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The map label for this gene is hemC [H]

Identifier: 150398808

GI number: 150398808

Start: 46591

End: 47505

Strand: Reverse

Name: hemC [H]

Synonym: Mevan_0048

Alternate gene names: 150398808

Gene position: 47505-46591 (Counterclockwise)

Preceding gene: 150398809

Following gene: 150398807

Centisome position: 2.76

GC content: 32.46

Gene sequence:

>915_bases
TTGAAATTAAGAATTGGAACAAGGGGAAGTAAGCTTGCAATGATTCAGACTAAATATATTGCGAGTCTTTTAAATGAACT
CGGCGTAGAAACGGAGATAATTATTATAAAAACGACGGGGGATAAAGACCAGAATAAAAAACTTGCTGATCTTGGAATAG
GCGTCTTTACAAAAGAACTCGACAATAAAATGCTTGAAAATGAAATTGATATTGCAGTTCATAGTTTAAAAGACGTTCCA
ACACTATGGAGTGATGAATTACAAATTACTGCAACTCCAAAACGTGAAAGTCCTGATGACTTAATTTTATGGAATAAAAA
TAGTAATTTTAATATCGAATATGATGAATTAATCGTTGGAACGTCAAGCATTCGAAGAACTGCATTTTTAGAGCTTTCAA
ACCCCAATTTAAAAGTAAAGCTATTACGTGGAAATGTTGCAACAAGAATTGATAAACTTCGAAACAATGAATATGATGGA
ATAATCATGGCAAAAGCAGGGCTTATTCGACAAGGTATTGATTTATCAGATTTTAACTATGAAAAACTTGAAATACTTCC
AGCACCTGCTCAAGGCGTAATAGGCGTTGCTTCAAGAAAAAAAGATTATGAAATAAACGAAATCCTAGAAAAGATAAATG
ATAAAAAAACTTACCTTGAAGCAGTTGCAGAACGGTGGTCTTTAAAAGAATATGGTGGCGGATGTCAAGCCCCATTTGGA
GCTTTTGCCTTTTATGATTTTGATGAAGGGATACTTACACTTAAATGCGACCTTGTAAAAGAGATTCATGGAAAAAAAAT
CTCAATTTCAAAAGAAGGATTTGTTTACTGTAATGTAAATGATGTTGAACTTTCAAAAGACCTCGGAAAAAGAGTTGGAC
TATCATTTAAAGAATCAGATATTTTTGAGATATAA

Upstream 100 bases:

>100_bases
TGTAGCACATTTTACCTTTAAAATGATGCCATAGTAACCTAGTTTAAATTTCAGTGTTTTTATATAATATAATGTTTTTA
ATTATTTTAGCGGTGAAATT

Downstream 100 bases:

>100_bases
CATAAAATTTTTAAATAACTATAAATGATTTTAACAATTATATTTTTTATCCATTAGGTATACTGAGGGAGTCATATATG
GCCGATTATAACAATGCAGT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKLRIGTRGSKLAMIQTKYIASLLNELGVETEIIIIKTTGDKDQNKKLADLGIGVFTKELDNKMLENEIDIAVHSLKDVP
TLWSDELQITATPKRESPDDLILWNKNSNFNIEYDELIVGTSSIRRTAFLELSNPNLKVKLLRGNVATRIDKLRNNEYDG
IIMAKAGLIRQGIDLSDFNYEKLEILPAPAQGVIGVASRKKDYEINEILEKINDKKTYLEAVAERWSLKEYGGGCQAPFG
AFAFYDFDEGILTLKCDLVKEIHGKKISISKEGFVYCNVNDVELSKDLGKRVGLSFKESDIFEI

Sequences:

>Translated_304_residues
MKLRIGTRGSKLAMIQTKYIASLLNELGVETEIIIIKTTGDKDQNKKLADLGIGVFTKELDNKMLENEIDIAVHSLKDVP
TLWSDELQITATPKRESPDDLILWNKNSNFNIEYDELIVGTSSIRRTAFLELSNPNLKVKLLRGNVATRIDKLRNNEYDG
IIMAKAGLIRQGIDLSDFNYEKLEILPAPAQGVIGVASRKKDYEINEILEKINDKKTYLEAVAERWSLKEYGGGCQAPFG
AFAFYDFDEGILTLKCDLVKEIHGKKISISKEGFVYCNVNDVELSKDLGKRVGLSFKESDIFEI
>Mature_304_residues
MKLRIGTRGSKLAMIQTKYIASLLNELGVETEIIIIKTTGDKDQNKKLADLGIGVFTKELDNKMLENEIDIAVHSLKDVP
TLWSDELQITATPKRESPDDLILWNKNSNFNIEYDELIVGTSSIRRTAFLELSNPNLKVKLLRGNVATRIDKLRNNEYDG
IIMAKAGLIRQGIDLSDFNYEKLEILPAPAQGVIGVASRKKDYEINEILEKINDKKTYLEAVAERWSLKEYGGGCQAPFG
AFAFYDFDEGILTLKCDLVKEIHGKKISISKEGFVYCNVNDVELSKDLGKRVGLSFKESDIFEI

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=247, Percent_Identity=37.6518218623482, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI20149500, Length=247, Percent_Identity=37.6518218623482, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI48994974, Length=245, Percent_Identity=40.4081632653061, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319996, Length=277, Percent_Identity=34.2960288808664, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI20130425, Length=250, Percent_Identity=34.8, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34214; Mature: 34214

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRIGTRGSKLAMIQTKYIASLLNELGVETEIIIIKTTGDKDQNKKLADLGIGVFTKEL
CEEEECCCCCEEEEEHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCHHHHHHH
DNKMLENEIDIAVHSLKDVPTLWSDELQITATPKRESPDDLILWNKNSNFNIEYDELIVG
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEHHHEEEE
TSSIRRTAFLELSNPNLKVKLLRGNVATRIDKLRNNEYDGIIMAKAGLIRQGIDLSDFNY
CCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHCCCCCCEEEEEECCHHHCCCCCCCCCC
EKLEILPAPAQGVIGVASRKKDYEINEILEKINDKKTYLEAVAERWSLKEYGGGCQAPFG
CEEEEECCCCCCEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCCCC
AFAFYDFDEGILTLKCDLVKEIHGKKISISKEGFVYCNVNDVELSKDLGKRVGLSFKESD
EEEEEECCCCEEEEEEHHHHHHCCCEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCC
IFEI
CCCC
>Mature Secondary Structure
MKLRIGTRGSKLAMIQTKYIASLLNELGVETEIIIIKTTGDKDQNKKLADLGIGVFTKEL
CEEEECCCCCEEEEEHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCHHHHHHH
DNKMLENEIDIAVHSLKDVPTLWSDELQITATPKRESPDDLILWNKNSNFNIEYDELIVG
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEHHHEEEE
TSSIRRTAFLELSNPNLKVKLLRGNVATRIDKLRNNEYDGIIMAKAGLIRQGIDLSDFNY
CCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHCCCCCCEEEEEECCHHHCCCCCCCCCC
EKLEILPAPAQGVIGVASRKKDYEINEILEKINDKKTYLEAVAERWSLKEYGGGCQAPFG
CEEEEECCCCCCEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCCCC
AFAFYDFDEGILTLKCDLVKEIHGKKISISKEGFVYCNVNDVELSKDLGKRVGLSFKESD
EEEEEECCCCEEEEEEHHHHHHCCCEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCC
IFEI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]