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The map label for this gene is dxs

Identifier: 150009262

GI number: 150009262

Start: 3158221

End: 3160119

Strand: Reverse

Name: dxs

Synonym: BDI_2664

Alternate gene names: 150009262

Gene position: 3160119-3158221 (Counterclockwise)

Preceding gene: 150009263

Following gene: 150009261

Centisome position: 65.68

GC content: 44.66

Gene sequence:

>1899_bases
ATGGCTGAAAGCAAAGTTGAACACCTATTGGATAGCATTCATTTTCCGGAAGACTTGAGACATTTGTCACAGGATAAGTT
GGAGCAGGTATGTGCCGATTTGCGTCAATATATTATCGATGTTTTGTCTGAGAATCCCGGCCACCTAGGTGCAAGCCTTG
GTACGGTAGAGCTGACAGTCGCCCTTCATTATGTATTCAATACCCCCTATGACCGTATTGTCTGGGATGTCGGGCATCAA
GCTTACGGACATAAAATACTTACAGGAAGGAAAGATATTTTCCATACGCTCCGTAAGTTTAAAGGAATTAGTGGCTTCCC
TAATCCTGCGGAAAGTGAGTATGACGCTTTTATCGCCGGACACGCCTCAAATTCAATCTCTGCGGCGATGGGTATGTCGG
TAGCCTCGGCCTTGAAGAAGGAACTGGATCGCCATGTGATCGCCGTGATCGGGGATGGCGCTATGACCGGAGGACTCGCC
TTCGAGGGGTTGAATAATGCGTCTGCCAACCCTAATAATTTGTTGATTATCCTGAATGATAACGATATGGCGATAGATCA
TAGCGTAGGTGGTCTTAGCCAGTATTTAGTGGATATAACGACGAGTCAAGCCTATAATAAAATGAGATACGATGTGTATC
GAGGCTTAAAGAAGATCAAGCTCATCAATAACGATCGCAGGGAAAACATCTTACGTTTTAACAATAGCCTTAAAGCATTG
CTTACCCAGCAACATAATTTATTTGAAGGCTTCAGCATCCGTTACTTTGGTCCGGTGGATGGGCATGATGTAAATTATCT
GGTGAAGGTATTGAATGATATAAAAGATATGCAAGGCCCTAAGCTGTTGCACATCAAAACGAAAAAAGGAAAAGGCTTTA
AACCTGCGGAAGAGTCCGCTACGGAATGGCATGCTCCCGGAAAGTTCAATAAGGAAACCGGCCAGCGTATTATCGTTCGT
AAATTAGATGAGCCTCAATTATATCAAGACGTATTCGGTCATACATTGGTAGAGCTTGCGGAGAATGATGAACGTATTGT
AGGCGTAACTCCGGCTATGCCTTCCGGTTGCTCGATGACTTATATGATGAAAGCCTTCCCGGATCGTGCGTTTGACGTGG
GAATTGCGGAAGGACATTCCGTAACTTTCTCTGCTGGATTAGCTAAGGAGGGAATGATACCTTTCTGCAACGTGTATTCC
TCGTTTATGCAGCGTGCGTATGATATGGTTATCCATGATGTAGCTTTGCAAAAACTACATATGGTGATCTGTCTGGATCG
TGCGGGATTAGTGGGAGAGGATGGAGCTACACATCATGGCGTGTTTGATTTAGCATATCTTCGTCCGATACCGAATTTGG
TAATCGCTTCCCCATTGAATGAGTTGGATTTACGGAATTTGATGTATACAGGCTATGCCGCTTTTGATGGCCCGTTCGTA
ATCCGTTACCCTAGAGGTAAGGGGGAGATGAAAGATTGGCGTAACGAGATGCAAGTATTGCCTATTGGAAAAGGAAAAAA
GTTGCGTGACGGGGATGATATCGCCGTACTTTCTATCGGACCGATCGGAAACGAGGTGATCAAAGCCATCGAGATGGTGA
AAGAAGAGAGGGTATCGATAGCCCATTACGATATGATCTACTTGAAACCGTTGGATGAGGAGCTGTTGCATGAGATCGGG
CAGAAATATAACCGTATTATTACGGTAGAGAATGGAGTGATAAAAGGAGGTTTTGGTAGCGCTGTCCTTGAGTTTATGGC
AGACAATGGCTATACGCCTCATGTAAAGCGTATCGGAGTGCCGGATGCGTTTATCGAGCATGGTTCTATACCGGAACTGT
ATCAATTATGTGGTATGGATGCCGAGAGTATCGCGAAACAGTTGAAAAAGGAGAATTGA

Upstream 100 bases:

>100_bases
GTTAAAATCAATATGGATTTCCCCCTTGTCTAAGAAATGACAGGACAATACTATTATATATGCCGTTTATTCTGTATTTT
TGCCAGAAAAATTAGCAGAC

Downstream 100 bases:

>100_bases
TTATTGTCAATTAATAAAATATGAAAATTGTCATAGCCGGTGCGGGAGAAGTAGGTACACATTTAGCGAAAATGTTATCT
CAAGAGAATCAGGACATCAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MAESKVEHLLDSIHFPEDLRHLSQDKLEQVCADLRQYIIDVLSENPGHLGASLGTVELTVALHYVFNTPYDRIVWDVGHQ
AYGHKILTGRKDIFHTLRKFKGISGFPNPAESEYDAFIAGHASNSISAAMGMSVASALKKELDRHVIAVIGDGAMTGGLA
FEGLNNASANPNNLLIILNDNDMAIDHSVGGLSQYLVDITTSQAYNKMRYDVYRGLKKIKLINNDRRENILRFNNSLKAL
LTQQHNLFEGFSIRYFGPVDGHDVNYLVKVLNDIKDMQGPKLLHIKTKKGKGFKPAEESATEWHAPGKFNKETGQRIIVR
KLDEPQLYQDVFGHTLVELAENDERIVGVTPAMPSGCSMTYMMKAFPDRAFDVGIAEGHSVTFSAGLAKEGMIPFCNVYS
SFMQRAYDMVIHDVALQKLHMVICLDRAGLVGEDGATHHGVFDLAYLRPIPNLVIASPLNELDLRNLMYTGYAAFDGPFV
IRYPRGKGEMKDWRNEMQVLPIGKGKKLRDGDDIAVLSIGPIGNEVIKAIEMVKEERVSIAHYDMIYLKPLDEELLHEIG
QKYNRIITVENGVIKGGFGSAVLEFMADNGYTPHVKRIGVPDAFIEHGSIPELYQLCGMDAESIAKQLKKEN

Sequences:

>Translated_632_residues
MAESKVEHLLDSIHFPEDLRHLSQDKLEQVCADLRQYIIDVLSENPGHLGASLGTVELTVALHYVFNTPYDRIVWDVGHQ
AYGHKILTGRKDIFHTLRKFKGISGFPNPAESEYDAFIAGHASNSISAAMGMSVASALKKELDRHVIAVIGDGAMTGGLA
FEGLNNASANPNNLLIILNDNDMAIDHSVGGLSQYLVDITTSQAYNKMRYDVYRGLKKIKLINNDRRENILRFNNSLKAL
LTQQHNLFEGFSIRYFGPVDGHDVNYLVKVLNDIKDMQGPKLLHIKTKKGKGFKPAEESATEWHAPGKFNKETGQRIIVR
KLDEPQLYQDVFGHTLVELAENDERIVGVTPAMPSGCSMTYMMKAFPDRAFDVGIAEGHSVTFSAGLAKEGMIPFCNVYS
SFMQRAYDMVIHDVALQKLHMVICLDRAGLVGEDGATHHGVFDLAYLRPIPNLVIASPLNELDLRNLMYTGYAAFDGPFV
IRYPRGKGEMKDWRNEMQVLPIGKGKKLRDGDDIAVLSIGPIGNEVIKAIEMVKEERVSIAHYDMIYLKPLDEELLHEIG
QKYNRIITVENGVIKGGFGSAVLEFMADNGYTPHVKRIGVPDAFIEHGSIPELYQLCGMDAESIAKQLKKEN
>Mature_631_residues
AESKVEHLLDSIHFPEDLRHLSQDKLEQVCADLRQYIIDVLSENPGHLGASLGTVELTVALHYVFNTPYDRIVWDVGHQA
YGHKILTGRKDIFHTLRKFKGISGFPNPAESEYDAFIAGHASNSISAAMGMSVASALKKELDRHVIAVIGDGAMTGGLAF
EGLNNASANPNNLLIILNDNDMAIDHSVGGLSQYLVDITTSQAYNKMRYDVYRGLKKIKLINNDRRENILRFNNSLKALL
TQQHNLFEGFSIRYFGPVDGHDVNYLVKVLNDIKDMQGPKLLHIKTKKGKGFKPAEESATEWHAPGKFNKETGQRIIVRK
LDEPQLYQDVFGHTLVELAENDERIVGVTPAMPSGCSMTYMMKAFPDRAFDVGIAEGHSVTFSAGLAKEGMIPFCNVYSS
FMQRAYDMVIHDVALQKLHMVICLDRAGLVGEDGATHHGVFDLAYLRPIPNLVIASPLNELDLRNLMYTGYAAFDGPFVI
RYPRGKGEMKDWRNEMQVLPIGKGKKLRDGDDIAVLSIGPIGNEVIKAIEMVKEERVSIAHYDMIYLKPLDEELLHEIGQ
KYNRIITVENGVIKGGFGSAVLEFMADNGYTPHVKRIGVPDAFIEHGSIPELYQLCGMDAESIAKQLKKEN

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=613, Percent_Identity=22.8384991843393, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4507521, Length=613, Percent_Identity=22.8384991843393, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI225637459, Length=415, Percent_Identity=25.7831325301205, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI225637463, Length=415, Percent_Identity=25.7831325301205, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI225637461, Length=415, Percent_Identity=25.7831325301205, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI133778974, Length=379, Percent_Identity=23.2189973614776, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=43.2692307692308, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17539652, Length=395, Percent_Identity=23.5443037974684, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24666278, Length=595, Percent_Identity=23.5294117647059, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24645119, Length=608, Percent_Identity=23.6842105263158, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45551847, Length=608, Percent_Identity=23.6842105263158, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550715, Length=608, Percent_Identity=23.6842105263158, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PARD8 (A6LFB9)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001304005.1
- STRING:   A6LFB9
- GeneID:   5307813
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_2664
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   IIYAPIN
- ProtClustDB:   PRK05444
- BioCyc:   PDIS435591:BDI_2664-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70399; Mature: 70268

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESKVEHLLDSIHFPEDLRHLSQDKLEQVCADLRQYIIDVLSENPGHLGASLGTVELTV
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
ALHYVFNTPYDRIVWDVGHQAYGHKILTGRKDIFHTLRKFKGISGFPNPAESEYDAFIAG
EEEEHHCCCHHHHHHHCCCHHHCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
HASNSISAAMGMSVASALKKELDRHVIAVIGDGAMTGGLAFEGLNNASANPNNLLIILND
CCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEECCCCCCCCCCCEEEEEECC
NDMAIDHSVGGLSQYLVDITTSQAYNKMRYDVYRGLKKIKLINNDRRENILRFNNSLKAL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LTQQHNLFEGFSIRYFGPVDGHDVNYLVKVLNDIKDMQGPKLLHIKTKKGKGFKPAEESA
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCC
TEWHAPGKFNKETGQRIIVRKLDEPQLYQDVFGHTLVELAENDERIVGVTPAMPSGCSMT
CCCCCCCCCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
YMMKAFPDRAFDVGIAEGHSVTFSAGLAKEGMIPFCNVYSSFMQRAYDMVIHDVALQKLH
HHHHHCCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVICLDRAGLVGEDGATHHGVFDLAYLRPIPNLVIASPLNELDLRNLMYTGYAAFDGPFV
HHEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCEEEECCCEE
IRYPRGKGEMKDWRNEMQVLPIGKGKKLRDGDDIAVLSIGPIGNEVIKAIEMVKEERVSI
EEECCCCCCHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCEE
AHYDMIYLKPLDEELLHEIGQKYNRIITVENGVIKGGFGSAVLEFMADNGYTPHVKRIGV
EEEEEEEECCCCHHHHHHHHHHHCEEEEEECCEEECCHHHHHHHHHHCCCCCCCCEECCC
PDAFIEHGSIPELYQLCGMDAESIAKQLKKEN
CHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AESKVEHLLDSIHFPEDLRHLSQDKLEQVCADLRQYIIDVLSENPGHLGASLGTVELTV
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
ALHYVFNTPYDRIVWDVGHQAYGHKILTGRKDIFHTLRKFKGISGFPNPAESEYDAFIAG
EEEEHHCCCHHHHHHHCCCHHHCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
HASNSISAAMGMSVASALKKELDRHVIAVIGDGAMTGGLAFEGLNNASANPNNLLIILND
CCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEECCCCCCCCCCCEEEEEECC
NDMAIDHSVGGLSQYLVDITTSQAYNKMRYDVYRGLKKIKLINNDRRENILRFNNSLKAL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LTQQHNLFEGFSIRYFGPVDGHDVNYLVKVLNDIKDMQGPKLLHIKTKKGKGFKPAEESA
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCC
TEWHAPGKFNKETGQRIIVRKLDEPQLYQDVFGHTLVELAENDERIVGVTPAMPSGCSMT
CCCCCCCCCCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
YMMKAFPDRAFDVGIAEGHSVTFSAGLAKEGMIPFCNVYSSFMQRAYDMVIHDVALQKLH
HHHHHCCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVICLDRAGLVGEDGATHHGVFDLAYLRPIPNLVIASPLNELDLRNLMYTGYAAFDGPFV
HHEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCEEEECCCEE
IRYPRGKGEMKDWRNEMQVLPIGKGKKLRDGDDIAVLSIGPIGNEVIKAIEMVKEERVSI
EEECCCCCCHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCEE
AHYDMIYLKPLDEELLHEIGQKYNRIITVENGVIKGGFGSAVLEFMADNGYTPHVKRIGV
EEEEEEEECCCCHHHHHHHHHHHCEEEEEECCEEECCHHHHHHHHHHCCCCCCCCEECCC
PDAFIEHGSIPELYQLCGMDAESIAKQLKKEN
CHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA