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The map label for this gene is lytS [H]

Identifier: 150008948

GI number: 150008948

Start: 2766640

End: 2767821

Strand: Direct

Name: lytS [H]

Synonym: BDI_2344

Alternate gene names: 150008948

Gene position: 2766640-2767821 (Clockwise)

Preceding gene: 150008945

Following gene: 150008949

Centisome position: 57.5

GC content: 46.79

Gene sequence:

>1182_bases
ATGTTACAATTAAAAAGAAATGACTTATTGATCGGCTTCACGATATCCGTCTTGCTTAGTATTTTCGTGAACTTCGCCCT
TCTGATGCGTAAATATGAGTTCGAGACCGGAAACCCGAGCATGGGTATCCAGCCTCCGGATCGCACCATGTATTATTTGC
TAATCTGGTTCTTCGTGTTCTCCTTCATCTTATTTATTGTCAACAGCTTGATGTATAAGTTCGGGGACAAGCTTTTCCGC
AGGAAAGAGTATAAAAGGGTATTGGTGGTTTGCGTAACTTGTATCAGCATCGCCTACGGCATGTTTCATCTGTCGCCGGT
TTTGTACACGGCCATTGTTGTAGAATGGCTGGGAGAAGACGGACCTCAGCCAGCTACCCGGGATATCATGATCCGCATCA
ACCGGGACAGGATGGCTACGCAAACCATCAGGCCTGCCGAGCATCGGGACATACCGGTACCGCCCAATCCTTTCACGGTC
CCTAACTCTTTCATGACGGAGCATCTTTTCGTCTTCCTCACGGTCATGCTAAGCTCCATACTGATCCGGCTGCTGGGCAG
CAAGCAGCAAATGAAACTGGAATATGAGCAATTGAAGACCGAGAAGCTACAGAATTCCTATAACGCCTTGATGGGACAAA
TCAACCCGCATTTCTTCTTCAACTCCTTAAATGGATTGAACGCCTTGATACAGAGCGGAGAGAAACAACAGACGCTGGCT
TATCTGGATGAGCTATCCAACGTCTTCCGGTATATCTTGCAAAGCAACAAGAAAGAGCTGGTTACGCTAGCGGAAGAACT
TCAATTCGTAAAGGCGTACACCTATCTGCTAAGCGTGCGCTACGAGGGAAAGCTATTCTTCTCCATCCAAGCGGATACCC
CTTACTTGCTTTGGTATCTGCCGATATTGAGCGTACTCCCCCTGATCGAGAACGCCGTAAAGCACAACGTTATCAGCAAG
CAATACCCACTACAGATCGATATCTATACCACCCATGAGGACAAACTAATCATATCCAATAAAATACATCCTAAGTCGGA
AGATAGCAAAGGCAGCGGTATCGGATTGAAGAACCTATGGGGGCGCTACCGGATGCTTACCGGAAAGGACATCCAGATCT
CCAACCGCAAGGAATATTTCAAGGTCACGCTTCCTTTACTTAATAAACCCATTCACTCATGA

Upstream 100 bases:

>100_bases
AAGCCCGGGCGATTCACCGATATTTTTATCCGTTTCGTCGATTCCTTTTCCCGCTCGGATAAGGAAGCCCTATCTTTGTA
AGCAGACAAAGGGTTTATCT

Downstream 100 bases:

>100_bases
AAGCAGTTATTATAGAAGATGAGACTACCGCCGTTAATAGCCTAAAGGCGATCTTGGCGCAAAATACGGTTACTCAGATC
GAAGTGATCGCCGAGTTGGA

Product: putative two-component system sensor protein histidine kinase

Products: NA

Alternate protein names: Autolysin sensor kinase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MLQLKRNDLLIGFTISVLLSIFVNFALLMRKYEFETGNPSMGIQPPDRTMYYLLIWFFVFSFILFIVNSLMYKFGDKLFR
RKEYKRVLVVCVTCISIAYGMFHLSPVLYTAIVVEWLGEDGPQPATRDIMIRINRDRMATQTIRPAEHRDIPVPPNPFTV
PNSFMTEHLFVFLTVMLSSILIRLLGSKQQMKLEYEQLKTEKLQNSYNALMGQINPHFFFNSLNGLNALIQSGEKQQTLA
YLDELSNVFRYILQSNKKELVTLAEELQFVKAYTYLLSVRYEGKLFFSIQADTPYLLWYLPILSVLPLIENAVKHNVISK
QYPLQIDIYTTHEDKLIISNKIHPKSEDSKGSGIGLKNLWGRYRMLTGKDIQISNRKEYFKVTLPLLNKPIHS

Sequences:

>Translated_393_residues
MLQLKRNDLLIGFTISVLLSIFVNFALLMRKYEFETGNPSMGIQPPDRTMYYLLIWFFVFSFILFIVNSLMYKFGDKLFR
RKEYKRVLVVCVTCISIAYGMFHLSPVLYTAIVVEWLGEDGPQPATRDIMIRINRDRMATQTIRPAEHRDIPVPPNPFTV
PNSFMTEHLFVFLTVMLSSILIRLLGSKQQMKLEYEQLKTEKLQNSYNALMGQINPHFFFNSLNGLNALIQSGEKQQTLA
YLDELSNVFRYILQSNKKELVTLAEELQFVKAYTYLLSVRYEGKLFFSIQADTPYLLWYLPILSVLPLIENAVKHNVISK
QYPLQIDIYTTHEDKLIISNKIHPKSEDSKGSGIGLKNLWGRYRMLTGKDIQISNRKEYFKVTLPLLNKPIHS
>Mature_393_residues
MLQLKRNDLLIGFTISVLLSIFVNFALLMRKYEFETGNPSMGIQPPDRTMYYLLIWFFVFSFILFIVNSLMYKFGDKLFR
RKEYKRVLVVCVTCISIAYGMFHLSPVLYTAIVVEWLGEDGPQPATRDIMIRINRDRMATQTIRPAEHRDIPVPPNPFTV
PNSFMTEHLFVFLTVMLSSILIRLLGSKQQMKLEYEQLKTEKLQNSYNALMGQINPHFFFNSLNGLNALIQSGEKQQTLA
YLDELSNVFRYILQSNKKELVTLAEELQFVKAYTYLLSVRYEGKLFFSIQADTPYLLWYLPILSVLPLIENAVKHNVISK
QYPLQIDIYTTHEDKLIISNKIHPKSEDSKGSGIGLKNLWGRYRMLTGKDIQISNRKEYFKVTLPLLNKPIHS

Specific function: Member of the two-component regulatory system lytR/lytS that regulates genes involved in autolysis and cell wall metabolism. Regulates the activity of the cell wall-associated murein hydrolase through regulation of lrgA and lrgB [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=224, Percent_Identity=29.9107142857143, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45740; Mature: 45740

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLKRNDLLIGFTISVLLSIFVNFALLMRKYEFETGNPSMGIQPPDRTMYYLLIWFFVF
CCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SFILFIVNSLMYKFGDKLFRRKEYKRVLVVCVTCISIAYGMFHLSPVLYTAIVVEWLGED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPQPATRDIMIRINRDRMATQTIRPAEHRDIPVPPNPFTVPNSFMTEHLFVFLTVMLSSI
CCCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LIRLLGSKQQMKLEYEQLKTEKLQNSYNALMGQINPHFFFNSLNGLNALIQSGEKQQTLA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHH
YLDELSNVFRYILQSNKKELVTLAEELQFVKAYTYLLSVRYEGKLFFSIQADTPYLLWYL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEECCCCHHHHHH
PILSVLPLIENAVKHNVISKQYPLQIDIYTTHEDKLIISNKIHPKSEDSKGSGIGLKNLW
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHH
GRYRMLTGKDIQISNRKEYFKVTLPLLNKPIHS
HHHEEECCCCEEECCCCCEEEEEHHHHCCCCCC
>Mature Secondary Structure
MLQLKRNDLLIGFTISVLLSIFVNFALLMRKYEFETGNPSMGIQPPDRTMYYLLIWFFVF
CCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SFILFIVNSLMYKFGDKLFRRKEYKRVLVVCVTCISIAYGMFHLSPVLYTAIVVEWLGED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPQPATRDIMIRINRDRMATQTIRPAEHRDIPVPPNPFTVPNSFMTEHLFVFLTVMLSSI
CCCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LIRLLGSKQQMKLEYEQLKTEKLQNSYNALMGQINPHFFFNSLNGLNALIQSGEKQQTLA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHH
YLDELSNVFRYILQSNKKELVTLAEELQFVKAYTYLLSVRYEGKLFFSIQADTPYLLWYL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEECCCCHHHHHH
PILSVLPLIENAVKHNVISKQYPLQIDIYTTHEDKLIISNKIHPKSEDSKGSGIGLKNLW
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHH
GRYRMLTGKDIQISNRKEYFKVTLPLLNKPIHS
HHHEEECCCCEEECCCCCEEEEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA