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The map label for this gene is lepB [H]

Identifier: 150009440

GI number: 150009440

Start: 3397919

End: 3399316

Strand: Direct

Name: lepB [H]

Synonym: BDI_2848

Alternate gene names: 150009440

Gene position: 3397919-3399316 (Clockwise)

Preceding gene: 150009439

Following gene: 150009441

Centisome position: 70.62

GC content: 49.71

Gene sequence:

>1398_bases
ATGAAGAAGTTCACGAAAAAACAATGGATCAAGTTTAGTATAGCGGCCGTATTATACACGTTGTTCGCTATCTGGATGCA
AAACTTATGGTTACTGCTGGGATTAATCGTCCTAGTCGATATATTCTTGACGCACTACATCCCTTGGGGAGCTTGGAAAC
GGTCTAAGAACCCGGCGGTACGCAACGTATTGGAATGGGTGGACGATATCGTATTCGCACTGGTAGCCGTTTATTTCATC
AATTTGTTCGTCTTCCAGAACTATCAGATACCGAGTTCTTCCCTAGAGAAATCCTTGCTGGTAGGAGATTACCTGTTCGT
CAGCAAATTAAGTTACGGCCCTCGCATTCCGAACACTCCGATCTCCTTCCCGTTGGTACAAAATACGTTGCCGATCTTTA
ACTGCAAATCGTATCTGGATTGGCCGGAATGGGGCTACAAACGGGTGAAAGGTTTGGGCCACGTGAAACGTAATGATATC
GTAGTGTTCAACTTCCCCGCAGGCGACACGATCGCCGTGAAAGTGCAAAACCCGGATTACTACTCCTTGGTCGAGGAGTA
CGGACGGGAACGTATCTTATTGGATAAGGCCACGTTCGGCGAGGTAATGTACCGCCCGGTCGACAAACGGGAGAATTACG
TGAAACGTTGTATCGGTATGCCGGGTGATACGCTCCAACTCATAGACAACCAAGTGTACATAGACGGTAAACCCGCCGAG
AACCCGAAAGATATGCAGTTCAACTACTTCATCGAAACAGACGGTTCCCCGATCACAGAGGAGCAATTCCGTTTGATGGA
CGTAAGCAAGGATGACCGTATGCTGGCCTCCAGCGGCGGTTATTACCAAAACCTATTGTCATACCTAGGCTTTACGCCTA
ACGCGAAGGGACAGTACAACCCGGTATATCGCCTGCCACTCACGAAAAAGGCCTTGGCGATAGCGGAGAAGTTACCTACC
GTGAAGAAGGTTATCATCGAGCCGGAGACGTTGGGCGGCCCTACCTATCCGGTCGGATACAATACTGGCTGGACCCGTGA
TAACTTCGGGCCGCTTTGGATCCCGAAGAAAGGGGCTACCATCCCGTTGGACGAACGTAATCTGGCGTTGTACAGCCGTT
GTATCAAGAATTACGAGAACAACACCTTGGAAGTGAAGGACGGCAAGGTCTACATCAACGGCAAGCCCGAGACTTCCTAT
ACGTTTAAATACGATTATTACTGGATGATGGGCGATAACCGCCATAATAGCGCAGATAGCCGCTCATGGGGTTTCGTACC
CGAGGATCACATTGTCGGCAAGCCGATCTTGGTTTGGCTATCCTTGGACAAGGATCGCAGCCTGTTCGACGGTGGTATCC
GTTGGAACCGCCTGTTCCGCTGGGTTCATCCGGATTAA

Upstream 100 bases:

>100_bases
TTTGCGCTAGGCGCCGTAATAGCGGCAGAGTTTACCGCCGGAAAGAAAGGTTTCCTAGGCATGAATGACTTATTCAAATT
CTAAACGTATTAGCTAAAAG

Downstream 100 bases:

>100_bases
GAGGTGAAAACTTCGTATTATGACAATCCAACGATTCCTGATAGTTCTCATGAAATGGCTGGCAGCTTTCGCGCTAGCCT
CGGGGATCGTCATGCTCATA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKKFTKKQWIKFSIAAVLYTLFAIWMQNLWLLLGLIVLVDIFLTHYIPWGAWKRSKNPAVRNVLEWVDDIVFALVAVYFI
NLFVFQNYQIPSSSLEKSLLVGDYLFVSKLSYGPRIPNTPISFPLVQNTLPIFNCKSYLDWPEWGYKRVKGLGHVKRNDI
VVFNFPAGDTIAVKVQNPDYYSLVEEYGRERILLDKATFGEVMYRPVDKRENYVKRCIGMPGDTLQLIDNQVYIDGKPAE
NPKDMQFNYFIETDGSPITEEQFRLMDVSKDDRMLASSGGYYQNLLSYLGFTPNAKGQYNPVYRLPLTKKALAIAEKLPT
VKKVIIEPETLGGPTYPVGYNTGWTRDNFGPLWIPKKGATIPLDERNLALYSRCIKNYENNTLEVKDGKVYINGKPETSY
TFKYDYYWMMGDNRHNSADSRSWGFVPEDHIVGKPILVWLSLDKDRSLFDGGIRWNRLFRWVHPD

Sequences:

>Translated_465_residues
MKKFTKKQWIKFSIAAVLYTLFAIWMQNLWLLLGLIVLVDIFLTHYIPWGAWKRSKNPAVRNVLEWVDDIVFALVAVYFI
NLFVFQNYQIPSSSLEKSLLVGDYLFVSKLSYGPRIPNTPISFPLVQNTLPIFNCKSYLDWPEWGYKRVKGLGHVKRNDI
VVFNFPAGDTIAVKVQNPDYYSLVEEYGRERILLDKATFGEVMYRPVDKRENYVKRCIGMPGDTLQLIDNQVYIDGKPAE
NPKDMQFNYFIETDGSPITEEQFRLMDVSKDDRMLASSGGYYQNLLSYLGFTPNAKGQYNPVYRLPLTKKALAIAEKLPT
VKKVIIEPETLGGPTYPVGYNTGWTRDNFGPLWIPKKGATIPLDERNLALYSRCIKNYENNTLEVKDGKVYINGKPETSY
TFKYDYYWMMGDNRHNSADSRSWGFVPEDHIVGKPILVWLSLDKDRSLFDGGIRWNRLFRWVHPD
>Mature_465_residues
MKKFTKKQWIKFSIAAVLYTLFAIWMQNLWLLLGLIVLVDIFLTHYIPWGAWKRSKNPAVRNVLEWVDDIVFALVAVYFI
NLFVFQNYQIPSSSLEKSLLVGDYLFVSKLSYGPRIPNTPISFPLVQNTLPIFNCKSYLDWPEWGYKRVKGLGHVKRNDI
VVFNFPAGDTIAVKVQNPDYYSLVEEYGRERILLDKATFGEVMYRPVDKRENYVKRCIGMPGDTLQLIDNQVYIDGKPAE
NPKDMQFNYFIETDGSPITEEQFRLMDVSKDDRMLASSGGYYQNLLSYLGFTPNAKGQYNPVYRLPLTKKALAIAEKLPT
VKKVIIEPETLGGPTYPVGYNTGWTRDNFGPLWIPKKGATIPLDERNLALYSRCIKNYENNTLEVKDGKVYINGKPETSY
TFKYDYYWMMGDNRHNSADSRSWGFVPEDHIVGKPILVWLSLDKDRSLFDGGIRWNRLFRWVHPD

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=52, Percent_Identity=53.8461538461538, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 53908; Mature: 53908

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFTKKQWIKFSIAAVLYTLFAIWMQNLWLLLGLIVLVDIFLTHYIPWGAWKRSKNPAV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
RNVLEWVDDIVFALVAVYFINLFVFQNYQIPSSSLEKSLLVGDYLFVSKLSYGPRIPNTP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ISFPLVQNTLPIFNCKSYLDWPEWGYKRVKGLGHVKRNDIVVFNFPAGDTIAVKVQNPDY
CCCCHHHCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCH
YSLVEEYGRERILLDKATFGEVMYRPVDKRENYVKRCIGMPGDTLQLIDNQVYIDGKPAE
HHHHHHCCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCC
NPKDMQFNYFIETDGSPITEEQFRLMDVSKDDRMLASSGGYYQNLLSYLGFTPNAKGQYN
CCCCCEEEEEEECCCCCCCHHHHEEECCCCCCCEECCCCCHHHHHHHHHCCCCCCCCCCC
PVYRLPLTKKALAIAEKLPTVKKVIIEPETLGGPTYPVGYNTGWTRDNFGPLWIPKKGAT
CEEECCCHHHHHHHHHHCCHHHHEEECCHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
IPLDERNLALYSRCIKNYENNTLEVKDGKVYINGKPETSYTFKYDYYWMMGDNRHNSADS
CCCCCCCHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCEEEEEEEEEEECCCCCCCCCC
RSWGFVPEDHIVGKPILVWLSLDKDRSLFDGGIRWNRLFRWVHPD
CCCCCCCCCCCCCCEEEEEEEECCCCCHHCCCCCHHHEEEECCCC
>Mature Secondary Structure
MKKFTKKQWIKFSIAAVLYTLFAIWMQNLWLLLGLIVLVDIFLTHYIPWGAWKRSKNPAV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
RNVLEWVDDIVFALVAVYFINLFVFQNYQIPSSSLEKSLLVGDYLFVSKLSYGPRIPNTP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ISFPLVQNTLPIFNCKSYLDWPEWGYKRVKGLGHVKRNDIVVFNFPAGDTIAVKVQNPDY
CCCCHHHCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCH
YSLVEEYGRERILLDKATFGEVMYRPVDKRENYVKRCIGMPGDTLQLIDNQVYIDGKPAE
HHHHHHCCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCC
NPKDMQFNYFIETDGSPITEEQFRLMDVSKDDRMLASSGGYYQNLLSYLGFTPNAKGQYN
CCCCCEEEEEEECCCCCCCHHHHEEECCCCCCCEECCCCCHHHHHHHHHCCCCCCCCCCC
PVYRLPLTKKALAIAEKLPTVKKVIIEPETLGGPTYPVGYNTGWTRDNFGPLWIPKKGAT
CEEECCCHHHHHHHHHHCCHHHHEEECCHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
IPLDERNLALYSRCIKNYENNTLEVKDGKVYINGKPETSYTFKYDYYWMMGDNRHNSADS
CCCCCCCHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCEEEEEEEEEEECCCCCCCCCC
RSWGFVPEDHIVGKPILVWLSLDKDRSLFDGGIRWNRLFRWVHPD
CCCCCCCCCCCCCCEEEEEEEECCCCCHHCCCCCHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]