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The map label for this gene is vipA [H]

Identifier: 150008829

GI number: 150008829

Start: 2608678

End: 2609943

Strand: Reverse

Name: vipA [H]

Synonym: BDI_2219

Alternate gene names: 150008829

Gene position: 2609943-2608678 (Counterclockwise)

Preceding gene: 150008830

Following gene: 150008828

Centisome position: 54.25

GC content: 43.21

Gene sequence:

>1266_bases
ATGGACAACATAAAAATCGCCGTAATAGGCTTGGGTTACGTAGGACTTCCTCTTGCCCGACTGTTTTCAACTAAGTTTGC
CACTGTTGGCTTCGATATGAACCAGGCACGTGTAGATGCTTTGATGACCGGTCATGATGCAACTCTCGAAGTTGATGATT
GTTTGCTTCAGGATGCTATTGCAAATGGCTTCAAGTGTACAACTGATTTGGAAGAAATTCGCGATTGTAATTTCTACGTG
GTAGCAGTTCCCACTCCGGTTGACGATAACAATCGTCCCGATTTAAAGCCGCTTTGGGGTGCCAGTGAAACTGTAGGAAA
GGTCATTTCGAAAGGCGACATTGTAGTTTACGAATCAACAGTTTATCCCGGTGTAACCGAAGAAGAGTGTCTTCCCGTTG
TAGAGCGCATATCGGGTCTGAAATTTAATGAAGATTTTTTTGCCGGTTATTCGCCCGAACGTATCAATCCGGGAGACAAG
GAGCACACGGTGGAGAAAATCAAAAAAGTGACTTCCGGTTCTACTCCGGAAATAGCTGATATTGTAGATAGTGTGTACAA
TGCTGTATTGGTAAATGGAACGCATAAAGCCCCTTCAATCAAAGTGGCCGAAGCTTCGAAAATTATCGAAAATTCACAGC
GCGATGTGAACATTGCCTTTATGAACGAGCTTGCCAAGATTTTCAATGCTATGGGTATTGATACGCATGATGTGATTGAA
GCAGCAGCAAGCAAGTGGAACTTTATTAAGCTCAACCCTGGACTCGTAGGTGGTCATTGTATCAGTGTTGACCCTTATTA
TCTCATTCAAAAAGCACAGGTATATGGTGTACTTCCACGCATTATGTTTTCTGCTCGCCGCTTGAATGATGGTATGGGTG
CATACGTGGCTAACCAAACCATCAAGTGCATGAACAAAAAGGGTGTGATGGTGAAAAATGCCAAGATATTGCTGATGGGT
GTTACCTTCAAAGAAAACTGCCCCGATGTGCGCAACACCAAAATTGTAGATATTTATACTACTTTGCAGGAGTATACCAA
CAATGTTACGGTGTACGATCCTTGGGCCAATGCCGATGTGGTAAAACATGAATATGGCATAGATATAACCACCGAACTTC
CCATCGAAAAATTCGATGCTGTTATTCTGGGTGTAGCCCACAAGCAGTTCCTTGAACTAGACGTGAAATCGCTTGTCAAA
GAAGGTGGTGTAATCTACGATGTTAAAGGCTTATTGCCCCGTGATATTGTGGACGGACGATTGTAA

Upstream 100 bases:

>100_bases
TCTTTTATGGGTGGTTGAAAATAAAAATGATGGTTCTTGCATCAATTTGTATAGGTATGAGCTAAGAATTAGAGATAATA
ATTAAACCAATTTATTAAAG

Downstream 100 bases:

>100_bases
TAGATAAAGGCTTGCCGTCATACAAGTGATAAAATTGCATTTTATGTGACTCAATCCACTGACAGCAACTAAAACGTCAA
TACATGGCAAATGTTTCTGA

Product: putative UDP-glucose-6 dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDNIKIAVIGLGYVGLPLARLFSTKFATVGFDMNQARVDALMTGHDATLEVDDCLLQDAIANGFKCTTDLEEIRDCNFYV
VAVPTPVDDNNRPDLKPLWGASETVGKVISKGDIVVYESTVYPGVTEEECLPVVERISGLKFNEDFFAGYSPERINPGDK
EHTVEKIKKVTSGSTPEIADIVDSVYNAVLVNGTHKAPSIKVAEASKIIENSQRDVNIAFMNELAKIFNAMGIDTHDVIE
AAASKWNFIKLNPGLVGGHCISVDPYYLIQKAQVYGVLPRIMFSARRLNDGMGAYVANQTIKCMNKKGVMVKNAKILLMG
VTFKENCPDVRNTKIVDIYTTLQEYTNNVTVYDPWANADVVKHEYGIDITTELPIEKFDAVILGVAHKQFLELDVKSLVK
EGGVIYDVKGLLPRDIVDGRL

Sequences:

>Translated_421_residues
MDNIKIAVIGLGYVGLPLARLFSTKFATVGFDMNQARVDALMTGHDATLEVDDCLLQDAIANGFKCTTDLEEIRDCNFYV
VAVPTPVDDNNRPDLKPLWGASETVGKVISKGDIVVYESTVYPGVTEEECLPVVERISGLKFNEDFFAGYSPERINPGDK
EHTVEKIKKVTSGSTPEIADIVDSVYNAVLVNGTHKAPSIKVAEASKIIENSQRDVNIAFMNELAKIFNAMGIDTHDVIE
AAASKWNFIKLNPGLVGGHCISVDPYYLIQKAQVYGVLPRIMFSARRLNDGMGAYVANQTIKCMNKKGVMVKNAKILLMG
VTFKENCPDVRNTKIVDIYTTLQEYTNNVTVYDPWANADVVKHEYGIDITTELPIEKFDAVILGVAHKQFLELDVKSLVK
EGGVIYDVKGLLPRDIVDGRL
>Mature_421_residues
MDNIKIAVIGLGYVGLPLARLFSTKFATVGFDMNQARVDALMTGHDATLEVDDCLLQDAIANGFKCTTDLEEIRDCNFYV
VAVPTPVDDNNRPDLKPLWGASETVGKVISKGDIVVYESTVYPGVTEEECLPVVERISGLKFNEDFFAGYSPERINPGDK
EHTVEKIKKVTSGSTPEIADIVDSVYNAVLVNGTHKAPSIKVAEASKIIENSQRDVNIAFMNELAKIFNAMGIDTHDVIE
AAASKWNFIKLNPGLVGGHCISVDPYYLIQKAQVYGVLPRIMFSARRLNDGMGAYVANQTIKCMNKKGVMVKNAKILLMG
VTFKENCPDVRNTKIVDIYTTLQEYTNNVTVYDPWANADVVKHEYGIDITTELPIEKFDAVILGVAHKQFLELDVKSLVK
EGGVIYDVKGLLPRDIVDGRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=408, Percent_Identity=30.1470588235294, Blast_Score=161, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46403; Mature: 46403

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNIKIAVIGLGYVGLPLARLFSTKFATVGFDMNQARVDALMTGHDATLEVDDCLLQDAI
CCCEEEEEEECCHHHHHHHHHHHHHHEEECCCCCHHHHHHEECCCCCEEEHHHHHHHHHH
ANGFKCTTDLEEIRDCNFYVVAVPTPVDDNNRPDLKPLWGASETVGKVISKGDIVVYEST
CCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECC
VYPGVTEEECLPVVERISGLKFNEDFFAGYSPERINPGDKEHTVEKIKKVTSGSTPEIAD
CCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
IVDSVYNAVLVNGTHKAPSIKVAEASKIIENSQRDVNIAFMNELAKIFNAMGIDTHDVIE
HHHHHHHEEEEECCCCCCCEEHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCHHHHHH
AAASKWNFIKLNPGLVGGHCISVDPYYLIQKAQVYGVLPRIMFSARRLNDGMGAYVANQT
HHHCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCH
IKCMNKKGVMVKNAKILLMGVTFKENCPDVRNTKIVDIYTTLQEYTNNVTVYDPWANADV
HHHHCCCCEEEECCEEEEEEEEECCCCCCCCCCEEEEHHHHHHHHHCCEEEECCCCCCCE
VKHEYGIDITTELPIEKFDAVILGVAHKQFLELDVKSLVKEGGVIYDVKGLLPRDIVDGR
EEEECCCEEEECCCHHHHHHHEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
L
C
>Mature Secondary Structure
MDNIKIAVIGLGYVGLPLARLFSTKFATVGFDMNQARVDALMTGHDATLEVDDCLLQDAI
CCCEEEEEEECCHHHHHHHHHHHHHHEEECCCCCHHHHHHEECCCCCEEEHHHHHHHHHH
ANGFKCTTDLEEIRDCNFYVVAVPTPVDDNNRPDLKPLWGASETVGKVISKGDIVVYEST
CCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEECC
VYPGVTEEECLPVVERISGLKFNEDFFAGYSPERINPGDKEHTVEKIKKVTSGSTPEIAD
CCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
IVDSVYNAVLVNGTHKAPSIKVAEASKIIENSQRDVNIAFMNELAKIFNAMGIDTHDVIE
HHHHHHHEEEEECCCCCCCEEHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCHHHHHH
AAASKWNFIKLNPGLVGGHCISVDPYYLIQKAQVYGVLPRIMFSARRLNDGMGAYVANQT
HHHCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCH
IKCMNKKGVMVKNAKILLMGVTFKENCPDVRNTKIVDIYTTLQEYTNNVTVYDPWANADV
HHHHCCCCEEEECCEEEEEEEEECCCCCCCCCCEEEEHHHHHHHHHCCEEEECCCCCCCE
VKHEYGIDITTELPIEKFDAVILGVAHKQFLELDVKSLVKEGGVIYDVKGLLPRDIVDGR
EEEECCCEEEECCCHHHHHHHEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]