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The map label for this gene is hisI [H]

Identifier: 150008631

GI number: 150008631

Start: 2384878

End: 2385474

Strand: Direct

Name: hisI [H]

Synonym: BDI_2019

Alternate gene names: 150008631

Gene position: 2384878-2385474 (Clockwise)

Preceding gene: 150008630

Following gene: 150008632

Centisome position: 49.57

GC content: 46.23

Gene sequence:

>597_bases
ATGAAATTAGATTTCGAGAAAATGGGCGGATTAATACCCGCTATCGTACAAGACAACAACACGAGTAAGGTATTAATGTT
GGGCTTCATGAATCAAGAAGCTTATGATGAGACAGTAAGTACGGGTAAGGTTACATTCTTTAGCCGCACGAAAAACCGTT
TGTGGATGAAGGGAGAGAGTAGCGGAAATACGTTGCAGGTAGTTAGCATCACGGCGGATTGCGACAACGATACATTATTG
ATCAAGGCGATTCCAGCCGGACCGGTTTGTCATACGGGAGCGGATACTTGTTTCGGCGAGAAGAACGTAGAGGATATCAT
GTTCTTGAAATACTTGCAGAACTTCATCGAGCGTCGCCGTCAAGAAATGCCGGAAGGTTCCTATACGACTACCTTATTCC
AGAAAGGCGTGAATCGCATGGCCCAGAAAGTCGGCGAAGAAGCGGTAGAGACCGTTATCGAGGCGACCAACGGAACCGAG
GACGGCTTCATCTATGAGGCATCCGACTTGGTTTACCACTTAATCGTATTATTGACAAGCAAGGGACTTCGTCTGGAAGA
CCTCGCCCGTGAATTAAAGAAAAGACATAAAGGTTGA

Upstream 100 bases:

>100_bases
GCCAGCGTTTTCCATTTCGGCGAGATACGGATTAGCGACTTGAAGCAATACCTCAAGGACGAGGGGATCAATGTAAGGAT
ATAACACATTATATATAAAG

Downstream 100 bases:

>100_bases
TAAATTCTATGGAAGAAGATATTCTACTCAAATTAGAGAACGTGGAGATATGCCGTGAGGAAAACAGGGTATTACACGAC
GCATGCCTCACGCTTCGTAA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MKLDFEKMGGLIPAIVQDNNTSKVLMLGFMNQEAYDETVSTGKVTFFSRTKNRLWMKGESSGNTLQVVSITADCDNDTLL
IKAIPAGPVCHTGADTCFGEKNVEDIMFLKYLQNFIERRRQEMPEGSYTTTLFQKGVNRMAQKVGEEAVETVIEATNGTE
DGFIYEASDLVYHLIVLLTSKGLRLEDLARELKKRHKG

Sequences:

>Translated_198_residues
MKLDFEKMGGLIPAIVQDNNTSKVLMLGFMNQEAYDETVSTGKVTFFSRTKNRLWMKGESSGNTLQVVSITADCDNDTLL
IKAIPAGPVCHTGADTCFGEKNVEDIMFLKYLQNFIERRRQEMPEGSYTTTLFQKGVNRMAQKVGEEAVETVIEATNGTE
DGFIYEASDLVYHLIVLLTSKGLRLEDLARELKKRHKG
>Mature_198_residues
MKLDFEKMGGLIPAIVQDNNTSKVLMLGFMNQEAYDETVSTGKVTFFSRTKNRLWMKGESSGNTLQVVSITADCDNDTLL
IKAIPAGPVCHTGADTCFGEKNVEDIMFLKYLQNFIERRRQEMPEGSYTTTLFQKGVNRMAQKVGEEAVETVIEATNGTE
DGFIYEASDLVYHLIVLLTSKGLRLEDLARELKKRHKG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=196, Percent_Identity=53.5714285714286, Blast_Score=213, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6319819, Length=193, Percent_Identity=30.5699481865285, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22198; Mature: 22198

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDFEKMGGLIPAIVQDNNTSKVLMLGFMNQEAYDETVSTGKVTFFSRTKNRLWMKGES
CCCCHHHHCCEEEEEEECCCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCEEEEEECC
SGNTLQVVSITADCDNDTLLIKAIPAGPVCHTGADTCFGEKNVEDIMFLKYLQNFIERRR
CCCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
QEMPEGSYTTTLFQKGVNRMAQKVGEEAVETVIEATNGTEDGFIYEASDLVYHLIVLLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHC
KGLRLEDLARELKKRHKG
CCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLDFEKMGGLIPAIVQDNNTSKVLMLGFMNQEAYDETVSTGKVTFFSRTKNRLWMKGES
CCCCHHHHCCEEEEEEECCCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCEEEEEECC
SGNTLQVVSITADCDNDTLLIKAIPAGPVCHTGADTCFGEKNVEDIMFLKYLQNFIERRR
CCCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
QEMPEGSYTTTLFQKGVNRMAQKVGEEAVETVIEATNGTEDGFIYEASDLVYHLIVLLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHC
KGLRLEDLARELKKRHKG
CCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]