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The map label for this gene is guaA2 [H]

Identifier: 150008446

GI number: 150008446

Start: 2178959

End: 2180266

Strand: Reverse

Name: guaA2 [H]

Synonym: BDI_1828

Alternate gene names: 150008446

Gene position: 2180266-2178959 (Counterclockwise)

Preceding gene: 150008447

Following gene: 150008438

Centisome position: 45.31

GC content: 47.02

Gene sequence:

>1308_bases
ATGAAGCAAGATATGATTGTTATCTTGGATTTAGGTAGTCATGAGAATACGGTGTTGGCTCGTGCTATTCGTGCGTTAGG
CGTTTATAGTGAGATTTATCCGCATGACATCACGGTTGAGGAATTAAAAGCCTTGCCAAACGTGAAAGGTATCATTATCA
ATGGTGGCCCAAACAATGTTATCGACGGTGTAGCTATCGACGTGAATCCGGGTATTTACGAGATGGGCACTCCTGTAATG
GCCGCAGGTCATGATAAGGCGTTGTGCGAGGTTAAATTACCGGAGTTTACGGATGATGTCGAGGCGATCAAGGGCGCTGT
CAAGTCTTTCGTGTTCGATACTTGCAAGGCTGAGGCAAACTGGAATATGACGAATTTTGTCAATGACCAGATTGAATTGG
TAAAGCGTCAGGTAGGGGATAAGAAAGTTCTGCTGGCCTTGTCTGGAGGTGTCGATAGCTCTGTAGTAGCCGCTTTACTT
TTGAAAGCGATCGGCGATAAATTGGTTTGCGTGCATGTGAACCATGGTTTGATGCGTAAGGGCGAGTCCGAGGATGTCGT
TGAGGTCTTCAAGAACCAGTTGAATGCCAATTTGGTGTATGTAGACGCTACCGATCGTTTCTTGAATAAGCTAGCTGACG
TGGAAGATCCGGAGCAAAAGCGTAAGATTATCGGTGGTGAGTTTATCCGTGTATTTGAGGAAGAAGCTCGCAAATTAGAT
GGAATCGATTTCTTGGCTCAAGGAACGATCTATCCGGATATCGTGGAGAGTGGAACGAAGACGGCTAAGATGGTGAAATC
CCATCATAACGTAGGCGGTCTGCCGGAAGATTTGCAATTTGAGTTGGTTGAGCCTTTGCGTCAATTATTCAAGGACGAGG
TTCGTGCTTGTGGCGTAGAGTTAGGTTTGCCTTATGATATGGTTTATCGCCAGCCGTTCCCCGGACCTGGTTTAGGCGTA
CGTTGCTTGGGCGCTATCACTCGTGACAGACTGGAAGCGGTACGTGAGTCGGATGCGATCTTACGGGAGGAGTTCAAGAA
CGCCGGATTGGATAAAAAGGTATGGCAATACTTTACGGTAGTACCCGACTTTAAGTCGGTTGGCGTACGTGATAACGCCC
GTTCTTTCGAATGGCCCGTGATTATCCGTGCCGTCAATACGGTAGATGCCATGACCGCTACGATCGAACCGGTTGATTGG
CCTATCTTGATGAAGATTACGGATCGTATTTTGAAAGAGGTGAAGAACGTGAACCGTGTATGCTACGATATGTCTCCGAA
ACCGAATGCGACAATTGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
CGTGTACGACATCAGCTCGAAGCCGCCTGCAACCATCGAGTGGGAGTGACATTTGTCTTAGGTATAACAAAGTGTAAAAT
CAATAAAATTTAAAAGTCAC

Downstream 100 bases:

>100_bases
TTAGGCTTACTTATTAAACAGATATAAAAAGGCCCGGTGATTTATCTGAATCCCGGGCTTTTTATTTATATACGATAGAT
TCGAAGAACTATTTTAGTTC

Product: putative GMP synthase

Products: NA

Alternate protein names: GMP synthetase 2; Glutamine amidotransferase 2 [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGPNNVIDGVAIDVNPGIYEMGTPVM
AAGHDKALCEVKLPEFTDDVEAIKGAVKSFVFDTCKAEANWNMTNFVNDQIELVKRQVGDKKVLLALSGGVDSSVVAALL
LKAIGDKLVCVHVNHGLMRKGESEDVVEVFKNQLNANLVYVDATDRFLNKLADVEDPEQKRKIIGGEFIRVFEEEARKLD
GIDFLAQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVELGLPYDMVYRQPFPGPGLGV
RCLGAITRDRLEAVRESDAILREEFKNAGLDKKVWQYFTVVPDFKSVGVRDNARSFEWPVIIRAVNTVDAMTATIEPVDW
PILMKITDRILKEVKNVNRVCYDMSPKPNATIEWE

Sequences:

>Translated_435_residues
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGPNNVIDGVAIDVNPGIYEMGTPVM
AAGHDKALCEVKLPEFTDDVEAIKGAVKSFVFDTCKAEANWNMTNFVNDQIELVKRQVGDKKVLLALSGGVDSSVVAALL
LKAIGDKLVCVHVNHGLMRKGESEDVVEVFKNQLNANLVYVDATDRFLNKLADVEDPEQKRKIIGGEFIRVFEEEARKLD
GIDFLAQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVELGLPYDMVYRQPFPGPGLGV
RCLGAITRDRLEAVRESDAILREEFKNAGLDKKVWQYFTVVPDFKSVGVRDNARSFEWPVIIRAVNTVDAMTATIEPVDW
PILMKITDRILKEVKNVNRVCYDMSPKPNATIEWE
>Mature_435_residues
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGPNNVIDGVAIDVNPGIYEMGTPVM
AAGHDKALCEVKLPEFTDDVEAIKGAVKSFVFDTCKAEANWNMTNFVNDQIELVKRQVGDKKVLLALSGGVDSSVVAALL
LKAIGDKLVCVHVNHGLMRKGESEDVVEVFKNQLNANLVYVDATDRFLNKLADVEDPEQKRKIIGGEFIRVFEEEARKLD
GIDFLAQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVELGLPYDMVYRQPFPGPGLGV
RCLGAITRDRLEAVRESDAILREEFKNAGLDKKVWQYFTVVPDFKSVGVRDNARSFEWPVIIRAVNTVDAMTATIEPVDW
PILMKITDRILKEVKNVNRVCYDMSPKPNATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=375, Percent_Identity=31.7333333333333, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1788854, Length=345, Percent_Identity=51.0144927536232, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI133901714, Length=386, Percent_Identity=32.1243523316062, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71992717, Length=402, Percent_Identity=31.592039800995, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71992710, Length=402, Percent_Identity=31.592039800995, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323873, Length=350, Percent_Identity=45.4285714285714, Blast_Score=311, Evalue=1e-85,
Organism=Drosophila melanogaster, GI281365319, Length=371, Percent_Identity=32.6145552560647, Blast_Score=162, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 48388; Mature: 48388

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGPNNV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCCCCC
IDGVAIDVNPGIYEMGTPVMAAGHDKALCEVKLPEFTDDVEAIKGAVKSFVFDTCKAEAN
CCCEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
WNMTNFVNDQIELVKRQVGDKKVLLALSGGVDSSVVAALLLKAIGDKLVCVHVNHGLMRK
CCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHCC
GESEDVVEVFKNQLNANLVYVDATDRFLNKLADVEDPEQKRKIIGGEFIRVFEEEARKLD
CCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GIDFLAQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVE
CCHHEECCCCCHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LGLPYDMVYRQPFPGPGLGVRCLGAITRDRLEAVRESDAILREEFKNAGLDKKVWQYFTV
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPDFKSVGVRDNARSFEWPVIIRAVNTVDAMTATIEPVDWPILMKITDRILKEVKNVNRV
CCCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
CYDMSPKPNATIEWE
EECCCCCCCCEEECC
>Mature Secondary Structure
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGPNNV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCCCCC
IDGVAIDVNPGIYEMGTPVMAAGHDKALCEVKLPEFTDDVEAIKGAVKSFVFDTCKAEAN
CCCEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
WNMTNFVNDQIELVKRQVGDKKVLLALSGGVDSSVVAALLLKAIGDKLVCVHVNHGLMRK
CCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHCC
GESEDVVEVFKNQLNANLVYVDATDRFLNKLADVEDPEQKRKIIGGEFIRVFEEEARKLD
CCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GIDFLAQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLQFELVEPLRQLFKDEVRACGVE
CCHHEECCCCCHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LGLPYDMVYRQPFPGPGLGVRCLGAITRDRLEAVRESDAILREEFKNAGLDKKVWQYFTV
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPDFKSVGVRDNARSFEWPVIIRAVNTVDAMTATIEPVDWPILMKITDRILKEVKNVNRV
CCCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
CYDMSPKPNATIEWE
EECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]