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The map label for this gene is trxA [H]

Identifier: 150008538

GI number: 150008538

Start: 2285189

End: 2285659

Strand: Reverse

Name: trxA [H]

Synonym: BDI_1924

Alternate gene names: 150008538

Gene position: 2285659-2285189 (Counterclockwise)

Preceding gene: 150008539

Following gene: 150008537

Centisome position: 47.51

GC content: 38.43

Gene sequence:

>471_bases
ATGGGTTTTATTAAGGTCGGTGCCGTATTGTTCGCAAGTCTTTTGGTAGGAATGGCGAACGCTAGTAATGGAAATAAGAA
TAATAACAATAAAACAGAAAATAAAATGACAGTAACAGAATTAACACAAGAAGATTTCGTAAAGAAAGTGTATGACTTTG
AGACAAACCCGAACGCATGGAAGTTCGAGGGTGATAAACCTGCGGTTATCGATTTCTATGCCACTTGGTGTGGCCCTTGT
AAGATGATGTCTCCTATCTTGGATGAGATCAGCAAAGAGTACGAGGGTAAAATCAACGTATATAAGGTGAATGTCGATAA
AGAGGCGGATTTAGCGAGTGTTTTCGGTATCCGTAGTATTCCTTCTTTATTGTTTGTACCGATGAAGAAAGAACCGAGTA
TGGTTCAAGGGGCTATGCCGAAGAATGAGTTGAAGAAATTGGTAGATGATATTTTATTAGAGTCGAAATAA

Upstream 100 bases:

>100_bases
CAAACTTATCCGGCGATATGGCCATTTCTTAATCGTGGAAATAAGATGAACTTTGCAATGTAAATAGAAGACAAAGTAAT
AAATAAAAAGGAGGTTCAAG

Downstream 100 bases:

>100_bases
CTCGTATAGTGTGTTTTGGGGATTAGTGACGCGGAAGTTTGCTGGGAATAAAGTGAACTTTCGCTTTTTGTTTATATAAT
ATTGTTATCTTTATCCGTCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MGFIKVGAVLFASLLVGMANASNGNKNNNNKTENKMTVTELTQEDFVKKVYDFETNPNAWKFEGDKPAVIDFYATWCGPC
KMMSPILDEISKEYEGKINVYKVNVDKEADLASVFGIRSIPSLLFVPMKKEPSMVQGAMPKNELKKLVDDILLESK

Sequences:

>Translated_156_residues
MGFIKVGAVLFASLLVGMANASNGNKNNNNKTENKMTVTELTQEDFVKKVYDFETNPNAWKFEGDKPAVIDFYATWCGPC
KMMSPILDEISKEYEGKINVYKVNVDKEADLASVFGIRSIPSLLFVPMKKEPSMVQGAMPKNELKKLVDDILLESK
>Mature_155_residues
GFIKVGAVLFASLLVGMANASNGNKNNNNKTENKMTVTELTQEDFVKKVYDFETNPNAWKFEGDKPAVIDFYATWCGPCK
MMSPILDEISKEYEGKINVYKVNVDKEADLASVFGIRSIPSLLFVPMKKEPSMVQGAMPKNELKKLVDDILLESK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=88, Percent_Identity=44.3181818181818, Blast_Score=91, Evalue=3e-20,
Organism=Escherichia coli, GI1788936, Length=77, Percent_Identity=45.4545454545455, Blast_Score=84, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17507705, Length=76, Percent_Identity=38.1578947368421, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=109, Percent_Identity=29.3577981651376, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=84, Percent_Identity=34.5238095238095, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=84, Percent_Identity=34.5238095238095, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6321648, Length=77, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=76, Percent_Identity=43.421052631579, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639826, Length=62, Percent_Identity=46.7741935483871, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=32.9411764705882, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17530795, Length=74, Percent_Identity=39.1891891891892, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17648013, Length=61, Percent_Identity=47.5409836065574, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=61, Percent_Identity=47.5409836065574, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664269, Length=72, Percent_Identity=36.1111111111111, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 17435; Mature: 17304

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFIKVGAVLFASLLVGMANASNGNKNNNNKTENKMTVTELTQEDFVKKVYDFETNPNAW
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
KFEGDKPAVIDFYATWCGPCKMMSPILDEISKEYEGKINVYKVNVDKEADLASVFGIRSI
EECCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHC
PSLLFVPMKKEPSMVQGAMPKNELKKLVDDILLESK
CHHEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GFIKVGAVLFASLLVGMANASNGNKNNNNKTENKMTVTELTQEDFVKKVYDFETNPNAW
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
KFEGDKPAVIDFYATWCGPCKMMSPILDEISKEYEGKINVYKVNVDKEADLASVFGIRSI
EECCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHC
PSLLFVPMKKEPSMVQGAMPKNELKKLVDDILLESK
CHHEEECCCCCCCHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]