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The map label for this gene is paaJ [C]

Identifier: 150400460

GI number: 150400460

Start: 22945

End: 24129

Strand: Direct

Name: paaJ [C]

Synonym: Maeo_0021

Alternate gene names: 150400460

Gene position: 22945-24129 (Clockwise)

Preceding gene: 150400459

Following gene: 150400461

Centisome position: 1.46

GC content: 37.81

Gene sequence:

>1185_bases
ATGAGAGATGTGGCTATAATAGGATATGGACAAACGAAATTTGGAGAATTATGGGATAAATCTTTTAGAGATACAATTGT
AGAGGCTGGAGCAAATGCAATAATAGATGCAAATATTGAGGGTGCCGACATTGATGCCATGTATATCGGAAATATGAGTG
GAGGTTTGTTTGTAGGGCAGGAACATATATCTTCGCTTATTGCCGACTACACGGGATTTAATCCAATTCCATGCACCAGA
GTAGAAGCCGCCTGTGCATCTGGAAGTTTAGCTATTAGAAGTGCATATTTATCTGTTGCTAGTGGTGCCCATGATGTGGT
TTTAGCTGGAGGAGTAGAAAAAATGACAGATGTTGAAGATGCTACTTCGGCAATAGCTACGGCAGCCGACCAAGAATGGG
AATCATTTTTTGGGGCAACATTTCCATCATTATATGCCATGATGGCAAAAAGATATATGTATGAATTTGGAATGACAATT
GACGAATTATCTATGTGGAGCGTTATAGCTCATGACAACGCATCAAAAAACCCTTATGCACAATTTCAATTTAAAACTAC
GCTGGAAAAAGTTTTAAATGCTTCGCCTGTGGCTGACCCCCTTACACTTATGCACTGCTCTCCTGTTTCAGATGGGGGTG
CGGCACTTATTATTTGTGATGCAGATAAAGCAGAAGAATATGCACCAAAAGATGAAATAATGTATATTAGGGCTTCAACA
CAGGCATCAGATACAATAGCACTACACAGTAGAAAAAGTATGACTACACTTAATGCTGCAAAAGTTGCATCAGAACAGGC
ATATAAATTAGCTGGTGTAGATGCAAATAAAATAGATGTTGCAGAGGTTCATGACTGTTTTGCAATAAATGGGCTCATAT
TATTGGAGGATTTAGGTTTCTGTAAAAAAGGAGAGGCTAAAACAGTAATTGGTCAAGAAGAAAAAATAAGAATTGATTAT
GATAATTTTGTAACTGTAAATCCAAGTGGTGGTTTAAAGGCAGCAGGACATGCTTTGGGAGCTACTGGAATAAGACAGGT
GGGAGAAATATATTGGCAGTTAAAACAGGATAAAAATTGTAAAAATAGGCAAGTGCAAATAAATAATGGATATGGAATTA
CGGCAAATGTTGGGGGAACTGGTGGAACGGTATGCACCCATATTATTTCAGATAAAAGGAAATAA

Upstream 100 bases:

>100_bases
AAAGAAATTAGAAATATATCTTAATACAACAATATAATAATATAATAATCTAACATATAGGGATAGCAATATATAACAAT
ATTAAAATTAAGGTGAAATA

Downstream 100 bases:

>100_bases
ACTAAGAATGATAAATCATATTATAAATTATATGGGGAAATAATAAAGAAAAGAGTATATAGTCAATCTTCGGTCTTTTT
CAGGCGACATACAATAAACT

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRDVAIIGYGQTKFGELWDKSFRDTIVEAGANAIIDANIEGADIDAMYIGNMSGGLFVGQEHISSLIADYTGFNPIPCTR
VEAACASGSLAIRSAYLSVASGAHDVVLAGGVEKMTDVEDATSAIATAADQEWESFFGATFPSLYAMMAKRYMYEFGMTI
DELSMWSVIAHDNASKNPYAQFQFKTTLEKVLNASPVADPLTLMHCSPVSDGGAALIICDADKAEEYAPKDEIMYIRAST
QASDTIALHSRKSMTTLNAAKVASEQAYKLAGVDANKIDVAEVHDCFAINGLILLEDLGFCKKGEAKTVIGQEEKIRIDY
DNFVTVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKNCKNRQVQINNGYGITANVGGTGGTVCTHIISDKRK

Sequences:

>Translated_394_residues
MRDVAIIGYGQTKFGELWDKSFRDTIVEAGANAIIDANIEGADIDAMYIGNMSGGLFVGQEHISSLIADYTGFNPIPCTR
VEAACASGSLAIRSAYLSVASGAHDVVLAGGVEKMTDVEDATSAIATAADQEWESFFGATFPSLYAMMAKRYMYEFGMTI
DELSMWSVIAHDNASKNPYAQFQFKTTLEKVLNASPVADPLTLMHCSPVSDGGAALIICDADKAEEYAPKDEIMYIRAST
QASDTIALHSRKSMTTLNAAKVASEQAYKLAGVDANKIDVAEVHDCFAINGLILLEDLGFCKKGEAKTVIGQEEKIRIDY
DNFVTVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKNCKNRQVQINNGYGITANVGGTGGTVCTHIISDKRK
>Mature_394_residues
MRDVAIIGYGQTKFGELWDKSFRDTIVEAGANAIIDANIEGADIDAMYIGNMSGGLFVGQEHISSLIADYTGFNPIPCTR
VEAACASGSLAIRSAYLSVASGAHDVVLAGGVEKMTDVEDATSAIATAADQEWESFFGATFPSLYAMMAKRYMYEFGMTI
DELSMWSVIAHDNASKNPYAQFQFKTTLEKVLNASPVADPLTLMHCSPVSDGGAALIICDADKAEEYAPKDEIMYIRAST
QASDTIALHSRKSMTTLNAAKVASEQAYKLAGVDANKIDVAEVHDCFAINGLILLEDLGFCKKGEAKTVIGQEEKIRIDY
DNFVTVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKNCKNRQVQINNGYGITANVGGTGGTVCTHIISDKRK

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=380, Percent_Identity=31.3157894736842, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI302344760, Length=380, Percent_Identity=29.4736842105263, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI302344767, Length=302, Percent_Identity=31.7880794701987, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI302344762, Length=392, Percent_Identity=28.8265306122449, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI55956775, Length=349, Percent_Identity=28.6532951289398, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17537653, Length=384, Percent_Identity=30.2083333333333, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19921506, Length=393, Percent_Identity=29.2620865139949, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24585051, Length=393, Percent_Identity=29.0076335877863, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42278; Mature: 42278

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVAIIGYGQTKFGELWDKSFRDTIVEAGANAIIDANIEGADIDAMYIGNMSGGLFVGQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCEEECH
EHISSLIADYTGFNPIPCTRVEAACASGSLAIRSAYLSVASGAHDVVLAGGVEKMTDVED
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
ATSAIATAADQEWESFFGATFPSLYAMMAKRYMYEFGMTIDELSMWSVIAHDNASKNPYA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCE
QFQFKTTLEKVLNASPVADPLTLMHCSPVSDGGAALIICDADKAEEYAPKDEIMYIRAST
EEEHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHCCCCCEEEEEECC
QASDTIALHSRKSMTTLNAAKVASEQAYKLAGVDANKIDVAEVHDCFAINGLILLEDLGF
CCCCEEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCEEHHHHHHHHHCCCEEEEECCCC
CKKGEAKTVIGQEEKIRIDYDNFVTVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKNC
CCCCCCCEECCCCCEEEEECCCEEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCCC
KNRQVQINNGYGITANVGGTGGTVCTHIISDKRK
CCCEEEEECCEEEEEECCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRDVAIIGYGQTKFGELWDKSFRDTIVEAGANAIIDANIEGADIDAMYIGNMSGGLFVGQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCEEECH
EHISSLIADYTGFNPIPCTRVEAACASGSLAIRSAYLSVASGAHDVVLAGGVEKMTDVED
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
ATSAIATAADQEWESFFGATFPSLYAMMAKRYMYEFGMTIDELSMWSVIAHDNASKNPYA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCE
QFQFKTTLEKVLNASPVADPLTLMHCSPVSDGGAALIICDADKAEEYAPKDEIMYIRAST
EEEHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHCCCCCEEEEEECC
QASDTIALHSRKSMTTLNAAKVASEQAYKLAGVDANKIDVAEVHDCFAINGLILLEDLGF
CCCCEEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCEEHHHHHHHHHCCCEEEEECCCC
CKKGEAKTVIGQEEKIRIDYDNFVTVNPSGGLKAAGHALGATGIRQVGEIYWQLKQDKNC
CCCCCCCEECCCCCEEEEECCCEEEECCCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCCC
KNRQVQINNGYGITANVGGTGGTVCTHIISDKRK
CCCEEEEECCEEEEEECCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]