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The map label for this gene is zraS [H]

Identifier: 150010170

GI number: 150010170

Start: 4403480

End: 4404580

Strand: Direct

Name: zraS [H]

Synonym: BDI_3593

Alternate gene names: 150010170

Gene position: 4403480-4404580 (Clockwise)

Preceding gene: 150010169

Following gene: 150010171

Centisome position: 91.52

GC content: 45.78

Gene sequence:

>1101_bases
ATGGGCGACATAAATATCAAACAACTGGAAAGCCTTCGCTGGAGGATGCGGGTGATCGAGACGCTGACCGTGATCGGGAC
GGCGTGGATCGCCTTGGCGGTTTACCAGAAGAAGGAAGAACTGGTTTATTATTTGGTGGGAGCCGTAGTCCTTCTATTCC
TGTTAAAGTATTATACGCAATTCCGTCTGCGAAAAAGACAGTTCGTCTCTAATCTCGTTGAACAGCGGACGATGGAATTG
CGTTTCCAGCGGGATGCGATGCAAGCGGAGTCGGAGAAACTATCCCGTGCCCTTTCTGCCTTGGCGGACGCTCAAGACGA
GTTGGTTCGTAAGGAACGTCTGGCATCGATCGGCCAATTAACGAAAGGTCTGGTGGATCGTATCTTGAATCCCTTGAATT
ATATCAATAACTTCGCTCATTTGTCTGCTGCATTAGCGAAAGATATCAAGCAGAATATCGATGAGGACGAAGAGACCGGT
AAACACGATAATTATAATGATACGCAAGAACTGCTGGTTCTTTTGACCGGCAATCTGGATAAGATCGCCAAGCATGGTGA
TAACACGGTGCGAATCGTAAAAGCGATGGAAGAATTGCTGAAAGATCATTCGGCGAATCGAACCTGCGTGGATATTAATG
ATTTATGTAAGGTCAATCTGGATATCTTGCGAAAGAATTATGCGAAGGAGATCGAGAAGAATCAAGTAGATCTATCATTC
TCCGGGCTTTCCGTACCGTTGACAATCGAGGTGAATATCGATCAGATGGGAAAAGCCTTGTCGCAGATATTGGATAATAG
TATATATGCGGTCTTGAAAAAGGCCGGAGAGCCGGGATATCAGCCTTCTGTCTCGTTGGTATTGCGTATTCAAGCGGATA
AGTTGCAAGTGGTTATCCGTGATAATGGCGTCGGTATAGAAGAAACGATAAAGACGAAAGTCTTTTCTCCGTTCTTTACC
ACCAAACCGACCGCGGAAGCGGCAGGAACAGGTCTTTACTTGAGTCGGGAGGTCGTGTTGAACCATAAGGGTACGATCGC
TATCGAGTCGGAGAAAGATAAATATACGGAAGTTACGATTACGTTGCCTATTTATAGTTAG

Upstream 100 bases:

>100_bases
CTTTGCCAGAAGTACGAACTGTATTACGGTTATCCGATGCAGAGTTTTAATGCGATGTTGGGCGTGAATATCAATTTCTG
ATATCCGGAGGACAGGAAGG

Downstream 100 bases:

>100_bases
GAAAGGAGGTTCATCATGATACAGGATTTACATACCGAGATCGATCGGTTAAAAAGGCGGATTAAACTTTGCGAGCGGGT
TACGCTGGGTAGCTTGGTCG

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MGDINIKQLESLRWRMRVIETLTVIGTAWIALAVYQKKEELVYYLVGAVVLLFLLKYYTQFRLRKRQFVSNLVEQRTMEL
RFQRDAMQAESEKLSRALSALADAQDELVRKERLASIGQLTKGLVDRILNPLNYINNFAHLSAALAKDIKQNIDEDEETG
KHDNYNDTQELLVLLTGNLDKIAKHGDNTVRIVKAMEELLKDHSANRTCVDINDLCKVNLDILRKNYAKEIEKNQVDLSF
SGLSVPLTIEVNIDQMGKALSQILDNSIYAVLKKAGEPGYQPSVSLVLRIQADKLQVVIRDNGVGIEETIKTKVFSPFFT
TKPTAEAAGTGLYLSREVVLNHKGTIAIESEKDKYTEVTITLPIYS

Sequences:

>Translated_366_residues
MGDINIKQLESLRWRMRVIETLTVIGTAWIALAVYQKKEELVYYLVGAVVLLFLLKYYTQFRLRKRQFVSNLVEQRTMEL
RFQRDAMQAESEKLSRALSALADAQDELVRKERLASIGQLTKGLVDRILNPLNYINNFAHLSAALAKDIKQNIDEDEETG
KHDNYNDTQELLVLLTGNLDKIAKHGDNTVRIVKAMEELLKDHSANRTCVDINDLCKVNLDILRKNYAKEIEKNQVDLSF
SGLSVPLTIEVNIDQMGKALSQILDNSIYAVLKKAGEPGYQPSVSLVLRIQADKLQVVIRDNGVGIEETIKTKVFSPFFT
TKPTAEAAGTGLYLSREVVLNHKGTIAIESEKDKYTEVTITLPIYS
>Mature_365_residues
GDINIKQLESLRWRMRVIETLTVIGTAWIALAVYQKKEELVYYLVGAVVLLFLLKYYTQFRLRKRQFVSNLVEQRTMELR
FQRDAMQAESEKLSRALSALADAQDELVRKERLASIGQLTKGLVDRILNPLNYINNFAHLSAALAKDIKQNIDEDEETGK
HDNYNDTQELLVLLTGNLDKIAKHGDNTVRIVKAMEELLKDHSANRTCVDINDLCKVNLDILRKNYAKEIEKNQVDLSFS
GLSVPLTIEVNIDQMGKALSQILDNSIYAVLKKAGEPGYQPSVSLVLRIQADKLQVVIRDNGVGIEETIKTKVFSPFFTT
KPTAEAAGTGLYLSREVVLNHKGTIAIESEKDKYTEVTITLPIYS

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=260, Percent_Identity=26.1538461538462, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788549, Length=274, Percent_Identity=25.9124087591241, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41375; Mature: 41244

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50109 HIS_KIN ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDINIKQLESLRWRMRVIETLTVIGTAWIALAVYQKKEELVYYLVGAVVLLFLLKYYTQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRLRKRQFVSNLVEQRTMELRFQRDAMQAESEKLSRALSALADAQDELVRKERLASIGQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKGLVDRILNPLNYINNFAHLSAALAKDIKQNIDEDEETGKHDNYNDTQELLVLLTGNLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHCCCHH
KIAKHGDNTVRIVKAMEELLKDHSANRTCVDINDLCKVNLDILRKNYAKEIEKNQVDLSF
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
SGLSVPLTIEVNIDQMGKALSQILDNSIYAVLKKAGEPGYQPSVSLVLRIQADKLQVVIR
CCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEEEE
DNGVGIEETIKTKVFSPFFTTKPTAEAAGTGLYLSREVVLNHKGTIAIESEKDKYTEVTI
CCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEHEEEECCCCEEEEECCCCCEEEEEE
TLPIYS
EEECCC
>Mature Secondary Structure 
GDINIKQLESLRWRMRVIETLTVIGTAWIALAVYQKKEELVYYLVGAVVLLFLLKYYTQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRLRKRQFVSNLVEQRTMELRFQRDAMQAESEKLSRALSALADAQDELVRKERLASIGQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKGLVDRILNPLNYINNFAHLSAALAKDIKQNIDEDEETGKHDNYNDTQELLVLLTGNLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHCCCHH
KIAKHGDNTVRIVKAMEELLKDHSANRTCVDINDLCKVNLDILRKNYAKEIEKNQVDLSF
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
SGLSVPLTIEVNIDQMGKALSQILDNSIYAVLKKAGEPGYQPSVSLVLRIQADKLQVVIR
CCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEEEE
DNGVGIEETIKTKVFSPFFTTKPTAEAAGTGLYLSREVVLNHKGTIAIESEKDKYTEVTI
CCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEHEEEECCCCEEEEECCCCCEEEEEE
TLPIYS
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]