Click here to switch to the map view.

The map label for this gene is hlb [H]

Identifier: 150394473

GI number: 150394473

Start: 2128653

End: 2128859

Strand: Direct

Name: hlb [H]

Synonym: SaurJH1_2030

Alternate gene names: 150394473

Gene position: 2128653-2128859 (Clockwise)

Preceding gene: 150394472

Following gene: 150394474

Centisome position: 73.24

GC content: 30.92

Gene sequence:

>207_bases
GTGATAATGATGGTAAAAAAAACAAAATCCAATTCACTAAAAAAAGTTGCAACACTTGCATTAGCAAATTTATTATTAGT
TGGTGCACTTACTGACAATAGTGCCAAAGCCGAATCTAAGAAAGATGATACTGATTTGAAGTTAGTTAGTCATAACGTTT
ATATGTTATCGACCGTTTTGTATCCAAACTGGAGACTTTTAACATAA

Upstream 100 bases:

>100_bases
TCAAAAAACATTTACTTAAAAATATAAATTCGATTTAATAATTAATTTAAATTTAGTTAATCAATTTTGCATCTATTTTG
TTGTAAGCTATATAAAAGGA

Downstream 100 bases:

>100_bases
AATTACTTATCATTCAAAAAGTAAAACAGCATAATATCAAGGTTTATAACTTTATCATTATCAATAATACCTCATATAAA
ATAAAATTTTAGGGACTTTT

Product: truncated beta-hemolysin

Products: NA

Alternate protein names: Beta-hemolysin; Beta-toxin; Sphingomyelinase; SMase [H]

Number of amino acids: Translated: 68; Mature: 68

Protein sequence:

>68_residues
MIMMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT

Sequences:

>Translated_68_residues
MIMMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT
>Mature_68_residues
MIMMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.3 [H]

Molecular weight: Translated: 7551; Mature: 7551

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVL
CEEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEECCEEEEEEEE
YPNWRLLT
CCCEEEEC
>Mature Secondary Structure
MIMMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVL
CEEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEECCEEEEEEEE
YPNWRLLT
CCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8914839 [H]