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The map label for this gene is aslA [H]

Identifier: 150008306

GI number: 150008306

Start: 1980912

End: 1982342

Strand: Reverse

Name: aslA [H]

Synonym: BDI_1675

Alternate gene names: 150008306

Gene position: 1982342-1980912 (Counterclockwise)

Preceding gene: 150008307

Following gene: 150008305

Centisome position: 41.2

GC content: 47.59

Gene sequence:

>1431_bases
ATGAAGAATAAACTAATGTTACTGACGGCCGCCTCAGCTTTTTCAATGGCAGGCATAGCCGCTGATTACACGAATATCGT
CCTAATCAATTTGGATGATGTGGGTTACGGAGATTTTTCTTTTAATGGAGCTTACGGATATACCACTCCGAATATCGATA
AGATGGCGGCGGAAGGCGTTCGTTTTACGCACTTTTTGGTAGGACAGCCGATCAGTGGAGCCTCTCGTGCCGGCTTGTTG
ACCGGCTGCTATCCGAATCGTATCGGTTTTTCCGGCGCTCCGGGGCCAGATTCGAACTACGGTGTCCATCCAGAGGAGAT
GACGATCGCAGAGGTATTGAAACAGAAAGGATATAGTACCGCTATCTTCGGTAAATGGCATTTAGGTAGCCAAAAGGAGT
TCCTCCCCTTGCAAAATGGCTTCGATGAGTATTATGGGTTGCCGTATTCTAACGATATGTGGCCATTCCACCCGCAACAA
GGTGAGGTCTTTAATTTCCCGGATTTGCCGACTTATGACGGAAATGAGATTATCGGTTATAATACGGACCAAACACGGTT
GACTACGGATTATACCACCCGTTCTGTTAATTTCATCAAGAAGAATAAGAATAAGCCTTTCTTCTTGTATCTGGCCCATA
ATATGCCCCATGTACCGTTGGCCGTTTCCGATAAATTCAAGGGAAAGAGCGAGCAGGGTTTATATGGCGACGTGATGATG
GAGATCGACTGGAGTGTAGGTGAGATATTCAAGGCATTGCGTGAGCTGGGCTTGGAAGATAATACGTTGGTGATCTTGAC
TTCCGATAATGGCCCTTGGACCAATTACGGGAATCATGCCGGTTCAGCCGGTGGGTTACGTGAGGCAAAGGCTACGACCT
TTGATGGTGGTAACCGGGTTCCTTGTATCATGTACTGGAAAGGTAAGACGTTACCGGGCACGACTTGTAATAAGTTAGCT
TCTAATATCGACCTTCTTCCTACGTTCGCCGAGATCACGCAGGCTCCGCTTCCTCCTCGCAAGATTGACGGAGTAAGTAT
CTTGCCGTTGATCGAGGGTAAAAAAGACGCCAACCCACGTGAGTCTTTCGTCTATTACTATCGAAAGAATGACTTGGAGG
CTGTTACGGATGGAATGTTCAAATTGGTATTCCCCCATAAATACGTTACTTATGGGGCTTATGAGCCGGGAAACGACGGC
CAGCCGGGTAAGTTGACGAATCTGGAGATCATGAAGCCGGAGATGTACGACCTGCGCCGTGATCCGGGAGAGCGTTATAA
CGTGATTACCCAATATCCGGAGGAAGCCGCTAAATTGATGAAGATCGCGGACCAGAAACGCCATGAGTTAGGGGATGACT
TGACTCGTATGAAGGGTACGGAACGTAGGGAACCGGGTTTAGTACAAGGGAAAAAACGTCATGACTTATGA

Upstream 100 bases:

>100_bases
TCCGAACTGGGATTAATTCTTGGGTAAATTAAAAACTGTTATCTTTGAAGTGCCAAACACAGGATGGCACTTCAAAGCCA
ATATTTCAATAAATAATATC

Downstream 100 bases:

>100_bases
AACAATCGATCATTAGTATCGGAATGACTGCCTGTTGCCTTTCGGGAAACGGGCAGTCTCTCTTTGCCGCCAATAAACCG
GCGCAAGAGGAACGTCCCAA

Product: arylsulfatase A

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKNKLMLLTAASAFSMAGIAADYTNIVLINLDDVGYGDFSFNGAYGYTTPNIDKMAAEGVRFTHFLVGQPISGASRAGLL
TGCYPNRIGFSGAPGPDSNYGVHPEEMTIAEVLKQKGYSTAIFGKWHLGSQKEFLPLQNGFDEYYGLPYSNDMWPFHPQQ
GEVFNFPDLPTYDGNEIIGYNTDQTRLTTDYTTRSVNFIKKNKNKPFFLYLAHNMPHVPLAVSDKFKGKSEQGLYGDVMM
EIDWSVGEIFKALRELGLEDNTLVILTSDNGPWTNYGNHAGSAGGLREAKATTFDGGNRVPCIMYWKGKTLPGTTCNKLA
SNIDLLPTFAEITQAPLPPRKIDGVSILPLIEGKKDANPRESFVYYYRKNDLEAVTDGMFKLVFPHKYVTYGAYEPGNDG
QPGKLTNLEIMKPEMYDLRRDPGERYNVITQYPEEAAKLMKIADQKRHELGDDLTRMKGTERREPGLVQGKKRHDL

Sequences:

>Translated_476_residues
MKNKLMLLTAASAFSMAGIAADYTNIVLINLDDVGYGDFSFNGAYGYTTPNIDKMAAEGVRFTHFLVGQPISGASRAGLL
TGCYPNRIGFSGAPGPDSNYGVHPEEMTIAEVLKQKGYSTAIFGKWHLGSQKEFLPLQNGFDEYYGLPYSNDMWPFHPQQ
GEVFNFPDLPTYDGNEIIGYNTDQTRLTTDYTTRSVNFIKKNKNKPFFLYLAHNMPHVPLAVSDKFKGKSEQGLYGDVMM
EIDWSVGEIFKALRELGLEDNTLVILTSDNGPWTNYGNHAGSAGGLREAKATTFDGGNRVPCIMYWKGKTLPGTTCNKLA
SNIDLLPTFAEITQAPLPPRKIDGVSILPLIEGKKDANPRESFVYYYRKNDLEAVTDGMFKLVFPHKYVTYGAYEPGNDG
QPGKLTNLEIMKPEMYDLRRDPGERYNVITQYPEEAAKLMKIADQKRHELGDDLTRMKGTERREPGLVQGKKRHDL
>Mature_476_residues
MKNKLMLLTAASAFSMAGIAADYTNIVLINLDDVGYGDFSFNGAYGYTTPNIDKMAAEGVRFTHFLVGQPISGASRAGLL
TGCYPNRIGFSGAPGPDSNYGVHPEEMTIAEVLKQKGYSTAIFGKWHLGSQKEFLPLQNGFDEYYGLPYSNDMWPFHPQQ
GEVFNFPDLPTYDGNEIIGYNTDQTRLTTDYTTRSVNFIKKNKNKPFFLYLAHNMPHVPLAVSDKFKGKSEQGLYGDVMM
EIDWSVGEIFKALRELGLEDNTLVILTSDNGPWTNYGNHAGSAGGLREAKATTFDGGNRVPCIMYWKGKTLPGTTCNKLA
SNIDLLPTFAEITQAPLPPRKIDGVSILPLIEGKKDANPRESFVYYYRKNDLEAVTDGMFKLVFPHKYVTYGAYEPGNDG
QPGKLTNLEIMKPEMYDLRRDPGERYNVITQYPEEAAKLMKIADQKRHELGDDLTRMKGTERREPGLVQGKKRHDL

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=431, Percent_Identity=38.0510440835267, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI146229329, Length=431, Percent_Identity=38.0510440835267, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI6005990, Length=431, Percent_Identity=38.0510440835267, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI146229324, Length=431, Percent_Identity=38.0510440835267, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI4503899, Length=479, Percent_Identity=34.6555323590814, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI45430057, Length=437, Percent_Identity=34.0961098398169, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI146229327, Length=359, Percent_Identity=35.6545961002786, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI71852584, Length=485, Percent_Identity=28.0412371134021, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI53831991, Length=305, Percent_Identity=32.4590163934426, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI109389362, Length=461, Percent_Identity=27.114967462039, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI59797060, Length=462, Percent_Identity=27.7056277056277, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI38569405, Length=468, Percent_Identity=27.1367521367521, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI71852586, Length=302, Percent_Identity=29.8013245033113, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI38569407, Length=324, Percent_Identity=30.8641975308642, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI157266309, Length=158, Percent_Identity=37.3417721518987, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI31742482, Length=269, Percent_Identity=30.4832713754647, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI58743319, Length=266, Percent_Identity=30.4511278195489, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1790233, Length=444, Percent_Identity=30.8558558558559, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI87081924, Length=403, Percent_Identity=28.7841191066998, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI115533416, Length=462, Percent_Identity=24.8917748917749, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI115533418, Length=455, Percent_Identity=24.8351648351648, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17559078, Length=235, Percent_Identity=32.3404255319149, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI281366397, Length=368, Percent_Identity=31.25, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281366395, Length=368, Percent_Identity=31.25, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24666163, Length=368, Percent_Identity=31.25, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24666175, Length=463, Percent_Identity=27.8617710583153, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24666109, Length=383, Percent_Identity=29.242819843342, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281363223, Length=505, Percent_Identity=27.7227722772277, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 53183; Mature: 53183

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLMLLTAASAFSMAGIAADYTNIVLINLDDVGYGDFSFNGAYGYTTPNIDKMAAEGV
CCCCEEEEEECCHHHHHHEEECCCEEEEEEECCCCCCCEECCCCCCCCCCCHHHHHHCCC
RFTHFLVGQPISGASRAGLLTGCYPNRIGFSGAPGPDSNYGVHPEEMTIAEVLKQKGYST
EEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
AIFGKWHLGSQKEFLPLQNGFDEYYGLPYSNDMWPFHPQQGEVFNFPDLPTYDGNEIIGY
EEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEE
NTDQTRLTTDYTTRSVNFIKKNKNKPFFLYLAHNMPHVPLAVSDKFKGKSEQGLYGDVMM
CCCCCEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCEEEEEE
EIDWSVGEIFKALRELGLEDNTLVILTSDNGPWTNYGNHAGSAGGLREAKATTFDGGNRV
EECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
PCIMYWKGKTLPGTTCNKLASNIDLLPTFAEITQAPLPPRKIDGVSILPLIEGKKDANPR
EEEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCC
ESFVYYYRKNDLEAVTDGMFKLVFPHKYVTYGAYEPGNDGQPGKLTNLEIMKPEMYDLRR
HHEEEEEECCCHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCEECCEEEECCHHHHHHC
DPGERYNVITQYPEEAAKLMKIADQKRHELGDDLTRMKGTERREPGLVQGKKRHDL
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MKNKLMLLTAASAFSMAGIAADYTNIVLINLDDVGYGDFSFNGAYGYTTPNIDKMAAEGV
CCCCEEEEEECCHHHHHHEEECCCEEEEEEECCCCCCCEECCCCCCCCCCCHHHHHHCCC
RFTHFLVGQPISGASRAGLLTGCYPNRIGFSGAPGPDSNYGVHPEEMTIAEVLKQKGYST
EEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
AIFGKWHLGSQKEFLPLQNGFDEYYGLPYSNDMWPFHPQQGEVFNFPDLPTYDGNEIIGY
EEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEE
NTDQTRLTTDYTTRSVNFIKKNKNKPFFLYLAHNMPHVPLAVSDKFKGKSEQGLYGDVMM
CCCCCEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCEEEEEE
EIDWSVGEIFKALRELGLEDNTLVILTSDNGPWTNYGNHAGSAGGLREAKATTFDGGNRV
EECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
PCIMYWKGKTLPGTTCNKLASNIDLLPTFAEITQAPLPPRKIDGVSILPLIEGKKDANPR
EEEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCC
ESFVYYYRKNDLEAVTDGMFKLVFPHKYVTYGAYEPGNDGQPGKLTNLEIMKPEMYDLRR
HHEEEEEECCCHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCEECCEEEECCHHHHHHC
DPGERYNVITQYPEEAAKLMKIADQKRHELGDDLTRMKGTERREPGLVQGKKRHDL
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]