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The map label for this gene is fabH [C]

Identifier: 150400459

GI number: 150400459

Start: 21796

End: 22842

Strand: Direct

Name: fabH [C]

Synonym: Maeo_0020

Alternate gene names: 150400459

Gene position: 21796-22842 (Clockwise)

Preceding gene: 150400458

Following gene: 150400460

Centisome position: 1.39

GC content: 38.01

Gene sequence:

>1047_bases
ATGACAGTAGGTATTGTAGGCTATGGTAGTCATATTCCAAAATATAGAATTAAAGTAGAAGAAATAGCAGCCGTATGGGG
GAAAAATCCAGAATCCATAAAAAACGGATTAATTGTAAATGAAAAAAGTCTTCCTGGTCCAGACGAGGATACGGCAACCA
TAGCAGTTGAATCAAGTAGGAGGGCTTTAAAAAGAGCAGGAATTGATGCAAAAGATATTGGGGCTGTTTATGTTGGTAGT
GAAAGTCATCCATATGCCGTGAAACCTACTTCTTCAATAGTGGCGGAGGCAATAGGTGCTACGCCTGATTTAACAGCCGC
AGATTTGGAATTCGCCTGTAAAGCTGGAACCGCAGGAATTCAAATGTGCATGGGGCTTGTAGGTAGTGGAATGATAGATT
ATGGTATGGCAGTTGGTGCAGATACAGCTCAGGGAGCTCCGGGTGATGCACTTGAATACACCGCAGCAGCAGGCGGTGCC
TCATATATTATAGGAAATAAAAAACAAGAATTAATTGCAGAAATAAACAAAACATATTCATTTACCACAGATACGCCTGA
TTTTTGGAGAAGAGAGGGACAATCATATCCAAAACATGGCGGTAGATTTACAGGAGAACCGGCTTTCTTTAAGCATGTTA
TAAGTGCAGCAAAAGGTATGATGGAAAAAATGGATACTACGGCAAAAGACTACGATTATTGTGTATTCCACCAACCAAAT
GGAAAATTCTATATAAGGGCGGCAAAAATGTTAGGATTTAGCGAAGAACAATATAAATACGGACTTTTAACACCATATTT
AGGAAATACCTATTCGGGAGCTGTTCCATTGGGATTATCTAATGTGTTGGACAATGCAAAGGACGGGGATAAAATATTTG
TAGTATCTTATGGTAGTGGTTCTGGTAGTGATGCCTTTGATATGACTGTAAAGGATAGAATTGAAGAGGTAAAGGATAAA
GCTCTTAAAACCATGGAAATACTTGGAAATAAAAAATATGTAAATTATTCGGTTTATTTAAAATACAGAGGAGGAATTAA
ACTTTAA

Upstream 100 bases:

>100_bases
ATAATATCAAATATAATATATTAAATACAATAATATACAATAAAATAAGATATTTTTGTTTTTGTTTTTTGAATTATACA
ATTATATAAAAGGTGATTAA

Downstream 100 bases:

>100_bases
TTAAAGAAATTAGAAATATATCTTAATACAACAATATAATAATATAATAATCTAACATATAGGGATAGCAATATATAACA
ATATTAAAATTAAGGTGAAA

Product: hypothetical protein

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTVGIVGYGSHIPKYRIKVEEIAAVWGKNPESIKNGLIVNEKSLPGPDEDTATIAVESSRRALKRAGIDAKDIGAVYVGS
ESHPYAVKPTSSIVAEAIGATPDLTAADLEFACKAGTAGIQMCMGLVGSGMIDYGMAVGADTAQGAPGDALEYTAAAGGA
SYIIGNKKQELIAEINKTYSFTTDTPDFWRREGQSYPKHGGRFTGEPAFFKHVISAAKGMMEKMDTTAKDYDYCVFHQPN
GKFYIRAAKMLGFSEEQYKYGLLTPYLGNTYSGAVPLGLSNVLDNAKDGDKIFVVSYGSGSGSDAFDMTVKDRIEEVKDK
ALKTMEILGNKKYVNYSVYLKYRGGIKL

Sequences:

>Translated_348_residues
MTVGIVGYGSHIPKYRIKVEEIAAVWGKNPESIKNGLIVNEKSLPGPDEDTATIAVESSRRALKRAGIDAKDIGAVYVGS
ESHPYAVKPTSSIVAEAIGATPDLTAADLEFACKAGTAGIQMCMGLVGSGMIDYGMAVGADTAQGAPGDALEYTAAAGGA
SYIIGNKKQELIAEINKTYSFTTDTPDFWRREGQSYPKHGGRFTGEPAFFKHVISAAKGMMEKMDTTAKDYDYCVFHQPN
GKFYIRAAKMLGFSEEQYKYGLLTPYLGNTYSGAVPLGLSNVLDNAKDGDKIFVVSYGSGSGSDAFDMTVKDRIEEVKDK
ALKTMEILGNKKYVNYSVYLKYRGGIKL
>Mature_347_residues
TVGIVGYGSHIPKYRIKVEEIAAVWGKNPESIKNGLIVNEKSLPGPDEDTATIAVESSRRALKRAGIDAKDIGAVYVGSE
SHPYAVKPTSSIVAEAIGATPDLTAADLEFACKAGTAGIQMCMGLVGSGMIDYGMAVGADTAQGAPGDALEYTAAAGGAS
YIIGNKKQELIAEINKTYSFTTDTPDFWRREGQSYPKHGGRFTGEPAFFKHVISAAKGMMEKMDTTAKDYDYCVFHQPNG
KFYIRAAKMLGFSEEQYKYGLLTPYLGNTYSGAVPLGLSNVLDNAKDGDKIFVVSYGSGSGSDAFDMTVKDRIEEVKDKA
LKTMEILGNKKYVNYSVYLKYRGGIKL

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Catalyzes The First Condensation Reaction Which Initiates Fatty Acid Synthesis And May Therefore Play A Role In Governing The

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0219 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013747
- InterPro:   IPR004656
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08541 ACP_syn_III_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.1.41

Molecular weight: Translated: 37448; Mature: 37317

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVGIVGYGSHIPKYRIKVEEIAAVWGKNPESIKNGLIVNEKSLPGPDEDTATIAVESSR
CEEEEEECCCCCCCEEEEHHHHHHHHCCCHHHHHCCEEEECCCCCCCCCCCEEEEECHHH
RALKRAGIDAKDIGAVYVGSESHPYAVKPTSSIVAEAIGATPDLTAADLEFACKAGTAGI
HHHHHCCCCHHHCCEEEECCCCCCEEECCHHHHHHHHHCCCCCCCHHCHHHHHCCCCHHH
QMCMGLVGSGMIDYGMAVGADTAQGAPGDALEYTAAAGGASYIIGNKKQELIAEINKTYS
HHHHHHHCCCHHHHHHEECCCCCCCCCCCCCEEECCCCCCEEEECCCHHHHHHHHHCCEE
FTTDTPDFWRREGQSYPKHGGRFTGEPAFFKHVISAAKGMMEKMDTTAKDYDYCVFHQPN
ECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
GKFYIRAAKMLGFSEEQYKYGLLTPYLGNTYSGAVPLGLSNVLDNAKDGDKIFVVSYGSG
CCEEEEEEHHHCCCHHHCEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCC
SGSDAFDMTVKDRIEEVKDKALKTMEILGNKKYVNYSVYLKYRGGIKL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCC
>Mature Secondary Structure 
TVGIVGYGSHIPKYRIKVEEIAAVWGKNPESIKNGLIVNEKSLPGPDEDTATIAVESSR
EEEEEECCCCCCCEEEEHHHHHHHHCCCHHHHHCCEEEECCCCCCCCCCCEEEEECHHH
RALKRAGIDAKDIGAVYVGSESHPYAVKPTSSIVAEAIGATPDLTAADLEFACKAGTAGI
HHHHHCCCCHHHCCEEEECCCCCCEEECCHHHHHHHHHCCCCCCCHHCHHHHHCCCCHHH
QMCMGLVGSGMIDYGMAVGADTAQGAPGDALEYTAAAGGASYIIGNKKQELIAEINKTYS
HHHHHHHCCCHHHHHHEECCCCCCCCCCCCCEEECCCCCCEEEECCCHHHHHHHHHCCEE
FTTDTPDFWRREGQSYPKHGGRFTGEPAFFKHVISAAKGMMEKMDTTAKDYDYCVFHQPN
ECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
GKFYIRAAKMLGFSEEQYKYGLLTPYLGNTYSGAVPLGLSNVLDNAKDGDKIFVVSYGSG
CCEEEEEEHHHCCCHHHCEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCC
SGSDAFDMTVKDRIEEVKDKALKTMEILGNKKYVNYSVYLKYRGGIKL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; DTT; EDTA [C]

Metal ions: Phosphate [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl -ACP-decarboxyl ation, [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA