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The map label for this gene is pepD [H]

Identifier: 150008702

GI number: 150008702

Start: 2474016

End: 2475473

Strand: Direct

Name: pepD [H]

Synonym: BDI_2092

Alternate gene names: 150008702

Gene position: 2474016-2475473 (Clockwise)

Preceding gene: 150008700

Following gene: 150008703

Centisome position: 51.42

GC content: 47.46

Gene sequence:

>1458_bases
ATGAAGATTACTGATTTAAAGCCTACTATCGTATGGAAGTTCTTCCATCAAGTAACCCAAGTGCCTCGCCCCTCAAAAAA
GGAAGGCAAAATGATTGAATTCCTAGAATCATTCGCGAAAGAGTATAAAATAGCTATCAAGAAAGATGAAGCCGGCAACC
TTTTAATGTCAAAGCCTGCCACTCCGGGAATGGAGGATCGTCCGGTAGTCGTATTGCAGTCTCACATGGATATGGTTTGC
GAGAAAAATAACGGTACGAAACACGATTTCGACAATGATCCGATCGAGACGATCGTCGACGGCGAATGGCTGCGTGCCAA
CGGCACTACTTTGGGAGCCGATAATGGTATCGGTGTAGCGGCCGAGTTGGCTTTGCTTGCCTCCGATGATATCCAACACG
GTCCGATCGAATGTTTGTTCACAGTAGACGAAGAAACAGGTTTGACCGGAGCGAAAGCCTTGAAAGAAGGTTTCATGACC
GGAGATATCTTGTTAAATCTCGATAGCGAGGACGAGGGAGAGATCTTTATGGGTTGCGCCGGAGGTAAAGACACACAAGC
GACTTTCCATTATGAGCCAGTTCCTACGTCCGATAAGATGCAGTATTTCCGTATCGATGTGAAAGGGTTGAATGGCGGTC
ACTCCGGTGGCGAGATCCACAAAGGATTAGGCAATGCCAACAAGATATTGGTTCGTTTCTTATTCTTATTGAAAAAGAAA
TATGATTTCGTTCTTTGCTCTATCGATGGAGGAAACTTACGTAACGCAATCGCTCGCGAGGCACACGCCGTGATCGGCTT
GCATCCGGAAAATAAGGAGGATGTACGTATCTTGCTGAACCATTTCGCCGCCGACGTTGAAAATGAGTTGAAACATGTAG
ACCCGAGCGTTCAGTTAGCGATGGAGTCCACGGATCGTCCGGAGTATCATATCGACAATGCCACCGCCGAGAAATTAATC
TACGCCTTGCACGCTTGTCCGCACGGCGTAATCGGTATGAGCCACGATATAGAAGGCTTGGTAGAGACTTCTACCAACCT
TGCTTCCATAAAGATGAAAGAAGGCAATACGATCTTGATCGGTACCAGCCAGCGTAGCTCTATCGAATCATGCAAGATCG
CTATCGCCAATACGGTAGCCTCCACGTTCCTATTGGCTGGAGCAGATGTAAAACATGGCGATGGCTATCCGGGATGGGCC
CCGAACCCCGACTCTAAGATCTTGAAGATCGCACAGGAGACTTACAAACGCCTATTCAACAAAGACGCCAAGATCATGGC
CATCCACGCCGGATTAGAGTGCGGTTTGTTCTTGGAAAAATATCCGAAACTGGATATGATCTCTTTCGGGCCTACTTTGC
GTGACGTACATTCACCCAACGAGCGTATCGAGATCGCTACGGTCGGTTTATGGTGGAGCCACCTTCTTGAATTATTAAAG
AGCATCCCCGCAAAATAA

Upstream 100 bases:

>100_bases
AGTGTCTTTTTGGCATTTTATTCTACTTTTTTTCGAACTAAGCTCTTTCAGTTGCGGTTTTATTAACTTTAGAGTAACAT
CTATAATACATTGTAACATT

Downstream 100 bases:

>100_bases
ACCAACGTTTTTTGCGTTATAAGAAGAGGAAAGACACGATAACCGTGTCTATCCTCTTTTTTTATGTTAATGTCTTGCAA
CTTTTTTATGATAATTTTGT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKITDLKPTIVWKFFHQVTQVPRPSKKEGKMIEFLESFAKEYKIAIKKDEAGNLLMSKPATPGMEDRPVVVLQSHMDMVC
EKNNGTKHDFDNDPIETIVDGEWLRANGTTLGADNGIGVAAELALLASDDIQHGPIECLFTVDEETGLTGAKALKEGFMT
GDILLNLDSEDEGEIFMGCAGGKDTQATFHYEPVPTSDKMQYFRIDVKGLNGGHSGGEIHKGLGNANKILVRFLFLLKKK
YDFVLCSIDGGNLRNAIAREAHAVIGLHPENKEDVRILLNHFAADVENELKHVDPSVQLAMESTDRPEYHIDNATAEKLI
YALHACPHGVIGMSHDIEGLVETSTNLASIKMKEGNTILIGTSQRSSIESCKIAIANTVASTFLLAGADVKHGDGYPGWA
PNPDSKILKIAQETYKRLFNKDAKIMAIHAGLECGLFLEKYPKLDMISFGPTLRDVHSPNERIEIATVGLWWSHLLELLK
SIPAK

Sequences:

>Translated_485_residues
MKITDLKPTIVWKFFHQVTQVPRPSKKEGKMIEFLESFAKEYKIAIKKDEAGNLLMSKPATPGMEDRPVVVLQSHMDMVC
EKNNGTKHDFDNDPIETIVDGEWLRANGTTLGADNGIGVAAELALLASDDIQHGPIECLFTVDEETGLTGAKALKEGFMT
GDILLNLDSEDEGEIFMGCAGGKDTQATFHYEPVPTSDKMQYFRIDVKGLNGGHSGGEIHKGLGNANKILVRFLFLLKKK
YDFVLCSIDGGNLRNAIAREAHAVIGLHPENKEDVRILLNHFAADVENELKHVDPSVQLAMESTDRPEYHIDNATAEKLI
YALHACPHGVIGMSHDIEGLVETSTNLASIKMKEGNTILIGTSQRSSIESCKIAIANTVASTFLLAGADVKHGDGYPGWA
PNPDSKILKIAQETYKRLFNKDAKIMAIHAGLECGLFLEKYPKLDMISFGPTLRDVHSPNERIEIATVGLWWSHLLELLK
SIPAK
>Mature_485_residues
MKITDLKPTIVWKFFHQVTQVPRPSKKEGKMIEFLESFAKEYKIAIKKDEAGNLLMSKPATPGMEDRPVVVLQSHMDMVC
EKNNGTKHDFDNDPIETIVDGEWLRANGTTLGADNGIGVAAELALLASDDIQHGPIECLFTVDEETGLTGAKALKEGFMT
GDILLNLDSEDEGEIFMGCAGGKDTQATFHYEPVPTSDKMQYFRIDVKGLNGGHSGGEIHKGLGNANKILVRFLFLLKKK
YDFVLCSIDGGNLRNAIAREAHAVIGLHPENKEDVRILLNHFAADVENELKHVDPSVQLAMESTDRPEYHIDNATAEKLI
YALHACPHGVIGMSHDIEGLVETSTNLASIKMKEGNTILIGTSQRSSIESCKIAIANTVASTFLLAGADVKHGDGYPGWA
PNPDSKILKIAQETYKRLFNKDAKIMAIHAGLECGLFLEKYPKLDMISFGPTLRDVHSPNERIEIATVGLWWSHLLELLK
SIPAK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=484, Percent_Identity=44.8347107438017, Blast_Score=435, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53351; Mature: 53351

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITDLKPTIVWKFFHQVTQVPRPSKKEGKMIEFLESFAKEYKIAIKKDEAGNLLMSKPA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEECCC
TPGMEDRPVVVLQSHMDMVCEKNNGTKHDFDNDPIETIVDGEWLRANGTTLGADNGIGVA
CCCCCCCCEEEEECCCHHEEECCCCCCCCCCCCCHHHHCCCCEEEECCCEECCCCCCCHH
AELALLASDDIQHGPIECLFTVDEETGLTGAKALKEGFMTGDILLNLDSEDEGEIFMGCA
HHEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEC
GGKDTQATFHYEPVPTSDKMQYFRIDVKGLNGGHSGGEIHKGLGNANKILVRFLFLLKKK
CCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHCC
YDFVLCSIDGGNLRNAIAREAHAVIGLHPENKEDVRILLNHFAADVENELKHVDPSVQLA
CCEEEEEECCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
MESTDRPEYHIDNATAEKLIYALHACPHGVIGMSHDIEGLVETSTNLASIKMKEGNTILI
ECCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCEEEE
GTSQRSSIESCKIAIANTVASTFLLAGADVKHGDGYPGWAPNPDSKILKIAQETYKRLFN
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
KDAKIMAIHAGLECGLFLEKYPKLDMISFGPTLRDVHSPNERIEIATVGLWWSHLLELLK
CCCEEEEEECCCCCCHHHHHCCCCCEEECCCCHHHCCCCCCEEEEEEEHHHHHHHHHHHH
SIPAK
HCCCC
>Mature Secondary Structure
MKITDLKPTIVWKFFHQVTQVPRPSKKEGKMIEFLESFAKEYKIAIKKDEAGNLLMSKPA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEECCC
TPGMEDRPVVVLQSHMDMVCEKNNGTKHDFDNDPIETIVDGEWLRANGTTLGADNGIGVA
CCCCCCCCEEEEECCCHHEEECCCCCCCCCCCCCHHHHCCCCEEEECCCEECCCCCCCHH
AELALLASDDIQHGPIECLFTVDEETGLTGAKALKEGFMTGDILLNLDSEDEGEIFMGCA
HHEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEC
GGKDTQATFHYEPVPTSDKMQYFRIDVKGLNGGHSGGEIHKGLGNANKILVRFLFLLKKK
CCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHCC
YDFVLCSIDGGNLRNAIAREAHAVIGLHPENKEDVRILLNHFAADVENELKHVDPSVQLA
CCEEEEEECCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
MESTDRPEYHIDNATAEKLIYALHACPHGVIGMSHDIEGLVETSTNLASIKMKEGNTILI
ECCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCEEEE
GTSQRSSIESCKIAIANTVASTFLLAGADVKHGDGYPGWAPNPDSKILKIAQETYKRLFN
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
KDAKIMAIHAGLECGLFLEKYPKLDMISFGPTLRDVHSPNERIEIATVGLWWSHLLELLK
CCCEEEEEECCCCCCHHHHHCCCCCEEECCCCHHHCCCCCCEEEEEEEHHHHHHHHHHHH
SIPAK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]