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The map label for this gene is hpt [H]

Identifier: 150008513

GI number: 150008513

Start: 2254787

End: 2255392

Strand: Reverse

Name: hpt [H]

Synonym: BDI_1899

Alternate gene names: 150008513

Gene position: 2255392-2254787 (Counterclockwise)

Preceding gene: 150008519

Following gene: 150008512

Centisome position: 46.88

GC content: 45.54

Gene sequence:

>606_bases
ATGTTGCTACACTTTTTTGTGCATCGCCGAAAAAGTTGTACATTTGTCCCCTCGAAAACCGAAAGATTTATGGACAGAAT
TCGTCTAAAAGACAAAGAATTTGAACTGTTTATTCCGGAGTCGGATATTCAGGCGGCTATCGCTAAAATGGCCGTTCAGA
TTAAAGCGGATGTGGAAGGGAAAAATCCTCTATTCGTGGGTGTGCTAAACGGGGCTTTTATGTTTGTCGCCGAGCTGATG
CGTGAGCTGGATGTTCCGTATGAGCTGACATTCGCTCGTTATTCCTCGTATCAAGGAACTTCCAGTACGGGCATATTGAA
TGAGATCATGCCGGTGCAGGCTGATATTCGCGGACGTATGGTGATCTTATTGGAGGATATTATCGATACGGGCTTTACGA
TGAGCTACGTGATGGAGAAGCTTCGGAGCGAGGGTGCCGCCGATGTAAGATTGGCAACGATGCTTTTCAAGCCGGAATCC
TTGAAATGCGAGTTGACTCCGGATTATGTAGGCTTACAGATACCCGCTGATTTTATCGTGGGACATGGTTTGGATTATGA
TGAGTTGGGCCGCTCATATAAGGATATCTACAAGGTTGTGGAATAA

Upstream 100 bases:

>100_bases
ATTGGTCGAGCTCCTTTACCTTGTCTGTAGCGAATATCTTAATCATAATTCTAGATGTCTGGGGTTTTATTCTGCTTACA
AATGTATAACAAACTTTGGT

Downstream 100 bases:

>100_bases
AATAGTATACATTATATATAATAAAGGAACAATAGTATGTTGAACGTGGTTATTTTTGGTGCTCCCGGTTCAGGTAAGGG
AACACAAAGTGAGTTGATTA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MLLHFFVHRRKSCTFVPSKTERFMDRIRLKDKEFELFIPESDIQAAIAKMAVQIKADVEGKNPLFVGVLNGAFMFVAELM
RELDVPYELTFARYSSYQGTSSTGILNEIMPVQADIRGRMVILLEDIIDTGFTMSYVMEKLRSEGAADVRLATMLFKPES
LKCELTPDYVGLQIPADFIVGHGLDYDELGRSYKDIYKVVE

Sequences:

>Translated_201_residues
MLLHFFVHRRKSCTFVPSKTERFMDRIRLKDKEFELFIPESDIQAAIAKMAVQIKADVEGKNPLFVGVLNGAFMFVAELM
RELDVPYELTFARYSSYQGTSSTGILNEIMPVQADIRGRMVILLEDIIDTGFTMSYVMEKLRSEGAADVRLATMLFKPES
LKCELTPDYVGLQIPADFIVGHGLDYDELGRSYKDIYKVVE
>Mature_201_residues
MLLHFFVHRRKSCTFVPSKTERFMDRIRLKDKEFELFIPESDIQAAIAKMAVQIKADVEGKNPLFVGVLNGAFMFVAELM
RELDVPYELTFARYSSYQGTSSTGILNEIMPVQADIRGRMVILLEDIIDTGFTMSYVMEKLRSEGAADVRLATMLFKPES
LKCELTPDYVGLQIPADFIVGHGLDYDELGRSYKDIYKVVE

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=179, Percent_Identity=30.7262569832402, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI9910262, Length=179, Percent_Identity=28.4916201117318, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=37.8698224852071, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17510817, Length=162, Percent_Identity=30.2469135802469, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 22926; Mature: 22926

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLHFFVHRRKSCTFVPSKTERFMDRIRLKDKEFELFIPESDIQAAIAKMAVQIKADVEG
CEEEEEECCCCCCEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHEEECCCC
KNPLFVGVLNGAFMFVAELMRELDVPYELTFARYSSYQGTSSTGILNEIMPVQADIRGRM
CCCEEEEEHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCHHHHHCCCCCCCCCCE
VILLEDIIDTGFTMSYVMEKLRSEGAADVRLATMLFKPESLKCELTPDYVGLQIPADFIV
EEEEHHHHCCCCCHHHHHHHHHCCCCCCEEEEHEEECCCCCEEEECCCEEEEEECHHHHE
GHGLDYDELGRSYKDIYKVVE
ECCCCHHHHCHHHHHHHHHCC
>Mature Secondary Structure
MLLHFFVHRRKSCTFVPSKTERFMDRIRLKDKEFELFIPESDIQAAIAKMAVQIKADVEG
CEEEEEECCCCCCEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHEEECCCC
KNPLFVGVLNGAFMFVAELMRELDVPYELTFARYSSYQGTSSTGILNEIMPVQADIRGRM
CCCEEEEEHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCHHHHHCCCCCCCCCCE
VILLEDIIDTGFTMSYVMEKLRSEGAADVRLATMLFKPESLKCELTPDYVGLQIPADFIV
EEEEHHHHCCCCCHHHHHHHHHCCCCCCEEEEHEEECCCCCEEEECCCEEEEEECHHHHE
GHGLDYDELGRSYKDIYKVVE
ECCCCHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]