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The map label for this gene is uppS [H]

Identifier: 150010269

GI number: 150010269

Start: 4516337

End: 4517080

Strand: Direct

Name: uppS [H]

Synonym: BDI_3698

Alternate gene names: 150010269

Gene position: 4516337-4517080 (Clockwise)

Preceding gene: 150010268

Following gene: 150010270

Centisome position: 93.87

GC content: 48.25

Gene sequence:

>744_bases
ATGTCGTTGATTGAGAAAATAGACAAGAATCGCTTGCCACGGCACGTGGCAATTATTATGGACGGGAACGGACGTTGGGC
CAAGGCGAAGGGGAAAGACCGTAGCTTCGGGCATCAGGAAGGCGTTGTTTCGGTCCGTAAGATTATGGATGCGGTCACTC
AACTCGGATTGAAATATCTGACGTTGTACACTTTCTCTACCGAGAACTGGAATCGTCCGGAAGAAGAGGTCCAAGCGCTG
ATGAGCTTGCTGGTCTCCGCCATTCACCGGGAGACTCCGGACATGATGAAGAAAAACGTTCGCCTTACCGCCATAGGCGA
CCTTTCCCGCTTGCGTGAGGATGCTTATAATACATTGCAAGAATGTATCGATACGACTTCGGCGAATACGGGAACCACAC
TTGTTCTGGCGCTTAGTTATTCTTCCCGGTGGGAGATCACCAGAGCGGCTAGGCAACTCGCCCAAGAGGTCTTGGAACAG
AAAATAAACCCCAATGATATAACCGAGGCTATGGTCTCGGACCACTTGACGACCAAAAATATCCCCGATCCCGATCTTTT
GATACGGACCGGAGGAGAGAAACGCATCAGTAACTTCTTGCTATGGCAGTTGTCATATGCTGAATTCTTCTTTACGGATG
TGTTTTGGCCGGATTTCAGAGAAGAAGAGTTGTATGAGGCTATATTGTATTACCAGCAACGTGAGCGTCGTTTCGGTAAG
ACAAGTGAGCAATTAATCTTATAA

Upstream 100 bases:

>100_bases
GGTACTCTTTTTTGTTGTTGTCTGTTACATGGGATTTCGGCCCGAGGTGCCGTACTTGTAACAATGCGAAAAATATAAGT
GAATATTAGTAAGATAAAAA

Downstream 100 bases:

>100_bases
ACAATAGCTGTTATATGTACAAAAGAATAGTGCTGTTTTTTATTTGCTTGGGTTTCGCTTGCGGTGCGTTTGCCCAAGAA
ATAGACACTACCCAAGTTGA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSLIEKIDKNRLPRHVAIIMDGNGRWAKAKGKDRSFGHQEGVVSVRKIMDAVTQLGLKYLTLYTFSTENWNRPEEEVQAL
MSLLVSAIHRETPDMMKKNVRLTAIGDLSRLREDAYNTLQECIDTTSANTGTTLVLALSYSSRWEITRAARQLAQEVLEQ
KINPNDITEAMVSDHLTTKNIPDPDLLIRTGGEKRISNFLLWQLSYAEFFFTDVFWPDFREEELYEAILYYQQRERRFGK
TSEQLIL

Sequences:

>Translated_247_residues
MSLIEKIDKNRLPRHVAIIMDGNGRWAKAKGKDRSFGHQEGVVSVRKIMDAVTQLGLKYLTLYTFSTENWNRPEEEVQAL
MSLLVSAIHRETPDMMKKNVRLTAIGDLSRLREDAYNTLQECIDTTSANTGTTLVLALSYSSRWEITRAARQLAQEVLEQ
KINPNDITEAMVSDHLTTKNIPDPDLLIRTGGEKRISNFLLWQLSYAEFFFTDVFWPDFREEELYEAILYYQQRERRFGK
TSEQLIL
>Mature_246_residues
SLIEKIDKNRLPRHVAIIMDGNGRWAKAKGKDRSFGHQEGVVSVRKIMDAVTQLGLKYLTLYTFSTENWNRPEEEVQALM
SLLVSAIHRETPDMMKKNVRLTAIGDLSRLREDAYNTLQECIDTTSANTGTTLVLALSYSSRWEITRAARQLAQEVLEQK
INPNDITEAMVSDHLTTKNIPDPDLLIRTGGEKRISNFLLWQLSYAEFFFTDVFWPDFREEELYEAILYYQQRERRFGKT
SEQLIL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=36.2445414847162, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=36.2445414847162, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=50, Blast_Score=243, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=36.7256637168142, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=36.7441860465116, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=237, Percent_Identity=30.8016877637131, Blast_Score=108, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=32.8888888888889, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28611; Mature: 28480

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIEKIDKNRLPRHVAIIMDGNGRWAKAKGKDRSFGHQEGVVSVRKIMDAVTQLGLKYL
CCHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLYTFSTENWNRPEEEVQALMSLLVSAIHRETPDMMKKNVRLTAIGDLSRLREDAYNTLQ
HEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHH
ECIDTTSANTGTTLVLALSYSSRWEITRAARQLAQEVLEQKINPNDITEAMVSDHLTTKN
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
IPDPDLLIRTGGEKRISNFLLWQLSYAEFFFTDVFWPDFREEELYEAILYYQQRERRFGK
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
TSEQLIL
CHHHHCC
>Mature Secondary Structure 
SLIEKIDKNRLPRHVAIIMDGNGRWAKAKGKDRSFGHQEGVVSVRKIMDAVTQLGLKYL
CHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLYTFSTENWNRPEEEVQALMSLLVSAIHRETPDMMKKNVRLTAIGDLSRLREDAYNTLQ
HEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHH
ECIDTTSANTGTTLVLALSYSSRWEITRAARQLAQEVLEQKINPNDITEAMVSDHLTTKN
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
IPDPDLLIRTGGEKRISNFLLWQLSYAEFFFTDVFWPDFREEELYEAILYYQQRERRFGK
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
TSEQLIL
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]