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The map label for this gene is gmd [H]

Identifier: 150008813

GI number: 150008813

Start: 2592523

End: 2593611

Strand: Reverse

Name: gmd [H]

Synonym: BDI_2203

Alternate gene names: 150008813

Gene position: 2593611-2592523 (Counterclockwise)

Preceding gene: 150008814

Following gene: 150008812

Centisome position: 53.91

GC content: 48.21

Gene sequence:

>1089_bases
ATGAAGACAGCTTTAATTACCGGTATCACCGGACAGGACGGCTCATATCTTGCTGAATTGCTTTTAGAAAAAGGATATGA
CGTGCATGGTACTATACGTCGTTCATCGGTAGACTTCCGTGAGCGTATCGCACATTTGGAAGGGCATCCTAACTTCCATC
TCCACTATGCCGACCTGGGCGACTCGATGAGCATCTTACAGGTGGTGAAAAAAGTAAAGCCAAACGAAATATACAACCTC
GCCGCACAGAGTCATGTACAGGTGTCGTTTGACTCTCCGGAGTTTACCGCTGATGTCGATGCCACTGGCGTACTACGCAT
TTTGGAAGCTGTACGACAGTGCGATCTGACTGAAACCTGCCGTATCTATCAGGCTTCCACGTCAGAACTATACGGCAAGG
TGGAAGAAGTACCCCAGAATGAGAATACTCCTTTTCATCCCTACTCTCCCTATGCCGTAGCAAAACAGTATGGGTTCTGG
ATTACCAAAGAATACCGCGAAGCGTACAACATGTTCTGCTGTTCAGGTATTCTGTTCAACCACGAGTCGGAACGCCGCGG
AGAAACGTTCGTTACCCGTAAGATAACCCTCGCCGCTGCACGTATTGCCCAAGGCAAACAGGATAAATTATATTTAGGTA
ATTTGTCATCGCTCCGTGACTGGGGCTATGCCAAGGATTACGTGGAATGCATGTGGCTGATCCTCCAAAACGACAAGCCG
GAAGATTTTGTCATTGCCACCGGCGAGCAGCATTCGGTACGTGAGTTCTGCCAATTGGCTTTCCGTTATGCCGGAATCGA
ACTGTGTTTTGAGGGTGAAGGTGAAAACGAAAAAGGCATCGACTGCAAGAGCGGTAAAGTACTTGTCGAGGTTTCTCCCG
ACTTCTACCGCCCAACCGATGTGGTAAATCTTTTGGGAGACCCGTCGAAAGCGAAACGTGAACTGGGTTGGAATCCGCAG
AAGACATCGTTTGAGCAACTTGTAAAAATCATGGTGGATGCCGATCTGGCAAAAGTGGCCGTGGAGCGTGCATCGCAACA
GGTAAGAACCAACCTTGCCGAATATCTCGAAAAAGGAATCGTAAAATAA

Upstream 100 bases:

>100_bases
AGTAATGTTTTGCTGGAATCGTTGAGATACATTTACAAAATATATGAGATCTTCGAAACTAAAGTTTCACGAAATAATAC
ATCGCAAATTTGATATTTAT

Downstream 100 bases:

>100_bases
TCGAGAAAACAATGGAGAAGAACGCAAAAATCTATGTAGCAGGACACCGTGGAATGGTAGGCTCTGCCATTGTACGGGAA
CTGCAACGCCAGGGATATAC

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKTALITGITGQDGSYLAELLLEKGYDVHGTIRRSSVDFRERIAHLEGHPNFHLHYADLGDSMSILQVVKKVKPNEIYNL
AAQSHVQVSFDSPEFTADVDATGVLRILEAVRQCDLTETCRIYQASTSELYGKVEEVPQNENTPFHPYSPYAVAKQYGFW
ITKEYREAYNMFCCSGILFNHESERRGETFVTRKITLAAARIAQGKQDKLYLGNLSSLRDWGYAKDYVECMWLILQNDKP
EDFVIATGEQHSVREFCQLAFRYAGIELCFEGEGENEKGIDCKSGKVLVEVSPDFYRPTDVVNLLGDPSKAKRELGWNPQ
KTSFEQLVKIMVDADLAKVAVERASQQVRTNLAEYLEKGIVK

Sequences:

>Translated_362_residues
MKTALITGITGQDGSYLAELLLEKGYDVHGTIRRSSVDFRERIAHLEGHPNFHLHYADLGDSMSILQVVKKVKPNEIYNL
AAQSHVQVSFDSPEFTADVDATGVLRILEAVRQCDLTETCRIYQASTSELYGKVEEVPQNENTPFHPYSPYAVAKQYGFW
ITKEYREAYNMFCCSGILFNHESERRGETFVTRKITLAAARIAQGKQDKLYLGNLSSLRDWGYAKDYVECMWLILQNDKP
EDFVIATGEQHSVREFCQLAFRYAGIELCFEGEGENEKGIDCKSGKVLVEVSPDFYRPTDVVNLLGDPSKAKRELGWNPQ
KTSFEQLVKIMVDADLAKVAVERASQQVRTNLAEYLEKGIVK
>Mature_362_residues
MKTALITGITGQDGSYLAELLLEKGYDVHGTIRRSSVDFRERIAHLEGHPNFHLHYADLGDSMSILQVVKKVKPNEIYNL
AAQSHVQVSFDSPEFTADVDATGVLRILEAVRQCDLTETCRIYQASTSELYGKVEEVPQNENTPFHPYSPYAVAKQYGFW
ITKEYREAYNMFCCSGILFNHESERRGETFVTRKITLAAARIAQGKQDKLYLGNLSSLRDWGYAKDYVECMWLILQNDKP
EDFVIATGEQHSVREFCQLAFRYAGIELCFEGEGENEKGIDCKSGKVLVEVSPDFYRPTDVVNLLGDPSKAKRELGWNPQ
KTSFEQLVKIMVDADLAKVAVERASQQVRTNLAEYLEKGIVK

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=339, Percent_Identity=58.1120943952802, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI42516563, Length=328, Percent_Identity=25.609756097561, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788366, Length=350, Percent_Identity=58, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI48994969, Length=350, Percent_Identity=25.4285714285714, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788353, Length=346, Percent_Identity=23.6994219653179, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=343, Percent_Identity=62.3906705539359, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17539424, Length=342, Percent_Identity=61.4035087719298, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI133901788, Length=342, Percent_Identity=61.4035087719298, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI133901786, Length=342, Percent_Identity=61.4035087719298, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17539422, Length=342, Percent_Identity=61.4035087719298, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI133901790, Length=342, Percent_Identity=61.4035087719298, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24158427, Length=341, Percent_Identity=58.6510263929619, Blast_Score=418, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 41007; Mature: 41007

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTALITGITGQDGSYLAELLLEKGYDVHGTIRRSSVDFRERIAHLEGHPNFHLHYADLG
CCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCC
DSMSILQVVKKVKPNEIYNLAAQSHVQVSFDSPEFTADVDATGVLRILEAVRQCDLTETC
CCHHHHHHHHHCCCCHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHH
RIYQASTSELYGKVEEVPQNENTPFHPYSPYAVAKQYGFWITKEYREAYNMFCCSGILFN
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCEEEHHHHHHHHHHHHHHHEEC
HESERRGETFVTRKITLAAARIAQGKQDKLYLGNLSSLRDWGYAKDYVECMWLILQNDKP
CCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHCCCHHHHHHHHHHHHCCCCC
EDFVIATGEQHSVREFCQLAFRYAGIELCFEGEGENEKGIDCKSGKVLVEVSPDFYRPTD
CCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHH
VVNLLGDPSKAKRELGWNPQKTSFEQLVKIMVDADLAKVAVERASQQVRTNLAEYLEKGI
HHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VK
CC
>Mature Secondary Structure
MKTALITGITGQDGSYLAELLLEKGYDVHGTIRRSSVDFRERIAHLEGHPNFHLHYADLG
CCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCC
DSMSILQVVKKVKPNEIYNLAAQSHVQVSFDSPEFTADVDATGVLRILEAVRQCDLTETC
CCHHHHHHHHHCCCCHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHH
RIYQASTSELYGKVEEVPQNENTPFHPYSPYAVAKQYGFWITKEYREAYNMFCCSGILFN
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCEEEHHHHHHHHHHHHHHHEEC
HESERRGETFVTRKITLAAARIAQGKQDKLYLGNLSSLRDWGYAKDYVECMWLILQNDKP
CCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHCCCHHHHHHHHHHHHCCCCC
EDFVIATGEQHSVREFCQLAFRYAGIELCFEGEGENEKGIDCKSGKVLVEVSPDFYRPTD
CCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHH
VVNLLGDPSKAKRELGWNPQKTSFEQLVKIMVDADLAKVAVERASQQVRTNLAEYLEKGI
HHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]