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The map label for this gene is cadA [H]

Identifier: 150399974

GI number: 150399974

Start: 1261832

End: 1263922

Strand: Reverse

Name: cadA [H]

Synonym: Mevan_1231

Alternate gene names: 150399974

Gene position: 1263922-1261832 (Counterclockwise)

Preceding gene: 150399975

Following gene: 150399972

Centisome position: 73.48

GC content: 30.22

Gene sequence:

>2091_bases
ATGTACCGACATTATGAACTAAAAGGGCTTTGTTGTGCAAATTGTGCTTTAAAAATCGAGAGAATCCTATGTGAAAACGG
ATATCCTTCAGCAAGAATTAATTTTTCAACTTCAGAACTGTTATTCGCGGAAAAAAGCGTTGATATTAACTTTGTTAAAA
AATTAATCCATTCAATAGAACCAGAAATTATATTAATAGAAAAAGAAAACTTAGATTATAAATTAAGTTCCAATTTAACA
TTTAAAGACTTTGTTGATTTTAAGGAATTAAAAATTATCATATTTTCGCTTATCCTGTTTATTTTTGGTATTTTTGGAAG
TTATTTAAATTTTGAACCGTTTATAGTATTGATGATTTTTTTAACTAGCTACATGATTTCAGGAAATAAGGTATTTAAAA
AAACATTCAAAAATGTAAAAAGAGGAGACTTTTTTGATGAAAACTTTTTAATGACTATTGCAACAGTTGGTGCATTTTTA
ATTCACGAATATCCTGAAGGCGTTGCAGTAATGCTTTTTTACCGAATAGGTGAATTTTTACAGGATTTAGCGGTTTCAAA
ATCTCGAAGTTCTGTAAAATCATTATTGTCTTTAAAAGCAGAGTATGCAAACTTAAAAAAAGATGACAAACTTTTAAAGG
TCAGTCCTGAAACCGTTAAAAAGGGCCAAATAATTATAATAAATCCTGGAGAAAAAACTCCTTTAGATGGGATAATTTTA
AACGGAAATTCATCGATAGATGTTTCGGCATTAACTGGTGAAAGCTCACCAAGATATTTAAAAGATGGTGATGAAATATT
ATCAGGAATGGTTAACCTTACAGGGCCACTTACTGTAAAAGTAACTAAAGAGTTTGAAGAATCAACAGTTTATAAAATTC
TTGAATTAATAGAAACTGCAAATGTAAAAAAGGCAAAAACTGAAAAATTTGTAACCAAATTTGCTAGGTATTACACCCCT
TTTATTGTATTTTTAGCATTTTTAGTCGTTGCAATACCAATACTAGCTTTTAATGAACCAATAATTCCTTGGGTTTATAA
AGCTCTTGTTCTTTTGGTTATTTCATGCCCTTGTGCACTAGTTTTATCCATCCCTTTAAGTTACTTTGCAGGAATTGGTA
AACTTTCAAAGGATGGAATACTGGTTAAAGGTTCAAATTACATAGATATGTTGAGTAAAACTAACTATGTAATATTCGAT
AAAACAGGAACACTTACAAAAGGTAGCTTAAAAGTCAAGGAAGTATTTCCAAAAAACGGGTTTTCTAAAGAAGAATTAAT
CGAAATTGCGATAACTTCTGAATCACGATCTAACCACCCCGTTGCAAAGGCCATTATATCCAAATATGGAACAAATAGAT
TTTTCGAGTTTAGCGAATATAAGGAAATCCCTGGAAAAGGTATTGTTGCAAAGATACATGGTTTTGAAGTGATTTCAGGA
AATGAAAAATTAATGGAAGAAAGCGGAATTGATGTAAAACCAATGGATTCTTTCGATATAGCGGTGCATTTTGCAATTGA
TAAAAAGTATGCAGGATACATTTTAGTTTCTGATGAATTAAAAAAAGACTCAAAAAACGCCATTTTAGAATTAAAAAAGC
TTGGAATCAAAAAAATTTCAATGTTTACGGGAGATAGTTATCCTGTTTCTAAAAAAATTTCAGAGGAAATTTCAATTGAT
GAATTTTATTCAGATTTACTTCCAAAGGATAAAGTAACACTTTTAGAAGAAATTGAAAGAAAAAAAGACAAAAATGAATC
AATTGTTTTTGTAGGGGAGGGAATTAACGACGCTCCAGCAATTAAAAGGGCAGATGTAGGGATATCAATGGGAACTCTTG
GAAGCGATGCTGCAATTGAATCTTCAGACGTTGTGATTATGGATGATAATCCTTTAAAAGTAGCCCAGTCAATTAAACTA
TCAAAAAGAACAAAAAATATCGTCTGGCAAAATATTTTCATGATTTTTGGAGTTAAAATAGCATTCATAACTCTTTCAAT
ATTTGGTAGGGTAACAATGTGGGAAGCAGTATTTGCAGATGTGGGAATTACCATTATTTCAGTTTTAAACTCCCTTAGGA
TTCTAAAATGA

Upstream 100 bases:

>100_bases
TTTACGATGAAAAAATTAAGAAGTTTTTAGAAGTAATCCTTGAATTAAATAAATAAAAATGTATTATATAATTGTAAAAA
AGTATTAAAAAGGTAGTAAA

Downstream 100 bases:

>100_bases
AAAAATAAATAATTAAAAAGAATAAAAATAAATATTTATTTCCTGTGTTTTAACATTTCTAAACCTTTATCTGTTATTGT
ATATCCGTCCCCGATTTTTG

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MYRHYELKGLCCANCALKIERILCENGYPSARINFSTSELLFAEKSVDINFVKKLIHSIEPEIILIEKENLDYKLSSNLT
FKDFVDFKELKIIIFSLILFIFGIFGSYLNFEPFIVLMIFLTSYMISGNKVFKKTFKNVKRGDFFDENFLMTIATVGAFL
IHEYPEGVAVMLFYRIGEFLQDLAVSKSRSSVKSLLSLKAEYANLKKDDKLLKVSPETVKKGQIIIINPGEKTPLDGIIL
NGNSSIDVSALTGESSPRYLKDGDEILSGMVNLTGPLTVKVTKEFEESTVYKILELIETANVKKAKTEKFVTKFARYYTP
FIVFLAFLVVAIPILAFNEPIIPWVYKALVLLVISCPCALVLSIPLSYFAGIGKLSKDGILVKGSNYIDMLSKTNYVIFD
KTGTLTKGSLKVKEVFPKNGFSKEELIEIAITSESRSNHPVAKAIISKYGTNRFFEFSEYKEIPGKGIVAKIHGFEVISG
NEKLMEESGIDVKPMDSFDIAVHFAIDKKYAGYILVSDELKKDSKNAILELKKLGIKKISMFTGDSYPVSKKISEEISID
EFYSDLLPKDKVTLLEEIERKKDKNESIVFVGEGINDAPAIKRADVGISMGTLGSDAAIESSDVVIMDDNPLKVAQSIKL
SKRTKNIVWQNIFMIFGVKIAFITLSIFGRVTMWEAVFADVGITIISVLNSLRILK

Sequences:

>Translated_696_residues
MYRHYELKGLCCANCALKIERILCENGYPSARINFSTSELLFAEKSVDINFVKKLIHSIEPEIILIEKENLDYKLSSNLT
FKDFVDFKELKIIIFSLILFIFGIFGSYLNFEPFIVLMIFLTSYMISGNKVFKKTFKNVKRGDFFDENFLMTIATVGAFL
IHEYPEGVAVMLFYRIGEFLQDLAVSKSRSSVKSLLSLKAEYANLKKDDKLLKVSPETVKKGQIIIINPGEKTPLDGIIL
NGNSSIDVSALTGESSPRYLKDGDEILSGMVNLTGPLTVKVTKEFEESTVYKILELIETANVKKAKTEKFVTKFARYYTP
FIVFLAFLVVAIPILAFNEPIIPWVYKALVLLVISCPCALVLSIPLSYFAGIGKLSKDGILVKGSNYIDMLSKTNYVIFD
KTGTLTKGSLKVKEVFPKNGFSKEELIEIAITSESRSNHPVAKAIISKYGTNRFFEFSEYKEIPGKGIVAKIHGFEVISG
NEKLMEESGIDVKPMDSFDIAVHFAIDKKYAGYILVSDELKKDSKNAILELKKLGIKKISMFTGDSYPVSKKISEEISID
EFYSDLLPKDKVTLLEEIERKKDKNESIVFVGEGINDAPAIKRADVGISMGTLGSDAAIESSDVVIMDDNPLKVAQSIKL
SKRTKNIVWQNIFMIFGVKIAFITLSIFGRVTMWEAVFADVGITIISVLNSLRILK
>Mature_696_residues
MYRHYELKGLCCANCALKIERILCENGYPSARINFSTSELLFAEKSVDINFVKKLIHSIEPEIILIEKENLDYKLSSNLT
FKDFVDFKELKIIIFSLILFIFGIFGSYLNFEPFIVLMIFLTSYMISGNKVFKKTFKNVKRGDFFDENFLMTIATVGAFL
IHEYPEGVAVMLFYRIGEFLQDLAVSKSRSSVKSLLSLKAEYANLKKDDKLLKVSPETVKKGQIIIINPGEKTPLDGIIL
NGNSSIDVSALTGESSPRYLKDGDEILSGMVNLTGPLTVKVTKEFEESTVYKILELIETANVKKAKTEKFVTKFARYYTP
FIVFLAFLVVAIPILAFNEPIIPWVYKALVLLVISCPCALVLSIPLSYFAGIGKLSKDGILVKGSNYIDMLSKTNYVIFD
KTGTLTKGSLKVKEVFPKNGFSKEELIEIAITSESRSNHPVAKAIISKYGTNRFFEFSEYKEIPGKGIVAKIHGFEVISG
NEKLMEESGIDVKPMDSFDIAVHFAIDKKYAGYILVSDELKKDSKNAILELKKLGIKKISMFTGDSYPVSKKISEEISID
EFYSDLLPKDKVTLLEEIERKKDKNESIVFVGEGINDAPAIKRADVGISMGTLGSDAAIESSDVVIMDDNPLKVAQSIKL
SKRTKNIVWQNIFMIFGVKIAFITLSIFGRVTMWEAVFADVGITIISVLNSLRILK

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=782, Percent_Identity=26.4705882352941, Blast_Score=263, Evalue=5e-70,
Organism=Homo sapiens, GI115529486, Length=591, Percent_Identity=29.9492385786802, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI55743073, Length=539, Percent_Identity=28.5714285714286, Blast_Score=225, Evalue=1e-58,
Organism=Escherichia coli, GI1789879, Length=700, Percent_Identity=31.1428571428571, Blast_Score=334, Evalue=1e-92,
Organism=Escherichia coli, GI1786691, Length=739, Percent_Identity=26.3870094722598, Blast_Score=250, Evalue=3e-67,
Organism=Escherichia coli, GI1786914, Length=503, Percent_Identity=24.0556660039761, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17556548, Length=676, Percent_Identity=27.3668639053254, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17541776, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17557486, Length=103, Percent_Identity=30.0970873786408, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995298, Length=213, Percent_Identity=23.4741784037559, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995291, Length=213, Percent_Identity=23.4741784037559, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995286, Length=213, Percent_Identity=23.4741784037559, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=544, Percent_Identity=30.3308823529412, Blast_Score=220, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6319772, Length=523, Percent_Identity=26.1950286806883, Blast_Score=165, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6325221, Length=635, Percent_Identity=21.4173228346457, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321430, Length=610, Percent_Identity=20.8196721311475, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321271, Length=218, Percent_Identity=27.9816513761468, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320245, Length=202, Percent_Identity=25.2475247524752, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320243, Length=202, Percent_Identity=25.2475247524752, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320244, Length=202, Percent_Identity=25.2475247524752, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221329854, Length=352, Percent_Identity=28.9772727272727, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI281366676, Length=117, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 77945; Mature: 77945

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRHYELKGLCCANCALKIERILCENGYPSARINFSTSELLFAEKSVDINFVKKLIHSIE
CCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHEEEEECCCCHHHHHHHHHHCC
PEIILIEKENLDYKLSSNLTFKDFVDFKELKIIIFSLILFIFGIFGSYLNFEPFIVLMIF
CCEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LTSYMISGNKVFKKTFKNVKRGDFFDENFLMTIATVGAFLIHEYPEGVAVMLFYRIGEFL
HHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QDLAVSKSRSSVKSLLSLKAEYANLKKDDKLLKVSPETVKKGQIIIINPGEKTPLDGIIL
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCEEEEECCCCCCCCCEEEE
NGNSSIDVSALTGESSPRYLKDGDEILSGMVNLTGPLTVKVTKEFEESTVYKILELIETA
CCCCCEEEEEECCCCCCCHHCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHC
NVKKAKTEKFVTKFARYYTPFIVFLAFLVVAIPILAFNEPIIPWVYKALVLLVISCPCAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VLSIPLSYFAGIGKLSKDGILVKGSNYIDMLSKTNYVIFDKTGTLTKGSLKVKEVFPKNG
HHHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCEEEEECCCCEECCCEEEEEECCCCC
FSKEELIEIAITSESRSNHPVAKAIISKYGTNRFFEFSEYKEIPGKGIVAKIHGFEVISG
CCHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCEECHHHHCCCCCCEEEEEECEEEECC
NEKLMEESGIDVKPMDSFDIAVHFAIDKKYAGYILVSDELKKDSKNAILELKKLGIKKIS
CHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEEHHHCCCHHHHHHHHHHCCCEEEE
MFTGDSYPVSKKISEEISIDEFYSDLLPKDKVTLLEEIERKKDKNESIVFVGEGINDAPA
EECCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
IKRADVGISMGTLGSDAAIESSDVVIMDDNPLKVAQSIKLSKRTKNIVWQNIFMIFGVKI
CEECCCCEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFITLSIFGRVTMWEAVFADVGITIISVLNSLRILK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYRHYELKGLCCANCALKIERILCENGYPSARINFSTSELLFAEKSVDINFVKKLIHSIE
CCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHEEEEECCCCHHHHHHHHHHCC
PEIILIEKENLDYKLSSNLTFKDFVDFKELKIIIFSLILFIFGIFGSYLNFEPFIVLMIF
CCEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LTSYMISGNKVFKKTFKNVKRGDFFDENFLMTIATVGAFLIHEYPEGVAVMLFYRIGEFL
HHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QDLAVSKSRSSVKSLLSLKAEYANLKKDDKLLKVSPETVKKGQIIIINPGEKTPLDGIIL
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHCCCEEEEECCCCCCCCCEEEE
NGNSSIDVSALTGESSPRYLKDGDEILSGMVNLTGPLTVKVTKEFEESTVYKILELIETA
CCCCCEEEEEECCCCCCCHHCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHC
NVKKAKTEKFVTKFARYYTPFIVFLAFLVVAIPILAFNEPIIPWVYKALVLLVISCPCAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
VLSIPLSYFAGIGKLSKDGILVKGSNYIDMLSKTNYVIFDKTGTLTKGSLKVKEVFPKNG
HHHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCEEEEECCCCEECCCEEEEEECCCCC
FSKEELIEIAITSESRSNHPVAKAIISKYGTNRFFEFSEYKEIPGKGIVAKIHGFEVISG
CCHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCEECHHHHCCCCCCEEEEEECEEEECC
NEKLMEESGIDVKPMDSFDIAVHFAIDKKYAGYILVSDELKKDSKNAILELKKLGIKKIS
CHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEEHHHCCCHHHHHHHHHHCCCEEEE
MFTGDSYPVSKKISEEISIDEFYSDLLPKDKVTLLEEIERKKDKNESIVFVGEGINDAPA
EECCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
IKRADVGISMGTLGSDAAIESSDVVIMDDNPLKVAQSIKLSKRTKNIVWQNIFMIFGVKI
CEECCCCEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFITLSIFGRVTMWEAVFADVGITIISVLNSLRILK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]