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The map label for this gene is hemD [H]

Identifier: 150400513

GI number: 150400513

Start: 79961

End: 80701

Strand: Direct

Name: hemD [H]

Synonym: Maeo_0075

Alternate gene names: 150400513

Gene position: 79961-80701 (Clockwise)

Preceding gene: 150400512

Following gene: 150400514

Centisome position: 5.09

GC content: 27.94

Gene sequence:

>741_bases
ATGAAGGTAATTATCACACGACCTACTGAAACAGGGCTTCAATTTGCCAATTTATTAGATGATGATTTTGAACCAATTCT
TATTCCAACCTTGGAGCTCCGATTTAAAAAAATAGACACCGATTTAAAAAAATATAATTGGATAGTATTTACAAGTCCCA
GGGGTGTAATGGGATTATATAAAAATAAAAATAACATTAAAAATTTTGACCTGGCCAATAAAAAAATAGGAGTAATTGGG
GTAGAAACCGAAAAAGAGGTTAAAAAACTATTCGGCAGGGGTGCAGATATTATTCCTAAAAAATACACTGCGGAACGACT
ATTGGAGGAATTAAAAAAGCATATAAACGAACAGGATAAAATATTAATACCAACCACACCATCGGCAAGAGATATATTAC
ATAAAAATTTAAATGCTGATTTGGAATTTGTGTATTGTTCAGAAGAACCTTCAAATATAGCTCAAAAATTAAAAGACTTA
AAAGAAATAATAAAATATGAAGAATTAAAAAATAATAAAATAATTTTGACTTTCACAAGTGGTTTAACGGCAAAAAATTT
CTTTAAAAATGCAGATTCTGAACTTAGGGAGTTATTAAAAAATCATTACATTGTTTCTATTGGGGAAATAACTAAAAAAA
CAGTTGATTCATATGGGGAGGAATATAATTCAATAATTCCTAAAAAATACACAATTAATGGTATGGTGGAAATCATTAAA
AAATTGAGGAATAAAAATTAA

Upstream 100 bases:

>100_bases
TTTGAGAAAGTTGTAGAGTTAGAGAATGAATTAGAAAGAATAAGTTCTTATTTAAGAGAAGTAAATTTAAAAACTATATA
GATATAAAATAGAGGATATA

Downstream 100 bases:

>100_bases
TAAAGATTAATAAATAAGCCTAAGTGAATCGACAATTAAATTAGGCTAATCAAAGATTAGCCAAACCAAGATGTCTTTTA
GGGGTTCTAAATATCTCTAT

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKVIITRPTETGLQFANLLDDDFEPILIPTLELRFKKIDTDLKKYNWIVFTSPRGVMGLYKNKNNIKNFDLANKKIGVIG
VETEKEVKKLFGRGADIIPKKYTAERLLEELKKHINEQDKILIPTTPSARDILHKNLNADLEFVYCSEEPSNIAQKLKDL
KEIIKYEELKNNKIILTFTSGLTAKNFFKNADSELRELLKNHYIVSIGEITKKTVDSYGEEYNSIIPKKYTINGMVEIIK
KLRNKN

Sequences:

>Translated_246_residues
MKVIITRPTETGLQFANLLDDDFEPILIPTLELRFKKIDTDLKKYNWIVFTSPRGVMGLYKNKNNIKNFDLANKKIGVIG
VETEKEVKKLFGRGADIIPKKYTAERLLEELKKHINEQDKILIPTTPSARDILHKNLNADLEFVYCSEEPSNIAQKLKDL
KEIIKYEELKNNKIILTFTSGLTAKNFFKNADSELRELLKNHYIVSIGEITKKTVDSYGEEYNSIIPKKYTINGMVEIIK
KLRNKN
>Mature_246_residues
MKVIITRPTETGLQFANLLDDDFEPILIPTLELRFKKIDTDLKKYNWIVFTSPRGVMGLYKNKNNIKNFDLANKKIGVIG
VETEKEVKKLFGRGADIIPKKYTAERLLEELKKHINEQDKILIPTTPSARDILHKNLNADLEFVYCSEEPSNIAQKLKDL
KEIIKYEELKNNKIILTFTSGLTAKNFFKNADSELRELLKNHYIVSIGEITKKTVDSYGEEYNSIIPKKYTINGMVEIIK
KLRNKN

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28436; Mature: 28436

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIITRPTETGLQFANLLDDDFEPILIPTLELRFKKIDTDLKKYNWIVFTSPRGVMGLY
CEEEEECCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCEEEEECCCCCEEEE
KNKNNIKNFDLANKKIGVIGVETEKEVKKLFGRGADIIPKKYTAERLLEELKKHINEQDK
CCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
ILIPTTPSARDILHKNLNADLEFVYCSEEPSNIAQKLKDLKEIIKYEELKNNKIILTFTS
EEEECCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GLTAKNFFKNADSELRELLKNHYIVSIGEITKKTVDSYGEEYNSIIPKKYTINGMVEIIK
CCCHHHHHHCCCHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
KLRNKN
HHHCCC
>Mature Secondary Structure
MKVIITRPTETGLQFANLLDDDFEPILIPTLELRFKKIDTDLKKYNWIVFTSPRGVMGLY
CEEEEECCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCEEEEECCCCCEEEE
KNKNNIKNFDLANKKIGVIGVETEKEVKKLFGRGADIIPKKYTAERLLEELKKHINEQDK
CCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
ILIPTTPSARDILHKNLNADLEFVYCSEEPSNIAQKLKDLKEIIKYEELKNNKIILTFTS
EEEECCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GLTAKNFFKNADSELRELLKNHYIVSIGEITKKTVDSYGEEYNSIIPKKYTINGMVEIIK
CCCHHHHHHCCCHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
KLRNKN
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]