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The map label for this gene is ppiA [C]

Identifier: 150008377

GI number: 150008377

Start: 2077260

End: 2078069

Strand: Direct

Name: ppiA [C]

Synonym: BDI_1751

Alternate gene names: 150008377

Gene position: 2077260-2078069 (Clockwise)

Preceding gene: 150008373

Following gene: 150008383

Centisome position: 43.17

GC content: 50.37

Gene sequence:

>810_bases
ATGAAAAAGATATATTACATTTTATCAGCATTGTTCCTTTGCGTGGTAGCCACCTCGGCGCAAGAAGCTGGAAAAACGGT
AGTTATTAAAACCAATGTAGGTACTATGAAGGCCATCCTGTACGATGATGTGCCTAATCACACCCGTACTTTCATCGAAC
GGGCAAAACGGGGGGATTTCAACGGGACCTTATTCACCCGTGTCCTGCCGGAGTTTATGATCCAAGGAGGAGCCCCGGAT
TCCAAGAACGCTCCCGCCGGTGCTAAATGCGGCTTTGGAGATCCTTCCGCCGAGATACCGCCCGAGATCAACGAGAAATA
TTTCCATAAGAAAGGAGCCTTGGCCGCTCCCCGCCAACCGGACGATATCAACCCGCAAAAGAAATCGGATATGTCGCAAT
TCTTTATCGTGCAGGGGAAGGTCTATAGGGAAACCGAACTGGATACGTTAGAGCGTACCGCCAACTATCCGGCCCGGCAA
AAGGCCCTGAAGGAGTTTTATGCGCCGGTACGTGCGGAGCTGAATATGATAAAGATGAGTAACAAACGGGAGTACCAGAA
GCGATTGAGAGCGATCAACGCCCAGATAGACTCCGTTATTCAAGCAACTCCCGGGCATTTGCTATTTACGGACGAGCAAC
GGAAGGCTTATACCACCGTAGGCGGTTGCCATCATCTGGACGGCACCTATACGATCTTCGGGGAGCTGACGGAGGGATTC
GACGTTTTGGATCAGATCGCCACCCAGCCAAAAGACCAGAATGACCGTCCGAAGAAAGACATCCGCATCCAAAGTATAAC
GATCGAATAA

Upstream 100 bases:

>100_bases
CTTTAAAAATCTTATTACCTATTAATAAAGACGCGAAGTTAGGCATTTACTTTGTGTTTTACAACATAACACCTATATTT
ACCTTTTAAATTAAAATCTC

Downstream 100 bases:

>100_bases
TTCACCACTCCTATGTTAAAGAGAGATTTCATCATGGTACAGATCGAGGAACTGGGCAAAGTGATCGCCCAGATCATCTT
CAATCGTAATTCCAACGATG

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: Peptidylproline (omega=0) [C]

Alternate protein names: Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase Cyclophilin-Type; Peptidyl-Prolyl Cis-Trans Isomerase Cyclophilin; Peptidylprolyl Isomerase; Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase; PeptidyL-Prolyl Cis-Trans Isomerase Cyclophilin Type; Peptidylprolyl Isomerase A

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKKIYYILSALFLCVVATSAQEAGKTVVIKTNVGTMKAILYDDVPNHTRTFIERAKRGDFNGTLFTRVLPEFMIQGGAPD
SKNAPAGAKCGFGDPSAEIPPEINEKYFHKKGALAAPRQPDDINPQKKSDMSQFFIVQGKVYRETELDTLERTANYPARQ
KALKEFYAPVRAELNMIKMSNKREYQKRLRAINAQIDSVIQATPGHLLFTDEQRKAYTTVGGCHHLDGTYTIFGELTEGF
DVLDQIATQPKDQNDRPKKDIRIQSITIE

Sequences:

>Translated_269_residues
MKKIYYILSALFLCVVATSAQEAGKTVVIKTNVGTMKAILYDDVPNHTRTFIERAKRGDFNGTLFTRVLPEFMIQGGAPD
SKNAPAGAKCGFGDPSAEIPPEINEKYFHKKGALAAPRQPDDINPQKKSDMSQFFIVQGKVYRETELDTLERTANYPARQ
KALKEFYAPVRAELNMIKMSNKREYQKRLRAINAQIDSVIQATPGHLLFTDEQRKAYTTVGGCHHLDGTYTIFGELTEGF
DVLDQIATQPKDQNDRPKKDIRIQSITIE
>Mature_269_residues
MKKIYYILSALFLCVVATSAQEAGKTVVIKTNVGTMKAILYDDVPNHTRTFIERAKRGDFNGTLFTRVLPEFMIQGGAPD
SKNAPAGAKCGFGDPSAEIPPEINEKYFHKKGALAAPRQPDDINPQKKSDMSQFFIVQGKVYRETELDTLERTANYPARQ
KALKEFYAPVRAELNMIKMSNKREYQKRLRAINAQIDSVIQATPGHLLFTDEQRKAYTTVGGCHHLDGTYTIFGELTEGF
DVLDQIATQPKDQNDRPKKDIRIQSITIE

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 30250; Mature: 30250

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIYYILSALFLCVVATSAQEAGKTVVIKTNVGTMKAILYDDVPNHTRTFIERAKRGDF
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHCCCCCCHHHHHHHHHHCCCC
NGTLFTRVLPEFMIQGGAPDSKNAPAGAKCGFGDPSAEIPPEINEKYFHKKGALAAPRQP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
DDINPQKKSDMSQFFIVQGKVYRETELDTLERTANYPARQKALKEFYAPVRAELNMIKMS
CCCCCHHHHCHHHEEEECCEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
NKREYQKRLRAINAQIDSVIQATPGHLLFTDEQRKAYTTVGGCHHLDGTYTIFGELTEGF
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCEEECCCCEEEEECHHHHH
DVLDQIATQPKDQNDRPKKDIRIQSITIE
HHHHHHHCCCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure
MKKIYYILSALFLCVVATSAQEAGKTVVIKTNVGTMKAILYDDVPNHTRTFIERAKRGDF
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEHHHCCCCCCHHHHHHHHHHCCCC
NGTLFTRVLPEFMIQGGAPDSKNAPAGAKCGFGDPSAEIPPEINEKYFHKKGALAAPRQP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
DDINPQKKSDMSQFFIVQGKVYRETELDTLERTANYPARQKALKEFYAPVRAELNMIKMS
CCCCCHHHHCHHHEEEECCEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
NKREYQKRLRAINAQIDSVIQATPGHLLFTDEQRKAYTTVGGCHHLDGTYTIFGELTEGF
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCEEECCCCEEEEECHHHHH
DVLDQIATQPKDQNDRPKKDIRIQSITIE
HHHHHHHCCCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA