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The map label for this gene is ppiB [H]

Identifier: 150399203

GI number: 150399203

Start: 505034

End: 505525

Strand: Reverse

Name: ppiB [H]

Synonym: Mevan_0451

Alternate gene names: 150399203

Gene position: 505525-505034 (Counterclockwise)

Preceding gene: 150399204

Following gene: 150399198

Centisome position: 29.39

GC content: 31.5

Gene sequence:

>492_bases
ATGATTGCAGAAATTAAAACAAATATGGGATCAATGAAATTAAAGTTATTTGACGATAAAGCCCCAATTACTGTTAAAAA
CTTTAAAAAATATGCTGAAACTGGTTTTTATGATGAAATAATATTTCATAGGGTAATCAAAGGATTTATGGCACAAGGTG
GCGGATTTACAAAAGACGGACTTCAAAAAGACACATTTGAACCTATCAAGAATGAAGCTAAGAATGGCCTTTCAAATAAA
CGGGGAACTATCGCAATGGCTAGAACTAATGCTATTAACTCTGCAACAAGCCAATTTTTCATAAATACGGTTGATAATGC
ATTTTTAAACTACCAAAACGACCAAAACTATGGATATGCAGTATTTGGTGAAATGATTGAAGGTTTTGACGTACTTGATA
AAATAGAGTTGGTAAAAACTGGAAATAGGGGATACTTTCAAGACTGGCCTGTTACAGATGTAATAATTGAAAAAGTTATA
ATTGAAGAATAA

Upstream 100 bases:

>100_bases
TTGAAATACTTAAAAAGTAAATGATTTATAATGTAAATACGAAAGATTAATAAACATTTTTAAACCAACGCTAAGATAAA
CAATATTTGAAGGTGAAACT

Downstream 100 bases:

>100_bases
TATTTAAATTTATAAAAAAATAGAATATTAAAAATTTTAATACCCTTTTATTTTTTTTAGTATTATTTTTAGAACTTATT
TAAATATTATTTAAAAATTA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MIAEIKTNMGSMKLKLFDDKAPITVKNFKKYAETGFYDEIIFHRVIKGFMAQGGGFTKDGLQKDTFEPIKNEAKNGLSNK
RGTIAMARTNAINSATSQFFINTVDNAFLNYQNDQNYGYAVFGEMIEGFDVLDKIELVKTGNRGYFQDWPVTDVIIEKVI
IEE

Sequences:

>Translated_163_residues
MIAEIKTNMGSMKLKLFDDKAPITVKNFKKYAETGFYDEIIFHRVIKGFMAQGGGFTKDGLQKDTFEPIKNEAKNGLSNK
RGTIAMARTNAINSATSQFFINTVDNAFLNYQNDQNYGYAVFGEMIEGFDVLDKIELVKTGNRGYFQDWPVTDVIIEKVI
IEE
>Mature_163_residues
MIAEIKTNMGSMKLKLFDDKAPITVKNFKKYAETGFYDEIIFHRVIKGFMAQGGGFTKDGLQKDTFEPIKNEAKNGLSNK
RGTIAMARTNAINSATSQFFINTVDNAFLNYQNDQNYGYAVFGEMIEGFDVLDKIELVKTGNRGYFQDWPVTDVIIEKVI
IEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=32.1212121212121, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=34.3949044585987, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI22547212, Length=160, Percent_Identity=33.125, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI7657473, Length=160, Percent_Identity=33.125, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI22547215, Length=139, Percent_Identity=35.9712230215827, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7706339, Length=158, Percent_Identity=31.6455696202532, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4758950, Length=155, Percent_Identity=38.0645161290323, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI310110104, Length=133, Percent_Identity=36.0902255639098, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310129267, Length=133, Percent_Identity=35.3383458646617, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310120620, Length=133, Percent_Identity=35.3383458646617, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI10863927, Length=133, Percent_Identity=34.5864661654135, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI64276486, Length=124, Percent_Identity=32.258064516129, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1786736, Length=159, Percent_Identity=60.377358490566, Blast_Score=187, Evalue=3e-49,
Organism=Escherichia coli, GI1789763, Length=152, Percent_Identity=53.9473684210526, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.9315068493151, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.9315068493151, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=153, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=145, Percent_Identity=32.4137931034483, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=153, Percent_Identity=34.640522875817, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=156, Percent_Identity=36.5384615384615, Blast_Score=68, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=136, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922376, Length=156, Percent_Identity=32.6923076923077, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24652460, Length=165, Percent_Identity=30.9090909090909, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45549139, Length=137, Percent_Identity=38.6861313868613, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17986117, Length=161, Percent_Identity=27.3291925465839, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI20130249, Length=152, Percent_Identity=34.8684210526316, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18462; Mature: 18462

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAEIKTNMGSMKLKLFDDKAPITVKNFKKYAETGFYDEIIFHRVIKGFMAQGGGFTKDG
CCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
LQKDTFEPIKNEAKNGLSNKRGTIAMARTNAINSATSQFFINTVDNAFLNYQNDQNYGYA
CCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
VFGEMIEGFDVLDKIELVKTGNRGYFQDWPVTDVIIEKVIIEE
HHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIAEIKTNMGSMKLKLFDDKAPITVKNFKKYAETGFYDEIIFHRVIKGFMAQGGGFTKDG
CCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
LQKDTFEPIKNEAKNGLSNKRGTIAMARTNAINSATSQFFINTVDNAFLNYQNDQNYGYA
CCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
VFGEMIEGFDVLDKIELVKTGNRGYFQDWPVTDVIIEKVIIEE
HHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]