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The map label for this gene is aqpM [H]

Identifier: 150398903

GI number: 150398903

Start: 167352

End: 168071

Strand: Reverse

Name: aqpM [H]

Synonym: Mevan_0147

Alternate gene names: 150398903

Gene position: 168071-167352 (Counterclockwise)

Preceding gene: 150398904

Following gene: 150398901

Centisome position: 9.77

GC content: 37.22

Gene sequence:

>720_bases
ATGAGCTTGCTAAAAAGAGCGATTGCTGAAGCACTTGGAACGCTAATTTTAGTATTTTTTGGGCCCGGTGCCGCAGTAAT
TACTCTATTAATTGCAAATAGTGCAGGAAGTCCTGGAATTGGTCTTTTAGGTGGATTGGGAGATTGGTTTTCAATTGGGT
TTGCATTTGCAATGTCTATTGCTGCAGTAATTTATTCTATTGGAAGAATTTCTGGTGCACATATAAATCCTGCCGTAACA
ATTGCACTTTGGTCTATTAAAAAATTTCCTACAAAAGAAGTTATTCCATATATTTTAGCGCAGTTAATAGGTGCTTCAAT
TGGTTCCGTACTATTCTTCTCTTGTATCGGACTTGATGCAGTAACAATTGGAGGACTTGGGGCTACTGCACCTTTTGTAG
GGATTAGCTATACCCAAGCAATACTTGCAGAATTTATCGGGACGTTCCTTTTAATGTTTACAATAATGGGCGTTGCCGTA
GATAAACGTGCACCTAATGGATTTGCAGGCATAGTAATAGGTTTAACGGTTGGTGCAATAATTGTTACAACTGGAAATAT
TGCTGGATCATCGCTAAACCCTGCAAGGACTTTTGGGCCTTATTTAATTAACAGCATTTATGGATTAAATCTCTGGGAAT
TTTTCCCAATATATATAATAGGCCCCATTCTTGGAGCAATTTTTGCTGCATTTACTTATGAATACTTAAATTCAGAATAA

Upstream 100 bases:

>100_bases
TATGGGAAGGAGGATACCCTTTTCCATCTAAAAAATTAAAAAATAAAATTCCAAGAATGCTATGTATTCCGTGCCATGAA
GCTTATAAAGAGGGTAAAAA

Downstream 100 bases:

>100_bases
TCCTTATTTTTTCCTTTTTTTAGTTAGGTATTACTTAAAAATAATATTAAATACATTTATTTAAAAATTTTGAAAATTAA
ATAGTATTAAAATAAAAATA

Product: MIP family channel protein

Products: glycerol [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSLLKRAIAEALGTLILVFFGPGAAVITLLIANSAGSPGIGLLGGLGDWFSIGFAFAMSIAAVIYSIGRISGAHINPAVT
IALWSIKKFPTKEVIPYILAQLIGASIGSVLFFSCIGLDAVTIGGLGATAPFVGISYTQAILAEFIGTFLLMFTIMGVAV
DKRAPNGFAGIVIGLTVGAIIVTTGNIAGSSLNPARTFGPYLINSIYGLNLWEFFPIYIIGPILGAIFAAFTYEYLNSE

Sequences:

>Translated_239_residues
MSLLKRAIAEALGTLILVFFGPGAAVITLLIANSAGSPGIGLLGGLGDWFSIGFAFAMSIAAVIYSIGRISGAHINPAVT
IALWSIKKFPTKEVIPYILAQLIGASIGSVLFFSCIGLDAVTIGGLGATAPFVGISYTQAILAEFIGTFLLMFTIMGVAV
DKRAPNGFAGIVIGLTVGAIIVTTGNIAGSSLNPARTFGPYLINSIYGLNLWEFFPIYIIGPILGAIFAAFTYEYLNSE
>Mature_238_residues
SLLKRAIAEALGTLILVFFGPGAAVITLLIANSAGSPGIGLLGGLGDWFSIGFAFAMSIAAVIYSIGRISGAHINPAVTI
ALWSIKKFPTKEVIPYILAQLIGASIGSVLFFSCIGLDAVTIGGLGATAPFVGISYTQAILAEFIGTFLLMFTIMGVAVD
KRAPNGFAGIVIGLTVGAIIVTTGNIAGSSLNPARTFGPYLINSIYGLNLWEFFPIYIIGPILGAIFAAFTYEYLNSE

Specific function: Channel that permits osmotically driven movement of water in both directions [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4755125, Length=190, Percent_Identity=37.3684210526316, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4502181, Length=190, Percent_Identity=37.3684210526316, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4826645, Length=259, Percent_Identity=30.5019305019305, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4502183, Length=242, Percent_Identity=33.4710743801653, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4502179, Length=234, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI37694062, Length=235, Percent_Identity=28.936170212766, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI157266307, Length=254, Percent_Identity=29.1338582677165, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI22538420, Length=260, Percent_Identity=27.3076923076923, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI6912506, Length=238, Percent_Identity=30.2521008403361, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI86792455, Length=234, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI45446752, Length=174, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790362, Length=264, Percent_Identity=32.1969696969697, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787101, Length=224, Percent_Identity=34.8214285714286, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994009, Length=256, Percent_Identity=33.203125, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71993722, Length=242, Percent_Identity=33.0578512396694, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17558372, Length=241, Percent_Identity=28.6307053941909, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71992966, Length=258, Percent_Identity=31.0077519379845, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531431, Length=253, Percent_Identity=28.4584980237154, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531429, Length=253, Percent_Identity=28.4584980237154, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17544068, Length=220, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=218, Percent_Identity=35.3211009174312, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24652747, Length=236, Percent_Identity=28.3898305084746, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551084, Length=236, Percent_Identity=28.3898305084746, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24762344, Length=229, Percent_Identity=31.8777292576419, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24762346, Length=229, Percent_Identity=31.8777292576419, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24762348, Length=229, Percent_Identity=31.8777292576419, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130305, Length=229, Percent_Identity=31.8777292576419, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550503, Length=239, Percent_Identity=25.9414225941423, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24762342, Length=236, Percent_Identity=29.2372881355932, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922038, Length=235, Percent_Identity=28.936170212766, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24821; Mature: 24689

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLKRAIAEALGTLILVFFGPGAAVITLLIANSAGSPGIGLLGGLGDWFSIGFAFAMSI
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHH
AAVIYSIGRISGAHINPAVTIALWSIKKFPTKEVIPYILAQLIGASIGSVLFFSCIGLDA
HHHHHHHHHCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTIGGLGATAPFVGISYTQAILAEFIGTFLLMFTIMGVAVDKRAPNGFAGIVIGLTVGAI
HEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IVTTGNIAGSSLNPARTFGPYLINSIYGLNLWEFFPIYIIGPILGAIFAAFTYEYLNSE
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLLKRAIAEALGTLILVFFGPGAAVITLLIANSAGSPGIGLLGGLGDWFSIGFAFAMSI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHH
AAVIYSIGRISGAHINPAVTIALWSIKKFPTKEVIPYILAQLIGASIGSVLFFSCIGLDA
HHHHHHHHHCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTIGGLGATAPFVGISYTQAILAEFIGTFLLMFTIMGVAVDKRAPNGFAGIVIGLTVGAI
HEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IVTTGNIAGSSLNPARTFGPYLINSIYGLNLWEFFPIYIIGPILGAIFAAFTYEYLNSE
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]