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The map label for this gene is eif6

Identifier: 150399821

GI number: 150399821

Start: 1091325

End: 1092008

Strand: Reverse

Name: eif6

Synonym: Mevan_1076

Alternate gene names: 150399821

Gene position: 1092008-1091325 (Counterclockwise)

Preceding gene: 150399822

Following gene: 150399820

Centisome position: 63.49

GC content: 35.09

Gene sequence:

>684_bases
ATGATAATCAAAACATACTTTTCTGGAGTATCTACTATAGGAGTACTTTCACTTGCAACTGAAGACTATGGACTTTTTCC
TCTTTCAGTTGAAAAAAACACTTTGGAAAAAATGAAGGAAGTACTCAATATTCCAGTAACCCAGTTAAACATATCTAACA
GTTCATTAATCGGTTCTTTATGTGTTGGAAACTCCAACGGACTATTAGTACCTAACATTGTAACGAGTAAGGAAATTGCA
TTAATTAAAGACTTTTTAAAAGAAAATAGTCTTGATGTTAATTTAGAAAAACTTAAAGCTAAAAACACGGCATTTGGTAA
TTTAATATTAACAAATAATAAAGGATGCATAATTTCAGAAGAGTTACAGAACTTTAGAAAAGTCATTGAAGATGTACTTG
GAGTAGAATCTGGAGTCGGAAACTATGCTAGTCTTCCAACGGTTGGTTCTAACGGAGTTGCTACTGATAAAGGATGCCTC
GTTCACCCGTTAACTGATGAATTAGAATTAGAGTGGATAACAGACGTTTTAAAAGTGGACTATGTTGGAAGAGGTACTGC
AAACCGGGGCGTAACTTCAGTTGGCTCATGTATTCTTGCAAACACTAAGGGTGCAGTTATCGGTGGCGACACTTCAGGCC
CTGAACTCTTAAAAATTGAAGAAGCTCTCGATTTAATCGATTAA

Upstream 100 bases:

>100_bases
TGCAAAAGTCAGAGTTAAAGCTGTCAAAGAAGGAGATGTTGTTAAAGCTACATTGATAGAATAATGCAACTTATTCTTTC
CTAAAAAACATTGTGGTACT

Downstream 100 bases:

>100_bases
TAAATTCATCTGGTGATATTATGGCAAAAATCATAAGAATAAAAGGAAAAATTGTTGGAAAAGACGAACCTATGGTATTC
TCAAAAGAATACAACGTATT

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MIIKTYFSGVSTIGVLSLATEDYGLFPLSVEKNTLEKMKEVLNIPVTQLNISNSSLIGSLCVGNSNGLLVPNIVTSKEIA
LIKDFLKENSLDVNLEKLKAKNTAFGNLILTNNKGCIISEELQNFRKVIEDVLGVESGVGNYASLPTVGSNGVATDKGCL
VHPLTDELELEWITDVLKVDYVGRGTANRGVTSVGSCILANTKGAVIGGDTSGPELLKIEEALDLID

Sequences:

>Translated_227_residues
MIIKTYFSGVSTIGVLSLATEDYGLFPLSVEKNTLEKMKEVLNIPVTQLNISNSSLIGSLCVGNSNGLLVPNIVTSKEIA
LIKDFLKENSLDVNLEKLKAKNTAFGNLILTNNKGCIISEELQNFRKVIEDVLGVESGVGNYASLPTVGSNGVATDKGCL
VHPLTDELELEWITDVLKVDYVGRGTANRGVTSVGSCILANTKGAVIGGDTSGPELLKIEEALDLID
>Mature_227_residues
MIIKTYFSGVSTIGVLSLATEDYGLFPLSVEKNTLEKMKEVLNIPVTQLNISNSSLIGSLCVGNSNGLLVPNIVTSKEIA
LIKDFLKENSLDVNLEKLKAKNTAFGNLILTNNKGCIISEELQNFRKVIEDVLGVESGVGNYASLPTVGSNGVATDKGCL
VHPLTDELELEWITDVLKVDYVGRGTANRGVTSVGSCILANTKGAVIGGDTSGPELLKIEEALDLID

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=228, Percent_Identity=29.8245614035088, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI31563378, Length=228, Percent_Identity=29.8245614035088, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506075, Length=228, Percent_Identity=28.5087719298246, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325273, Length=239, Percent_Identity=32.2175732217573, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21492634, Length=228, Percent_Identity=29.3859649122807, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_METVS (A6UR54)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323588.1
- ProteinModelPortal:   A6UR54
- SMR:   A6UR54
- STRING:   A6UR54
- GeneID:   5325349
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1076
- eggNOG:   arNOG10240
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- ProtClustDB:   PRK04046
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 24155; Mature: 24155

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKTYFSGVSTIGVLSLATEDYGLFPLSVEKNTLEKMKEVLNIPVTQLNISNSSLIGSL
CEEEEECCCHHHHHHEEEECCCCCEEEEEECHHHHHHHHHHHCCCCEEEECCCCCEEEEE
CVGNSNGLLVPNIVTSKEIALIKDFLKENSLDVNLEKLKAKNTAFGNLILTNNKGCIISE
EECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCCEEHH
ELQNFRKVIEDVLGVESGVGNYASLPTVGSNGVATDKGCLVHPLTDELELEWITDVLKVD
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHC
YVGRGTANRGVTSVGSCILANTKGAVIGGDTSGPELLKIEEALDLID
CCCCCCCCCCHHHHCCEEEECCCCCEEECCCCCCCEEEHHHHHHHCC
>Mature Secondary Structure
MIIKTYFSGVSTIGVLSLATEDYGLFPLSVEKNTLEKMKEVLNIPVTQLNISNSSLIGSL
CEEEEECCCHHHHHHEEEECCCCCEEEEEECHHHHHHHHHHHCCCCEEEECCCCCEEEEE
CVGNSNGLLVPNIVTSKEIALIKDFLKENSLDVNLEKLKAKNTAFGNLILTNNKGCIISE
EECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCCEEHH
ELQNFRKVIEDVLGVESGVGNYASLPTVGSNGVATDKGCLVHPLTDELELEWITDVLKVD
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHC
YVGRGTANRGVTSVGSCILANTKGAVIGGDTSGPELLKIEEALDLID
CCCCCCCCCCHHHHCCEEEECCCCCEEECCCCCCCEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA