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The map label for this gene is ptpA [H]

Identifier: 150010284

GI number: 150010284

Start: 4532231

End: 4534645

Strand: Direct

Name: ptpA [H]

Synonym: BDI_3713

Alternate gene names: 150010284

Gene position: 4532231-4534645 (Clockwise)

Preceding gene: 150010278

Following gene: 150010285

Centisome position: 94.2

GC content: 46.0

Gene sequence:

>2415_bases
ATGAATGTAAAAACACTTTTTTATGCGGTAGCCTTCTTGAGTTTATCATGGGTGCCTTTTACCTATGCGCAAGATGTCCT
ACCGGAATATACGCAAGCACGCCGTTTCGCCCCGTCGAATGCGGAACAGCTACTTTTCTCTTATACCCTTACCCCCAATT
ATTTTAATAATAGTGACAAGTTCTGGTATGAGTATAAGACGAGTGAGGGGACAAACTGGTATCTGGTGGACCCCAATTCG
AGAAATAAACGATTATTATTCGATCGGGATGAGTTGGCGGCACAGATAAGCGAGATCGTGAGAGAGCCTTTTACCGGACA
ACAACTTCCTATCGAAGATTTACGCTTAAAGGAAGATGATCGCACGTTTACTTTCTCGATAAAGGGTACGAACGGGAACT
ATTTTTTCTCGTATGATTATCCGTCCTCCCGGTTGACTCGGATTACGAAAGACGAGATTCCTGCTAAAATCCGTTGGGCG
AATATATCGCCGGATAAAAAGCGGGTCGTCTTCGCGAAAGATTTGAACCTGTATGTCATGAGTTATGAGGATTATGAGAA
GGCCGTGAAGGACCCGGAGGATAAGACGATATCCGAGATCGCCTTGACTACGGATGGCGAAAAAGATTTTGGCTTTGGTA
TGCCCCGGACCTTCTTGAATACCGATACTTTATGTGACCATAAGCGGAAATATGTAATGGGGAACTGGTCTCCCGATGGT
CGTTATTTCGCCGCGACTTTGTCGGATCAACGTGCGGTGCAAGATTTATGGGTGATTAACTCGATCGCCAAACCTCGTCC
TACACTTGAGACCTATAAATATCAGATGCCGGGAGAGGCGGGTTCTCCAATCGTTCATTTATATCTCTTTGATTTGGAAA
ATACCGGGAAGCGGAAAGAAATCCGGGTGGATTGTTTTAAAGATCAAACAATCAATCTAGCCTCCAAGCCGGATAAGGAG
CGTACGGGACTCACTCGGAACTCGATCTGGTTGGGAGATAACCAGACCTTCTATTTGACCCGTGTCAGCCGGGATATGAA
ACGGGTGGATATCTGTTCGTATACGATCGGGGAGGATTCGGTAAAAGCGATCATTGAGGAACGTCTAAATACCTCTATGG
AAACGCGCCCGCTAGCGATGACCGATAATGGTAAGGAATTGATCCATTGGAGCGAACGGGATGGTTGGGCGCATCTGTAT
CTATATGATGCGCAAGGAAATTTGAAAAACCGTATCACCAAAGGGCCTTGGCATGTGGACGCCATCGTAGACGTGGACAG
TAAGAATCGTGTCGTTTACTTCAAGGCGAATGCCCGGGAAAAGGGAGATACGACTCCTTATTACGAGCATTTGTATCGGG
TGAATCTGGATGGTTCGGGCTTAAAGCTGATTACTCCGGGCGATTATTTCCACCTGGTCTCTATGGATAAATCCATGCGA
TATATCGTGGATAACTATTCTCGTGTCAATACGATCCCGGCTACGGCATTGTATGATAACCAAGGTAATCGATTGATGAC
CTTGGAGGAGAGTGACTTCTCCCAATTATTCATGGCAGGTTATAAATTCCCTGAGCCTTTTTCGGTAAAGGCGGCCGATG
GGGTGACCGATTTGTATGGTGTCATGTATAAGCCTTTTGATTTTGATTCCACGAAAGTATATCCGGTCATTAACTATGTA
TACCCCGGACCGCAACAGGAGGGAACTTTCTTTCGCTACATCCCGATGAATCCTCGTACGGATCGTTTGGCGCAAGCCGG
ATTTGTCGTGGTTTGCATGGGACACAGGGGAGGGCATCCCAGTCGCTCCAAGTGGTATCATAATTATGGATATGGAAATT
TGCGTGATTATCCGATGGCGGATCATAAAGTGGCTATCGAGCAGTTGTGCGCTCGTTATAAATTCATGGATATCAACCGG
GTCGGCATACACGGACACTCCGGTGGCGGTTTCATGTCTACAGCGGCTATGCTGCTTTATCCGGATTTCTTTAAGGTGGC
GGTATCTTGTGCCGGCAATCATGACAATAACATTTATAACCGGTGGTGGGGAGAGAAACACCATGGAGTAAAGGAGATCA
CGGATGATATGGGAAATATCTCGTTCGATATTCGCATCCCGACCAATCAGGAATTGGCGAGGAACTTGAAAGGCCATCTG
TTATTAATCCATGGCGATATCGATAATAATGTGCATCCGGCAAATACCATTGTTGTCGTGGACGAGTTGATCAAGGCGGG
CAAGCGCTTTGATATGTTGATCGTACCGGGAAAACGTCATCATTTTGATGACTATAATGAATATTATTACTGGCGGATGG
TCGATTACTTCTCTGAGTATTTGAGAGGCGAACGGGAAACAGGTGCGGATATAAAAGATTTGAAGCTGGGCAATTGGTTT
CAGGGGTATCAGTGA

Upstream 100 bases:

>100_bases
TAGAAGAAGTATCTTACACATAACTAATGATCGCTATCTGCTTGGTATCTTGCGGAAAGTTTATATTTTTGAGGCGAATA
ACAGACAATACTAAGAATCT

Downstream 100 bases:

>100_bases
TGAGAAGTAGTACTGACTTTGCCAAGTAATACATACTAACATCGCTAACGCAGTATATATTACTTGGCCAATGCAGTATA
TCTTCTGCGAACTCATCCAT

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 804; Mature: 804

Protein sequence:

>804_residues
MNVKTLFYAVAFLSLSWVPFTYAQDVLPEYTQARRFAPSNAEQLLFSYTLTPNYFNNSDKFWYEYKTSEGTNWYLVDPNS
RNKRLLFDRDELAAQISEIVREPFTGQQLPIEDLRLKEDDRTFTFSIKGTNGNYFFSYDYPSSRLTRITKDEIPAKIRWA
NISPDKKRVVFAKDLNLYVMSYEDYEKAVKDPEDKTISEIALTTDGEKDFGFGMPRTFLNTDTLCDHKRKYVMGNWSPDG
RYFAATLSDQRAVQDLWVINSIAKPRPTLETYKYQMPGEAGSPIVHLYLFDLENTGKRKEIRVDCFKDQTINLASKPDKE
RTGLTRNSIWLGDNQTFYLTRVSRDMKRVDICSYTIGEDSVKAIIEERLNTSMETRPLAMTDNGKELIHWSERDGWAHLY
LYDAQGNLKNRITKGPWHVDAIVDVDSKNRVVYFKANAREKGDTTPYYEHLYRVNLDGSGLKLITPGDYFHLVSMDKSMR
YIVDNYSRVNTIPATALYDNQGNRLMTLEESDFSQLFMAGYKFPEPFSVKAADGVTDLYGVMYKPFDFDSTKVYPVINYV
YPGPQQEGTFFRYIPMNPRTDRLAQAGFVVVCMGHRGGHPSRSKWYHNYGYGNLRDYPMADHKVAIEQLCARYKFMDINR
VGIHGHSGGGFMSTAAMLLYPDFFKVAVSCAGNHDNNIYNRWWGEKHHGVKEITDDMGNISFDIRIPTNQELARNLKGHL
LLIHGDIDNNVHPANTIVVVDELIKAGKRFDMLIVPGKRHHFDDYNEYYYWRMVDYFSEYLRGERETGADIKDLKLGNWF
QGYQ

Sequences:

>Translated_804_residues
MNVKTLFYAVAFLSLSWVPFTYAQDVLPEYTQARRFAPSNAEQLLFSYTLTPNYFNNSDKFWYEYKTSEGTNWYLVDPNS
RNKRLLFDRDELAAQISEIVREPFTGQQLPIEDLRLKEDDRTFTFSIKGTNGNYFFSYDYPSSRLTRITKDEIPAKIRWA
NISPDKKRVVFAKDLNLYVMSYEDYEKAVKDPEDKTISEIALTTDGEKDFGFGMPRTFLNTDTLCDHKRKYVMGNWSPDG
RYFAATLSDQRAVQDLWVINSIAKPRPTLETYKYQMPGEAGSPIVHLYLFDLENTGKRKEIRVDCFKDQTINLASKPDKE
RTGLTRNSIWLGDNQTFYLTRVSRDMKRVDICSYTIGEDSVKAIIEERLNTSMETRPLAMTDNGKELIHWSERDGWAHLY
LYDAQGNLKNRITKGPWHVDAIVDVDSKNRVVYFKANAREKGDTTPYYEHLYRVNLDGSGLKLITPGDYFHLVSMDKSMR
YIVDNYSRVNTIPATALYDNQGNRLMTLEESDFSQLFMAGYKFPEPFSVKAADGVTDLYGVMYKPFDFDSTKVYPVINYV
YPGPQQEGTFFRYIPMNPRTDRLAQAGFVVVCMGHRGGHPSRSKWYHNYGYGNLRDYPMADHKVAIEQLCARYKFMDINR
VGIHGHSGGGFMSTAAMLLYPDFFKVAVSCAGNHDNNIYNRWWGEKHHGVKEITDDMGNISFDIRIPTNQELARNLKGHL
LLIHGDIDNNVHPANTIVVVDELIKAGKRFDMLIVPGKRHHFDDYNEYYYWRMVDYFSEYLRGERETGADIKDLKLGNWF
QGYQ
>Mature_804_residues
MNVKTLFYAVAFLSLSWVPFTYAQDVLPEYTQARRFAPSNAEQLLFSYTLTPNYFNNSDKFWYEYKTSEGTNWYLVDPNS
RNKRLLFDRDELAAQISEIVREPFTGQQLPIEDLRLKEDDRTFTFSIKGTNGNYFFSYDYPSSRLTRITKDEIPAKIRWA
NISPDKKRVVFAKDLNLYVMSYEDYEKAVKDPEDKTISEIALTTDGEKDFGFGMPRTFLNTDTLCDHKRKYVMGNWSPDG
RYFAATLSDQRAVQDLWVINSIAKPRPTLETYKYQMPGEAGSPIVHLYLFDLENTGKRKEIRVDCFKDQTINLASKPDKE
RTGLTRNSIWLGDNQTFYLTRVSRDMKRVDICSYTIGEDSVKAIIEERLNTSMETRPLAMTDNGKELIHWSERDGWAHLY
LYDAQGNLKNRITKGPWHVDAIVDVDSKNRVVYFKANAREKGDTTPYYEHLYRVNLDGSGLKLITPGDYFHLVSMDKSMR
YIVDNYSRVNTIPATALYDNQGNRLMTLEESDFSQLFMAGYKFPEPFSVKAADGVTDLYGVMYKPFDFDSTKVYPVINYV
YPGPQQEGTFFRYIPMNPRTDRLAQAGFVVVCMGHRGGHPSRSKWYHNYGYGNLRDYPMADHKVAIEQLCARYKFMDINR
VGIHGHSGGGFMSTAAMLLYPDFFKVAVSCAGNHDNNIYNRWWGEKHHGVKEITDDMGNISFDIRIPTNQELARNLKGHL
LLIHGDIDNNVHPANTIVVVDELIKAGKRFDMLIVPGKRHHFDDYNEYYYWRMVDYFSEYLRGERETGADIKDLKLGNWF
QGYQ

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=404, Percent_Identity=29.4554455445545, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI18450280, Length=404, Percent_Identity=29.4554455445545, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI194394146, Length=393, Percent_Identity=28.7531806615776, Blast_Score=138, Evalue=3e-32,
Organism=Homo sapiens, GI16933540, Length=651, Percent_Identity=21.6589861751152, Blast_Score=76, Evalue=2e-13,
Organism=Homo sapiens, GI18765694, Length=676, Percent_Identity=21.301775147929, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI37577091, Length=200, Percent_Identity=30.5, Blast_Score=69, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508019, Length=259, Percent_Identity=28.1853281853282, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17508017, Length=259, Percent_Identity=28.1853281853282, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17564632, Length=263, Percent_Identity=26.2357414448669, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17564634, Length=263, Percent_Identity=26.2357414448669, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324793, Length=680, Percent_Identity=22.7941176470588, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550825, Length=456, Percent_Identity=25.8771929824561, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45553511, Length=456, Percent_Identity=25.8771929824561, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551969, Length=456, Percent_Identity=25.8771929824561, Blast_Score=118, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 93275; Mature: 93275

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKTLFYAVAFLSLSWVPFTYAQDVLPEYTQARRFAPSNAEQLLFSYTLTPNYFNNSDK
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHEEEEEEEECCCCCCCCCC
FWYEYKTSEGTNWYLVDPNSRNKRLLFDRDELAAQISEIVREPFTGQQLPIEDLRLKEDD
EEEEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHCEECCCC
RTFTFSIKGTNGNYFFSYDYPSSRLTRITKDEIPAKIRWANISPDKKRVVFAKDLNLYVM
CEEEEEEEECCCCEEEEECCCCHHHEECHHHCCCCEEEEECCCCCCCEEEEEECCEEEEE
SYEDYEKAVKDPEDKTISEIALTTDGEKDFGFGMPRTFLNTDTLCDHKRKYVMGNWSPDG
ECHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHCCCCHHHCCCCCEEECCCCCCC
RYFAATLSDQRAVQDLWVINSIAKPRPTLETYKYQMPGEAGSPIVHLYLFDLENTGKRKE
CEEEEECCCHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCEEEEEEEECCCCCCCCE
IRVDCFKDQTINLASKPDKERTGLTRNSIWLGDNQTFYLTRVSRDMKRVDICSYTIGEDS
EEEEEECCCEEECCCCCCHHHCCCCCCEEEECCCCEEEEEECCCCCHHEEEEEEECCCHH
VKAIIEERLNTSMETRPLAMTDNGKELIHWSERDGWAHLYLYDAQGNLKNRITKGPWHVD
HHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCEEEEEEECCCCCHHHCCCCCCEEEE
AIVDVDSKNRVVYFKANAREKGDTTPYYEHLYRVNLDGSGLKLITPGDYFHLVSMDKSMR
EEEEECCCCEEEEEECCCCCCCCCCCHHHEEEEEEECCCCEEEECCCCEEEEEECCCCHH
YIVDNYSRVNTIPATALYDNQGNRLMTLEESDFSQLFMAGYKFPEPFSVKAADGVTDLYG
HHHCCCHHCCCCCEEEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCEEECCCCHHHHHH
VMYKPFDFDSTKVYPVINYVYPGPQQEGTFFRYIPMNPRTDRLAQAGFVVVCMGHRGGHP
HEECCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCHHHHHHCCEEEEEECCCCCCC
SRSKWYHNYGYGNLRDYPMADHKVAIEQLCARYKFMDINRVGIHGHSGGGFMSTAAMLLY
CCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCEEEECEEEEEECCCCCCHHHHHHHHHC
PDFFKVAVSCAGNHDNNIYNRWWGEKHHGVKEITDDMGNISFDIRIPTNQELARNLKGHL
CCHHHEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHCCEEEEEECCCCHHHHHCCCCCE
LLIHGDIDNNVHPANTIVVVDELIKAGKRFDMLIVPGKRHHFDDYNEYYYWRMVDYFSEY
EEEEECCCCCCCCCCEEEEEHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHHHH
LRGERETGADIKDLKLGNWFQGYQ
HCCCCCCCCCHHEEECCCCCCCCC
>Mature Secondary Structure
MNVKTLFYAVAFLSLSWVPFTYAQDVLPEYTQARRFAPSNAEQLLFSYTLTPNYFNNSDK
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHEEEEEEEECCCCCCCCCC
FWYEYKTSEGTNWYLVDPNSRNKRLLFDRDELAAQISEIVREPFTGQQLPIEDLRLKEDD
EEEEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHCEECCCC
RTFTFSIKGTNGNYFFSYDYPSSRLTRITKDEIPAKIRWANISPDKKRVVFAKDLNLYVM
CEEEEEEEECCCCEEEEECCCCHHHEECHHHCCCCEEEEECCCCCCCEEEEEECCEEEEE
SYEDYEKAVKDPEDKTISEIALTTDGEKDFGFGMPRTFLNTDTLCDHKRKYVMGNWSPDG
ECHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHCCCCHHHCCCCCEEECCCCCCC
RYFAATLSDQRAVQDLWVINSIAKPRPTLETYKYQMPGEAGSPIVHLYLFDLENTGKRKE
CEEEEECCCHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCEEEEEEEECCCCCCCCE
IRVDCFKDQTINLASKPDKERTGLTRNSIWLGDNQTFYLTRVSRDMKRVDICSYTIGEDS
EEEEEECCCEEECCCCCCHHHCCCCCCEEEECCCCEEEEEECCCCCHHEEEEEEECCCHH
VKAIIEERLNTSMETRPLAMTDNGKELIHWSERDGWAHLYLYDAQGNLKNRITKGPWHVD
HHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCEEEEEEECCCCCHHHCCCCCCEEEE
AIVDVDSKNRVVYFKANAREKGDTTPYYEHLYRVNLDGSGLKLITPGDYFHLVSMDKSMR
EEEEECCCCEEEEEECCCCCCCCCCCHHHEEEEEEECCCCEEEECCCCEEEEEECCCCHH
YIVDNYSRVNTIPATALYDNQGNRLMTLEESDFSQLFMAGYKFPEPFSVKAADGVTDLYG
HHHCCCHHCCCCCEEEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCEEECCCCHHHHHH
VMYKPFDFDSTKVYPVINYVYPGPQQEGTFFRYIPMNPRTDRLAQAGFVVVCMGHRGGHP
HEECCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCHHHHHHCCEEEEEECCCCCCC
SRSKWYHNYGYGNLRDYPMADHKVAIEQLCARYKFMDINRVGIHGHSGGGFMSTAAMLLY
CCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCEEEECEEEEEECCCCCCHHHHHHHHHC
PDFFKVAVSCAGNHDNNIYNRWWGEKHHGVKEITDDMGNISFDIRIPTNQELARNLKGHL
CCHHHEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHCCEEEEEECCCCHHHHHCCCCCE
LLIHGDIDNNVHPANTIVVVDELIKAGKRFDMLIVPGKRHHFDDYNEYYYWRMVDYFSEY
EEEEECCCCCCCCCCEEEEEHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHHHH
LRGERETGADIKDLKLGNWFQGYQ
HCCCCCCCCCHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA