Click here to switch to the map view.

The map label for this gene is kbl [C]

Identifier: 150009538

GI number: 150009538

Start: 3533872

End: 3535125

Strand: Direct

Name: kbl [C]

Synonym: BDI_2951

Alternate gene names: 150009538

Gene position: 3533872-3535125 (Clockwise)

Preceding gene: 150009537

Following gene: 150009539

Centisome position: 73.45

GC content: 40.03

Gene sequence:

>1254_bases
ATGCAAAACGAATTTGACAACATGACATTAAAAGACTTCGAAAATAGAGGTCAAGACTTATTAACCAGAGCAAAACAGGT
TGATGATTATATATCGTATAGACATAGAATCCAGCATTTACCTTATCGTGTCATCTCTTTGACCGGTTCTAGTGCCCACA
TGAGAGTGATCGATCCATATTCAAATAAAGAAAAAGAAATGATCAGTTTCGTTTCCAATGATTATCTGGGCTTATCACAC
CATCCAGAGGTTATAAAAGCAGGGATTGATGCGCTTGAACAATATGGAGCCGGAGCGGGGGCCAGCCCTTTGATTGGCGG
GCACAACTTCTTGCATGAGCAGTTAGAGCAAGAGATCGCTCATTTCTTGAAAAATGAGTATGCAATAACCTATACATCCG
GATACGCCGCAAATTGTAGCACATTACTAGCCATGATGGGTAAAGAAGATATCGCAATCATGGATATGTTTACTCATGCG
AGTGTATTTGACGGTTGTTTATGTACCAATACAAAGAGGTTCCTTCACAACGACATCGATTCCTTGGTGCATGTCCTAAA
CAACGCAAAGAGCTTCAAAAATCGCTTTGTAATTATTGATGGCGTTTACTCCCAAGATGGGGATATCGCCTTTCTTGATC
AAATTTATACCGTATGTAAAGAGCATGACGCATTCCTCATTGTTGATGACGCTCATGGTATTGGTGTATTAGGCAAAACA
GGCCGAGGAATTATTGAGGATTATGATCTTCTCGACAAAGTAGATATAATTACCGGAACATTCAGCAAAGCTTTCGGATG
CGTGGGAGGTTATGCCATAGCCAGAAAAGAGATCATAACTTTACTCAGATATTATTCAAGGCAAAATATATTTTCCGCTG
CCGCTACACCCCAAACCGCCGCATCCGCAATAAAAGCCATCCAACTGATTGACCAAGAACCCCAATGGAGAAACACACTA
GCCGACAATATCGAATATTTTAAAACCGGACTTGAAACCTTAGGTCTTGATTATGGTAATACCGAATCAGCGATATTCCC
CGTAATGGTACGTAATGAACACTATGTGAAAGAAGCAGCTCGCATATTATTTGAGCAAGGAATATATGTAAACCCAATCA
GTTATCCAGCTGTACCGGAAAAATTATCCCGTCTTCGCTTCAGCTTAACAGCTATGCATACGAAGGAGGAGTTGGATAAG
ACATTTAGTATCCTTGAAAACATTAGGAAGAAATACAAACTAGCACAAATATAA

Upstream 100 bases:

>100_bases
TCTTTATAAAGCAAGAAACCTAAGTAAATAATTAAAATAGTTTCATTTCATAATATAATAACTGTCAATAATTTTGTCAA
ATTAAAAGAGAGGAGTTTAT

Downstream 100 bases:

>100_bases
TCACATTTATAAATTATATAAAGATTAGCAGCTTTGTTATTTACAGCAAAAATCAATAATTTAGAAACCTTCACTTTTAC
AAAGAAAACAATCATGATAA

Product: 2-amino-3-ketobutyrate CoA ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MQNEFDNMTLKDFENRGQDLLTRAKQVDDYISYRHRIQHLPYRVISLTGSSAHMRVIDPYSNKEKEMISFVSNDYLGLSH
HPEVIKAGIDALEQYGAGAGASPLIGGHNFLHEQLEQEIAHFLKNEYAITYTSGYAANCSTLLAMMGKEDIAIMDMFTHA
SVFDGCLCTNTKRFLHNDIDSLVHVLNNAKSFKNRFVIIDGVYSQDGDIAFLDQIYTVCKEHDAFLIVDDAHGIGVLGKT
GRGIIEDYDLLDKVDIITGTFSKAFGCVGGYAIARKEIITLLRYYSRQNIFSAAATPQTAASAIKAIQLIDQEPQWRNTL
ADNIEYFKTGLETLGLDYGNTESAIFPVMVRNEHYVKEAARILFEQGIYVNPISYPAVPEKLSRLRFSLTAMHTKEELDK
TFSILENIRKKYKLAQI

Sequences:

>Translated_417_residues
MQNEFDNMTLKDFENRGQDLLTRAKQVDDYISYRHRIQHLPYRVISLTGSSAHMRVIDPYSNKEKEMISFVSNDYLGLSH
HPEVIKAGIDALEQYGAGAGASPLIGGHNFLHEQLEQEIAHFLKNEYAITYTSGYAANCSTLLAMMGKEDIAIMDMFTHA
SVFDGCLCTNTKRFLHNDIDSLVHVLNNAKSFKNRFVIIDGVYSQDGDIAFLDQIYTVCKEHDAFLIVDDAHGIGVLGKT
GRGIIEDYDLLDKVDIITGTFSKAFGCVGGYAIARKEIITLLRYYSRQNIFSAAATPQTAASAIKAIQLIDQEPQWRNTL
ADNIEYFKTGLETLGLDYGNTESAIFPVMVRNEHYVKEAARILFEQGIYVNPISYPAVPEKLSRLRFSLTAMHTKEELDK
TFSILENIRKKYKLAQI
>Mature_417_residues
MQNEFDNMTLKDFENRGQDLLTRAKQVDDYISYRHRIQHLPYRVISLTGSSAHMRVIDPYSNKEKEMISFVSNDYLGLSH
HPEVIKAGIDALEQYGAGAGASPLIGGHNFLHEQLEQEIAHFLKNEYAITYTSGYAANCSTLLAMMGKEDIAIMDMFTHA
SVFDGCLCTNTKRFLHNDIDSLVHVLNNAKSFKNRFVIIDGVYSQDGDIAFLDQIYTVCKEHDAFLIVDDAHGIGVLGKT
GRGIIEDYDLLDKVDIITGTFSKAFGCVGGYAIARKEIITLLRYYSRQNIFSAAATPQTAASAIKAIQLIDQEPQWRNTL
ADNIEYFKTGLETLGLDYGNTESAIFPVMVRNEHYVKEAARILFEQGIYVNPISYPAVPEKLSRLRFSLTAMHTKEELDK
TFSILENIRKKYKLAQI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=362, Percent_Identity=35.9116022099448, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI284448556, Length=338, Percent_Identity=36.094674556213, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=32.967032967033, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=32.6923076923077, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=32.183908045977, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=32.183908045977, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=32.183908045977, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4502025, Length=383, Percent_Identity=32.3759791122715, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI40316939, Length=383, Percent_Identity=32.3759791122715, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI5454084, Length=395, Percent_Identity=26.8354430379747, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1790046, Length=350, Percent_Identity=36.5714285714286, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=35.0574712643678, Blast_Score=208, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71994529, Length=364, Percent_Identity=34.8901098901099, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=31.1653116531165, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17560912, Length=369, Percent_Identity=29.810298102981, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17560914, Length=369, Percent_Identity=29.810298102981, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=235, Percent_Identity=28.0851063829787, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=235, Percent_Identity=28.0851063829787, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=390, Percent_Identity=30.2564102564103, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6320267, Length=360, Percent_Identity=28.3333333333333, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6323954, Length=262, Percent_Identity=26.7175572519084, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24662918, Length=355, Percent_Identity=33.8028169014084, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17137420, Length=382, Percent_Identity=31.151832460733, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17136286, Length=322, Percent_Identity=30.4347826086957, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653280, Length=281, Percent_Identity=26.3345195729537, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24653276, Length=281, Percent_Identity=26.3345195729537, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24653278, Length=281, Percent_Identity=26.3345195729537, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 47014; Mature: 47014

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNEFDNMTLKDFENRGQDLLTRAKQVDDYISYRHRIQHLPYRVISLTGSSAHMRVIDPY
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCC
SNKEKEMISFVSNDYLGLSHHPEVIKAGIDALEQYGAGAGASPLIGGHNFLHEQLEQEIA
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
HFLKNEYAITYTSGYAANCSTLLAMMGKEDIAIMDMFTHASVFDGCLCTNTKRFLHNDID
HHHHCCEEEEEECCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHCCCHHHHHHHHH
SLVHVLNNAKSFKNRFVIIDGVYSQDGDIAFLDQIYTVCKEHDAFLIVDDAHGIGVLGKT
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEECCC
GRGIIEDYDLLDKVDIITGTFSKAFGCVGGYAIARKEIITLLRYYSRQNIFSAAATPQTA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ASAIKAIQLIDQEPQWRNTLADNIEYFKTGLETLGLDYGNTESAIFPVMVRNEHYVKEAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
RILFEQGIYVNPISYPAVPEKLSRLRFSLTAMHTKEELDKTFSILENIRKKYKLAQI
HHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNEFDNMTLKDFENRGQDLLTRAKQVDDYISYRHRIQHLPYRVISLTGSSAHMRVIDPY
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCC
SNKEKEMISFVSNDYLGLSHHPEVIKAGIDALEQYGAGAGASPLIGGHNFLHEQLEQEIA
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
HFLKNEYAITYTSGYAANCSTLLAMMGKEDIAIMDMFTHASVFDGCLCTNTKRFLHNDID
HHHHCCEEEEEECCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHCCCHHHHHHHHH
SLVHVLNNAKSFKNRFVIIDGVYSQDGDIAFLDQIYTVCKEHDAFLIVDDAHGIGVLGKT
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEECCC
GRGIIEDYDLLDKVDIITGTFSKAFGCVGGYAIARKEIITLLRYYSRQNIFSAAATPQTA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ASAIKAIQLIDQEPQWRNTLADNIEYFKTGLETLGLDYGNTESAIFPVMVRNEHYVKEAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
RILFEQGIYVNPISYPAVPEKLSRLRFSLTAMHTKEELDKTFSILENIRKKYKLAQI
HHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA