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The map label for this gene is lon

Identifier: 150008488

GI number: 150008488

Start: 2227643

End: 2230114

Strand: Reverse

Name: lon

Synonym: BDI_1874

Alternate gene names: 150008488

Gene position: 2230114-2227643 (Counterclockwise)

Preceding gene: 150008490

Following gene: 150008482

Centisome position: 46.35

GC content: 45.67

Gene sequence:

>2472_bases
ATGAATGTATATATGAAAGAAAAGACGAGAGTATTTTGCCAGAATTCGTTTGATGACTTGGATGACAATATTGGTATCGT
AATGCCAATTCTTACAGAATGCGATGTAGATGAGGATTTCACAGAAGGAATAGAGAAAGTTGGAGACACTATACCCATTC
TTCCGTTAAGGAATATGGTACTCTTTCCGGGTGTTGCCTTGCCGGTGATTATCGGGCGTCCTAAATCGATGCGCCTGATT
AAAGAGGCTGTACATAAAAAGAGTTTGATCGGAGTTGTTTGCCAGAAAGAGATGGGTACGGAAGATCCTATCTTAGAGGA
TTTATATACAACCGGGGTAATCGCTGACATCGTTCGTGTCTTAGAGATGCCGGACGGTAGTACTACTGTTATTCTTCAAG
GTAAGAAACGCTTTGAATTGAATGAGTTGACCGAGACAGATCCGTATCTTTCCGGTAAGATCACCGTGTTGGAGGACACG
AAGCCGGACAAGACAGACCGCGAGTTCGAGGCTTTGATCTCAACGATCAAGGATTTGACCATCAAGATGCTTGGGGCCGT
GGCTGAACCTCCCCGGGATTTGATCTTCTCGATCAAGAATAATAAGAATGTCTTGTATGTGGTCAATTTCTCTTGTAGCA
ATATACCGAGTGGATCGGCCGAGAAACAGCAATTGTTATTGATCGGGGACTTAAAAGAGCGTGCGTATCGGTTACTTTTT
ATCTTGAACCGCGAGTATCAGCTGGTGGAGTTGAAAGCTTCCATCCAGATGAAGACACATGAGGATATCAATCAACAACA
AAAAGAATATTTCCTTCAACAGCAAATCAAGACGATTCAAGAGGAATTGGGCGGGAATATCAATGAGTTGGAGATAAAAG
AATTACGGGAGAAAGCCAGTCGTAAGAAATGGCCTGCCGAGGTAGCGCAGGTCTTTGAGAAGGAATTGCGAAAATTGGAA
CGATTGCATCCGCAATCTCCGGATTATTCCGTACAGACGCAATATGTCCAGAATATCGTTAACTTGCCGTGGAACGAGTA
TAGTAAGGACAATTTCAACTTATCTCATGCCCAGAAGGTCTTAGATCGTGATCATTATGGTTTGGAGAAGGTGAAAGAGC
GTATTATCGAGCATCTGGCGGTATTGAAGCTGAAAGGGGATATGAAATCTCCGATTATCTGTTTGTACGGTCCTCCGGGA
GTCGGCAAGACTTCATTGGGGCGTTCCATCGCAGAGGCTTTGCGCCGCAAATATGTACGTGTTTCTTTAGGTGGATTGCA
CGATGAGGCCGAGATCCGCGGACATCGTCGTACCTATATCGGCGCTATGTGCGGACGTATCATCCAGAATATACAGAAGG
CGGGAACATCGAACCCTGTCTTTATCTTAGATGAGATCGATAAGATCACGAATGATTTCAAGGGGGATCCGGCATCCGCT
TTATTGGAGGTCTTGGACCCGGAGCAGAATAATGCGTTTCACGATAATTATCTGGATATCGATTACGATTTAAGCAAGGT
GATGTTTATCGCTACCGCTAATAATTTGAATACGATTTCCCAGCCATTGCTGGATCGTATGGAACTGATCGAGGTGAGCG
GTTATATCATGGAGGAGAAGGTAGAGATCGCAGCGAAGCATCTCGTGCCTAAGCAGATGGATGTACACGGCTTGAAGAAA
GGTTCCGTGAAATTCCCCAAGAAAACCTTACAAGTGATCGTTGAAGCCTATACACGCGAGAGCGGTGTCCGGGAATTGGA
TAAGAAAATCGCCAAAATCATGCGTAAGCTAGCCCGTAAGGTCGCTAGCGACGAGCCTATCCCGACGAGCATTAAGCCGG
AGGATTTGTATGAATATCTAGGGGCGGTCGAATATTCCCGCGATAAATATCAAGGGAATGACTATGCCGGCGTGGTTACG
GGATTAGCTTGGACGGCTGTTGGTGGTGAGATTCTTTTCGTGGAGTCGAGCTTAAGTAAAGGTAAGGGGTCAAAGCTTAC
TTTGACCGGGAATCTGGGAGATGTGATGAAAGAGTCTGCCATGTTGGCACTTGAGTATATCCATGCGCATGCGGCTCAGT
TTAATATCAACGAGGAGTTGTTCGAGAACTGGAATGTGCATGTCCACGTACCGGAGGGGGCGATCCCGAAAGACGGACCG
AGTGCCGGAATAACGATGGTGACTTCTCTTGTCTCCGCCTTTACTCAGCGTAAGGTGAAAAAGAACTTGGCTATGACAGG
CGAGATCACGTTGCGTGGCAAAGTGCTTCCCGTGGGAGGTATCAAAGAGAAGATCTTGGCGGCTAAACGTGCCGGGATTA
AGGAATTGATTCTTTGCAAGGAGAATGAGAAGGATATCAATGAGATTAAACCGGAGTATTTGAAAGGCTTGGTGTTCCAT
TATGTGAGTGACATTCAACAGGTGGTGGATCTGGCGTTGCTGAGAGAAAAGGTGGATAATCCATTGTTTTAA

Upstream 100 bases:

>100_bases
AGGATTTGCCATATCTCTATCGATTGTATGCCGCGAAATTAGTAAGAATTGAATGAAAAGCTGTAACTTTGGCACGTTTA
TTGTATTAACATATACAATG

Downstream 100 bases:

>100_bases
TAACGACTTTTTATGCATATATTGGTGTGGGCTTATACGTATATACGTGTAGGCCCATATTAATATCGGCGTAAGCCTAT
ACGTATATACGTGTGGGCCT

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 823; Mature: 823

Protein sequence:

>823_residues
MNVYMKEKTRVFCQNSFDDLDDNIGIVMPILTECDVDEDFTEGIEKVGDTIPILPLRNMVLFPGVALPVIIGRPKSMRLI
KEAVHKKSLIGVVCQKEMGTEDPILEDLYTTGVIADIVRVLEMPDGSTTVILQGKKRFELNELTETDPYLSGKITVLEDT
KPDKTDREFEALISTIKDLTIKMLGAVAEPPRDLIFSIKNNKNVLYVVNFSCSNIPSGSAEKQQLLLIGDLKERAYRLLF
ILNREYQLVELKASIQMKTHEDINQQQKEYFLQQQIKTIQEELGGNINELEIKELREKASRKKWPAEVAQVFEKELRKLE
RLHPQSPDYSVQTQYVQNIVNLPWNEYSKDNFNLSHAQKVLDRDHYGLEKVKERIIEHLAVLKLKGDMKSPIICLYGPPG
VGKTSLGRSIAEALRRKYVRVSLGGLHDEAEIRGHRRTYIGAMCGRIIQNIQKAGTSNPVFILDEIDKITNDFKGDPASA
LLEVLDPEQNNAFHDNYLDIDYDLSKVMFIATANNLNTISQPLLDRMELIEVSGYIMEEKVEIAAKHLVPKQMDVHGLKK
GSVKFPKKTLQVIVEAYTRESGVRELDKKIAKIMRKLARKVASDEPIPTSIKPEDLYEYLGAVEYSRDKYQGNDYAGVVT
GLAWTAVGGEILFVESSLSKGKGSKLTLTGNLGDVMKESAMLALEYIHAHAAQFNINEELFENWNVHVHVPEGAIPKDGP
SAGITMVTSLVSAFTQRKVKKNLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKELILCKENEKDINEIKPEYLKGLVFH
YVSDIQQVVDLALLREKVDNPLF

Sequences:

>Translated_823_residues
MNVYMKEKTRVFCQNSFDDLDDNIGIVMPILTECDVDEDFTEGIEKVGDTIPILPLRNMVLFPGVALPVIIGRPKSMRLI
KEAVHKKSLIGVVCQKEMGTEDPILEDLYTTGVIADIVRVLEMPDGSTTVILQGKKRFELNELTETDPYLSGKITVLEDT
KPDKTDREFEALISTIKDLTIKMLGAVAEPPRDLIFSIKNNKNVLYVVNFSCSNIPSGSAEKQQLLLIGDLKERAYRLLF
ILNREYQLVELKASIQMKTHEDINQQQKEYFLQQQIKTIQEELGGNINELEIKELREKASRKKWPAEVAQVFEKELRKLE
RLHPQSPDYSVQTQYVQNIVNLPWNEYSKDNFNLSHAQKVLDRDHYGLEKVKERIIEHLAVLKLKGDMKSPIICLYGPPG
VGKTSLGRSIAEALRRKYVRVSLGGLHDEAEIRGHRRTYIGAMCGRIIQNIQKAGTSNPVFILDEIDKITNDFKGDPASA
LLEVLDPEQNNAFHDNYLDIDYDLSKVMFIATANNLNTISQPLLDRMELIEVSGYIMEEKVEIAAKHLVPKQMDVHGLKK
GSVKFPKKTLQVIVEAYTRESGVRELDKKIAKIMRKLARKVASDEPIPTSIKPEDLYEYLGAVEYSRDKYQGNDYAGVVT
GLAWTAVGGEILFVESSLSKGKGSKLTLTGNLGDVMKESAMLALEYIHAHAAQFNINEELFENWNVHVHVPEGAIPKDGP
SAGITMVTSLVSAFTQRKVKKNLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKELILCKENEKDINEIKPEYLKGLVFH
YVSDIQQVVDLALLREKVDNPLF
>Mature_823_residues
MNVYMKEKTRVFCQNSFDDLDDNIGIVMPILTECDVDEDFTEGIEKVGDTIPILPLRNMVLFPGVALPVIIGRPKSMRLI
KEAVHKKSLIGVVCQKEMGTEDPILEDLYTTGVIADIVRVLEMPDGSTTVILQGKKRFELNELTETDPYLSGKITVLEDT
KPDKTDREFEALISTIKDLTIKMLGAVAEPPRDLIFSIKNNKNVLYVVNFSCSNIPSGSAEKQQLLLIGDLKERAYRLLF
ILNREYQLVELKASIQMKTHEDINQQQKEYFLQQQIKTIQEELGGNINELEIKELREKASRKKWPAEVAQVFEKELRKLE
RLHPQSPDYSVQTQYVQNIVNLPWNEYSKDNFNLSHAQKVLDRDHYGLEKVKERIIEHLAVLKLKGDMKSPIICLYGPPG
VGKTSLGRSIAEALRRKYVRVSLGGLHDEAEIRGHRRTYIGAMCGRIIQNIQKAGTSNPVFILDEIDKITNDFKGDPASA
LLEVLDPEQNNAFHDNYLDIDYDLSKVMFIATANNLNTISQPLLDRMELIEVSGYIMEEKVEIAAKHLVPKQMDVHGLKK
GSVKFPKKTLQVIVEAYTRESGVRELDKKIAKIMRKLARKVASDEPIPTSIKPEDLYEYLGAVEYSRDKYQGNDYAGVVT
GLAWTAVGGEILFVESSLSKGKGSKLTLTGNLGDVMKESAMLALEYIHAHAAQFNINEELFENWNVHVHVPEGAIPKDGP
SAGITMVTSLVSAFTQRKVKKNLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKELILCKENEKDINEIKPEYLKGLVFH
YVSDIQQVVDLALLREKVDNPLF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=44.4976076555024, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI31377667, Length=843, Percent_Identity=37.3665480427046, Blast_Score=516, Evalue=1e-146,
Organism=Escherichia coli, GI1786643, Length=768, Percent_Identity=44.6614583333333, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=697, Percent_Identity=38.7374461979914, Blast_Score=470, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17556486, Length=520, Percent_Identity=40.9615384615385, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=664, Percent_Identity=40.8132530120482, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24666867, Length=623, Percent_Identity=43.8202247191011, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=623, Percent_Identity=43.8202247191011, Blast_Score=515, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_PARD8 (A6LD45)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001303231.1
- ProteinModelPortal:   A6LD45
- STRING:   A6LD45
- GeneID:   5307024
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_1874
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   GAMCGRI
- BioCyc:   PDIS435591:BDI_1874-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 92727; Mature: 92727

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 721-721 ACT_SITE 764-764

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYMKEKTRVFCQNSFDDLDDNIGIVMPILTECDVDEDFTEGIEKVGDTIPILPLRNMV
CCCEECCHHHHHHCCCCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHCCCCCCHHCCCHH
LFPGVALPVIIGRPKSMRLIKEAVHKKSLIGVVCQKEMGTEDPILEDLYTTGVIADIVRV
HCCCCHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LEMPDGSTTVILQGKKRFELNELTETDPYLSGKITVLEDTKPDKTDREFEALISTIKDLT
HHCCCCCEEEEEECCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
IKMLGAVAEPPRDLIFSIKNNKNVLYVVNFSCSNIPSGSAEKQQLLLIGDLKERAYRLLF
HHHHHHHCCCCHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHE
ILNREYQLVELKASIQMKTHEDINQQQKEYFLQQQIKTIQEELGGNINELEIKELREKAS
EECCCEEEEEEEHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RKKWPAEVAQVFEKELRKLERLHPQSPDYSVQTQYVQNIVNLPWNEYSKDNFNLSHAQKV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LDRDHYGLEKVKERIIEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGRSIAEALRRKYVR
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VSLGGLHDEAEIRGHRRTYIGAMCGRIIQNIQKAGTSNPVFILDEIDKITNDFKGDPASA
HEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHCCCCCHHHH
LLEVLDPEQNNAFHDNYLDIDYDLSKVMFIATANNLNTISQPLLDRMELIEVSGYIMEEK
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHH
VEIAAKHLVPKQMDVHGLKKGSVKFPKKTLQVIVEAYTRESGVRELDKKIAKIMRKLARK
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASDEPIPTSIKPEDLYEYLGAVEYSRDKYQGNDYAGVVTGLAWTAVGGEILFVESSLSK
HCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCC
GKGSKLTLTGNLGDVMKESAMLALEYIHAHAAQFNINEELFENWNVHVHVPEGAIPKDGP
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCCCCCC
SAGITMVTSLVSAFTQRKVKKNLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKELILCK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCHHHHHHHHHHCCHHHEEEEC
ENEKDINEIKPEYLKGLVFHYVSDIQQVVDLALLREKVDNPLF
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNVYMKEKTRVFCQNSFDDLDDNIGIVMPILTECDVDEDFTEGIEKVGDTIPILPLRNMV
CCCEECCHHHHHHCCCCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHCCCCCCHHCCCHH
LFPGVALPVIIGRPKSMRLIKEAVHKKSLIGVVCQKEMGTEDPILEDLYTTGVIADIVRV
HCCCCHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LEMPDGSTTVILQGKKRFELNELTETDPYLSGKITVLEDTKPDKTDREFEALISTIKDLT
HHCCCCCEEEEEECCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
IKMLGAVAEPPRDLIFSIKNNKNVLYVVNFSCSNIPSGSAEKQQLLLIGDLKERAYRLLF
HHHHHHHCCCCHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHE
ILNREYQLVELKASIQMKTHEDINQQQKEYFLQQQIKTIQEELGGNINELEIKELREKAS
EECCCEEEEEEEHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RKKWPAEVAQVFEKELRKLERLHPQSPDYSVQTQYVQNIVNLPWNEYSKDNFNLSHAQKV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LDRDHYGLEKVKERIIEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGRSIAEALRRKYVR
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
VSLGGLHDEAEIRGHRRTYIGAMCGRIIQNIQKAGTSNPVFILDEIDKITNDFKGDPASA
HEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHCCCCCHHHH
LLEVLDPEQNNAFHDNYLDIDYDLSKVMFIATANNLNTISQPLLDRMELIEVSGYIMEEK
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHH
VEIAAKHLVPKQMDVHGLKKGSVKFPKKTLQVIVEAYTRESGVRELDKKIAKIMRKLARK
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASDEPIPTSIKPEDLYEYLGAVEYSRDKYQGNDYAGVVTGLAWTAVGGEILFVESSLSK
HCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCC
GKGSKLTLTGNLGDVMKESAMLALEYIHAHAAQFNINEELFENWNVHVHVPEGAIPKDGP
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCCCCCC
SAGITMVTSLVSAFTQRKVKKNLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKELILCK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCHHHHHHHHHHCCHHHEEEEC
ENEKDINEIKPEYLKGLVFHYVSDIQQVVDLALLREKVDNPLF
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA