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The map label for this gene is prs [H]

Identifier: 150010343

GI number: 150010343

Start: 4605318

End: 4606259

Strand: Direct

Name: prs [H]

Synonym: BDI_3777

Alternate gene names: 150010343

Gene position: 4605318-4606259 (Clockwise)

Preceding gene: 150010340

Following gene: 150010345

Centisome position: 95.72

GC content: 45.65

Gene sequence:

>942_bases
ATGAGTGCACAAACTCCTTTCTTGGTGTTTTCGGGAACGAACTCCCGGTATCTTGCAGAGAAAATTTGCAACAGTTTAGG
TTGTCCTCTGGGACAGATGAATATCCAGCACTTTGCCGATGGTGAGTTCTCTGTTTCTTATGAAGAGTCTATCCGCGGTA
GAGATGTATTCTTAGTACAATCTACATTCCCTAATTCAGACAATCTGATGGAGTTGCTTCTGATGATTGACGCGGCTAAA
CGTGCTTCCGCACATTCAATCATCGCTGTAGTCCCTTACTTCGGTTGGGCTCGTCAGGATAGAAAGGATAAGCCTCGTGT
TTCTATTGGCGCTAAGTTGATCGCTGATATGTTGAGTACGGCAGGTATCAATCGTTTGATTACGATGGACCTTCATGCGG
ATCAGATCCAAGGATTCTTTAATGTTCCGGTGGATCACTTATATGCTTCTTCCGTATTCTTGGATTATATCAAGACGTCT
TTGCCTTTGGATAACTTGTGTATCGCGACTCCGGATGTTGGTGGTACGAAACGTGCCAGCAGCTATTCTAAGTATTTAGG
CTTGCCGATGGTCATTTGCCACAAATCTCGTTTGCGTGCCAATGAGGTGGCCGAGATGCGTATTATCGGTGATGTGACGG
GCTTGGATGTCCTTTTGGTTGATGACATGGTGGATACGGCCGGAACAATTACGAAAGCCGCGAACTTGATGTTGGAGAAT
GGCGCTAAGTCTGTTCGTGCTATCGCCAGCCACGCTGTGATGTCTGATCCGGCTTCTACTCGTGTAGATCAGTCCGCTTT
AGCGGAAATGATCTTTACGGATTCTATTCCTTACGCTAAGAAATGCGAGAAAGTAAAGGTATTATCTGTCGCTGACATGT
TCGCTGAGGCGATCCGTCGTGTATGTAGTGGAGAGTCTATCAGCTCTTTGTATGCTATTTAA

Upstream 100 bases:

>100_bases
TATAGAAAGTTTTCCAAATATAAAGAGGTTATTGTAAATAAGTTTTGTACTTTTGCGGCACAATTTAAATCTATTCACTT
TAAGATAAATATTCGGAATA

Downstream 100 bases:

>100_bases
TAGAATAAGATAGAAAAATAAAAACGGTCGCTTCCTTTTGAGGCGACCGTTTTTTATTTAGAATAAATCTGAATATGCGT
TACTTGGTCTCATCAATAAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSAQTPFLVFSGTNSRYLAEKICNSLGCPLGQMNIQHFADGEFSVSYEESIRGRDVFLVQSTFPNSDNLMELLLMIDAAK
RASAHSIIAVVPYFGWARQDRKDKPRVSIGAKLIADMLSTAGINRLITMDLHADQIQGFFNVPVDHLYASSVFLDYIKTS
LPLDNLCIATPDVGGTKRASSYSKYLGLPMVICHKSRLRANEVAEMRIIGDVTGLDVLLVDDMVDTAGTITKAANLMLEN
GAKSVRAIASHAVMSDPASTRVDQSALAEMIFTDSIPYAKKCEKVKVLSVADMFAEAIRRVCSGESISSLYAI

Sequences:

>Translated_313_residues
MSAQTPFLVFSGTNSRYLAEKICNSLGCPLGQMNIQHFADGEFSVSYEESIRGRDVFLVQSTFPNSDNLMELLLMIDAAK
RASAHSIIAVVPYFGWARQDRKDKPRVSIGAKLIADMLSTAGINRLITMDLHADQIQGFFNVPVDHLYASSVFLDYIKTS
LPLDNLCIATPDVGGTKRASSYSKYLGLPMVICHKSRLRANEVAEMRIIGDVTGLDVLLVDDMVDTAGTITKAANLMLEN
GAKSVRAIASHAVMSDPASTRVDQSALAEMIFTDSIPYAKKCEKVKVLSVADMFAEAIRRVCSGESISSLYAI
>Mature_312_residues
SAQTPFLVFSGTNSRYLAEKICNSLGCPLGQMNIQHFADGEFSVSYEESIRGRDVFLVQSTFPNSDNLMELLLMIDAAKR
ASAHSIIAVVPYFGWARQDRKDKPRVSIGAKLIADMLSTAGINRLITMDLHADQIQGFFNVPVDHLYASSVFLDYIKTSL
PLDNLCIATPDVGGTKRASSYSKYLGLPMVICHKSRLRANEVAEMRIIGDVTGLDVLLVDDMVDTAGTITKAANLMLENG
AKSVRAIASHAVMSDPASTRVDQSALAEMIFTDSIPYAKKCEKVKVLSVADMFAEAIRRVCSGESISSLYAI

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=44.6945337620579, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI4506127, Length=309, Percent_Identity=45.6310679611651, Blast_Score=274, Evalue=7e-74,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=44.2675159235669, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI28557709, Length=309, Percent_Identity=44.9838187702265, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4506133, Length=341, Percent_Identity=33.7243401759531, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI194018537, Length=349, Percent_Identity=33.810888252149, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1787458, Length=309, Percent_Identity=46.9255663430421, Blast_Score=276, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25149168, Length=309, Percent_Identity=45.6310679611651, Blast_Score=273, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=45.6310679611651, Blast_Score=273, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17554702, Length=309, Percent_Identity=45.6310679611651, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71989924, Length=309, Percent_Identity=45.6310679611651, Blast_Score=272, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=32.258064516129, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321776, Length=301, Percent_Identity=46.843853820598, Blast_Score=269, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=306, Percent_Identity=43.1372549019608, Blast_Score=263, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319403, Length=307, Percent_Identity=42.9967426710098, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=32.994923857868, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=36.8421052631579, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355239, Length=309, Percent_Identity=47.2491909385113, Blast_Score=283, Evalue=8e-77,
Organism=Drosophila melanogaster, GI45551540, Length=332, Percent_Identity=43.9759036144578, Blast_Score=270, Evalue=9e-73,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=31.728045325779, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=31.728045325779, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=31.728045325779, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=31.728045325779, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24651462, Length=372, Percent_Identity=30.3763440860215, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651464, Length=372, Percent_Identity=30.3763440860215, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI45552010, Length=372, Percent_Identity=30.3763440860215, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34132; Mature: 34001

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQTPFLVFSGTNSRYLAEKICNSLGCPLGQMNIQHFADGEFSVSYEESIRGRDVFLVQ
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHCCCCCEEEEEE
STFPNSDNLMELLLMIDAAKRASAHSIIAVVPYFGWARQDRKDKPRVSIGAKLIADMLST
ECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AGINRLITMDLHADQIQGFFNVPVDHLYASSVFLDYIKTSLPLDNLCIATPDVGGTKRAS
CCCCEEEEEECCHHHHCHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
SYSKYLGLPMVICHKSRLRANEVAEMRIIGDVTGLDVLLVDDMVDTAGTITKAANLMLEN
HHHHHCCCCCEECCHHHCCHHHHHHEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHC
GAKSVRAIASHAVMSDPASTRVDQSALAEMIFTDSIPYAKKCEKVKVLSVADMFAEAIRR
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHH
VCSGESISSLYAI
HHCCCCHHHHHCC
>Mature Secondary Structure 
SAQTPFLVFSGTNSRYLAEKICNSLGCPLGQMNIQHFADGEFSVSYEESIRGRDVFLVQ
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHCCCCCEEEEEE
STFPNSDNLMELLLMIDAAKRASAHSIIAVVPYFGWARQDRKDKPRVSIGAKLIADMLST
ECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AGINRLITMDLHADQIQGFFNVPVDHLYASSVFLDYIKTSLPLDNLCIATPDVGGTKRAS
CCCCEEEEEECCHHHHCHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
SYSKYLGLPMVICHKSRLRANEVAEMRIIGDVTGLDVLLVDDMVDTAGTITKAANLMLEN
HHHHHCCCCCEECCHHHCCHHHHHHEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHC
GAKSVRAIASHAVMSDPASTRVDQSALAEMIFTDSIPYAKKCEKVKVLSVADMFAEAIRR
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHH
VCSGESISSLYAI
HHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12949112 [H]