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The map label for this gene is eIF2B

Identifier: 150400050

GI number: 150400050

Start: 1333994

End: 1334410

Strand: Reverse

Name: eIF2B

Synonym: Mevan_1308

Alternate gene names: 150400050

Gene position: 1334410-1333994 (Counterclockwise)

Preceding gene: 150400052

Following gene: 150400049

Centisome position: 77.58

GC content: 35.25

Gene sequence:

>417_bases
ATGGTCGATTACTTCGATTACAAAGAATTATTAAAAAGAGCGAGATCACAACTTCCAGAAGTAGTATTCAGTGATGTAAG
GTTTGAAATTCCATCCGCAGACAGTTTTGTGGAAGGAAATAGAACCATTATTAAAAATTTCAAGGATATTGCAAAATTCA
TGGAGCGGGATACTCACGAGTTTGCAAAATTCGTAATGAAAGAACTTGGTACTGCTGGAGACATGGAAGGAAACAGGTTA
ATACTACAAGGTAAGTTTGGATGGAGAATGGTAAATGAAAAAATCCAAAACTATGTAAACGAGTATGTTTTGTGTCCAGA
ATGCGGAAAACCCGACACAAAAATTATCAAAGAAGGAAGAATACACTTCTTAAAGTGTACTGCTTGCGGTGCAATGAAAC
CATTGAAATCATTATAA

Upstream 100 bases:

>100_bases
AATTTAACGGCAAGTATATAAATAATGGACTAGAAAACACATTTACAAATTGTTTACTTTTTTACAATTGTCTATTTTGT
AACTTAAATTTGGTGAAAAC

Downstream 100 bases:

>100_bases
AACTCTTTTTCTTTTTAACCTGAATTTTACATTACCCTAGTTTTTTATTATTTTAAAGACTAATTTTATTTGGTGATTAT
TATGAAAGGACTCTGTTACC

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MVDYFDYKELLKRARSQLPEVVFSDVRFEIPSADSFVEGNRTIIKNFKDIAKFMERDTHEFAKFVMKELGTAGDMEGNRL
ILQGKFGWRMVNEKIQNYVNEYVLCPECGKPDTKIIKEGRIHFLKCTACGAMKPLKSL

Sequences:

>Translated_138_residues
MVDYFDYKELLKRARSQLPEVVFSDVRFEIPSADSFVEGNRTIIKNFKDIAKFMERDTHEFAKFVMKELGTAGDMEGNRL
ILQGKFGWRMVNEKIQNYVNEYVLCPECGKPDTKIIKEGRIHFLKCTACGAMKPLKSL
>Mature_138_residues
MVDYFDYKELLKRARSQLPEVVFSDVRFEIPSADSFVEGNRTIIKNFKDIAKFMERDTHEFAKFVMKELGTAGDMEGNRL
ILQGKFGWRMVNEKIQNYVNEYVLCPECGKPDTKIIKEGRIHFLKCTACGAMKPLKSL

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family

Homologues:

Organism=Homo sapiens, GI29826335, Length=134, Percent_Identity=32.8358208955224, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508049, Length=92, Percent_Identity=35.8695652173913, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325018, Length=141, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647377, Length=99, Percent_Identity=37.3737373737374, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF2B_METVS (A6URT3)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323817.1
- ProteinModelPortal:   A6URT3
- SMR:   A6URT3
- STRING:   A6URT3
- GeneID:   5325155
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1308
- eggNOG:   arNOG13033
- HOGENOM:   HBG738095
- OMA:   FLKCEAC
- ProtClustDB:   PRK03988
- HAMAP:   MF_00232
- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190
- TIGRFAMs:   TIGR00311

Pfam domain/function: PF01873 eIF-5_eIF-2B; SSF100966 Transl_init_fac_IF2/IF5_N; SSF75689 Transl_init_fac_IF2/IF5_Zn-bd

EC number: NA

Molecular weight: Translated: 15994; Mature: 15994

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDYFDYKELLKRARSQLPEVVFSDVRFEIPSADSFVEGNRTIIKNFKDIAKFMERDTHE
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHH
FAKFVMKELGTAGDMEGNRLILQGKFGWRMVNEKIQNYVNEYVLCPECGKPDTKIIKEGR
HHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCC
IHFLKCTACGAMKPLKSL
EEEEEECCCCCCCHHHCC
>Mature Secondary Structure
MVDYFDYKELLKRARSQLPEVVFSDVRFEIPSADSFVEGNRTIIKNFKDIAKFMERDTHE
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHH
FAKFVMKELGTAGDMEGNRLILQGKFGWRMVNEKIQNYVNEYVLCPECGKPDTKIIKEGR
HHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCC
IHFLKCTACGAMKPLKSL
EEEEEECCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA