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The map label for this gene is uppS [H]

Identifier: 150399407

GI number: 150399407

Start: 706279

End: 707073

Strand: Reverse

Name: uppS [H]

Synonym: Mevan_0656

Alternate gene names: 150399407

Gene position: 707073-706279 (Counterclockwise)

Preceding gene: 150399408

Following gene: 150399406

Centisome position: 41.11

GC content: 32.83

Gene sequence:

>795_bases
TTGCCTCTTTTTATGTTTTACGAATATTTATGTAAATTTGGACTGTTAAAAATCTACGAAAAAGAAATCGAAGCTCGAGT
TATAAAGCATCCTCTTCCAAAACATGTTGGAATTATAATGGATGGAAACAGGAGGCTTGCAAAAAAAATAGGTGAAAATC
CGGAAATCGGGCACCATTTAGGGGCTTCAAAAGTTAGGGAAGTTATAAACTGGTGCGTTTCTCTTGGGATACATACTGTT
ACACTTTACGCATTCTCCCTTGAAAATTTTGAAAGGCCAAAAGATGAAGTTAATGTATTAATGAACCTTTTTGAACGTGA
ATTTCTGGAAATTGCAAAACATCCCGATATCCATAAGAATAAAATCCAGGTAAATGTAATAGGTCGAAAAAAACTACTTC
CAAAACATGTTCAAGATGCAATAAATTATGCAGAAGAACAAACAAAGTTTTATTCGGATTACTACGTTAATTTTGCAATA
GCCTATGGCGGTCAACAGGAAATTGTGGATAGCGTTAAGAAAATTGCAAAAAAGGTAAAAGATGGTAGTTTATCAATTGA
AGAAATAAATCTTGAACTAATTTCAGAAAATCTATATACTAGCCATTTACCATGTCCAAATCCTGATTTAATTATAAGAA
CATCTGGTGAAGAAAGAATAAGTAATTTTTTAACTTGGCAGTCATGCTATTCTGAACTATATTTTTGCGAAACTTACTGG
CCCACATTTAGAAGAGTAGACTTTTTAAGATCTATTCGGGAATACCAAAAACGTGAAAGACGCTATGGAAAGTGA

Upstream 100 bases:

>100_bases
GTTAAGTTTATAGATACAAGCCGTAGCGGAGATTCTAAAAGGTATTATAACGCAGTTAAATTTTTAAAAAATGGATTTTA
AGTAGTTACTGGTGATTTTT

Downstream 100 bases:

>100_bases
ATATCATGGAGAATTCTTTAATTGTTATTTTAATGTTAATCGTGTTTTCAGGCTGTATCTCTAATGAAAATCTTGAACCT
ACAAATGATAATATTAATTT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MPLFMFYEYLCKFGLLKIYEKEIEARVIKHPLPKHVGIIMDGNRRLAKKIGENPEIGHHLGASKVREVINWCVSLGIHTV
TLYAFSLENFERPKDEVNVLMNLFEREFLEIAKHPDIHKNKIQVNVIGRKKLLPKHVQDAINYAEEQTKFYSDYYVNFAI
AYGGQQEIVDSVKKIAKKVKDGSLSIEEINLELISENLYTSHLPCPNPDLIIRTSGEERISNFLTWQSCYSELYFCETYW
PTFRRVDFLRSIREYQKRERRYGK

Sequences:

>Translated_264_residues
MPLFMFYEYLCKFGLLKIYEKEIEARVIKHPLPKHVGIIMDGNRRLAKKIGENPEIGHHLGASKVREVINWCVSLGIHTV
TLYAFSLENFERPKDEVNVLMNLFEREFLEIAKHPDIHKNKIQVNVIGRKKLLPKHVQDAINYAEEQTKFYSDYYVNFAI
AYGGQQEIVDSVKKIAKKVKDGSLSIEEINLELISENLYTSHLPCPNPDLIIRTSGEERISNFLTWQSCYSELYFCETYW
PTFRRVDFLRSIREYQKRERRYGK
>Mature_263_residues
PLFMFYEYLCKFGLLKIYEKEIEARVIKHPLPKHVGIIMDGNRRLAKKIGENPEIGHHLGASKVREVINWCVSLGIHTVT
LYAFSLENFERPKDEVNVLMNLFEREFLEIAKHPDIHKNKIQVNVIGRKKLLPKHVQDAINYAEEQTKFYSDYYVNFAIA
YGGQQEIVDSVKKIAKKVKDGSLSIEEINLELISENLYTSHLPCPNPDLIIRTSGEERISNFLTWQSCYSELYFCETYWP
TFRRVDFLRSIREYQKRERRYGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=246, Percent_Identity=38.2113821138211, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI45580742, Length=246, Percent_Identity=38.2113821138211, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=40, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=36.2068965517241, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319474, Length=232, Percent_Identity=34.9137931034483, Blast_Score=121, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=31.651376146789, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=37.9912663755458, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 31113; Mature: 30982

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFMFYEYLCKFGLLKIYEKEIEARVIKHPLPKHVGIIMDGNRRLAKKIGENPEIGHHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCHHHC
GASKVREVINWCVSLGIHTVTLYAFSLENFERPKDEVNVLMNLFEREFLEIAKHPDIHKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
KIQVNVIGRKKLLPKHVQDAINYAEEQTKFYSDYYVNFAIAYGGQQEIVDSVKKIAKKVK
EEEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHC
DGSLSIEEINLELISENLYTSHLPCPNPDLIIRTSGEERISNFLTWQSCYSELYFCETYW
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
PTFRRVDFLRSIREYQKRERRYGK
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLFMFYEYLCKFGLLKIYEKEIEARVIKHPLPKHVGIIMDGNRRLAKKIGENPEIGHHL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCHHHC
GASKVREVINWCVSLGIHTVTLYAFSLENFERPKDEVNVLMNLFEREFLEIAKHPDIHKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
KIQVNVIGRKKLLPKHVQDAINYAEEQTKFYSDYYVNFAIAYGGQQEIVDSVKKIAKKVK
EEEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHC
DGSLSIEEINLELISENLYTSHLPCPNPDLIIRTSGEERISNFLTWQSCYSELYFCETYW
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
PTFRRVDFLRSIREYQKRERRYGK
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]