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The map label for this gene is hisS

Identifier: 150399673

GI number: 150399673

Start: 942010

End: 943266

Strand: Reverse

Name: hisS

Synonym: Mevan_0924

Alternate gene names: 150399673

Gene position: 943266-942010 (Counterclockwise)

Preceding gene: 150399674

Following gene: 150399671

Centisome position: 54.84

GC content: 31.9

Gene sequence:

>1257_bases
ATGTTTCAAAAACCCAAAGGTACACGGGATTTTTTACCTGTAGAAATGAAGAAGCGAAAATTAATAGAAAAAAAATTGCG
AAATATCTTTGATTCTTACAATTTTTCTGAAATAAATACGCCCACATTTGAAAGTTTTGAACTCCTTTCCAAAAAAACTG
GCGAAGAAATAAGGAATCAGTTGTTTGTGTTTAACGACCACGGGAATAGGGAAATGGGTTTAAGGCCAGAATTTACATCA
TCAGTTGCAAGATTTTACATAAACGAGTTTAAAAATACCCCAAAACCGGTTAAAATGTATTATTTTGGGAATTGTTTTAG
GTATGAAAACCCCCAAGCAGGTAGATACCGAGAATTTTGGCAAATGGGTGCAGAATTAATTGGTAGTAACAAGTCAATTT
CGGATGCAGAAGTACTTAACATGGCTATTGAAGGATTGAAATCAATTAACATGGACTTTGAAATTAATATTGGCCATTTG
GGTGTTTTAAAAGGTGTTTTTGAGAAATATTCTCTTTCAGAGGAGGATGAAACTTTAATTCGCCGTTTAATAGATAAAGA
GGATACTGAAGGGTTAAAACAAGTTTTATTGAAAATCGAGGAAGAAAAAAATATCGAAATTTCAAAAAAAGTGTTTGAAG
TTCTTACATTAAAAGGTGGAAAGGAAGTAATTTCTAAATTAAAAGAAAAACTTACGGACTTTGAAAAGTCGTTAGACGCG
CTAAATAACCTAGATGAAATTTTAGAACTTGTTCCACACGATTATGTTGTAAATTTTGGCATTGCAAGAGGCTTAGATTA
TTATACAGGCATGGTTTTTGAGATATATGGGAAAAAAGAAGGTGCACGACAGGTATGTGGCGGTGGAAGATACGACAACC
TAATAGAACTTTTTGAAGGGGAAAAATCACCTGCTGTAGGATTTGCATATGGTTTTGATAGGATTATATTAAATATCGAT
GATTTTGAAGTTCAGGACGATTCAATATTTATAATTCCGGTCAAAAATGACATTTTTTTACTTAAGGAATGTTTAAAAAT
AGCAAAAACTTTAAGGGATTTTGGAAACCCTGTTGAAATTGATCTCATGGGCAGAAAATTGAATAAAGCTTTAAACTATG
CAAACTCCAAAAATATCAAAAGAGTAATTATTATTGGGGAAAACGACATTTTTTCCGGAAAAATACCTTTAAAAAATATG
GAAACAGGAGAACAGGTTTTAATTGACGTAAAAGACCTTAAAAATTTCCCATGTTAA

Upstream 100 bases:

>100_bases
ACATTAACAAGATATTGGGCGATGAGCCAATTGAAAAAAAATAACTTTTTACTTTTTTTAATAAAATTTACACACGTTTA
GTATAGATAGAGTGATTAAA

Downstream 100 bases:

>100_bases
ATTTTAAATGTTATAATTTTTAACTGGCATTTAAAAATTATTTTTTAAGAATTATTTCGATAGTGGATATGTTTATGGAT
TTTCCTTCATCACTTTGAAC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFQKPKGTRDFLPVEMKKRKLIEKKLRNIFDSYNFSEINTPTFESFELLSKKTGEEIRNQLFVFNDHGNREMGLRPEFTS
SVARFYINEFKNTPKPVKMYYFGNCFRYENPQAGRYREFWQMGAELIGSNKSISDAEVLNMAIEGLKSINMDFEINIGHL
GVLKGVFEKYSLSEEDETLIRRLIDKEDTEGLKQVLLKIEEEKNIEISKKVFEVLTLKGGKEVISKLKEKLTDFEKSLDA
LNNLDEILELVPHDYVVNFGIARGLDYYTGMVFEIYGKKEGARQVCGGGRYDNLIELFEGEKSPAVGFAYGFDRIILNID
DFEVQDDSIFIIPVKNDIFLLKECLKIAKTLRDFGNPVEIDLMGRKLNKALNYANSKNIKRVIIIGENDIFSGKIPLKNM
ETGEQVLIDVKDLKNFPC

Sequences:

>Translated_418_residues
MFQKPKGTRDFLPVEMKKRKLIEKKLRNIFDSYNFSEINTPTFESFELLSKKTGEEIRNQLFVFNDHGNREMGLRPEFTS
SVARFYINEFKNTPKPVKMYYFGNCFRYENPQAGRYREFWQMGAELIGSNKSISDAEVLNMAIEGLKSINMDFEINIGHL
GVLKGVFEKYSLSEEDETLIRRLIDKEDTEGLKQVLLKIEEEKNIEISKKVFEVLTLKGGKEVISKLKEKLTDFEKSLDA
LNNLDEILELVPHDYVVNFGIARGLDYYTGMVFEIYGKKEGARQVCGGGRYDNLIELFEGEKSPAVGFAYGFDRIILNID
DFEVQDDSIFIIPVKNDIFLLKECLKIAKTLRDFGNPVEIDLMGRKLNKALNYANSKNIKRVIIIGENDIFSGKIPLKNM
ETGEQVLIDVKDLKNFPC
>Mature_418_residues
MFQKPKGTRDFLPVEMKKRKLIEKKLRNIFDSYNFSEINTPTFESFELLSKKTGEEIRNQLFVFNDHGNREMGLRPEFTS
SVARFYINEFKNTPKPVKMYYFGNCFRYENPQAGRYREFWQMGAELIGSNKSISDAEVLNMAIEGLKSINMDFEINIGHL
GVLKGVFEKYSLSEEDETLIRRLIDKEDTEGLKQVLLKIEEEKNIEISKKVFEVLTLKGGKEVISKLKEKLTDFEKSLDA
LNNLDEILELVPHDYVVNFGIARGLDYYTGMVFEIYGKKEGARQVCGGGRYDNLIELFEGEKSPAVGFAYGFDRIILNID
DFEVQDDSIFIIPVKNDIFLLKECLKIAKTLRDFGNPVEIDLMGRKLNKALNYANSKNIKRVIIIGENDIFSGKIPLKNM
ETGEQVLIDVKDLKNFPC

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=447, Percent_Identity=29.7539149888143, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI15029520, Length=447, Percent_Identity=29.082774049217, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1788861, Length=430, Percent_Identity=27.906976744186, Blast_Score=161, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71993693, Length=454, Percent_Identity=26.431718061674, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71993686, Length=454, Percent_Identity=26.431718061674, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325290, Length=456, Percent_Identity=27.8508771929825, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24643061, Length=458, Percent_Identity=26.6375545851528, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24643059, Length=477, Percent_Identity=25.5765199161426, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_METVS (A6UQQ6)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323440.1
- ProteinModelPortal:   A6UQQ6
- SMR:   A6UQQ6
- STRING:   A6UQQ6
- GeneID:   5326059
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0924
- eggNOG:   arNOG04127
- HOGENOM:   HBG616575
- OMA:   FDMSIVR
- ProtClustDB:   PRK00037
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48166; Mature: 48166

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKPKGTRDFLPVEMKKRKLIEKKLRNIFDSYNFSEINTPTFESFELLSKKTGEEIRNQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHCC
LFVFNDHGNREMGLRPEFTSSVARFYINEFKNTPKPVKMYYFGNCFRYENPQAGRYREFW
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCHHHHHH
QMGAELIGSNKSISDAEVLNMAIEGLKSINMDFEINIGHLGVLKGVFEKYSLSEEDETLI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHH
RRLIDKEDTEGLKQVLLKIEEEKNIEISKKVFEVLTLKGGKEVISKLKEKLTDFEKSLDA
HHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LNNLDEILELVPHDYVVNFGIARGLDYYTGMVFEIYGKKEGARQVCGGGRYDNLIELFEG
HHHHHHHHHHCCCHHEEHHHHHHCCHHHHCEEEEEECCCCCHHHHCCCCCHHHHHHHHCC
EKSPAVGFAYGFDRIILNIDDFEVQDDSIFIIPVKNDIFLLKECLKIAKTLRDFGNPVEI
CCCCCEEEEECCEEEEEECCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEE
DLMGRKLNKALNYANSKNIKRVIIIGENDIFSGKIPLKNMETGEQVLIDVKDLKNFPC
EEHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCCCHHEEEEHHHHCCCCC
>Mature Secondary Structure
MFQKPKGTRDFLPVEMKKRKLIEKKLRNIFDSYNFSEINTPTFESFELLSKKTGEEIRNQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHCC
LFVFNDHGNREMGLRPEFTSSVARFYINEFKNTPKPVKMYYFGNCFRYENPQAGRYREFW
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCHHHHHH
QMGAELIGSNKSISDAEVLNMAIEGLKSINMDFEINIGHLGVLKGVFEKYSLSEEDETLI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHH
RRLIDKEDTEGLKQVLLKIEEEKNIEISKKVFEVLTLKGGKEVISKLKEKLTDFEKSLDA
HHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LNNLDEILELVPHDYVVNFGIARGLDYYTGMVFEIYGKKEGARQVCGGGRYDNLIELFEG
HHHHHHHHHHCCCHHEEHHHHHHCCHHHHCEEEEEECCCCCHHHHCCCCCHHHHHHHHCC
EKSPAVGFAYGFDRIILNIDDFEVQDDSIFIIPVKNDIFLLKECLKIAKTLRDFGNPVEI
CCCCCEEEEECCEEEEEECCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEE
DLMGRKLNKALNYANSKNIKRVIIIGENDIFSGKIPLKNMETGEQVLIDVKDLKNFPC
EEHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCCCHHEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA