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The map label for this gene is mepA [H]

Identifier: 150400341

GI number: 150400341

Start: 1623063

End: 1624415

Strand: Reverse

Name: mepA [H]

Synonym: Mevan_1604

Alternate gene names: 150400341

Gene position: 1624415-1623063 (Counterclockwise)

Preceding gene: 150400345

Following gene: 150400340

Centisome position: 94.44

GC content: 28.38

Gene sequence:

>1353_bases
ATGAAACAAGTTTACGATTTAGGACTTGAAAACATTAATAAATTATTGGCTAGGTATTTAGTTCCATCAGTTCTTGGAAC
TACAATAATTGGAATTTACAGCATTATTGACGGCATTTTTATCGGTAGATACGTTGGTACTGACGGCCTTGCAGGAGTAA
CACTTGCATTTCCCATTTCTGTTGCAGTAGGATCTATTGGACTAATGATTGGTTACGGAGCTTGTGCAAATATATCCGTT
AAGCTTGGGAAAAGAGATTTTAACGGAGCAAATGCAATATTAAGTGTTTCTTTAATCTATATTTTAATATTTGGAACATT
TATTACATTTTTTGGTTCATTACTATTGAATAATTTAATAGAAATTATGAATATTCCAAAAAACCTTGAATCTTACGTTT
TAAATTATTCTAGAGTAATTATTTTTGGAAGCCTTGCAACAATTACTGCATATTCCCTTGATGCAATTTTAAGAAATGAT
GGCTTTCCGAAAAAATCCATGTATATTTTAATAATAGTGTCAATATCTAACATTGTTTTAGATTATATTTTAATTGCAAT
ACTTAATTTCGGAGTACTTGGTGCCGCATTTGCAACAATTATTGCACAAACATTAGGTTCTTTGATATATCTACACCACT
TTATATTTGGAACGTCAAACCTTGTTTTTCAAAAAAATAAAATACATTTAGAATATATAACAATAGTAAAAATCTTAAAA
ACAGGTTTTTCGCCGTTTATAATGGAATTGGCTTTTGGATTTTTAATGCTTATTCATAATATTCAATTTTTACGTTACGG
AAGTTCCATTGACGTTTCTGCATATGGTATCGTGATATATGTTACCTCTTTTTTATATATGGGATATTTAGGAATATCTG
ATGGCATCCAACCGCTAATTAGTTATAATTATGGTGCAAAGAAATTTAAAAGAGTTTTTGAAGTTTTAAAAAAGGCGATA
TTTATAAATTTTTTAATGGGGATAATATCGTTTATTTTAATTTTAAGGTATCCAAAAAAAATTATACATGTATTTAACCC
ATATGATGCATTATTAGTTACCCAAACAGTGCATGGTCTTATTATTCATAATTTTTCACTTTTAATCCTTGGAATTTCAA
TGATTATAATACTGTACTTTCAAGCAACAGAAAACTCAAAAATTGCAGGTTTTCTCTCATTAGGGCGAAGCATTTTATTT
ATTATACCAGCTCTGCTTATTTTTCCAAAGTATCTTGGAGTTAGCGGAATATGGCTTTCAACGGTATTTTCAGAATACTT
ATGTCTTTTATTTGGGTTATTTTTTTTCTTTAGAAGTGTTAAAAAAAATATCTGGGCAAAAAAAGATATTTAA

Upstream 100 bases:

>100_bases
TAAATAAAATTTATTAAAAGAAGTATATATTTATTATCTAACAAAAATAGATATTAATCTTAGTATGTGCCAAAAGTAAA
GCCAAATTATAAGGTTTTTT

Downstream 100 bases:

>100_bases
AAATGAACCCTTAGTACAATAATAAAGTTAAATTAATAATACTTAATTTATAAATTAATACATTTTTAATAGTAATACTC
CTTGTGTTTATTATTTAAAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKQVYDLGLENINKLLARYLVPSVLGTTIIGIYSIIDGIFIGRYVGTDGLAGVTLAFPISVAVGSIGLMIGYGACANISV
KLGKRDFNGANAILSVSLIYILIFGTFITFFGSLLLNNLIEIMNIPKNLESYVLNYSRVIIFGSLATITAYSLDAILRND
GFPKKSMYILIIVSISNIVLDYILIAILNFGVLGAAFATIIAQTLGSLIYLHHFIFGTSNLVFQKNKIHLEYITIVKILK
TGFSPFIMELAFGFLMLIHNIQFLRYGSSIDVSAYGIVIYVTSFLYMGYLGISDGIQPLISYNYGAKKFKRVFEVLKKAI
FINFLMGIISFILILRYPKKIIHVFNPYDALLVTQTVHGLIIHNFSLLILGISMIIILYFQATENSKIAGFLSLGRSILF
IIPALLIFPKYLGVSGIWLSTVFSEYLCLLFGLFFFFRSVKKNIWAKKDI

Sequences:

>Translated_450_residues
MKQVYDLGLENINKLLARYLVPSVLGTTIIGIYSIIDGIFIGRYVGTDGLAGVTLAFPISVAVGSIGLMIGYGACANISV
KLGKRDFNGANAILSVSLIYILIFGTFITFFGSLLLNNLIEIMNIPKNLESYVLNYSRVIIFGSLATITAYSLDAILRND
GFPKKSMYILIIVSISNIVLDYILIAILNFGVLGAAFATIIAQTLGSLIYLHHFIFGTSNLVFQKNKIHLEYITIVKILK
TGFSPFIMELAFGFLMLIHNIQFLRYGSSIDVSAYGIVIYVTSFLYMGYLGISDGIQPLISYNYGAKKFKRVFEVLKKAI
FINFLMGIISFILILRYPKKIIHVFNPYDALLVTQTVHGLIIHNFSLLILGISMIIILYFQATENSKIAGFLSLGRSILF
IIPALLIFPKYLGVSGIWLSTVFSEYLCLLFGLFFFFRSVKKNIWAKKDI
>Mature_450_residues
MKQVYDLGLENINKLLARYLVPSVLGTTIIGIYSIIDGIFIGRYVGTDGLAGVTLAFPISVAVGSIGLMIGYGACANISV
KLGKRDFNGANAILSVSLIYILIFGTFITFFGSLLLNNLIEIMNIPKNLESYVLNYSRVIIFGSLATITAYSLDAILRND
GFPKKSMYILIIVSISNIVLDYILIAILNFGVLGAAFATIIAQTLGSLIYLHHFIFGTSNLVFQKNKIHLEYITIVKILK
TGFSPFIMELAFGFLMLIHNIQFLRYGSSIDVSAYGIVIYVTSFLYMGYLGISDGIQPLISYNYGAKKFKRVFEVLKKAI
FINFLMGIISFILILRYPKKIIHVFNPYDALLVTQTVHGLIIHNFSLLILGISMIIILYFQATENSKIAGFLSLGRSILF
IIPALLIFPKYLGVSGIWLSTVFSEYLCLLFGLFFFFRSVKKNIWAKKDI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50144; Mature: 50144

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVYDLGLENINKLLARYLVPSVLGTTIIGIYSIIDGIFIGRYVGTDGLAGVTLAFPIS
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VAVGSIGLMIGYGACANISVKLGKRDFNGANAILSVSLIYILIFGTFITFFGSLLLNNLI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIMNIPKNLESYVLNYSRVIIFGSLATITAYSLDAILRNDGFPKKSMYILIIVSISNIVL
HHHCCCCHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
DYILIAILNFGVLGAAFATIIAQTLGSLIYLHHFIFGTSNLVFQKNKIHLEYITIVKILK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEHHHHHHHHHHH
TGFSPFIMELAFGFLMLIHNIQFLRYGSSIDVSAYGIVIYVTSFLYMGYLGISDGIQPLI
HCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SYNYGAKKFKRVFEVLKKAIFINFLMGIISFILILRYPKKIIHVFNPYDALLVTQTVHGL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHH
IIHNFSLLILGISMIIILYFQATENSKIAGFLSLGRSILFIIPALLIFPKYLGVSGIWLS
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TVFSEYLCLLFGLFFFFRSVKKNIWAKKDI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKQVYDLGLENINKLLARYLVPSVLGTTIIGIYSIIDGIFIGRYVGTDGLAGVTLAFPIS
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VAVGSIGLMIGYGACANISVKLGKRDFNGANAILSVSLIYILIFGTFITFFGSLLLNNLI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIMNIPKNLESYVLNYSRVIIFGSLATITAYSLDAILRNDGFPKKSMYILIIVSISNIVL
HHHCCCCHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
DYILIAILNFGVLGAAFATIIAQTLGSLIYLHHFIFGTSNLVFQKNKIHLEYITIVKILK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEHHHHHHHHHHH
TGFSPFIMELAFGFLMLIHNIQFLRYGSSIDVSAYGIVIYVTSFLYMGYLGISDGIQPLI
HCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SYNYGAKKFKRVFEVLKKAIFINFLMGIISFILILRYPKKIIHVFNPYDALLVTQTVHGL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHH
IIHNFSLLILGISMIIILYFQATENSKIAGFLSLGRSILFIIPALLIFPKYLGVSGIWLS
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TVFSEYLCLLFGLFFFFRSVKKNIWAKKDI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA