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The map label for this gene is moeA [C]

Identifier: 150400402

GI number: 150400402

Start: 1685388

End: 1686509

Strand: Reverse

Name: moeA [C]

Synonym: Mevan_1665

Alternate gene names: 150400402

Gene position: 1686509-1685388 (Counterclockwise)

Preceding gene: 150400410

Following gene: 150400396

Centisome position: 98.05

GC content: 32.62

Gene sequence:

>1122_bases
ATGATATCAGTTCCTGAAGCAGAACATATTTTGAAAAAATTTAATTTTGAAAAAACGGAAAAAATAAGCCTTTTTGACGC
CTACGGTAGAATCTTAGCTAAAGATATCGTATCTAAGTCTAACATTCCCGAATTTAGAAAGTCTAACATGGACGGCTATG
CGGTTACCGCCCCATTTCTTGAGCATTATACAGTTATTGATGAAGTTCATGCAGGGGATCTTAGAAACGTAAATATTGAA
AAAAATCAGTGTGTTTTTGTTGCAACTGGTGGAAAAGTTCCTAAAAATGCATACTGCATAATTCCAATTGAAAATACTAA
ACTTGAGGGGAATATTATAACCGTTTTTGACATACCTGAAAGTACATATATTGTTGAAAAAGGCTCAGATATTGTTTCAG
GACAGCTTGTTTTAGAAAAAGGTAGTACAATTAACGAAAGAAATGTTGGACTTTTAGCATCCTTGGGAATTTCTGAATTA
AAAGTTTATAAAATTCCAAAAGTTGCAATAATTTCAACTGGTGATGAACTTGAAAAAATTTCTGATGTGAATTCAAAAAC
GATTGCAGGAATTGTAAGAAAAGCAGGGGGAATTCCCGTATTTTTAGGGGTATCCAAAGATGATAGGGCCGAATTACGAA
ATAAAATACTTGAAGGTTTAAATTACGATATTATAGTTACTTCAGGAGGTGTTTCTGTTGGAAAAAGAGACTATACTCCA
GATGTGGTTAATGAACTTGGAACAGTCCTATTTCATGGCGTAAAAATGAGGCCTGGAAAACCAGTTCTTGCAGGAGAAAT
CGATGGAATTCCGATAATTTGTACTCCGGGAAAAGTAACTTCATGTATAATTTGTTCTTATTTATTTATATACCCATTAA
TATGCCGATATTCACACTCTAAAAACTGTAAAAAAATCGTTAGTGCTAAAATACTTGGTGAATTTAAAAAAGAAGTGGAT
AAAAGATTTTATGTACCGGTAATTTATCAAAATGGGTTTGTAAATCCAGTATTTAAAGATTCAAGTCATATAACTTCGAT
TGCATACTCTAATGGAATTGTTGAGCTAAAAGAAGGTATTGAAATTGCGGAAGGAGATGTCGAAGTTTGGCTTTATGATT
AA

Upstream 100 bases:

>100_bases
ATGCATATTGATTAAGTACTTATTATTTGAGTAATTAATATACGTTATCTATTCATCATCTATAACTTATCTCTTACATG
TCAAAACCTTGAGTGAAAAC

Downstream 100 bases:

>100_bases
TTAATGCTTAATGATTAATTAATACATTACAAACAAGGCAAGCATCCTTTTGAATAAATATTCCTTAATGATTAATTAAT
ACTTAATTTAAATTTAATTT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MISVPEAEHILKKFNFEKTEKISLFDAYGRILAKDIVSKSNIPEFRKSNMDGYAVTAPFLEHYTVIDEVHAGDLRNVNIE
KNQCVFVATGGKVPKNAYCIIPIENTKLEGNIITVFDIPESTYIVEKGSDIVSGQLVLEKGSTINERNVGLLASLGISEL
KVYKIPKVAIISTGDELEKISDVNSKTIAGIVRKAGGIPVFLGVSKDDRAELRNKILEGLNYDIIVTSGGVSVGKRDYTP
DVVNELGTVLFHGVKMRPGKPVLAGEIDGIPIICTPGKVTSCIICSYLFIYPLICRYSHSKNCKKIVSAKILGEFKKEVD
KRFYVPVIYQNGFVNPVFKDSSHITSIAYSNGIVELKEGIEIAEGDVEVWLYD

Sequences:

>Translated_373_residues
MISVPEAEHILKKFNFEKTEKISLFDAYGRILAKDIVSKSNIPEFRKSNMDGYAVTAPFLEHYTVIDEVHAGDLRNVNIE
KNQCVFVATGGKVPKNAYCIIPIENTKLEGNIITVFDIPESTYIVEKGSDIVSGQLVLEKGSTINERNVGLLASLGISEL
KVYKIPKVAIISTGDELEKISDVNSKTIAGIVRKAGGIPVFLGVSKDDRAELRNKILEGLNYDIIVTSGGVSVGKRDYTP
DVVNELGTVLFHGVKMRPGKPVLAGEIDGIPIICTPGKVTSCIICSYLFIYPLICRYSHSKNCKKIVSAKILGEFKKEVD
KRFYVPVIYQNGFVNPVFKDSSHITSIAYSNGIVELKEGIEIAEGDVEVWLYD
>Mature_373_residues
MISVPEAEHILKKFNFEKTEKISLFDAYGRILAKDIVSKSNIPEFRKSNMDGYAVTAPFLEHYTVIDEVHAGDLRNVNIE
KNQCVFVATGGKVPKNAYCIIPIENTKLEGNIITVFDIPESTYIVEKGSDIVSGQLVLEKGSTINERNVGLLASLGISEL
KVYKIPKVAIISTGDELEKISDVNSKTIAGIVRKAGGIPVFLGVSKDDRAELRNKILEGLNYDIIVTSGGVSVGKRDYTP
DVVNELGTVLFHGVKMRPGKPVLAGEIDGIPIICTPGKVTSCIICSYLFIYPLICRYSHSKNCKKIVSAKILGEFKKEVD
KRFYVPVIYQNGFVNPVFKDSSHITSIAYSNGIVELKEGIEIAEGDVEVWLYD

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=389, Percent_Identity=29.305912596401, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI10880983, Length=389, Percent_Identity=29.305912596401, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1787049, Length=293, Percent_Identity=30.3754266211604, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25147659, Length=348, Percent_Identity=30.4597701149425, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=357, Percent_Identity=27.1708683473389, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17136978, Length=307, Percent_Identity=27.6872964169381, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24638841, Length=307, Percent_Identity=27.6872964169381, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41069; Mature: 41069

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVPEAEHILKKFNFEKTEKISLFDAYGRILAKDIVSKSNIPEFRKSNMDGYAVTAPFL
CCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEECHHH
EHYTVIDEVHAGDLRNVNIEKNQCVFVATGGKVPKNAYCIIPIENTKLEGNIITVFDIPE
HHHHHHHHHCCCCCEECEECCCCEEEEEECCCCCCCCEEEEEECCCEECCCEEEEEECCC
STYIVEKGSDIVSGQLVLEKGSTINERNVGLLASLGISELKVYKIPKVAIISTGDELEKI
CEEEEECCCCEEECEEEEECCCCCCCCCCCEEEECCCCCEEEEECCEEEEEECCHHHHHH
SDVNSKTIAGIVRKAGGIPVFLGVSKDDRAELRNKILEGLNYDIIVTSGGVSVGKRDYTP
HCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCH
DVVNELGTVLFHGVKMRPGKPVLAGEIDGIPIICTPGKVTSCIICSYLFIYPLICRYSHS
HHHHHHHHHHHCCEEECCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
KNCKKIVSAKILGEFKKEVDKRFYVPVIYQNGFVNPVFKDSSHITSIAYSNGIVELKEGI
CCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEECCCCCEEEEEECCCEEEECCCC
EIAEGDVEVWLYD
EEECCCEEEEEEC
>Mature Secondary Structure
MISVPEAEHILKKFNFEKTEKISLFDAYGRILAKDIVSKSNIPEFRKSNMDGYAVTAPFL
CCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEECHHH
EHYTVIDEVHAGDLRNVNIEKNQCVFVATGGKVPKNAYCIIPIENTKLEGNIITVFDIPE
HHHHHHHHHCCCCCEECEECCCCEEEEEECCCCCCCCEEEEEECCCEECCCEEEEEECCC
STYIVEKGSDIVSGQLVLEKGSTINERNVGLLASLGISELKVYKIPKVAIISTGDELEKI
CEEEEECCCCEEECEEEEECCCCCCCCCCCEEEECCCCCEEEEECCEEEEEECCHHHHHH
SDVNSKTIAGIVRKAGGIPVFLGVSKDDRAELRNKILEGLNYDIIVTSGGVSVGKRDYTP
HCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCH
DVVNELGTVLFHGVKMRPGKPVLAGEIDGIPIICTPGKVTSCIICSYLFIYPLICRYSHS
HHHHHHHHHHHCCEEECCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
KNCKKIVSAKILGEFKKEVDKRFYVPVIYQNGFVNPVFKDSSHITSIAYSNGIVELKEGI
CCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEECCCCCEEEEEECCCEEEECCCC
EIAEGDVEVWLYD
EEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]