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The map label for this gene is fadD [C]

Identifier: 150009346

GI number: 150009346

Start: 3281726

End: 3283531

Strand: Reverse

Name: fadD [C]

Synonym: BDI_2754

Alternate gene names: 150009346

Gene position: 3283531-3281726 (Counterclockwise)

Preceding gene: 150009349

Following gene: 150009345

Centisome position: 68.25

GC content: 47.18

Gene sequence:

>1806_bases
ATGATTTATTATCATTTCGCCGAGTTAATACACCGTCAGGCAGAGAAATATGGGAACCGTACAGCGTTGAAACATAGAGA
TAACGCTACGGGGAAATGGTTGAAGATTTCTTGGAGGGAGTTTTCCGATAAAGTTATGCTTACGGCCAAGGCGATGGCTG
AGTTCGGGATAAAGGTACAAGAGAATATCGGAGTTTATTCCCAGAATATGCCTCAGTGTTTATATACGGACTTCGGTGCG
TATGGTAACCGGGTGGTTTCCATCCCGATGTACGCGACGAATTCTCCGGGACAAATCGAGTACATCATCAATGACGCTAA
GATCCGCACGTTGTTCGTGGGTGAGCAATTGCAGTATAATAACGCTTTCAAGGTACAGAAGGACTCTAAGTATCTGGAGC
GTCTGGTTGTCTTTGATCCGGCGGTCAAGATGAATCCGGAAGATAAGACGTCCATTTATTTTGATGATTTCTTGCGCTTG
GGGGATAACGCGCATGCGGAGAGCACGGTGAAAATACGTATGACGGAAGCCGTTCCGGAGGATCTGGCTACCATTATATA
TACGTCCGGTACGACAGGTGAGTCGAAAGGCGTAATGCTTCCTCATTCTTGCTATCTGGAGGCGATGCGGATACATGATG
TCCGTCTGCCTCTGGTAACCGACAAGGATCTATCCATGAGTTTCTTGCCAATGACTCATATCTTCGAGAAAGCTTGGTGC
TATTATTGTCTCCATAAAGGGGTTACGATCGCTATCAACCAAGACCCGAAAATGATCCAGAAGACATTGCCGGAGGTTCA
TCCTACTTTGATGTGCAATGTGCCTCGTTTCTGGGAGAAGGTGTATGCGGGCGTACACGAGAAGATCAACTCCGCCTCTC
CGGCCATGAAGAAGATTTTCTTGGATGCTATCGAGACCGGGCGAAAGTATAATCTGGAGTATAAGAATAAAGGTATTCCG
GCCCCGTGTGGTTTGAAGTTGAAGTTTCAATTTTACAATAAAACGGTTTTCACCTTATTGAAAAGGGTATTGGGTATTGA
GCGTGGACGGTTTTTCCCGGTGGCGGGCGCTCCGTTATCGGATACGGTTAATGAGTTCTTGCAGTCCGTGAATATCCCGA
TCGCTTATGGTTATGGACTGAGCGAGACGACGGCTACGGTTTGTTTCTACCCGGAGATCGGATTCCAGTTTGGTTCTATT
GGTGAGGTAATGCCGGGAGTTCAAGTGAAAATAGATCCGGGGAATAACGAGATCTTGGTGAAAGGCAAGACCGTGATGTC
CGGATATTATAATAAACCGGAAGAGACGAAGAGGGCTTTCACCGAAGATGGTTTCTTCCGTACCGGCGACGCTGGTCGTT
TGGAGGGTAATACGTTATTCTTTACGGAACGAATCAAGGATTTGTATAAGACTTCAAACGGAAAATATATCGCCCCGCAA
GCGATCGAGATGGTGATGAGCGGTGATAATTATATCGAGCAAATCGCTGTTATCGGCGATCAACGTAAGTTCGTGAGCGC
CTTGATCGTGCCGGCTTATCCATTGTTGGAGAAGTATGCCGGGGAAAAAGGCATCTCGTTCGAGAGCCGGGAGGAGTTGG
TGAAGAACAAGGATATCATTCGTTTCATCGAGGCTAGGGTAGAGGAGCATCAGAAGAACTTGGCTTCTTACGAGAAGATC
AAGCGCTTTACCTTGTTGCCGGAACCTTTCATGATGGGATGTGAGCTGACGGATACGCTAAAGTTGCGCCGTCCGGTCGT
ATTGCAGAAGTACGCTACCGAGATAGAGGCGATGTACGAGGAATAA

Upstream 100 bases:

>100_bases
CTTGCACAAAAAGAGCAATTATGTGTAAAAAAAGGACTGATGTCGTGTCTTTTAGAAGAGAAAAGCGTACTTTCGCGGTA
TCAATTCAAAATAAGGAATT

Downstream 100 bases:

>100_bases
CGAGTTTGTCGGCTATCAACTATTTCTTATCTTTGCGGTAAATTTAAAAAAGAAAAGAACATATGATCACATCAGACCAA
CTACATGACGTGTTGGAGCG

Product: putative long-chain-fatty-acid-CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MIYYHFAELIHRQAEKYGNRTALKHRDNATGKWLKISWREFSDKVMLTAKAMAEFGIKVQENIGVYSQNMPQCLYTDFGA
YGNRVVSIPMYATNSPGQIEYIINDAKIRTLFVGEQLQYNNAFKVQKDSKYLERLVVFDPAVKMNPEDKTSIYFDDFLRL
GDNAHAESTVKIRMTEAVPEDLATIIYTSGTTGESKGVMLPHSCYLEAMRIHDVRLPLVTDKDLSMSFLPMTHIFEKAWC
YYCLHKGVTIAINQDPKMIQKTLPEVHPTLMCNVPRFWEKVYAGVHEKINSASPAMKKIFLDAIETGRKYNLEYKNKGIP
APCGLKLKFQFYNKTVFTLLKRVLGIERGRFFPVAGAPLSDTVNEFLQSVNIPIAYGYGLSETTATVCFYPEIGFQFGSI
GEVMPGVQVKIDPGNNEILVKGKTVMSGYYNKPEETKRAFTEDGFFRTGDAGRLEGNTLFFTERIKDLYKTSNGKYIAPQ
AIEMVMSGDNYIEQIAVIGDQRKFVSALIVPAYPLLEKYAGEKGISFESREELVKNKDIIRFIEARVEEHQKNLASYEKI
KRFTLLPEPFMMGCELTDTLKLRRPVVLQKYATEIEAMYEE

Sequences:

>Translated_601_residues
MIYYHFAELIHRQAEKYGNRTALKHRDNATGKWLKISWREFSDKVMLTAKAMAEFGIKVQENIGVYSQNMPQCLYTDFGA
YGNRVVSIPMYATNSPGQIEYIINDAKIRTLFVGEQLQYNNAFKVQKDSKYLERLVVFDPAVKMNPEDKTSIYFDDFLRL
GDNAHAESTVKIRMTEAVPEDLATIIYTSGTTGESKGVMLPHSCYLEAMRIHDVRLPLVTDKDLSMSFLPMTHIFEKAWC
YYCLHKGVTIAINQDPKMIQKTLPEVHPTLMCNVPRFWEKVYAGVHEKINSASPAMKKIFLDAIETGRKYNLEYKNKGIP
APCGLKLKFQFYNKTVFTLLKRVLGIERGRFFPVAGAPLSDTVNEFLQSVNIPIAYGYGLSETTATVCFYPEIGFQFGSI
GEVMPGVQVKIDPGNNEILVKGKTVMSGYYNKPEETKRAFTEDGFFRTGDAGRLEGNTLFFTERIKDLYKTSNGKYIAPQ
AIEMVMSGDNYIEQIAVIGDQRKFVSALIVPAYPLLEKYAGEKGISFESREELVKNKDIIRFIEARVEEHQKNLASYEKI
KRFTLLPEPFMMGCELTDTLKLRRPVVLQKYATEIEAMYEE
>Mature_601_residues
MIYYHFAELIHRQAEKYGNRTALKHRDNATGKWLKISWREFSDKVMLTAKAMAEFGIKVQENIGVYSQNMPQCLYTDFGA
YGNRVVSIPMYATNSPGQIEYIINDAKIRTLFVGEQLQYNNAFKVQKDSKYLERLVVFDPAVKMNPEDKTSIYFDDFLRL
GDNAHAESTVKIRMTEAVPEDLATIIYTSGTTGESKGVMLPHSCYLEAMRIHDVRLPLVTDKDLSMSFLPMTHIFEKAWC
YYCLHKGVTIAINQDPKMIQKTLPEVHPTLMCNVPRFWEKVYAGVHEKINSASPAMKKIFLDAIETGRKYNLEYKNKGIP
APCGLKLKFQFYNKTVFTLLKRVLGIERGRFFPVAGAPLSDTVNEFLQSVNIPIAYGYGLSETTATVCFYPEIGFQFGSI
GEVMPGVQVKIDPGNNEILVKGKTVMSGYYNKPEETKRAFTEDGFFRTGDAGRLEGNTLFFTERIKDLYKTSNGKYIAPQ
AIEMVMSGDNYIEQIAVIGDQRKFVSALIVPAYPLLEKYAGEKGISFESREELVKNKDIIRFIEARVEEHQKNLASYEKI
KRFTLLPEPFMMGCELTDTLKLRRPVVLQKYATEIEAMYEE

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI27477105, Length=633, Percent_Identity=27.172195892575, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI42794756, Length=638, Percent_Identity=27.742946708464, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI42794760, Length=638, Percent_Identity=27.742946708464, Blast_Score=199, Evalue=9e-51,
Organism=Homo sapiens, GI42794758, Length=638, Percent_Identity=27.742946708464, Blast_Score=199, Evalue=9e-51,
Organism=Homo sapiens, GI57165412, Length=612, Percent_Identity=28.2679738562091, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI57165410, Length=609, Percent_Identity=28.0788177339901, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI40807491, Length=610, Percent_Identity=27.5409836065574, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI83745141, Length=627, Percent_Identity=25.9968102073365, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI42794754, Length=629, Percent_Identity=24.0063593004769, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI42794752, Length=629, Percent_Identity=24.0063593004769, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI12669909, Length=629, Percent_Identity=23.3704292527822, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI4758332, Length=629, Percent_Identity=23.3704292527822, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI187761345, Length=527, Percent_Identity=23.5294117647059, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI187761343, Length=527, Percent_Identity=23.5294117647059, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17541856, Length=620, Percent_Identity=27.4193548387097, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17510401, Length=624, Percent_Identity=28.0448717948718, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17553312, Length=606, Percent_Identity=26.2376237623762, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17556552, Length=582, Percent_Identity=26.2886597938144, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25147511, Length=655, Percent_Identity=26.5648854961832, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI193204819, Length=661, Percent_Identity=26.1724659606657, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17564090, Length=606, Percent_Identity=24.4224422442244, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17558820, Length=398, Percent_Identity=26.6331658291457, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=404, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI133901848, Length=241, Percent_Identity=27.8008298755187, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=159, Percent_Identity=32.0754716981132, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=167, Percent_Identity=29.940119760479, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324893, Length=495, Percent_Identity=29.8989898989899, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322182, Length=636, Percent_Identity=26.4150943396226, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320852, Length=583, Percent_Identity=25.0428816466552, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6323903, Length=558, Percent_Identity=26.8817204301075, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281366413, Length=615, Percent_Identity=27.479674796748, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24666501, Length=615, Percent_Identity=27.479674796748, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24666497, Length=615, Percent_Identity=27.479674796748, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17933690, Length=635, Percent_Identity=23.9370078740157, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI62471681, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI62471687, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24586634, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI22026970, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI62471679, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI62471683, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI62471685, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24586636, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI62471689, Length=615, Percent_Identity=27.3170731707317, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI19921316, Length=661, Percent_Identity=23.6006051437216, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355181, Length=516, Percent_Identity=23.6434108527132, Blast_Score=86, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 68597; Mature: 68597

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYYHFAELIHRQAEKYGNRTALKHRDNATGKWLKISWREFSDKVMLTAKAMAEFGIKVQ
CEEHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEECCCCEEEEEHHHHHHCCCEEE
ENIGVYSQNMPQCLYTDFGAYGNRVVSIPMYATNSPGQIEYIINDAKIRTLFVGEQLQYN
ECCCCCCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEEECCEEEEEEECCEEECC
NAFKVQKDSKYLERLVVFDPAVKMNPEDKTSIYFDDFLRLGDNAHAESTVKIRMTEAVPE
CCEEEECHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCEEEEEEHHHCCC
DLATIIYTSGTTGESKGVMLPHSCYLEAMRIHDVRLPLVTDKDLSMSFLPMTHIFEKAWC
CCEEEEEECCCCCCCCCEECCHHHHHHHHHHEEEEEEEEECCCCCEEECHHHHHHHHHHH
YYCLHKGVTIAINQDPKMIQKTLPEVHPTLMCNVPRFWEKVYAGVHEKINSASPAMKKIF
HHHHHCCEEEEECCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHH
LDAIETGRKYNLEYKNKGIPAPCGLKLKFQFYNKTVFTLLKRVLGIERGRFFPVAGAPLS
HHHHHCCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCHH
DTVNEFLQSVNIPIAYGYGLSETTATVCFYPEIGFQFGSIGEVMPGVQVKIDPGNNEILV
HHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCCCHHCCCCCEEEECCCCCEEEE
KGKTVMSGYYNKPEETKRAFTEDGFFRTGDAGRLEGNTLFFTERIKDLYKTSNGKYIAPQ
ECCCEECCCCCCCHHHHHHHCCCCCEECCCCCEECCCEEEHHHHHHHHHHCCCCCEECHH
AIEMVMSGDNYIEQIAVIGDQRKFVSALIVPAYPLLEKYAGEKGISFESREELVKNKDII
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHCHHHH
RFIEARVEEHQKNLASYEKIKRFTLLPEPFMMGCELTDTLKLRRPVVLQKYATEIEAMYE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHC
E
C
>Mature Secondary Structure
MIYYHFAELIHRQAEKYGNRTALKHRDNATGKWLKISWREFSDKVMLTAKAMAEFGIKVQ
CEEHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEECCCCEEEEEHHHHHHCCCEEE
ENIGVYSQNMPQCLYTDFGAYGNRVVSIPMYATNSPGQIEYIINDAKIRTLFVGEQLQYN
ECCCCCCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEEECCEEEEEEECCEEECC
NAFKVQKDSKYLERLVVFDPAVKMNPEDKTSIYFDDFLRLGDNAHAESTVKIRMTEAVPE
CCEEEECHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCEEEEEEHHHCCC
DLATIIYTSGTTGESKGVMLPHSCYLEAMRIHDVRLPLVTDKDLSMSFLPMTHIFEKAWC
CCEEEEEECCCCCCCCCEECCHHHHHHHHHHEEEEEEEEECCCCCEEECHHHHHHHHHHH
YYCLHKGVTIAINQDPKMIQKTLPEVHPTLMCNVPRFWEKVYAGVHEKINSASPAMKKIF
HHHHHCCEEEEECCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHH
LDAIETGRKYNLEYKNKGIPAPCGLKLKFQFYNKTVFTLLKRVLGIERGRFFPVAGAPLS
HHHHHCCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCHH
DTVNEFLQSVNIPIAYGYGLSETTATVCFYPEIGFQFGSIGEVMPGVQVKIDPGNNEILV
HHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCCCHHCCCCCEEEECCCCCEEEE
KGKTVMSGYYNKPEETKRAFTEDGFFRTGDAGRLEGNTLFFTERIKDLYKTSNGKYIAPQ
ECCCEECCCCCCCHHHHHHHCCCCCEECCCCCEECCCEEEHHHHHHHHHHCCCCCEECHH
AIEMVMSGDNYIEQIAVIGDQRKFVSALIVPAYPLLEKYAGEKGISFESREELVKNKDII
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHCHHHH
RFIEARVEEHQKNLASYEKIKRFTLLPEPFMMGCELTDTLKLRRPVVLQKYATEIEAMYE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]