAGGATTGGATTTAATAGATTAA

Upstream 100 bases:

>100_bases
GGTAATAGCTACATTAATTAAATAATTAATGTTAATATTTTTAGTTTTACTAAAAATTCAAAATCTTAGATTTTGTATAT
TTTTTAATTTTGTGATACTT

Downstream 100 bases:

>100_bases
ACCTAAAATATAAAATTAAACATAAAAAAGGAAAAAGGTGAAAATATGCCAAAAATATACAGAATAAAAGGAAAAATTGT
TGGAAAAGATGAACCAATGG

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MIIKEYISGISTIGVLSLSTEKFGLAPYFAEENTINKFKKVLDVPVKALNIGNSSLIGALCCANSYGIILPPFTLNREKT
ILSDFLKENDIDIIVKEINAKNTAFGNLILLNDKGCIISEELADFRKTFEDIFDVEVVAKNIAELPTVGSNGVATNKGAL
VHPDTTDEELELIKDVLKLKCIERGTASKGTPSVGACIVANSNGAVIGGDTTGPEMLKIEEGLDLID

Sequences:

>Translated_227_residues
MIIKEYISGISTIGVLSLSTEKFGLAPYFAEENTINKFKKVLDVPVKALNIGNSSLIGALCCANSYGIILPPFTLNREKT
ILSDFLKENDIDIIVKEINAKNTAFGNLILLNDKGCIISEELADFRKTFEDIFDVEVVAKNIAELPTVGSNGVATNKGAL
VHPDTTDEELELIKDVLKLKCIERGTASKGTPSVGACIVANSNGAVIGGDTTGPEMLKIEEGLDLID
>Mature_227_residues
MIIKEYISGISTIGVLSLSTEKFGLAPYFAEENTINKFKKVLDVPVKALNIGNSSLIGALCCANSYGIILPPFTLNREKT
ILSDFLKENDIDIIVKEINAKNTAFGNLILLNDKGCIISEELADFRKTFEDIFDVEVVAKNIAELPTVGSNGVATNKGAL
VHPDTTDEELELIKDVLKLKCIERGTASKGTPSVGACIVANSNGAVIGGDTTGPEMLKIEEGLDLID

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=228, Percent_Identity=25.8771929824561, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI31563378, Length=228, Percent_Identity=25.8771929824561, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17506075, Length=223, Percent_Identity=25.1121076233184, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325273, Length=218, Percent_Identity=29.3577981651376, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21492634, Length=211, Percent_Identity=27.4881516587678, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_META3 (A6UT95)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324329.1
- ProteinModelPortal:   A6UT95
- SMR:   A6UT95
- STRING:   A6UT95
- GeneID:   5326390
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0125
- eggNOG:   arNOG10240
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- ProtClustDB:   PRK04046
- BioCyc:   MAEO419665:MAEO_0125-MONOMER
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 24333; Mature: 24333

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKEYISGISTIGVLSLSTEKFGLAPYFAEENTINKFKKVLDVPVKALNIGNSSLIGAL
CCHHHHHCCHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHEEECCCCHHHHHH
CCANSYGIILPPFTLNREKTILSDFLKENDIDIIVKEINAKNTAFGNLILLNDKGCIISE
HHCCCCCEEECCEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCEEHH
ELADFRKTFEDIFDVEVVAKNIAELPTVGSNGVATNKGALVHPDTTDEELELIKDVLKLK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
CIERGTASKGTPSVGACIVANSNGAVIGGDTTGPEMLKIEEGLDLID
HHHCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MIIKEYISGISTIGVLSLSTEKFGLAPYFAEENTINKFKKVLDVPVKALNIGNSSLIGAL
CCHHHHHCCHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHEEECCCCHHHHHH
CCANSYGIILPPFTLNREKTILSDFLKENDIDIIVKEINAKNTAFGNLILLNDKGCIISE
HHCCCCCEEECCEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCEEHH
ELADFRKTFEDIFDVEVVAKNIAELPTVGSNGVATNKGALVHPDTTDEELELIKDVLKLK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
CIERGTASKGTPSVGACIVANSNGAVIGGDTTGPEMLKIEEGLDLID
HHHCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA