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The map label for this gene is wecC [H]

Identifier: 150398958

GI number: 150398958

Start: 236638

End: 237981

Strand: Reverse

Name: wecC [H]

Synonym: Mevan_0203

Alternate gene names: 150398958

Gene position: 237981-236638 (Counterclockwise)

Preceding gene: 150398959

Following gene: 150398950

Centisome position: 13.84

GC content: 31.4

Gene sequence:

>1344_bases
ATGGATTTATTAAATTGTAATTTGAATATTGATTCAATATTAAAAAATGGAGAAATCAAAGTTTCAGTGTTTGGGCAGGG
TAAAATGGGTTTACCTCTAGCTTTAGTTTTTGCAGAACACGGACTTAACGTAATTGGCGTAGATATTGATAAATCGGTTG
TTAATAATCTAAATAACGGGATAAATCATATTACTGAAGAACCTGGTTTAAGTGAACTTCTTTTAAGAAATATTGAAAAC
AAAAAGTACACTGCAACAACTGATGGCGTACAGGCTGCAAATGATTCTGACATAATGATTATACTTGTTCCAACATTAAT
TGATGAACGGGGAAATATTAAGTTAGATCCAGTTTACAGTGTTTCAGAAATAATTTCAAAAGGACTAAAAAAAGGAAATA
TTGTAATAACTGAAGCTACAATGCCTCCTGGAACAACTGAAAAATTAATTCCAATTTTAGAAAAATCTGGATTAAAATTA
GGTGAATTTGGACTTTCACATGCACCTGAACGAACAATGACTGGAACTGCATTAAGGGATATTAAAGGACAGTATCCAAA
AATAATTGGTTGTAGTGACGAAAAAACATATAATATTGTTTCAAAACTTTACAACCTAATTAATAAAAAAGGAACTATAA
AAATGAGTTCAATTAAAGCTGCAGAAACTGTAAAAGTATTTGAAGGGGTTTATCGGGATGTAAATATTGGGCTTTCAAAT
GAAATGGCTTTATGGTGTGAAGAACATTCAATAGATGCATTAGAAGTATTTGATGCTGCAAATACACAGCCATTTTGTCA
TTTCCATACTCCCGGGGCCGGGGTTGGTGGGCACTGTATTCCGGTTTACCCCTGGTTTATAATAAACACGTCAAACGAAG
TAAATCCTAAAATTACCAAAACTGCAAGGGAATTAAATGATTATATGGCGCATCACATGGTTGAACTAACAATAAAAGGA
TTAAACGAGTTTAAAAAATGCTTAAATGGAAGTAACATCCTTGTTTTGGGTTTGACATTTAGGGGCGGAGTTAAAGAGTT
CATGAAAAGTGCGGCAATTCCAATAATAAATGAATTGAAGTTATTCGGTGCAAATGTTTATTCGTACGATCCACTATGTG
ACGAATTAGATGCAAAAAAGTATAATTCAAAATTAAAAACAGATTTTACTGGAATCGACGCAATTATCGTCACATCTGAC
CATGAAGAATTTAAACATATAGATTTTGAAAAAATTTCAAAAGAGGTTTCTACAAAATTAATTATTGATGGAAGAAATGT
TATAAATGTTTCAAATGCATCTGAAAATGGATTTAGGATTATTAAAGTTGGAAATTTGAAATAA

Upstream 100 bases:

>100_bases
GCGTTGAAAATAATAAAAAACCCCTAGTTTCGGGTCTAGATGGAATACATGCATTAAAAGTTGCATTAGATGCGCTTAAA
AATTCAAAAGAGGAATAGTT

Downstream 100 bases:

>100_bases
ATTTTTATATTTTTTTAATTTCGTCATTTAGTATTTTTTGAGCATATATGTAAGTTACAAAATACACAATACACATAGCT
AAACTGTAAAGTCCAATGGC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDLLNCNLNIDSILKNGEIKVSVFGQGKMGLPLALVFAEHGLNVIGVDIDKSVVNNLNNGINHITEEPGLSELLLRNIEN
KKYTATTDGVQAANDSDIMIILVPTLIDERGNIKLDPVYSVSEIISKGLKKGNIVITEATMPPGTTEKLIPILEKSGLKL
GEFGLSHAPERTMTGTALRDIKGQYPKIIGCSDEKTYNIVSKLYNLINKKGTIKMSSIKAAETVKVFEGVYRDVNIGLSN
EMALWCEEHSIDALEVFDAANTQPFCHFHTPGAGVGGHCIPVYPWFIINTSNEVNPKITKTARELNDYMAHHMVELTIKG
LNEFKKCLNGSNILVLGLTFRGGVKEFMKSAAIPIINELKLFGANVYSYDPLCDELDAKKYNSKLKTDFTGIDAIIVTSD
HEEFKHIDFEKISKEVSTKLIIDGRNVINVSNASENGFRIIKVGNLK

Sequences:

>Translated_447_residues
MDLLNCNLNIDSILKNGEIKVSVFGQGKMGLPLALVFAEHGLNVIGVDIDKSVVNNLNNGINHITEEPGLSELLLRNIEN
KKYTATTDGVQAANDSDIMIILVPTLIDERGNIKLDPVYSVSEIISKGLKKGNIVITEATMPPGTTEKLIPILEKSGLKL
GEFGLSHAPERTMTGTALRDIKGQYPKIIGCSDEKTYNIVSKLYNLINKKGTIKMSSIKAAETVKVFEGVYRDVNIGLSN
EMALWCEEHSIDALEVFDAANTQPFCHFHTPGAGVGGHCIPVYPWFIINTSNEVNPKITKTARELNDYMAHHMVELTIKG
LNEFKKCLNGSNILVLGLTFRGGVKEFMKSAAIPIINELKLFGANVYSYDPLCDELDAKKYNSKLKTDFTGIDAIIVTSD
HEEFKHIDFEKISKEVSTKLIIDGRNVINVSNASENGFRIIKVGNLK
>Mature_447_residues
MDLLNCNLNIDSILKNGEIKVSVFGQGKMGLPLALVFAEHGLNVIGVDIDKSVVNNLNNGINHITEEPGLSELLLRNIEN
KKYTATTDGVQAANDSDIMIILVPTLIDERGNIKLDPVYSVSEIISKGLKKGNIVITEATMPPGTTEKLIPILEKSGLKL
GEFGLSHAPERTMTGTALRDIKGQYPKIIGCSDEKTYNIVSKLYNLINKKGTIKMSSIKAAETVKVFEGVYRDVNIGLSN
EMALWCEEHSIDALEVFDAANTQPFCHFHTPGAGVGGHCIPVYPWFIINTSNEVNPKITKTARELNDYMAHHMVELTIKG
LNEFKKCLNGSNILVLGLTFRGGVKEFMKSAAIPIINELKLFGANVYSYDPLCDELDAKKYNSKLKTDFTGIDAIIVTSD
HEEFKHIDFEKISKEVSTKLIIDGRNVINVSNASENGFRIIKVGNLK

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=463, Percent_Identity=21.8142548596112, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI48994968, Length=430, Percent_Identity=28.8372093023256, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1788340, Length=406, Percent_Identity=22.6600985221675, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=462, Percent_Identity=22.5108225108225, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136908, Length=460, Percent_Identity=22.1739130434783, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49195; Mature: 49195

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLNCNLNIDSILKNGEIKVSVFGQGKMGLPLALVFAEHGLNVIGVDIDKSVVNNLNNG
CCEEEECCCHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHH
INHITEEPGLSELLLRNIENKKYTATTDGVQAANDSDIMIILVPTLIDERGNIKLDPVYS
HHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEEECCCCC
VSEIISKGLKKGNIVITEATMPPGTTEKLIPILEKSGLKLGEFGLSHAPERTMTGTALRD
HHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHH
IKGQYPKIIGCSDEKTYNIVSKLYNLINKKGTIKMSSIKAAETVKVFEGVYRDVNIGLSN
HCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCC
EMALWCEEHSIDALEVFDAANTQPFCHFHTPGAGVGGHCIPVYPWFIINTSNEVNPKITK
CEEEEEECCCCCCEEEHHCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCHHHH
TARELNDYMAHHMVELTIKGLNEFKKCLNGSNILVLGLTFRGGVKEFMKSAAIPIINELK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHH
LFGANVYSYDPLCDELDAKKYNSKLKTDFTGIDAIIVTSDHEEFKHIDFEKISKEVSTKL
HHCCCCEECCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHCEEE
IIDGRNVINVSNASENGFRIIKVGNLK
EECCCCEEEECCCCCCCEEEEEECCCC
>Mature Secondary Structure
MDLLNCNLNIDSILKNGEIKVSVFGQGKMGLPLALVFAEHGLNVIGVDIDKSVVNNLNNG
CCEEEECCCHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHH
INHITEEPGLSELLLRNIENKKYTATTDGVQAANDSDIMIILVPTLIDERGNIKLDPVYS
HHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEEECCCCC
VSEIISKGLKKGNIVITEATMPPGTTEKLIPILEKSGLKLGEFGLSHAPERTMTGTALRD
HHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHH
IKGQYPKIIGCSDEKTYNIVSKLYNLINKKGTIKMSSIKAAETVKVFEGVYRDVNIGLSN
HCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCC
EMALWCEEHSIDALEVFDAANTQPFCHFHTPGAGVGGHCIPVYPWFIINTSNEVNPKITK
CEEEEEECCCCCCEEEHHCCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCHHHH
TARELNDYMAHHMVELTIKGLNEFKKCLNGSNILVLGLTFRGGVKEFMKSAAIPIINELK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHH
LFGANVYSYDPLCDELDAKKYNSKLKTDFTGIDAIIVTSDHEEFKHIDFEKISKEVSTKL
HHCCCCEECCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHCEEE
IIDGRNVINVSNASENGFRIIKVGNLK
EECCCCEEEECCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA