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The map label for this gene is mip [H]

Identifier: 150009304

GI number: 150009304

Start: 3213418

End: 3214005

Strand: Reverse

Name: mip [H]

Synonym: BDI_2706

Alternate gene names: 150009304

Gene position: 3214005-3213418 (Counterclockwise)

Preceding gene: 150009305

Following gene: 150009303

Centisome position: 66.8

GC content: 44.39

Gene sequence:

>588_bases
ATGGATAAAGTAAGTTATGCGCTTGGCTTAAGTATCGGAAATAATTTCCAGAACTCAGGCATCAAGGATCTTCAAGTGGA
AGATTTTGTACAGGGATTGAATGACGTCTTAACAGAGGCAAAACCTGCTCTTAGTTATGATGAGGCAAAACAAGTGATCA
ATGATTACTTCATGAAGCTTCAACAAGAGAAACTGGAAATCAATAAGAAAGCCGGTGAGGAGTTCCTTACTATCAATAAG
CATAAGGCTGGTGTGGTAGAGTTGCCTAGCGGTTTGCAATACGAGGTGCTGAAGAATGGTACAGGCGCTAAACCTACGGC
GAACGATAAGGTAAAATGCCACTATCACGGTACGTTAATCAACGGTCAGGTGTTTGATAGCTCCGTACAGAGAGGCGAGC
CTGCCGTATTCGGTGTTTCACAGGTAATCCCGGGATGGGTAGAGGCCTTGCAGTTGATGCCGGTCGGTTCTAAATGGAGA
TTGTTTATCCCGTCTAACCTTGCTTATGGCGAGCGTGGGGCAGGTGAGGCTATCGAGCCGAATAGTACATTGATCTTCGA
CGTTGAGTTATTAGATATCGAAAAATAA

Upstream 100 bases:

>100_bases
CTAAAAAGATTTGAATGAAATAAAAAGTTCTTACAAAATGCTGTTATACGATTAAAAGCATTACTTTTGTGGCTTATAAT
TAGTTGAACAAGAAAAAAGA

Downstream 100 bases:

>100_bases
TATATAAGAGTTAAAGAAAAATGAAAAAGTTAAGTGTATTAGTCGCTACAGTGATTGTAGCAATGGGCGCATCTTTCACC
TCTTGCGGTGATTCTCACAA

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MDKVSYALGLSIGNNFQNSGIKDLQVEDFVQGLNDVLTEAKPALSYDEAKQVINDYFMKLQQEKLEINKKAGEEFLTINK
HKAGVVELPSGLQYEVLKNGTGAKPTANDKVKCHYHGTLINGQVFDSSVQRGEPAVFGVSQVIPGWVEALQLMPVGSKWR
LFIPSNLAYGERGAGEAIEPNSTLIFDVELLDIEK

Sequences:

>Translated_195_residues
MDKVSYALGLSIGNNFQNSGIKDLQVEDFVQGLNDVLTEAKPALSYDEAKQVINDYFMKLQQEKLEINKKAGEEFLTINK
HKAGVVELPSGLQYEVLKNGTGAKPTANDKVKCHYHGTLINGQVFDSSVQRGEPAVFGVSQVIPGWVEALQLMPVGSKWR
LFIPSNLAYGERGAGEAIEPNSTLIFDVELLDIEK
>Mature_195_residues
MDKVSYALGLSIGNNFQNSGIKDLQVEDFVQGLNDVLTEAKPALSYDEAKQVINDYFMKLQQEKLEINKKAGEEFLTINK
HKAGVVELPSGLQYEVLKNGTGAKPTANDKVKCHYHGTLINGQVFDSSVQRGEPAVFGVSQVIPGWVEALQLMPVGSKWR
LFIPSNLAYGERGAGEAIEPNSTLIFDVELLDIEK

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=94, Percent_Identity=47.8723404255319, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI17149844, Length=94, Percent_Identity=47.8723404255319, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI17149842, Length=94, Percent_Identity=47.8723404255319, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503727, Length=119, Percent_Identity=42.8571428571429, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=41.1214953271028, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=41.1214953271028, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7706131, Length=94, Percent_Identity=41.4893617021277, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI224809329, Length=91, Percent_Identity=43.956043956044, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI224809327, Length=91, Percent_Identity=43.956043956044, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4758384, Length=91, Percent_Identity=43.956043956044, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI192448443, Length=100, Percent_Identity=37, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI224809331, Length=92, Percent_Identity=43.4782608695652, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI4503729, Length=101, Percent_Identity=37.6237623762376, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=42.2222222222222, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI87082390, Length=194, Percent_Identity=47.9381443298969, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1789745, Length=206, Percent_Identity=39.3203883495146, Blast_Score=120, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17540882, Length=94, Percent_Identity=46.8085106382979, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=42.4528301886792, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=125, Percent_Identity=38.4, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=52.1276595744681, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=50.4761904761905, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=50, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=50, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=43.9252336448598, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=40.3846153846154, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21456; Mature: 21456

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVSYALGLSIGNNFQNSGIKDLQVEDFVQGLNDVLTEAKPALSYDEAKQVINDYFMKL
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QQEKLEINKKAGEEFLTINKHKAGVVELPSGLQYEVLKNGTGAKPTANDKVKCHYHGTLI
HHHHHHHHHHCCCCEEEEECCCCCEEECCCCCEEEEECCCCCCCCCCCCEEEEEECCEEE
NGQVFDSSVQRGEPAVFGVSQVIPGWVEALQLMPVGSKWRLFIPSNLAYGERGAGEAIEP
CCEEECCHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCC
NSTLIFDVELLDIEK
CCEEEEEEEEEEECC
>Mature Secondary Structure
MDKVSYALGLSIGNNFQNSGIKDLQVEDFVQGLNDVLTEAKPALSYDEAKQVINDYFMKL
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QQEKLEINKKAGEEFLTINKHKAGVVELPSGLQYEVLKNGTGAKPTANDKVKCHYHGTLI
HHHHHHHHHHCCCCEEEEECCCCCEEECCCCCEEEEECCCCCCCCCCCCEEEEEECCEEE
NGQVFDSSVQRGEPAVFGVSQVIPGWVEALQLMPVGSKWRLFIPSNLAYGERGAGEAIEP
CCEEECCHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCC
NSTLIFDVELLDIEK
CCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7516906 [H]