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The map label for this gene is hssS [H]

Identifier: 150008545

GI number: 150008545

Start: 2289653

End: 2290924

Strand: Direct

Name: hssS [H]

Synonym: BDI_1931

Alternate gene names: 150008545

Gene position: 2289653-2290924 (Clockwise)

Preceding gene: 150008544

Following gene: 150008546

Centisome position: 47.59

GC content: 40.64

Gene sequence:

>1272_bases
ATGAAGCTAATCCATTACACCCTCCGCAATTTATTTGTCCCCATATTGGTCATTTTCGCCGCTTGGGGATGTGTTTTCTG
CCTTATGATTCTACATGAGGTAGAAGACGAGACAAATGACAGCCTTGAGAACTACAAAGAGATTATCATCCGCTCCGCCT
TAGCGGACAGCACATTGCTGAAAGATCATGTGGATATCATGACCCGGTACTACATTCGTGAGGTTCCGGAAAGCGAAGCG
AAACTAGATAAGGACGAGTTCTACGATACTACGGTATACATAGAGATAGAGCAAGAATACGAACCGGTTCGTGCCTTACG
CACTTATTTCATGACAAAAGATCGTAAATTCTACGAACTGACGCTGGAGTTATCCACCTTAGAACAAGAAGATATGATCG
AGACGATTATCTGGAGCATGGCCGTCTTATATATCGCATTGATAAGTTGTATCTTATTCGTGATCCATCGAGGATTCAAA
AGAAGCTTTAAGCCTTTATATAAGCTATTAAGCTGGCTGAAAAGTTTTCAAGTAGGCAAATATAATCCTCCATTAAACAA
CCCTACACCCATCGAGGAATTTAAGATATTAAACGAGACCGTTCAAGAAAGCGTCAACCAGAGCGACAAGCTATACAACA
AACAAAGACATTTCGTAGAGAATGCCGCCCACGAGTTACAAACTCCATTGGCCGTATGCATGAACAAATTAGAATTATTA
AGCGAACATCCAGATTGCACAGAAGATCAACTGAAAGAGATCGCTGGCTTGCATCAAGCGTTGAACGGCATCATCCGGTT
GAATAAATCCCTCCTATTACTTTCTCGGATAGATAACAAACAATTCCCCGAGACCCGGGATATTTGCCTAAATCATCTTA
TCCATAAGATATTAGAAGGAATTAATGACATATACGAAAGAAAAGCTCTCCACTTACGAGTTTCAGAAAAAGAGAGTTTG
GTATGCACCATGAATGAATCGCTGGCCACTACGTTAATCACCAATCTCATTAAAAACGCCTATGTCCATAATTACGAGAA
AGGGGATATAGGAATCACGATCTCTCGTCGTATGCTTACAATCGCAAATACGGGAATCGACAAAACCCTTGATAAGGAAT
TATTATTTGCCCGTTTTGCCAGCCAAAGCAAACAACAAGAATCGACGGGCCTTGGGTTGGCCATTGTCAAATCAATAGTC
GATCTATATTCGATCCGGATAGATTACCAATACGCAAATGGCATGCATACATTCACATTATTATTCTATTAA

Upstream 100 bases:

>100_bases
AAGTAAAAAACTTGCGAAAGAAATTAAAAGCCGCCGGAGCCATCCCCGAAATAAAGGCGGTCTATGGCTTCGGTTACAAA
ATGACCGACGAGGAATAAAT

Downstream 100 bases:

>100_bases
CGGCCGAAATTCCCAATTTTTTCCAAAATGCATCCTTTTCTTTGCGGTATAATAAAAAACAAGGCATATGAAAAGGATCA
ATTATTTACTGATAGTCTTA

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKLIHYTLRNLFVPILVIFAAWGCVFCLMILHEVEDETNDSLENYKEIIIRSALADSTLLKDHVDIMTRYYIREVPESEA
KLDKDEFYDTTVYIEIEQEYEPVRALRTYFMTKDRKFYELTLELSTLEQEDMIETIIWSMAVLYIALISCILFVIHRGFK
RSFKPLYKLLSWLKSFQVGKYNPPLNNPTPIEEFKILNETVQESVNQSDKLYNKQRHFVENAAHELQTPLAVCMNKLELL
SEHPDCTEDQLKEIAGLHQALNGIIRLNKSLLLLSRIDNKQFPETRDICLNHLIHKILEGINDIYERKALHLRVSEKESL
VCTMNESLATTLITNLIKNAYVHNYEKGDIGITISRRMLTIANTGIDKTLDKELLFARFASQSKQQESTGLGLAIVKSIV
DLYSIRIDYQYANGMHTFTLLFY

Sequences:

>Translated_423_residues
MKLIHYTLRNLFVPILVIFAAWGCVFCLMILHEVEDETNDSLENYKEIIIRSALADSTLLKDHVDIMTRYYIREVPESEA
KLDKDEFYDTTVYIEIEQEYEPVRALRTYFMTKDRKFYELTLELSTLEQEDMIETIIWSMAVLYIALISCILFVIHRGFK
RSFKPLYKLLSWLKSFQVGKYNPPLNNPTPIEEFKILNETVQESVNQSDKLYNKQRHFVENAAHELQTPLAVCMNKLELL
SEHPDCTEDQLKEIAGLHQALNGIIRLNKSLLLLSRIDNKQFPETRDICLNHLIHKILEGINDIYERKALHLRVSEKESL
VCTMNESLATTLITNLIKNAYVHNYEKGDIGITISRRMLTIANTGIDKTLDKELLFARFASQSKQQESTGLGLAIVKSIV
DLYSIRIDYQYANGMHTFTLLFY
>Mature_423_residues
MKLIHYTLRNLFVPILVIFAAWGCVFCLMILHEVEDETNDSLENYKEIIIRSALADSTLLKDHVDIMTRYYIREVPESEA
KLDKDEFYDTTVYIEIEQEYEPVRALRTYFMTKDRKFYELTLELSTLEQEDMIETIIWSMAVLYIALISCILFVIHRGFK
RSFKPLYKLLSWLKSFQVGKYNPPLNNPTPIEEFKILNETVQESVNQSDKLYNKQRHFVENAAHELQTPLAVCMNKLELL
SEHPDCTEDQLKEIAGLHQALNGIIRLNKSLLLLSRIDNKQFPETRDICLNHLIHKILEGINDIYERKALHLRVSEKESL
VCTMNESLATTLITNLIKNAYVHNYEKGDIGITISRRMLTIANTGIDKTLDKELLFARFASQSKQQESTGLGLAIVKSIV
DLYSIRIDYQYANGMHTFTLLFY

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=303, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789403, Length=310, Percent_Identity=22.9032258064516, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49239; Mature: 49239

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIHYTLRNLFVPILVIFAAWGCVFCLMILHEVEDETNDSLENYKEIIIRSALADSTLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KDHVDIMTRYYIREVPESEAKLDKDEFYDTTVYIEIEQEYEPVRALRTYFMTKDRKFYEL
HHHHHHHHHHHHHHCCCHHHCCCHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEE
TLELSTLEQEDMIETIIWSMAVLYIALISCILFVIHRGFKRSFKPLYKLLSWLKSFQVGK
EEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YNPPLNNPTPIEEFKILNETVQESVNQSDKLYNKQRHFVENAAHELQTPLAVCMNKLELL
CCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
SEHPDCTEDQLKEIAGLHQALNGIIRLNKSLLLLSRIDNKQFPETRDICLNHLIHKILEG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
INDIYERKALHLRVSEKESLVCTMNESLATTLITNLIKNAYVHNYEKGDIGITISRRMLT
HHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
IANTGIDKTLDKELLFARFASQSKQQESTGLGLAIVKSIVDLYSIRIDYQYANGMHTFTL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEE
LFY
EEC
>Mature Secondary Structure
MKLIHYTLRNLFVPILVIFAAWGCVFCLMILHEVEDETNDSLENYKEIIIRSALADSTLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KDHVDIMTRYYIREVPESEAKLDKDEFYDTTVYIEIEQEYEPVRALRTYFMTKDRKFYEL
HHHHHHHHHHHHHHCCCHHHCCCHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEE
TLELSTLEQEDMIETIIWSMAVLYIALISCILFVIHRGFKRSFKPLYKLLSWLKSFQVGK
EEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YNPPLNNPTPIEEFKILNETVQESVNQSDKLYNKQRHFVENAAHELQTPLAVCMNKLELL
CCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
SEHPDCTEDQLKEIAGLHQALNGIIRLNKSLLLLSRIDNKQFPETRDICLNHLIHKILEG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
INDIYERKALHLRVSEKESLVCTMNESLATTLITNLIKNAYVHNYEKGDIGITISRRMLT
HHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
IANTGIDKTLDKELLFARFASQSKQQESTGLGLAIVKSIVDLYSIRIDYQYANGMHTFTL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEE
LFY
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA