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The map label for this gene is mepA [H]

Identifier: 150010250

GI number: 150010250

Start: 4495767

End: 4497113

Strand: Direct

Name: mepA [H]

Synonym: BDI_3676

Alternate gene names: 150010250

Gene position: 4495767-4497113 (Clockwise)

Preceding gene: 150010249

Following gene: 150010251

Centisome position: 93.44

GC content: 45.81

Gene sequence:

>1347_bases
ATGTCAAATGAGATTACATGGCGGCTGGAAAATGAGAATATAGGCCGTTTGTTGGTACATTACGCAATTCCCGCCGTTAT
CGGGACCATGGTTAATGCTCTTTATAATATAGTAGATCGTATATTTATCGGACAAGGAGTGGGTGCGCTAGCTATCTCCG
GATTGACTTTGACTTTCCCGATACTACTCTTTATGCAGGCATTTGGAATGTTGATCGGCGCGGGAGCCGCTACAAGGGTC
TCCATTCATCTAGGCCGTAAGGCGAATGATCTGGCAGATAACGTATTAGGAAACGCTTTCATTTTGACATTCATTATCGG
AGCCTTGACGATTATCCCCAGTATGATTTTCTTGGATGATTTGTTAATGTGGTTCGGAGGAAGTGAGCAGACGATACCTT
ATGCGAAAGACTATTTATATATCGCTGTCCCGGGTAATTTGCTGGCTACATTAAGCTTTAGCTTTAATGCCGTGATGCGT
GCTTCCGGATATCCGAAAAAGGCGATGTTCACGATGATGATCGGTGCCGTCTTGAACGTGATCCTAGATCCGATCTTTAT
CTTTTGGCTGGATATGGGGATACAGGGTGCCGCTATCGCTACGGTGATCTCCATGGCTGCCGGTGCCGCTTTCGTGATGA
GTCATTTTATCAGCAAGGATAGTATCGTACGTTTCCATACGAAATATTTCCGGTTGAAAGGTCCCATTATTTGGAATATA
TTTACGATCGGCATGTCTCCATTTTCCATGCAGCTGGCGGGCAGTGTGGTTGTGGTGATCATGAACCATGCGTTGAAAGA
GAATGGAGGCGATTTGGCGATTGGTGCCAGCGGTATTATTTCCAGTATCGCCATGCTGCTGGTTATGTTGATTATCGGTA
TCGCCCAAGGGATGCAACCGATTGTCGGGTTTAATCATGGCGCTGGGCATCATGACCGGGTATTGGCTACCTTGCGGTTG
TCTATTATAGTATCGACCTTGATTACAGGGGTAGGATGTATCGTCAGTTTATTATTCCCTAGACTGATCGTTAGCGTATT
CTCGACGGATGCCGAATTGGTGTCGATTACGGACAATGGATTACGTCTGACGATGCTGGTCTTTTTCGTTGTCGGTTCCC
AGATTACGATCAGCCAGTTTTTTCAAAGTATCGGTGTCGCATGGAAAGCGATGTTTCTGAGTCTAAGTCGGCAGGTTTTA
TTCCTGATACCGGCTATCCTGCTATTTCCTCCGATCTGGGGATTGGATGGCGTTTGGCTAGCGCAACCTTTCTCCGATTT
CATTGCGGCGGTAACCGCATGGGGCTTTTTATGGTATCATGTTAAAAACGTGAAAAATAAGGGTTAA

Upstream 100 bases:

>100_bases
GATAGCCTGCGTATTCAGTTCCCTGCGGAAGAGGGCACGAGAATCGTAGGAAGTGTGGCGGAGATGATCTCAATCATAAT
TCATAAATCATAAGTTATAT

Downstream 100 bases:

>100_bases
AGATGAACTTATGTCGATGTTAATTGTATTTTTATTGTATGTATAAAAGTACTTTTATAGACAAACCTTTAAAAATGAGT
TAATATGAAGAAGATTGTAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSNEITWRLENENIGRLLVHYAIPAVIGTMVNALYNIVDRIFIGQGVGALAISGLTLTFPILLFMQAFGMLIGAGAATRV
SIHLGRKANDLADNVLGNAFILTFIIGALTIIPSMIFLDDLLMWFGGSEQTIPYAKDYLYIAVPGNLLATLSFSFNAVMR
ASGYPKKAMFTMMIGAVLNVILDPIFIFWLDMGIQGAAIATVISMAAGAAFVMSHFISKDSIVRFHTKYFRLKGPIIWNI
FTIGMSPFSMQLAGSVVVVIMNHALKENGGDLAIGASGIISSIAMLLVMLIIGIAQGMQPIVGFNHGAGHHDRVLATLRL
SIIVSTLITGVGCIVSLLFPRLIVSVFSTDAELVSITDNGLRLTMLVFFVVGSQITISQFFQSIGVAWKAMFLSLSRQVL
FLIPAILLFPPIWGLDGVWLAQPFSDFIAAVTAWGFLWYHVKNVKNKG

Sequences:

>Translated_448_residues
MSNEITWRLENENIGRLLVHYAIPAVIGTMVNALYNIVDRIFIGQGVGALAISGLTLTFPILLFMQAFGMLIGAGAATRV
SIHLGRKANDLADNVLGNAFILTFIIGALTIIPSMIFLDDLLMWFGGSEQTIPYAKDYLYIAVPGNLLATLSFSFNAVMR
ASGYPKKAMFTMMIGAVLNVILDPIFIFWLDMGIQGAAIATVISMAAGAAFVMSHFISKDSIVRFHTKYFRLKGPIIWNI
FTIGMSPFSMQLAGSVVVVIMNHALKENGGDLAIGASGIISSIAMLLVMLIIGIAQGMQPIVGFNHGAGHHDRVLATLRL
SIIVSTLITGVGCIVSLLFPRLIVSVFSTDAELVSITDNGLRLTMLVFFVVGSQITISQFFQSIGVAWKAMFLSLSRQVL
FLIPAILLFPPIWGLDGVWLAQPFSDFIAAVTAWGFLWYHVKNVKNKG
>Mature_447_residues
SNEITWRLENENIGRLLVHYAIPAVIGTMVNALYNIVDRIFIGQGVGALAISGLTLTFPILLFMQAFGMLIGAGAATRVS
IHLGRKANDLADNVLGNAFILTFIIGALTIIPSMIFLDDLLMWFGGSEQTIPYAKDYLYIAVPGNLLATLSFSFNAVMRA
SGYPKKAMFTMMIGAVLNVILDPIFIFWLDMGIQGAAIATVISMAAGAAFVMSHFISKDSIVRFHTKYFRLKGPIIWNIF
TIGMSPFSMQLAGSVVVVIMNHALKENGGDLAIGASGIISSIAMLLVMLIIGIAQGMQPIVGFNHGAGHHDRVLATLRLS
IIVSTLITGVGCIVSLLFPRLIVSVFSTDAELVSITDNGLRLTMLVFFVVGSQITISQFFQSIGVAWKAMFLSLSRQVLF
LIPAILLFPPIWGLDGVWLAQPFSDFIAAVTAWGFLWYHVKNVKNKG

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48615; Mature: 48484

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEITWRLENENIGRLLVHYAIPAVIGTMVNALYNIVDRIFIGQGVGALAISGLTLTFP
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHH
ILLFMQAFGMLIGAGAATRVSIHLGRKANDLADNVLGNAFILTFIIGALTIIPSMIFLDD
HHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMWFGGSEQTIPYAKDYLYIAVPGNLLATLSFSFNAVMRASGYPKKAMFTMMIGAVLNV
HHHHHCCCCCCCCCCCCEEEEEECCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ILDPIFIFWLDMGIQGAAIATVISMAAGAAFVMSHFISKDSIVRFHTKYFRLKGPIIWNI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCEEEEE
FTIGMSPFSMQLAGSVVVVIMNHALKENGGDLAIGASGIISSIAMLLVMLIIGIAQGMQP
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCH
IVGFNHGAGHHDRVLATLRLSIIVSTLITGVGCIVSLLFPRLIVSVFSTDAELVSITDNG
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LRLTMLVFFVVGSQITISQFFQSIGVAWKAMFLSLSRQVLFLIPAILLFPPIWGLDGVWL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AQPFSDFIAAVTAWGFLWYHVKNVKNKG
HCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNEITWRLENENIGRLLVHYAIPAVIGTMVNALYNIVDRIFIGQGVGALAISGLTLTFP
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHH
ILLFMQAFGMLIGAGAATRVSIHLGRKANDLADNVLGNAFILTFIIGALTIIPSMIFLDD
HHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMWFGGSEQTIPYAKDYLYIAVPGNLLATLSFSFNAVMRASGYPKKAMFTMMIGAVLNV
HHHHHCCCCCCCCCCCCEEEEEECCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ILDPIFIFWLDMGIQGAAIATVISMAAGAAFVMSHFISKDSIVRFHTKYFRLKGPIIWNI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCEEEEE
FTIGMSPFSMQLAGSVVVVIMNHALKENGGDLAIGASGIISSIAMLLVMLIIGIAQGMQP
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCH
IVGFNHGAGHHDRVLATLRLSIIVSTLITGVGCIVSLLFPRLIVSVFSTDAELVSITDNG
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LRLTMLVFFVVGSQITISQFFQSIGVAWKAMFLSLSRQVLFLIPAILLFPPIWGLDGVWL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AQPFSDFIAAVTAWGFLWYHVKNVKNKG
HCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA